CN104814821A - Medicine carrying intravascular stent based on nano medicine carrier - Google Patents
Medicine carrying intravascular stent based on nano medicine carrier Download PDFInfo
- Publication number
- CN104814821A CN104814821A CN201510197857.1A CN201510197857A CN104814821A CN 104814821 A CN104814821 A CN 104814821A CN 201510197857 A CN201510197857 A CN 201510197857A CN 104814821 A CN104814821 A CN 104814821A
- Authority
- CN
- China
- Prior art keywords
- intravascular stent
- nano
- medicine carrying
- medicament carrier
- stent based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention provides a medicine carrying intravascular stent based on a nano medicine carrier. The intravascular stent is tubular and comprises a plurality of supporting units evenly distributed in the axial direction, and a connecting piece for connecting the plurality of supporting units; each supporting unit is coated with a layer of nano medicine carrier for carrying medicine. The intravascular stent is implanted to target at treating the lesion sites.
Description
Technical field
The present invention relates to a kind of medicine carrying intravascular stent based on nano-medicament carrier, belong to technical field of medical instruments
Background technology
1977 in the world first case percutaneous coronary intervene operation (PCI) complete in Switzerland, this example operation expands by the left anterior descending branch stenosis of sacculus to patient, and achieves successfully.But after balloon expandable, the restenosis rate of blood vessel is very high, more than 50%.Main cause is, after blood vessel is expanded and removed external force, blood vessel can elastical retraction.In the eighties in last century, invent and be widely used in intravascular stent coronarius, mainly contain the metallic blood vessel bracket that rustless steel, cochrome or Nitinol are made, after in these stent implant, a lasting mechanical support can be provided to blood vessel, avoid the elastical retraction of blood vessel, reduce the restenosis rate of lesion vessels.But because the Permanent implantation of support, support can cause neointimal hyperplasia as foreign body, and the restenosis ratio of blood vessel is also very high.Since 2003, the application of drug stent makes the restenosis rate of blood vessel drop to about 10%.But drug stent is still forever present in body, in mechanical property, very big-difference is there is as between the support of foreign body and vascular tissue, the chronic injury of blood vessel can be caused, later stage can cause media atrophy, neointimal hyperplasia, the final restenosis that also can cause blood vessel, thus limit the further reduction of vascular restenosis rate.For child patient, implant the increase gradually of the intravascular stent meeting line artery of fixed dimension, the needs of its growth promoter can not be adapted to.
Above-mentioned two kinds of interventional therapeutic techniques for angiostenosis have shortcoming: adopt balloon expandable blood vessel, although short run effect is better, because the elastical retraction of blood vessel, the restenosis rate in later stage is very high; At Ink vessel transfusing implanted metal support, comprise bare bracket and drug stent, narrow blood vessel can be expanded, and a lasting mechanical support is provided, but can blood vessel internal membrane damage be caused in metal rack process of expansion, bring out vascellum endometrial hyperplasia and cause restenosis.Metal rack also exists thrombosis, goes out blood coagulation complication, flexibility does not mate, metal object forever retains in body can increase the defects such as restenosis incidence rate at a specified future date.
Therefore, target administration impaired normal cell reparation is become to the focus of scholar's research
Summary of the invention
The present invention, in order to solve the above-mentioned defect and deficiency that exist in prior art, provides a kind of medicine carrying intravascular stent based on nano-medicament carrier, after implantable intravascular support, and can targeted therapy diseased region.
For solving the problems of the technologies described above, the invention provides a kind of medicine carrying intravascular stent based on nano-medicament carrier, described intravascular stent is tubulose, the connector comprise several support units equally distributed vertically, connecting support unit described in several, on described support unit, coated one deck is used for the nano-medicament carrier of medicine carrying.
Preferably, described pharmaceutical carrier is cerium oxide nanoparticles.
Preferably, the particle diameter of described cerium oxide nanoparticles is 6-12nm.
Preferably, described support unit comprise flexible support part and in be connected on rigid support member in described flexible support part, described flexible support part is oval, and described rigid support member is rhombus.
