CN104721964A - Method and device for stimulating anterior thalamic nucleus by blue light - Google Patents
Method and device for stimulating anterior thalamic nucleus by blue light Download PDFInfo
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- CN104721964A CN104721964A CN201310699854.9A CN201310699854A CN104721964A CN 104721964 A CN104721964 A CN 104721964A CN 201310699854 A CN201310699854 A CN 201310699854A CN 104721964 A CN104721964 A CN 104721964A
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Abstract
The embodiment of the invention discloses a method of stimulating anterior thalamic nucleus by blue light. The method comprises steps: the surface of a human body is irradiated by red light and infrared light alternatively, and reflecting light signals of the red light and reflecting light signals of the infrared light absorbed by human body tissue are acquired respectively; according to the acquired reflecting light signals of the red light and the acquired reflecting light signals of the infrared light, blood oxygen saturation is calculated, and oxygen partial pressure is calculated according to the obtained blood oxygen saturation; and according to the obtained oxygen partial pressure, blue light of a corresponding frequency is transmitted to stimulate GABA nitrergic nerve fiber of the anterior thalamic nucleus. The embodiment of the invention also discloses a device for stimulating the anterior thalamic nucleus by the blue light. By adopting the method and the device of the invention, the nerve fiber can generate excitement through blue light stimulation, diaphragmatic fatigue does not happened, and the respiratory condition can be more accurately and efficiently regulated and controlled.
Description
Technical field
The present invention relates to a kind of electronic applications, particularly relate to method and device that a kind of blue light stimulates nucleus anterior thalami.
Background technology
Breathing is a kind of rhythmic movement, and present stage research thinks that respiratory rhythm is the generation by respiratory center respiratory nerve cell mass, participates in adjustment and the improvement of respiratory rhythm, jointly realizes the normal breathing movements of body.Due to organ injury after one's own heart lung failure, trachea blocking, pneumothorax, brain hypertension to multiple possible causes such as carbon dioxide sensitivity reductions, respiratory rhythm is damaged, occur shallow and breathe soon, cross dark slow breathing, asphyxia, Cheyne-Stokes respiration, the Sighing respiration etc. crossed, the serious consequence such as respiratory acidosis, alkalosis, respiratory arrest can be caused dead.Wherein, drug effect reaction is slow, and can not prevent in advance to breathe with real-time monitoring; Some physical means such as respirator etc. temporarily can only improve breath state, and portability is poor; Although widely used diaphragm pacing has the function of Real-Time Monitoring and regulation and control, respiratory center is overexcited the respiratory acidosis causing short of breath to cause, and also has Sighing respiration not within the scope of the effect of diaphragm pacemaker.In addition, continue to stimulate phrenic nerves to cause diaphragmatic fatigue, respiratory ventilation amount reduces, and respiratory ventilation still can be caused not enough, unsatisfactory for improving breath state.
Summary of the invention
Embodiment of the present invention technical problem to be solved is, a kind of method providing blue light to stimulate nucleus anterior thalami and device.Can be stimulated by blue light makes nerve fiber produce excitement to regulate breathing state, and can not cause diaphragmatic fatigue, regulation and control breathing state is more accurate effectively.
In order to solve the problems of the technologies described above, embodiments provide a kind of method that blue light stimulates nucleus anterior thalami, comprising:
Alternately irradiate human body surface by HONGGUANG and infrared light and obtain the reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light respectively;
Calculate blood oxygen saturation according to the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light, the described blood oxygen saturation according to calculating calculates partial pressure of oxygen;
According to the described partial pressure of oxygen calculated, the blue light launching respective frequencies stimulates the GABA energy nerve fiber of nucleus anterior thalami.
Wherein, the reflected light signal of the described HONGGUANG that described basis gets and the reflected light signal of described infrared light calculate blood oxygen saturation and comprise: the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light are carried out filter amplifying processing, and converts the voltage signal of HONGGUANG and the voltage signal of infrared light to; The voltage signal of the described HONGGUANG be converted to and the voltage signal of described infrared light are converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light; The digital voltage signal of described HONGGUANG obtained according to conversion and the digital voltage signal of described infrared light calculate described blood oxygen saturation.
