CN104844908A - Medical air-permeable and antibacterial microporous material and preparation method for same - Google Patents
Medical air-permeable and antibacterial microporous material and preparation method for same Download PDFInfo
- Publication number
- CN104844908A CN104844908A CN201510245672.3A CN201510245672A CN104844908A CN 104844908 A CN104844908 A CN 104844908A CN 201510245672 A CN201510245672 A CN 201510245672A CN 104844908 A CN104844908 A CN 104844908A
- Authority
- CN
- China
- Prior art keywords
- medical
- polymkeric substance
- permeable
- medical air
- resistance bacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000012229 microporous material Substances 0.000 title abstract 4
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 3
- 150000002576 ketones Chemical class 0.000 claims abstract description 22
- 241000894006 Bacteria Species 0.000 claims abstract description 21
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 21
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 19
- 229920003023 plastic Polymers 0.000 claims abstract description 18
- 239000004033 plastic Substances 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 239000006057 Non-nutritive feed additive Substances 0.000 claims abstract description 9
- 239000003504 photosensitizing agent Substances 0.000 claims abstract description 9
- 238000005469 granulation Methods 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims description 40
- 235000006708 antioxidants Nutrition 0.000 claims description 20
- 239000000126 substance Substances 0.000 claims description 14
- -1 polyethylene Polymers 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 12
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000007493 shaping process Methods 0.000 claims description 10
- 239000004698 Polyethylene Substances 0.000 claims description 9
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 6
- UAUDZVJPLUQNMU-KTKRTIGZSA-N erucamide Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(N)=O UAUDZVJPLUQNMU-KTKRTIGZSA-N 0.000 claims description 5
- 230000003179 granulation Effects 0.000 claims description 5
- 229960003742 phenol Drugs 0.000 claims description 5
- FUSUHKVFWTUUBE-UHFFFAOYSA-N buten-2-one Chemical compound CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 239000008188 pellet Substances 0.000 claims description 4
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000003848 UV Light-Curing Methods 0.000 claims description 3
- 239000005030 aluminium foil Substances 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 2
- FRVCGRDGKAINSV-UHFFFAOYSA-L iron(2+);octadecanoate Chemical compound [Fe+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O FRVCGRDGKAINSV-UHFFFAOYSA-L 0.000 claims description 2
- 229920002492 poly(sulfone) Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 239000012567 medical material Substances 0.000 abstract description 4
- 238000013461 design Methods 0.000 abstract description 3
- 244000005700 microbiome Species 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 2
- 238000001338 self-assembly Methods 0.000 abstract description 2
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000010096 film blowing Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 description 11
- 238000012856 packing Methods 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 238000009423 ventilation Methods 0.000 description 5
- 239000004744 fabric Substances 0.000 description 4
- 230000008676 import Effects 0.000 description 4
- 238000004026 adhesive bonding Methods 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 238000001782 photodegradation Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/04—Homopolymers or copolymers of ethene
- C08L23/06—Polyethene
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D7/00—Producing flat articles, e.g. films or sheets
- B29D7/01—Films or sheets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
- C08J7/123—Treatment by wave energy or particle radiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/04—Condition, form or state of moulded material or of the material to be shaped cellular or porous
- B29K2105/041—Microporous
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0065—Permeability to gases
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2323/04—Homopolymers or copolymers of ethene
- C08J2323/06—Polyethene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2423/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2423/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2423/04—Homopolymers or copolymers of ethene
- C08J2423/08—Copolymers of ethene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2425/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Derivatives of such polymers
- C08J2425/18—Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2429/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2429/12—Homopolymers or copolymers of unsaturated ketones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2481/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen, or carbon only; Polysulfones; Derivatives of such polymers
- C08J2481/06—Polysulfones; Polyethersulfones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/16—Applications used for films
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
Abstract
The invention discloses a medical air-permeable and antibacterial microporous material, which is prepared from the following raw materials in percentage by weight: 73.2 to 93.7 percent of medical plastics, 5 to 20 percent of a ketone polymer, 1 to 5 percent of a photosensitizer, 0.2 to 0.8 percent of an antioxidant and 0.1 to 1 percent of a processing aid. The invention further discloses a preparation method for the medical air-permeable and antibacterial microporous material. Re-granulation and film blowing forming methods are adopted for forming a nanometer microstructure in common medical plastics in a macromolecular self-assembly manner, and a special microporous material is finally formed by UV (ultraviolet) light degradation. Different proportion designs are selected, so that a special requirement on the air permeability of the medical material can be met, and a basic requirement on the resistance of microorganisms to bacteria can also be met.