Preferably, the ratio of the long and short diameter of described flexible support part is 3:2.
Preferably, the material of described flexible support part is magnesium alloy.
Preferably, the material of described rigid support member is medical stainless steel or cochrome.
Preferably, described connector is straight line connecting rod.
Preferably, the length of described intravascular stent is 2-30cm.
The Advantageous Effects that the present invention reaches:
The present invention's coated one deck on support unit is used for the nano-medicament carrier of medicine carrying, and after implantation, nano-medicament carrier is owing to being nano level, very easily enter in cell through cell membrane, then by drug release out, directly to sick cell effect, the effect of target administration is played.In order to reach better therapeutic effect, nano-medicament carrier adopts cerium oxide nanoparticles, the size of granule is 6-12nm, cerium oxide nanoparticles due to size less, not only can enter cell by medicine carrying, and himself there is the effect of free radical in scavenger cell, the cell that makes to suffer a loss well is repaired.In addition, support unit of the present invention is made up of flexible support part and rigid support member, and be connected in rigid support member in flexible support part, in use, only have flexible support part to contact blood vessel wall, damage can not be caused to blood vessel wall, and simultaneously, rigid support member is used to provide mechanical support, the restenosis of anti-hemostatic tube, effectively reduces the restenosis rate of blood vessel; In order to better ensure that flexible support part does not cause damage to blood vessel wall, flexible support part is designed to ellipse, and adopts magnesium alloy material.In order to better ensure the mechanical property of rigid support member, rigid support member is designed to rhombus, and material adopts medical stainless steel or cochrome; Straight line connecting rod is adopted between support unit, make the radial support power that intravascular stent can keep higher after expansion, there is again axially zero shortening, be conducive to the positioning precision after improving intravascular stent implantation and further reduce the loss rate of support injection to blood vessel wall.
Accompanying drawing explanation
Fig. 1 structure of the present invention launches schematic diagram.
Detailed description of the invention
In order to the technique effect that auditor can better understand technical characteristic of the present invention, technology contents and reach, now accompanying drawing of the present invention is described in detail in conjunction with the embodiments.But shown accompanying drawing, just in order to technical scheme of the present invention is better described, is not actual proportions of the present invention and best allocation, so, ask auditor not with regard to ratio and the configuration of accompanying drawing, limit claims of the present invention.
Below in conjunction with drawings and Examples, patent of the present invention is further illustrated.
As shown in Figure 1, the invention provides a kind of medicine carrying intravascular stent based on nano-medicament carrier, described intravascular stent is tubulose, the connector 2 comprise several support units 1 equally distributed vertically, connecting support unit described in several 1, on described support unit 1, coated one deck is used for the nano-medicament carrier of medicine carrying.On support unit 1, coated one deck is used for the nano-medicament carrier of medicine carrying, and after implantation, nano-medicament carrier is owing to being nano level, very easily enter in cell through cell membrane, then by drug release out, directly to sick cell effect, the effect of target administration is played.
The medicine for the treatment of cardiovascular and cerebrovascular disease in the market often side effect is very large, that is, while sick cell obtains medical treatment, and the free radical that normal cell also can produce because of drug effect and sustaining damage.Therefore; the present invention is in order to address this problem; described pharmaceutical carrier adopts cerium oxide nanoparticles; particle diameter is 6-12nm; cerium oxide nanoparticles has the characteristic of scavenging free radicals, and has good biocompatibility, after medicine carrying enters cell; effectively can remove the free radical in normal cell, play protection or repair Normocellular effect.