Wherein, described unlatching blue light stimulates the GABA of nucleus anterior thalami can comprise before nerve fiber: the gene C hR2 of photaesthesia ionophorous protein is expelled to nucleus anterior thalami, makes to express photaesthesia ionophorous protein in nerve fiber at the GABA of described nucleus anterior thalami.
Wherein, the described partial pressure of oxygen that described basis calculates, the blue light launching respective frequencies stimulates the GABA of nucleus anterior thalami nerve fiber to comprise: if the described partial pressure of oxygen calculated exceedes pre-set threshold value, then the blue light launching 20HZ frequency stimulates the GABA energy nerve fiber of described nucleus anterior thalami.
Wherein, if the described partial pressure of oxygen calculated described exceedes pre-set threshold value, the blue light then launching 20HZ frequency stimulates the GABA of described nucleus anterior thalami also can comprise before nerve fiber: sample to partial pressure of oxygen, and the oxygen tension meter got according to sampling calculates the average of described partial pressure of oxygen, standard deviation or variance; Described pre-set threshold value is set according to the average calculated, standard deviation or variance.
Correspondingly, the embodiment of the present invention additionally provides the device that a kind of blue light stimulates nucleus anterior thalami, comprising:
Reflected light acquisition module, obtains the reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light respectively for alternately irradiating human body surface by HONGGUANG and infrared light;
Partial pressure of oxygen computing module, for calculating blood oxygen saturation according to the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light, the described blood oxygen saturation according to calculating calculates partial pressure of oxygen;
Blue emission module, for according to the described partial pressure of oxygen calculated, launches the GABA energy nerve fiber of the blue light stimulation nucleus anterior thalami of respective frequencies.
Wherein, described partial pressure of oxygen computing module comprises: reflected light processing unit, for the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light are carried out filter amplifying processing, and convert the voltage signal of HONGGUANG and the voltage signal of infrared light to; Voltage signal processing unit, for being converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light by the voltage signal of the described HONGGUANG be converted to and the voltage signal of described infrared light; Saturation computation unit, for according to transforming the digital voltage signal of described HONGGUANG that obtains and the digital voltage signal of described infrared light calculates described blood oxygen saturation.
Wherein, described device also comprises: gene injection module, for the gene C hR2 of photaesthesia ionophorous protein is expelled to nucleus anterior thalami, makes to express photaesthesia ionophorous protein in nerve fiber at the GABA of described nucleus anterior thalami.
Wherein, described blue emission module comprises: judge transmitter unit, if exceed pre-set threshold value for the described partial pressure of oxygen calculated, then the blue light launching 20HZ frequency stimulates the GABA energy nerve fiber of described nucleus anterior thalami.
Wherein, described blue emission module also comprises: sampling computing unit, for sampling to partial pressure of oxygen, calculates the average of partial pressure of oxygen, standard deviation or variance according to the oxygen tension meter that gets of sampling; Threshold value setting unit, for setting described pre-set threshold value according to the average, standard deviation or the variance that calculate.