Description
Technical field
The present invention relates to micropore medical package poromeric material, particularly relate to a kind of ventilative resistance bacterium material and preparation method thereof for disposable medical instrument or medical treatment consumptive materials packaging.
Background technology
Conventional medical device package should meet relevant laws and regulations requirement, and possess and be easy to open, sealing is reliable, can be used for sterilizing, possesses resistance bacterium property simultaneously.At present, conventional on the market sterilization of medical instrument packing bag form is paper paper bag, paper plastic bag, overall plastic bag, aluminium plastic bag and have the middle envelope of poromeric material and top bag etc.Conventional sterilization method comprises high-temp steam sterilizing, dry sterilization, irradiation sterilization, ethylene oxide sterilizing and plasma sterilization.Because different packaged forms must be used for corresponding sterilization method, so in packing bag for medical use Material selec-tion, be mainly divided into two kinds, air-impermeable material and poromeric material.Wherein, medical permeable material is medical grade paper or rubber coated paper on the market, the special nonwoven cloth material of import or gluing nonwoven cloth material.For these materials, the problem often run into is:
1, because packing bag uses peelable material to make, so due to the concussion of transport in transportation, the edge sealing ratio of packing bag is easier to occur phenomenon of osmosis;
2, adopt medical grade paper or rubber coated paper lower due to physical strength, be difficult to use in the packaging of large-scale apparatus;
3, the special nonwoven cloth material of import or gluing nonwoven cloth material is adopted, as Du Pont
cost is high, and starting material depend on import, produce and transport turn around time long;
4, the packing bag for medical use of poromeric material (area≤30%) special construction is used, as middle envelope and top bag, although can be cost-saving, because vapor permeation area is less, sterilizing gas is difficult in medicine equipment internal divergence complete, is not easy to reach aseptic result.
Summary of the invention
The present invention solves above-mentioned technical problem, provides a kind of particular requirement that can meet medical material ventilation property, micropore medical air-permeable resistance bacterium material that can meet again the basic demand of microorganism resistance bacterium property and preparation method thereof.
A kind of micropore medical air-permeable resistance bacterium material that the present invention proposes, it is formed by the preparation of raw material of following weight percents content:
Medical plastic 73.2 ~ 93.7%, ketone polymkeric substance 5 ~ 20%, photosensitizers 1 ~ 5%, antioxidant 0.2 ~ 0.8%,
Processing aid 0.1 ~ 1%.
The present invention proposes the preparation method of a kind of micropore medical air-permeable resistance bacterium material, comprises the steps:
Step 1, medical plastic, ketone polymkeric substance, photosensitizers, antioxidant, processing aid to be weighed by proportion speed, and put in high-speed mixer, at temperature of charge 120 DEG C, mix and obtain compound in 10 minutes;
Step 2, described compound is dropped into twin screw extruder, extrude when extruder temperature is 200 ~ 220 DEG C, the compound extruded is put into tablets press and is carried out granulation after water cooling, pulverize through pellet pulverizer, granular size controls in 5 ~ 10mm, after drying, vacuumize with aluminium foil film and package spare;
Step 3, the particle of described compound is dropped into single shaft screw rod conveyor, temperature remains on 160 ~ 180 DEG C, after the die head of blowfilm shaping machine, blowfilm shaping, control blow-up ratio 1.3 ~ 2.0, blowfilm shaping temperature is 160 ~ 180 DEG C, and production rate is at 10 ~ 30 ms/min;
Step 4, described film is carried out UV process in UV curing, UV optical band controls at 200 ~ 280nm, and power is at 80 ~ 120W/cm, and irradiation distance is 80 ~ 150mm;
Step 5, by after the film take-up after UV process, isolation placement 24 hours.
The present invention will commonly use medical-grade plastics, utilize granulation again and blowfilm shaping mode, make plastics inner by the mode of Macromolecular self-assembly, form nano level microstructure, process by UV is photodegradative, the special porous material of final formation.By selecting different proportion design, the particular requirement of medical material ventilation property can be met, the basic demand of microorganism resistance bacterium property can be met again.