Described support unit 1 comprise flexible support part with 11 and in be connected on rigid support member 12 in described flexible support part 11, described flexible support part 11 is oval, and described rigid support member 12 is rhombus.Support unit 1 of the present invention is made up of flexible support part 11 and rigid support member 12, and be connected in rigid support member 12 in flexible support part 11, after implantation, flexible support part 11 is only had to contact blood vessel wall, can not cause damage to blood vessel wall, and simultaneously, rigid support member 12 is used to provide mechanical support, the restenosis of anti-hemostatic tube, effectively reduces the restenosis rate of blood vessel; In order to better ensure that flexible support part 11 pairs of blood vessel wall do not cause damage, flexible support part 11 is designed to ellipse, and adopts magnesium alloy material.In order to better ensure the mechanical property of rigid support member 12, rigid support member 12 is designed to rhombus, and material adopts medical stainless steel or cochrome.
Described connector 2 is straight line connecting rod, straight line connecting rod is adopted between support unit 1, make the radial support power that intravascular stent can keep higher after expansion, there is again axially zero shortening, be conducive to the positioning precision after improving intravascular stent implantation and further reduce the loss rate of support injection to blood vessel wall.
Preferably, the ratio of the long and short diameter of described flexible support part 11 is 3:2.
Preferably, the length of described intravascular stent is 2-30cm.
Below disclose the present invention with preferably embodiment, so it is not intended to limiting the invention, allly takes equivalent replacement or technical scheme that the scheme of equivalent transformation obtains, all drops in protection scope of the present invention.
Claims (9)
1. the medicine carrying intravascular stent based on nano-medicament carrier, it is characterized in that: described intravascular stent is tubulose, the connector comprise several support units equally distributed vertically, connecting support unit described in several, on described support unit, coated one deck is used for the nano-medicament carrier of medicine carrying.
2. the medicine carrying intravascular stent based on nano-medicament carrier according to claim 1, is characterized in that: described pharmaceutical carrier is cerium oxide nanoparticles.
3. the medicine carrying intravascular stent based on nano-medicament carrier according to claim 2, is characterized in that: the particle diameter of described cerium oxide nanoparticles is 6-12nm.
4. the medicine carrying intravascular stent based on nano-medicament carrier according to claim 1, it is characterized in that: described support unit comprise flexible support part and in be connected on rigid support member in described flexible support part, described flexible support part is oval, and described rigid support member is rhombus.
5. the medicine carrying intravascular stent based on nano-medicament carrier according to claim 4, is characterized in that: the ratio of the long and short diameter of described flexible support part is 3:2.
6. the medicine carrying intravascular stent based on nano-medicament carrier according to claim 4, is characterized in that: the material of described flexible support part is magnesium alloy.
7. the medicine carrying intravascular stent based on nano-medicament carrier according to claim 4, is characterized in that: the material of described rigid support member is medical stainless steel or cochrome.
8. the medicine carrying intravascular stent based on nano-medicament carrier according to claim 1, is characterized in that: described connector is straight line connecting rod.
9. the medicine carrying intravascular stent based on nano-medicament carrier according to claim 1-8 any one, is characterized in that: the length of described intravascular stent is 2-30cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510197857.1A CN104814821A (en) | 2015-04-24 | 2015-04-24 | Medicine carrying intravascular stent based on nano medicine carrier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510197857.1A CN104814821A (en) | 2015-04-24 | 2015-04-24 | Medicine carrying intravascular stent based on nano medicine carrier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104814821A true CN104814821A (en) | 2015-08-05 |
Family