Implement the embodiment of the present invention, there is following beneficial effect: alternately irradiate human body surface by HONGGUANG and infrared light and obtain the reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light respectively, and calculate blood oxygen saturation according to the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light, if calculate according to blood oxygen saturation the partial pressure of oxygen obtained to exceed pre-set threshold value, then the blue light launching respective frequencies stimulates the GABA energy nerve fiber of nucleus anterior thalami.Stimulate the GABA of nucleus anterior thalami nerve fiber can not cause diaphragmatic fatigue by blue light, regulation and control breathing state is more accurate effectively.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the method flow diagram of the blue light stimulation nucleus anterior thalami that the embodiment of the present invention provides;
Fig. 2 is the structural representation stimulating the device of nucleus anterior thalami for blue light that the embodiment of the present invention provides;
Fig. 3 is the structural representation of partial pressure of oxygen computing module in embodiment of the present invention device;
Fig. 4 is the structural representation of blue emission module in embodiment of the present invention device.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Fig. 1 is the method flow diagram of the blue light stimulation nucleus anterior thalami that the embodiment of the present invention provides, embodiments provide one and detect partial pressure of oxygen in real time, and launch according to the partial pressure of oxygen detected the method that corresponding blue light stimulates nucleus anterior thalami, described blue light stimulates the method for nucleus anterior thalami to comprise as shown in the figure:
Step S110, alternately irradiates human body surface by HONGGUANG and infrared light and obtains the reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light respectively.In specific implementation, when light is by tissue and blood vessel, non-tremulous pulse composition (as skin, muscle, skeleton, venous blood etc.) absorbing light signal is constant, obtains DC component DC after photelectric receiver; Tremulous pulse composition (as the arterial blood) absorption to optical signal does cyclically-varying along with pulse is beaten, after photelectric receiver, obtain AC compounent AC.Hemoglobin in blood has different absorbances to Red and blue light, and described hemoglobin comprises HbO2 Oxyhemoglobin HbO
2with reduced hemoglobin Hb, HbO2 Oxyhemoglobin HbO
2less to 660nm red light absorption amount, more to 940nm infrared Absorption amount; Reduced hemoglobin Hb is then more to 660nm red light absorption amount, less to 940nm infrared Absorption amount.Therefore alternate emission HONGGUANG and infrared light, reflected light direct current signal and the AC signal of HONGGUANG can be obtained, reflected light direct current signal and the AC signal of infrared light can be obtained simultaneously, and because hemoglobin is different to the absorbance of Red and blue light, so the AC compounent of the described HONGGUANG acquired is the reflected light after being mainly reduced Hb H b absorption, the AC compounent of the described infrared light acquired is mainly by HbO2 Oxyhemoglobin HbO
2reflected light after absorption.
Step S120, calculate blood oxygen saturation according to the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light, the described blood oxygen saturation according to calculating calculates partial pressure of oxygen.Before calculating blood oxygen saturation, need to process the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light.In specific implementation, first by optical-electrical converter, the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light are converted into the current signal of HONGGUANG and the current signal of infrared light, then this current signal is converted to the voltage signal of HONGGUANG and the voltage signal of infrared light by current/voltage conversion circuit, and filtration processing and amplifying is carried out to the voltage signal of described HONGGUANG and the voltage signal of infrared light, finally by A/D convertor circuit, the voltage signal of the voltage signal of described HONGGUANG and described infrared light is converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light, be treated to DC component and the AC compounent of HONGGUANG and infrared light by alternating current-direct current split circuit simultaneously.The digital voltage signal of described HONGGUANG comprises DC component Vrdc and the AC signal Vrac of HONGGUANG, and the digital voltage signal of described infrared light comprises DC component Virdc and the AC signal Virac of infrared light.
The digital voltage signal of described HONGGUANG obtained according to conversion and the digital voltage signal of described infrared light calculate described blood oxygen saturation.In specific implementation, light intensity absorbance in tissue of HONGGUANG can be expressed as the ratio of AC signal Vrac and DC component Vrdc, light intensity absorbance in tissue of infrared light can be expressed as the ratio of AC signal Virac and DC component Virdc, according to HONGGUANG and infrared light, absorbance in tissue can calculate the light absorption ratio R of hemoglobin to HONGGUANG and infrared light, and described light absorption ratio R can be expressed as: R=(Vrac/Vrdc)/(Virac/Virdc).
Just the percentage ratio of two kinds of content of hemoglobin can be calculated according to described light absorption ratio R.The computing formula of blood oxygen saturation is as follows:
Sp0
2=A-BR+CR
2, in (2 represent R square) formula, A, B, C are scaling constant, can be obtained by scaling experiment.
After calculating blood oxygen saturation, the partial pressure of oxygen of current brain can be calculated according to oxygen dissociation curve or partial pressure of oxygen and oxygen saturation curve, the reflection of described oxygen dissociation curve be relation between blood oxygen saturation and partial pressure of oxygen, axis of ordinates is blood oxygen saturation, axis of abscissas is partial pressure of oxygen, can obtain partial pressure of oxygen by the corresponding relation of the blood oxygen saturation in oxygen dissociation curve and partial pressure of oxygen.