Existing poromeric material, usually needs gluing on material, then seals with thermoplastic material.Therefore, by the present invention to the processing of traditional air-impermeable material and use, the use of the gas permeable material in product design can be removed from, avoid sterilizing gas in the incomplete harm of medicine equipment internal diffusion, avoid the heat-sealing of two kinds of unlike material materials simultaneously, reduce the risk that heat seal process is brought.The present invention is novel, easy to use, both ensure that dialysis and the resistance bacterium performance of original packing bag, has turn increased the Edge strength of packing bag, and can enrich the form of packaging.
Specific implementation method
Below in conjunction with specific embodiment, the present invention is described in detail, and following examples will contribute to those skilled in the art and understand the present invention further, but not limit the present invention in any form.
The micropore medical permeable material that the present invention proposes, it is formed by the preparation of raw material of following weight percents content:
Medical plastic 73.2 ~ 93.7%, ketone polymkeric substance 5 ~ 20%, photosensitizers 1 ~ 5%, antioxidant 0.2 ~ 0.8%,
Processing aid 0.1 ~ 1%.
Wherein, the medical plastic used can be at least the one of polyethylene, polypropylene, ethylene-vinyl acetate copolymer (EVA), and molecular weight is 1000-100000.Ketone polymkeric substance can be the polymkeric substance of methyl vinyl ketone, the polymkeric substance of ethenylphenyl ketone or the one of polysulfones, the polymerizable molecular amount of ketone polymkeric substance is 500 ~ 10000, polyethylene melting index is wherein 2 ~ 7g/10min, and density is 0.910 ~ 0.925g/cm
3; Polypropylene melt index is 0.5 ~ 10g/10min, and density is 0.89-0.91g/cm
3; Ethylene-vinyl acetate copolymer (EVA) melting index is 2-10g/10min, and density is 0.910-0.935g/cm
3.Photosensitizers can be ferric acetyl acetonade, iron stearate, ferric dialky dithiocarbamatc one wherein.Processing aid is the one in PE wax, erucicamide, amine hydroxybenzene and Sorbic Acid acid amides.Antioxidant be preferably: hindered phenol anti-oxidants, as, four-[β-(3,5-di-t-butyl-4 monohydroxy phenyl) propionic acid], pentaerythritol ester; Phosphite antioxidant, as, (2,4-di-tert-butyl-phenyl), tris phosphite.
The specific embodiment of micropore medical permeable material of the present invention is as follows:
Embodiment 1: raw material weight per-cent is prepared:
Polyethylene-93.7%, ketone polymkeric substance-5%, photosensitizers-1%, antioxidant 0.2%, PE wax 0.1%.
Embodiment 2: raw material weight per-cent is prepared:
Polyethylene-83.45%, ketone polymkeric substance-12.5%, photosensitizers-2.55%, antioxidant 0.5%, PE wax 1%.
Embodiment 3: raw material weight per-cent is prepared:
Polyethylene-73.2%, ketone polymkeric substance-20%, photosensitizers-5%, antioxidant 0.8%, PE wax 1%.
Embodiment 4: raw material weight per-cent is prepared:
Polypropylene-85.95%, ketone polymkeric substance-10%, photosensitizers-3%, antioxidant 0.5%, erucicamide 0.55%.
Embodiment 5: raw material weight per-cent is prepared:
Polypropylene-84.4%, ketone polymkeric substance-12%, photosensitizers-3%, antioxidant 0.2%, erucicamide 0.4%.
Embodiment 6: raw material weight per-cent is prepared:
Polypropylene-80.5%, ketone polymkeric substance-15%, photosensitizers-4%, antioxidant 0.4%, erucicamide 0.1%.
Embodiment 7: raw material weight per-cent is prepared:
Polyethylene-86.8%, EVA-6%, ketone polymkeric substance-5%, photosensitizers-1%, antioxidant 0.2%, Sorbic Acid acid amides 1%.
Embodiment 8: raw material weight per-cent is prepared:
Polyethylene-73.2%, EVA-6%, ketone polymkeric substance-18%, photosensitizers-2%, antioxidant 0.3%, amine hydroxybenzene 0.5%.
The present invention produces the gas permeable film that thickness is 55-170 μm, and medical plastic is linear pellet, and granular size is about 3-5mm, and purity is greater than 95%; Ketone polymericular weight is 500-10000; In order to reach the effect mixed, granulation again must be carried out in corresponding ratio.