ID=53725480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510197857.1A Pending CN104814821A (en) | 2015-04-24 | 2015-04-24 | Medicine carrying intravascular stent based on nano medicine carrier |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104814821A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114887117A (en) * | 2022-04-09 | 2022-08-12 | 中国医科大学附属第一医院 | Drug-loaded nanoparticle and intravascular stent for reducing postoperative restenosis rate |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0795304A1 (en) * | 1996-03-10 | 1997-09-17 | Terumo Kabushiki Kaisha | Implanting stent |
| EP0873728A2 (en) * | 1997-04-25 | 1998-10-28 | W.C. Heraeus GmbH | Radial expandable support device (stent) II |
| US20060265048A1 (en) * | 2005-05-18 | 2006-11-23 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
| CN202740162U (en) * | 2012-02-27 | 2013-02-20 | 江苏省华星医疗器械实业有限公司 | Novel vessel rack |
| CN203089467U (en) * | 2013-02-18 | 2013-07-31 | 南阳医学高等专科学校第一附属医院 | Novel vascular scaffold |
| CN104127269A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Vascular stent |
| CN104127268A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Vascular stent firm in supporting |
| CN104127266A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Drug-loading vascular stent |
-
2015
- 2015-04-24 CN CN201510197857.1A patent/CN104814821A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0795304A1 (en) * | 1996-03-10 | 1997-09-17 | Terumo Kabushiki Kaisha | Implanting stent |
| EP0873728A2 (en) * | 1997-04-25 | 1998-10-28 | W.C. Heraeus GmbH | Radial expandable support device (stent) II |
| US20060265048A1 (en) * | 2005-05-18 | 2006-11-23 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
| US7291166B2 (en) * | 2005-05-18 | 2007-11-06 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
| CN202740162U (en) * | 2012-02-27 | 2013-02-20 | 江苏省华星医疗器械实业有限公司 | Novel vessel rack |
| CN203089467U (en) * | 2013-02-18 | 2013-07-31 | 南阳医学高等专科学校第一附属医院 | Novel vascular scaffold |
| CN104127269A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Vascular stent |
| CN104127268A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Vascular stent firm in supporting |
| CN104127266A (en) * | 2014-06-16 | 2014-11-05 | 苏州固基电子科技有限公司 | Drug-loading vascular stent |
Non-Patent Citations (1)
| Title |
|---|
| 徐灿等: "《稀土二氧化铈在生物领域的最新研究进展》", 《中国科学：化学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114887117A (en) * | 2022-04-09 | 2022-08-12 | 中国医科大学附属第一医院 | Drug-loaded nanoparticle and intravascular stent for reducing postoperative restenosis rate |
| CN114887117B (en) * | 2022-04-09 | 2023-10-13 | 中国医科大学附属第一医院 | Drug-loaded nanoparticle and vascular stent for reducing restenosis rate in blood vessel after operation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106137484A (en) | A kind of self-expansion type conical blood vessel support | |
| WO2011131115A1 (en) | Stent for bifurcated vessel | |
| EP2656818A1 (en) | Absorbable blood vessel stent | |
| CN202843856U (en) | Recyclable stent for coronary disease interventional therapy | |
| CN108670509A (en) | A kind of self-expansion type taper coronary stent | |
| CN203988521U (en) | A kind of asymmetric conical intravascular stent | |
| CN109640882A (en) | A kind of complete biological absorbable blood vessel polymer support of implanted | |
| CN209137002U (en) | A kind of medicinal balloon | |
| CN103948455A (en) | Abdominal aorta stent | |
| CN106137486A (en) | A kind of bifurcated sacculus | |
| CN101239216A (en) | Novel sacculus dilating catheter | |
| CN104814821A (en) | Medicine carrying intravascular stent based on nano medicine carrier | |
| Abizaid et al. | The CardioMind™ coronary stent delivery system: stent delivery on a. 014" guidewire platform | |
| CN204698767U (en) | A kind of medicine carrying intravascular stent based on nano-medicament carrier | |
| CN107995869B (en) | Surface liquefied drug coating sacculus | |
| CN105769398A (en) | Biodegradable vascular stent based on polyhedron deformation mechanism | |
| CN105213074A (en) | A kind of overlay film frame and using method thereof | |
| CN204698764U (en) | A kind of intravascular stent | |
| CN104814820A (en) | Vascular support for preventing vascular restenosis | |
| CN205083716U (en) | Covered stent | |
| WO2018232772A1 (en) | Degradable and withdrawable 4d printing linear organic human body stent and using method therefor | |
| CN204698766U (en) | A kind of intravascular stent preventing vascular restenosis | |
| CN205054506U (en) | Blood vessel support with anti linear deformation | |
| Eliason et al. | Durability of percutaneous angioplasty and stent implantation for the treatment of abdominal aortic coarctation: a case report | |
| CN109602523B (en) | Recoverable medicine support |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150805 |