Step S130, according to the described partial pressure of oxygen calculated, the blue light launching respective frequencies stimulates the GABA energy nerve fiber of nucleus anterior thalami.Before launching the GABA energy nerve fiber of blue light stimulation nucleus anterior thalami, need the gene C hR2 of photaesthesia ionophorous protein to be expelled to nucleus anterior thalami, make to express photaesthesia ionophorous protein in nerve fiber at the GABA of described nucleus anterior thalami.In specific implementation, if the described partial pressure of oxygen that step S120 calculates exceeds pre-set threshold value, then the blue light launching 20HZ frequency stimulates the GABA energy nerve fiber of described nucleus anterior thalami.Stimulated in the process of nucleus anterior thalami by blue light, need to open HONGGUANG and Infrared irradiation human body surface to detect the blood oxygen saturation of brain in real time simultaneously, when detecting that the blood oxygen saturation of brain returns to normal condition, then stop launching the GABA energy nerve fiber that blue light stimulates nucleus anterior thalami.Wherein, HONGGUANG and infrared light irradiate human body surface with the tranmitting frequency of 200HZ, and blue light is the GABA energy nerve fiber stimulating nucleus anterior thalami with 20HZ tranmitting frequency.
Wherein, step S130 also comprises and sampling to partial pressure of oxygen, and the oxygen tension meter got according to sampling calculates the average of partial pressure of oxygen, standard deviation or variance, sets described pre-set threshold value according to the average calculated, standard deviation or variance.Partial pressure of oxygen normal range is 95 ~ 100mmHg, but this value can reduce with advancing age.Regional differences is large simultaneously, and different regions range of normal value is different, and the current conventional range of normal value 80 ~ 100mmHg in most domestic area, highlands is lower, is generally 60 ~ 80mmHg.Blood oxygen saturation general less than 94% regards as anaerobic condition, clinically with 90% for boundary judges.In order to the difference for different people physical condition, when setting pre-set threshold value, need to carry out real-time sampling to partial pressure of oxygen, carry out statistical analysis afterwards, calculating the statistical parameters such as the average of partial pressure of oxygen, standard deviation or variance, according to the predetermined threshold value of parameter setting partial pressure of oxygen, is pre-set threshold value as set 3 times of standard deviations, when detecting that described partial pressure of oxygen exceedes this pre-set threshold value, be namely in abnormal state depending on this partial pressure of oxygen.Especially, the embodiment of the present invention can directly utilize blood oxygen saturation to carry out threshold values setting and feedback as parameter.
Optionally, the slow virus carrier of the nucleotide sequence of cell specific promoter and encoded light sensitive ion channel albumen is carried by direct injection, the gene C hR2 of photaesthesia ionophorous protein can be delivered to nucleus anterior thalami, its GABA at nucleus anterior thalami can be expressed in nerve fiber.ChR2 albumen is a kind of rhodopsin, originates from unicellular class chlorella Chlamydomonas reinhardtii.Research finds, ChR2 gene code photoactivation type ionophorous protein, when this albumen is subject to blue light stimulation, will open ion channel, makes cell potential depolarization excited, produces action potential.By biotechnology, can at this albumen of mammal histiocyte Membrane surface expression, when the blue light that the cell of expressing this protein gene is subject to 472nm wavelength stimulates, can make stream in born of the same parents' outer cationic and make cell depolarization, excitatory cells are active.And the light of this wavelength is on the not impact of other neuron normal function in brain, other side effect can not be brought.
Optionally, process digital voltage signal in the embodiment of the present invention, calculate blood oxygen saturation, control to launch the very little PIC10F series monolithic of volume that infrared light and HONGGUANG, blue light can adopt MICROCHIP to release, this single-chip microcomputer is equipped with the accurate built-in agitator of 4MHz, 33 instructions, two layer stacks, 25 milliamperes of I/O electric current I/O, low-power consumption standby current (100 receive peace), wide operating voltage range, 8 bit clock by 2 to 5.5V, monitors clock (Watchdog Timer).3 I/O pins with independent, direction controlling functions are had in this single-chip microcomputer, the open and close of wherein two I/O mouth control HONGGUANG and infrared light can be adopted, an I/O controls the open and close of blue light, also have an input pin, receive the digital voltage signal passing through HONGGUANG and the infrared light processed.Wherein, the regulation and control of light frequency adopt the accurate built-in agitator of 4MHz in single-chip microcomputer to carry out timing regulation and control.