The preparation method of a kind of micropore medical air-permeable resistance bacterium material that the present invention proposes, step is as follows:
Step 1, medical plastic, ketone polymkeric substance, photosensitizers, antioxidant, processing aid to be weighed by proportion speed, and put in the high-speed mixer of 300 liters, at temperature of charge 120 DEG C, mix and obtain compound in 10 minutes;
Step 2, described compound is dropped into twin screw extruder, it is 200 ~ 220 DEG C at extruder temperature, engine speed is 250rpm, extrude when feeding rotating speed is 50rpm, the compound extruded is put into tablets press and is carried out granulation after water cooling, then pulverizes through pellet pulverizer, and granular size controls in 5 ~ 10mm, after drying, vacuumize with aluminium foil film and package spare;
Step 3, the particle of described compound is dropped into single shaft screw rod conveyor, temperature remains on 160 ~ 180 DEG C, after the die head of blowfilm shaping machine, blowfilm shaping, control blow-up ratio 1.3 ~ 2.0, blowfilm shaping temperature is 160 ~ 180 DEG C, and production rate is at 10 ~ 30 ms/min;
Step 4, described film is carried out UV process in UV curing, UV optical band controls at 200 ~ 280nm, and power is at 80 ~ 120W/cm, and irradiation distance is 80 ~ 150mm;
Step 5, by after the film take-up after UV process, isolation placement 24 hours.Then the cylinder material after shaping is carried out cutting into corresponding size.
In technique compared with prior art, the present invention passes through the selection of medical plastic and photodegradation auxiliary agent, not only meets the resistance bacterium ventilation property of medical material, and can reduce production cost.By rational post-treatment process, adopt economic operational path, make this gas permeable material even aperture distribution.
Get the medical permeable material obtained by above-mentioned 8 embodiments, carry out Gas permeability (Xiao Baierfa) test, water vapor transmission rate (WVTR), tensile strength and agar contact challenge trial, contrast with import ventilation property (non-woven fabrics) material.
Concrete embodiment performance data is as following table:
By above Data Comparison, the resistance bacterium ventilation property that the present invention possesses meets domestic and international industry standard.
Above specific embodiments of the invention are described.It is to be appreciated that the present invention is not limited to above-mentioned specific embodiment, those skilled in the art can make various distortion or amendment within the scope of the claims, and this does not affect flesh and blood of the present invention.
Claims (8)
1. a micropore medical air-permeable resistance bacterium material, it is characterized in that, it is formed by the preparation of raw material of following weight percentage:
Medical plastic 73.2 ~ 93.7%, ketone polymkeric substance 5 ~ 20%, photosensitizers 1 ~ 5%, antioxidant 0.2 ~ 0.8%,
Processing aid 0.1 ~ 1%.
2. micropore medical air-permeable resistance bacterium material as claimed in claim 1, it is characterized in that, described medical plastic is at least the one in polyethylene, polypropylene, ethylene-vinyl acetate copolymer, and the molecular weight of medical plastic is 1000 ~ 100000.
3. micropore medical air-permeable resistance bacterium material as claimed in claim 2, it is characterized in that, described polyethylene melting index is 2 ~ 7g/10min, and density is 0.910 ~ 0.925g/cm3; Described polypropylene melt index is 0.5 ~ 10g/10min, and density is 0.89 ~ 0.91g/cm3; Described ethylene-vinyl acetate copolymer melting index is 2 ~ 10g/10min, and density is 0.910 ~ 0.935g/cm3.
4. micropore medical air-permeable resistance bacterium material as claimed in claim 1, it is characterized in that, described ketone polymkeric substance is the one in the polymkeric substance of methyl vinyl ketone, the polymkeric substance of ethenylphenyl ketone or polysulfones, and the polymerizable molecular amount of ketone polymkeric substance is 500 ~ 10000.
5. micropore medical air-permeable resistance bacterium material as claimed in claim 1, it is characterized in that, described photosensitizers is the one in ferric acetyl acetonade, iron stearate, ferric dialky dithiocarbamatc.
6. micropore medical air-permeable resistance bacterium material as claimed in claim 1, it is characterized in that, described antioxidant is hindered phenol anti-oxidants or phosphite antioxidant.
7. micropore medical air-permeable resistance bacterium material as claimed in claim 1, it is characterized in that, described processing aid is the one in PE wax, erucicamide, amine hydroxybenzene and Sorbic Acid acid amides.