Fig. 2 is the structural representation stimulating the device of nucleus anterior thalami for blue light that the embodiment of the present invention provides.The device of described photostimulation nucleus anterior thalami comprises: reflected light acquisition module 210, partial pressure of oxygen computing module 220 and blue emission module 230, wherein:
Reflected light acquisition module 210, obtains the reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light respectively for alternately irradiating human body surface by HONGGUANG and infrared light.Concrete, when light is by tissue and blood vessel, non-tremulous pulse composition (as skin, muscle, skeleton, venous blood etc.) absorbing light signal is constant, obtains DC component DC after photelectric receiver; Tremulous pulse composition (as the arterial blood) absorption to optical signal does cyclically-varying along with pulse is beaten, after photelectric receiver, obtain AC compounent AC.Hemoglobin in blood has different absorbances to Red and blue light, and described hemoglobin comprises HbO2 Oxyhemoglobin HbO
2with reduced hemoglobin Hb, HbO2 Oxyhemoglobin HbO
2less to 660nm red light absorption amount, more to 940nm infrared Absorption amount; Reduced hemoglobin Hb is then more to 660nm red light absorption amount, less to 940nm infrared Absorption amount.Therefore alternate emission HONGGUANG and infrared light, utilizing emitted light direct current signal and the AC signal of HONGGUANG can be obtained, utilizing emitted light direct current signal and the AC signal of infrared light can be obtained simultaneously, and because hemoglobin is different to the absorbance of Red and blue light, so the AC compounent of the described HONGGUANG acquired is the reflected light after being mainly reduced Hb H b absorption, the AC compounent of the described infrared light acquired is mainly by HbO2 Oxyhemoglobin HbO
2reflected light after absorption.
Partial pressure of oxygen computing module 220, the reflected light signal for the reflected light signal of described HONGGUANG that gets according to reflected light acquisition module 210 and described infrared light calculates blood oxygen saturation, and the described blood oxygen saturation according to calculating calculates partial pressure of oxygen.Before calculating blood oxygen saturation, need to process the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light.Described partial pressure of oxygen computing module 220 comprises: reflected light processing unit 321, voltage signal processing unit 322 and saturation computation unit 323, wherein:
Reflected light processing unit 321, carries out filter amplifying processing for the reflected light signal of described HONGGUANG that got by reflected light acquisition module 210 and the reflected light signal of described infrared light, and converts the voltage signal of HONGGUANG and the voltage signal of infrared light to.Concrete, first by optical-electrical converter, the reflected light signal of the reflected light signal of described HONGGUANG and described infrared light is converted into the current signal of HONGGUANG and the current signal of infrared light, then convert this current signal to the voltage signal of HONGGUANG and the voltage signal of infrared light by current/voltage conversion circuit, carry out filtration processing and amplifying finally by the voltage signal of filter amplification circuit to the voltage signal of described HONGGUANG and infrared light.
Voltage signal processing unit 322, is converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light for the voltage signal of described HONGGUANG that is converted to by reflected light processing unit 321 and the voltage signal of described infrared light.Concrete, by A/D convertor circuit, the voltage signal of the voltage signal of described HONGGUANG and described infrared light the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light be can be converted into, DC component and the AC compounent of HONGGUANG and infrared light are treated to simultaneously by alternating current-direct current split circuit.
Saturation computation unit 323, for transforming the digital voltage signal of described HONGGUANG that obtains and the digital voltage signal of described infrared light calculates described blood oxygen saturation according to voltage signal processing unit 322.The digital voltage signal of described HONGGUANG comprises DC component Vrdc and the AC signal Vrac of HONGGUANG, and the digital voltage signal of described infrared light comprises DC component Virdc and the AC signal Virac of infrared light.Concrete, light intensity absorbance in tissue of HONGGUANG can be expressed as the ratio of AC signal Vrac and DC component Vrdc, light intensity absorbance in tissue of infrared light can be expressed as the ratio of AC signal Virac and DC component Virdc, according to HONGGUANG and infrared light, absorbance in tissue can calculate the light absorption ratio R of hemoglobin to HONGGUANG and infrared light, and described light absorption ratio R can be expressed as:
R=(Vrac/Vrdc)/(Virac/Virdc)
Just the percentage ratio of two kinds of content of hemoglobin can be calculated according to described light absorption ratio R.The computing formula of blood oxygen saturation is as follows:
Sp0
2=A-BR+CR
2, in (2 represent R square) formula, A, B, C are scaling constant, can be obtained by scaling experiment.
After calculating blood oxygen saturation, the partial pressure of oxygen of current brain can be calculated according to oxygen dissociation curve or partial pressure of oxygen and oxygen saturation curve, the reflection of described oxygen dissociation curve be relation between blood oxygen saturation and partial pressure of oxygen, axis of ordinates is blood oxygen saturation, axis of abscissas is partial pressure of oxygen, can obtain partial pressure of oxygen by the corresponding relation of the blood oxygen saturation in oxygen dissociation curve and partial pressure of oxygen.
Blue emission module 230, for the described partial pressure of oxygen calculated according to partial pressure of oxygen computing module 220, the blue light launching respective frequencies stimulates the GABA energy nerve fiber of nucleus anterior thalami.Before launching the GABA energy nerve fiber of blue light stimulation nucleus anterior thalami, need the gene C hR2 of photaesthesia ionophorous protein to be expelled to nucleus anterior thalami, make to express photaesthesia ionophorous protein in nerve fiber at the GABA of described nucleus anterior thalami.Concrete, if the described partial pressure of oxygen that partial pressure of oxygen computing module 220 calculates exceeds pre-set threshold value, then the blue light launching 20HZ frequency stimulates the GABA energy nerve fiber of described nucleus anterior thalami.Stimulated in the process of nucleus anterior thalami by blue light, the while of needs, red-emitting and Infrared irradiation human body surface are to detect the blood oxygen saturation of brain in real time, when detecting that the blood oxygen saturation of brain returns to normal condition, then stop launching the GABA energy nerve fiber that blue light stimulates nucleus anterior thalami.Wherein, HONGGUANG and infrared light irradiate human body surface with the tranmitting frequency of 200HZ, and blue light is the GABA energy nerve fiber stimulating nucleus anterior thalami with 20HZ tranmitting frequency.
Described blue emission module 230 also comprises sampling computing unit 431 as shown in Figure 4 and threshold value setting unit 432, wherein:
Sampling computing unit 431, for sampling to partial pressure of oxygen, calculates the average of partial pressure of oxygen, standard deviation or variance according to the oxygen tension meter that gets of sampling.Concrete, partial pressure of oxygen normal range is 95 ~ 100mmHg, but this value can reduce with advancing age.Regional differences is large simultaneously, and different regions range of normal value is different, and the current conventional range of normal value 80 ~ 100mmHg in most domestic area, highlands is lower, is generally 60 ~ 80mmHg.Blood oxygen saturation general less than 94% regards as anaerobic condition, clinically with 90% for boundary judges.In order to the difference for different people physical condition, when setting pre-set threshold value, needing to carry out real-time sampling to partial pressure of oxygen, carrying out statistical analysis afterwards, calculate the statistical parameters such as the average of described partial pressure of oxygen, standard deviation or variance.
Threshold value setting unit 432, sets described pre-set threshold value for the average according to the described partial pressure of oxygen that calculates of sampling computing unit 431, standard deviation or variance.Such as setting 3 times of standard deviations is pre-set threshold value, when detecting that described partial pressure of oxygen exceedes this pre-set threshold value, is namely in abnormal state depending on this partial pressure of oxygen.