8. a preparation method for micropore medical air-permeable resistance bacterium material, is characterized in that, comprise the steps:
Step 1, medical plastic, ketone polymkeric substance, photosensitizers, antioxidant, processing aid to be weighed by proportion speed, and put in high-speed mixer, at temperature of charge 120 DEG C, mix and obtain compound in 10 minutes;
Step 2, described compound is dropped into twin screw extruder, extrude when extruder temperature is 200 ~ 220 DEG C, the compound extruded is put into tablets press and is carried out granulation after water cooling, pulverize through pellet pulverizer, granular size controls in 5 ~ 10mm, after drying, vacuumize with aluminium foil film and package spare;
Step 3, the particle of described compound is dropped into single shaft screw rod conveyor, temperature remains on 160 ~ 180 DEG C, after die head, and blowfilm shaping, control blow-up ratio 1.3 ~ 2.0, blowfilm shaping temperature is 160 ~ 180 DEG C, and production rate is at 10 ~ 30 ms/min;
Step 4, described film is carried out UV process in UV curing, UV optical band controls at 200 ~ 280nm, and power is at 80 ~ 120W/cm, and irradiation distance is 80 ~ 150mm;
Step 5, by after the film take-up after UV process, isolation placement 24 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510245672.3A CN104844908B (en) | 2015-05-14 | 2015-05-14 | A kind of micropore medical air-permeable resistance bacterium material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510245672.3A CN104844908B (en) | 2015-05-14 | 2015-05-14 | A kind of micropore medical air-permeable resistance bacterium material and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104844908A true CN104844908A (en) | 2015-08-19 |
| CN104844908B CN104844908B (en) | 2017-06-20 |
Family
ID=53844925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510245672.3A Active CN104844908B (en) | 2015-05-14 | 2015-05-14 | A kind of micropore medical air-permeable resistance bacterium material and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104844908B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105694478A (en) * | 2016-03-31 | 2016-06-22 | 青岛百瑞吉生物工程有限公司 | Preparation method of degradable biological medical composite material |
| CN107057187A (en) * | 2017-04-12 | 2017-08-18 | 芜湖扬展新材料科技服务有限公司 | A kind of medical antibacterial packaging bag |
| CN107501624A (en) * | 2017-09-14 | 2017-12-22 | 南通荣成医药化工有限公司 | A kind of pharmaceutical packaging bag |
| CN107936416A (en) * | 2017-12-21 | 2018-04-20 | 宁波爱克创威新材料科技有限公司 | A kind of medical antibacterial thin-film material and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247498A (en) * | 1976-08-30 | 1981-01-27 | Akzona Incorporated | Methods for making microporous products |
| CN1789317A (en) * | 2004-12-17 | 2006-06-21 | 上海三成化工有限公司 | Antibacterial, ventilating, waterproof plastic granular materials for membrane and manufacturing method thereof |
| US20110244215A1 (en) * | 2009-01-16 | 2011-10-06 | Sartorius Stedim Biotech Gmbh | Electron beam induced modification of membranes by polymers |
| CN102731908A (en) * | 2012-06-27 | 2012-10-17 | 新乡市中科科技有限公司 | Method for continuous hydrophilic modification of polypropylene microporous membrane |
-
2015
- 2015-05-14 CN CN201510245672.3A patent/CN104844908B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247498A (en) * | 1976-08-30 | 1981-01-27 | Akzona Incorporated | Methods for making microporous products |
| CN1789317A (en) * | 2004-12-17 | 2006-06-21 | 上海三成化工有限公司 | Antibacterial, ventilating, waterproof plastic granular materials for membrane and manufacturing method thereof |
| US20110244215A1 (en) * | 2009-01-16 | 2011-10-06 | Sartorius Stedim Biotech Gmbh | Electron beam induced modification of membranes by polymers |
| CN102731908A (en) * | 2012-06-27 | 2012-10-17 | 新乡市中科科技有限公司 | Method for continuous hydrophilic modification of polypropylene microporous membrane |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105694478A (en) * | 2016-03-31 | 2016-06-22 | 青岛百瑞吉生物工程有限公司 | Preparation method of degradable biological medical composite material |
| CN107057187A (en) * | 2017-04-12 | 2017-08-18 | 芜湖扬展新材料科技服务有限公司 | A kind of medical antibacterial packaging bag |
| CN107501624A (en) * | 2017-09-14 | 2017-12-22 | 南通荣成医药化工有限公司 | A kind of pharmaceutical packaging bag |
| CN107936416A (en) * | 2017-12-21 | 2018-04-20 | 宁波爱克创威新材料科技有限公司 | A kind of medical antibacterial thin-film material and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104844908B (en) | 2017-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104844908A (en) | Medical air-permeable and antibacterial microporous material and preparation method for same | |