Optionally, the slow virus carrier of the nucleotide sequence of cell specific promoter and encoded light sensitive ion channel albumen is carried by direct injection, the gene C hR2 of photaesthesia ionophorous protein can be delivered to nucleus anterior thalami, its GABA at nucleus anterior thalami can be expressed in nerve fiber.ChR2 albumen is a kind of rhodopsin, originates from unicellular class chlorella Chlamydomonas reinhardtii.Research finds, ChR2 gene code photoactivation type ionophorous protein, when this albumen is subject to blue light stimulation, will open ion channel, makes cell potential depolarization excited, produces action potential.By biotechnology, can at this albumen of mammal histiocyte Membrane surface expression, when the blue light that the cell of expressing this protein gene is subject to 472nm wavelength stimulates, can make stream in born of the same parents' outer cationic and make cell depolarization, excitatory cells are active.And the light of this wavelength is on the not impact of other neuron normal function in brain, other side effect can not be brought.
Optionally, process digital voltage signal in the embodiment of the present invention, calculate blood oxygen saturation, control to launch the very little PIC10F series monolithic of volume that infrared light and HONGGUANG, blue light can adopt MICROCHIP to release, this single-chip microcomputer is equipped with the accurate built-in agitator of 4MHz, 33 instructions, two layer stacks, 25 milliamperes of I/O electric current I/O, low-power consumption standby current (100 receive peace), wide operating voltage range, 8 bit clock by 2 to 5.5V, monitors clock (Watchdog Timer).3 I/O pins with independent, direction controlling functions are had in this single-chip microcomputer, the open and close of wherein two I/O mouth control HONGGUANG and infrared light can be adopted, an I/O controls the open and close of blue light, also have an input pin, receive the digital voltage signal passing through HONGGUANG and the infrared light processed.Wherein, the regulation and control of light frequency adopt the accurate built-in agitator of 4MHz in single-chip microcomputer to carry out timing regulation and control.
Embodiments provide method and device that a kind of blue light stimulates nucleus anterior thalami, alternately irradiate human body surface by HONGGUANG and infrared light and obtain the reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light respectively, and calculate blood oxygen saturation according to the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light, if calculate according to blood oxygen saturation the partial pressure of oxygen obtained to exceed pre-set threshold value, then the blue light launching respective frequencies stimulates the GABA energy nerve fiber of nucleus anterior thalami.Stimulate the GABA of nucleus anterior thalami nerve fiber can not cause diaphragmatic fatigue by blue light, regulation and control breathing state is more accurate effectively.
One of ordinary skill in the art will appreciate that all or part of flow process realized in above-described embodiment method, that the hardware that can carry out instruction relevant by computer program has come, described program can be stored in a computer read/write memory medium, this program, when performing, can comprise the flow process of the embodiment as above-mentioned each side method.Wherein, described storage medium can be magnetic disc, CD, read-only store-memory body (Read-Only Memory, ROM) or random store-memory body (Random Access Memory, RAM) etc.
Above disclosedly be only present pre-ferred embodiments, certainly can not limit the interest field of the present invention with this, therefore according to the equivalent variations that the claims in the present invention are done, still belong to the scope that the present invention is contained.
Claims (10)
1. blue light stimulates a method for nucleus anterior thalami, and it is characterized in that, described method comprises:
Alternately irradiate human body surface by HONGGUANG and infrared light and obtain the reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light respectively;
Calculate blood oxygen saturation according to the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light, the described blood oxygen saturation according to calculating calculates partial pressure of oxygen;
According to the described partial pressure of oxygen calculated, the blue light launching respective frequencies stimulates the GABA energy nerve fiber of nucleus anterior thalami.
2. blue light as claimed in claim 1 stimulates the method for nucleus anterior thalami, it is characterized in that, the reflected light signal of the described HONGGUANG that described basis gets and the reflected light signal of described infrared light calculate blood oxygen saturation and comprise:
The reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light are carried out filter amplifying processing, and converts the voltage signal of HONGGUANG and the voltage signal of infrared light to;
The voltage signal of the described HONGGUANG be converted to and the voltage signal of described infrared light are converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light;
The digital voltage signal of described HONGGUANG obtained according to conversion and the digital voltage signal of described infrared light calculate described blood oxygen saturation.
3. blue light as claimed in claim 1 stimulates the method for nucleus anterior thalami, it is characterized in that, described transmitting blue light stimulates the GABA of nucleus anterior thalami can comprise before nerve fiber:
The gene C hR2 of photaesthesia ionophorous protein is expelled to nucleus anterior thalami, makes to express photaesthesia ionophorous protein in nerve fiber at the GABA of described nucleus anterior thalami.
4. blue light as claimed in claim 3 stimulates the method for nucleus anterior thalami, it is characterized in that, the described partial pressure of oxygen that described basis calculates, and the blue light launching respective frequencies stimulates the GABA of nucleus anterior thalami nerve fiber to comprise:
If the described partial pressure of oxygen calculated exceedes pre-set threshold value, then the blue light launching 20HZ frequency stimulates the GABA energy nerve fiber of described nucleus anterior thalami.
5. blue light as claimed in claim 4 stimulates the method for nucleus anterior thalami, and it is characterized in that, the described partial pressure of oxygen calculated if described exceedes pre-set threshold value, then the blue light launching 20HZ frequency stimulates the GABA of described nucleus anterior thalami also can comprise before nerve fiber:
Partial pressure of oxygen is sampled, calculates the average of described partial pressure of oxygen, standard deviation or variance according to the oxygen tension meter that gets of sampling;
Described pre-set threshold value is set according to the average calculated, standard deviation or variance.
6. blue light stimulates a device for nucleus anterior thalami, and it is characterized in that, described device comprises:
Reflected light acquisition module, obtains the reflected light signal of the HONGGUANG after being absorbed by tissue and the reflected light signal of infrared light respectively for alternately irradiating human body surface by HONGGUANG and infrared light;
Partial pressure of oxygen computing module, for calculating blood oxygen saturation according to the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light, the described blood oxygen saturation according to calculating calculates partial pressure of oxygen;
Blue emission module, for according to the described partial pressure of oxygen calculated, launches the GABA energy nerve fiber of the blue light stimulation nucleus anterior thalami of respective frequencies.
7. blue light as claimed in claim 6 stimulates the device of nucleus anterior thalami, and it is characterized in that, described partial pressure of oxygen computing module comprises:
Reflected light processing unit, for the reflected light signal of the described HONGGUANG got and the reflected light signal of described infrared light are carried out filter amplifying processing, and converts the voltage signal of HONGGUANG and the voltage signal of infrared light to;
Voltage signal processing unit, for being converted into the digital voltage signal of HONGGUANG and the digital voltage signal of infrared light by the voltage signal of the described HONGGUANG be converted to and the voltage signal of described infrared light;
Saturation computation unit, for according to transforming the digital voltage signal of described HONGGUANG that obtains and the digital voltage signal of described infrared light calculates described blood oxygen saturation.
8. blue light as claimed in claim 7 stimulates the device of nucleus anterior thalami, and it is characterized in that, described device also comprises:
Gene injection module, for the gene C hR2 of photaesthesia ionophorous protein is expelled to nucleus anterior thalami, makes to express photaesthesia ionophorous protein in nerve fiber at the GABA of described nucleus anterior thalami.
9. blue light as claimed in claim 8 stimulates the device of nucleus anterior thalami, and it is characterized in that, described blue emission module comprises:
Judge transmitter unit, if exceed pre-set threshold value for the described partial pressure of oxygen calculated, then the blue light launching 20HZ frequency stimulates the GABA energy nerve fiber of described nucleus anterior thalami.
10. blue light as claimed in claim 9 stimulates the device of nucleus anterior thalami, and it is characterized in that, described blue emission module also comprises:
Sampling computing unit, for sampling to partial pressure of oxygen, calculates the average of described partial pressure of oxygen, standard deviation or variance according to the oxygen tension meter that gets of sampling;
Threshold value setting unit, for setting described pre-set threshold value according to the average, standard deviation or the variance that calculate.
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| CN107582034A (en) * | 2017-10-16 | 2018-01-16 | 陕西特恩电子科技有限公司 | A kind of physiological parameter tester |
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