| CN104558751B (en) | A kind of composition and its method for preparing ultra-thin breathable film | |
| CN102504345B (en) | Disposable controlled completely-degradable plastic packing bag and preparation method thereof | |
| CN103571012B (en) | A kind of plastic foil, its preparation method and application of waterproof and breathable | |
| CN101747548A (en) | Compound for preparation of high-strength polyolefin permeable membrane and preparation method thereof | |
| CN107353485B (en) | Antibacterial breathable film master batch and preparation method thereof | |
| CN106046725A (en) | High-barrier-property biodegradable mulching film and preparation method thereof | |
| CN108715656A (en) | A kind of PE/CaCO3Ventilative film master batch and preparation method thereof | |
| CN111454474A (en) | Preparation method of activated carbon breathable film | |
| CN104448514A (en) | Breathable resin with high breathability and preparation method of breathable resin | |
| CN101040631A (en) | Film and Bag specially for keeping fresh of Jinling jujube | |
| CN109082086A (en) | A kind of preparation method of the high ventilated membrane of polylactic acid | |
| CN103030863B (en) | A kind of air-permeable masterbatch and the method using master batch manufacture ventilated membrane | |
| CN101845173A (en) | Manufacturing process and production equipment for medical infusion bags | |
| CN104610760A (en) | Peanut protein isolate and chitosan compounded fruit and vegetable packaging film | |
| CN109593330A (en) | For manufacturing the PP Pipe Compound and preparation method thereof of biodegradable antibacterial, ventilating film | |
| CN104292581A (en) | Medical grade gas-permeable membrane special material and preparation method thereof | |
| CN108623875A (en) | A kind of High-strength air-permeable film composite material and preparation method | |
| CN106633305A (en) | High permeability rate composite gas-permeable membrane and preparation method thereof | |
| CN105330932A (en) | Environmentally-friendly anti-microbial preservation bag and manufacturing method thereof | |
| CN101503535A (en) | Mildewproof air-conditioning preservative film for food | |
| CN103739913B (en) | A kind of polyethylene film material and preparation method thereof | |
| CN113462132A (en) | Biodegradable composite material, preparation method thereof and biodegradable breathable film | |
| CN105419111A (en) | Anti-bacterial, moisture-preserving and fresh-keeping packaging film for apples and pears | |
| CN102875868A (en) | Method for preparing food fresh-keeping film |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 518000, Guangdong, Longhua province Shenzhen New District Guanlan Hill head scared community Cheng Guang Industrial Park, building 4, 2, 1-2 floor Applicant after: Shenzhen security medical sensation Control Technology Co., Ltd. Address before: 518000, Guangdong, Shenzhen province Baoan District Guanlan street, library, hang the first village, Yang Cheng community Light Industrial Zone No. 4 Applicant before: Security packaging (Shenzhen) company limited |
|
| CB02 | Change of applicant information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder |
Address after: 518000 Minzhi Street Minzhi Community Minzhi Avenue 318 Jiaxi Ye Square 801, Longhua District, Shenzhen City, Guangdong Province Patentee after: Shenzhen security medical sensation Control Technology Co., Ltd. Address before: 518000 Guangzhou Longhua New District Guanlan Beitou Community Chengguang Industrial Park, Shenzhen City, Guangdong Province, 2 1-2 floors Patentee before: Shenzhen security medical sensation Control Technology Co., Ltd. |
|
| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 518000 Minzhi Street Minzhi Community Minzhi Avenue 318 Jiaxi Ye Square 801 Longhua District Shenzhen City, Guangdong Province Patentee after: Shenzhen security medical sensation Control Technology Co., Ltd. Address before: 518000 Minzhi Street Minzhi Community Minzhi Avenue 318 Jiaxi Ye Square 801, Longhua District, Shenzhen City, Guangdong Province Patentee before: Shenzhen security medical sensation Control Technology Co., Ltd. |
|
| CP02 | Change in the address of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 518000 Minzhi Street Minzhi Community Minzhi Avenue 318 Jiaxi Ye Square 801 Longhua District Shenzhen City, Guangdong Province Patentee after: Shenzhen security medical sense control technology Co.,Ltd. Address before: 518000 Minzhi Street Minzhi Community Minzhi Avenue 318 Jiaxi Ye Square 801 Longhua District Shenzhen City, Guangdong Province Patentee before: SHENZHEN ANBAO MEDICAL SENSING TECHNOLOGY Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |