CN104844908B - A kind of micropore medical air-permeable resistance bacterium material and preparation method thereof - Google Patents
A kind of micropore medical air-permeable resistance bacterium material and preparation method thereof Download PDFInfo
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- CN104844908B CN104844908B CN201510245672.3A CN201510245672A CN104844908B CN 104844908 B CN104844908 B CN 104844908B CN 201510245672 A CN201510245672 A CN 201510245672A CN 104844908 B CN104844908 B CN 104844908B
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- 239000000463 material Substances 0.000 title claims abstract description 46
- 241000894006 Bacteria Species 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 229920000642 polymer Polymers 0.000 claims abstract description 23
- 150000002576 ketones Chemical class 0.000 claims abstract description 22
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 21
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 20
- 229920003023 plastic Polymers 0.000 claims abstract description 18
- 239000004033 plastic Substances 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- 230000001235 sensitizing effect Effects 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 238000007493 shaping process Methods 0.000 claims abstract description 12
- 239000006057 Non-nutritive feed additive Substances 0.000 claims abstract description 9
- 239000011148 porous material Substances 0.000 claims abstract description 3
- -1 polypropylene, ethylene-vinyl acetate Polymers 0.000 claims description 22
- 239000004698 Polyethylene Substances 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 11
- 229920000573 polyethylene Polymers 0.000 claims description 8
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 229920001155 polypropylene Polymers 0.000 claims description 5
- 239000001993 wax Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000008188 pellet Substances 0.000 claims description 4
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 4
- 238000003848 UV Light-Curing Methods 0.000 claims description 3
- 239000005030 aluminium foil Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000015556 catabolic process Effects 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 238000001125 extrusion Methods 0.000 claims description 2
- XHQSLVIGPHXVAK-UHFFFAOYSA-K iron(3+);octadecanoate Chemical compound [Fe+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XHQSLVIGPHXVAK-UHFFFAOYSA-K 0.000 claims description 2
- FATBGEAMYMYZAF-KTKRTIGZSA-N oleamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(N)=O FATBGEAMYMYZAF-KTKRTIGZSA-N 0.000 claims description 2
- FATBGEAMYMYZAF-UHFFFAOYSA-N oleicacidamide-heptaglycolether Natural products CCCCCCCCC=CCCCCCCCC(N)=O FATBGEAMYMYZAF-UHFFFAOYSA-N 0.000 claims description 2
- 150000002989 phenols Chemical class 0.000 claims description 2
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 claims description 2
- 229920002492 poly(sulfone) Polymers 0.000 claims description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical group CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 241000219198 Brassica Species 0.000 claims 1
- 235000003351 Brassica cretica Nutrition 0.000 claims 1
- 235000003343 Brassica rupestris Nutrition 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 235000010460 mustard Nutrition 0.000 claims 1
- 230000035699 permeability Effects 0.000 abstract description 7
- 239000012567 medical material Substances 0.000 abstract description 4
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- 238000005469 granulation Methods 0.000 abstract description 2
- 230000003179 granulation Effects 0.000 abstract description 2
- 238000001338 self-assembly Methods 0.000 abstract description 2
- 235000006708 antioxidants Nutrition 0.000 description 14
- 230000001954 sterilising effect Effects 0.000 description 9
- 238000004806 packaging method and process Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- UAUDZVJPLUQNMU-KTKRTIGZSA-N erucamide Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(N)=O UAUDZVJPLUQNMU-KTKRTIGZSA-N 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 230000008676 import Effects 0.000 description 4
- 238000004026 adhesive bonding Methods 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012376 hot air sterilization Methods 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229920005735 poly(methyl vinyl ketone) Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical class C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/04—Homopolymers or copolymers of ethene
- C08L23/06—Polyethene
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D7/00—Producing flat articles, e.g. films or sheets
- B29D7/01—Films or sheets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
- C08J7/123—Treatment by wave energy or particle radiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/04—Condition, form or state of moulded material or of the material to be shaped cellular or porous
- B29K2105/041—Microporous
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0065—Permeability to gases
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2323/04—Homopolymers or copolymers of ethene
- C08J2323/06—Polyethene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2423/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2423/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2423/04—Homopolymers or copolymers of ethene
- C08J2423/08—Copolymers of ethene
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2425/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Derivatives of such polymers
- C08J2425/18—Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2429/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2429/12—Homopolymers or copolymers of unsaturated ketones
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08J2481/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen, or carbon only; Polysulfones; Derivatives of such polymers
- C08J2481/06—Polysulfones; Polyethersulfones
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08L2203/00—Applications
- C08L2203/16—Applications used for films
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention discloses a kind of micropore medical air-permeable resistance bacterium material, it is formulated by the raw material of following weight percentage:Medical plastic 73.2 ~ 93.7%, ketone polymer 5 ~ 20%, sensitising agent 1 ~ 5%, antioxidant 0.2 ~ 0.8%, processing aid 0.1 ~ 1%.The invention also discloses the preparation method that a kind of micropore medical air-permeable hinders bacterium material.Conventional medical-grade plastics using granulation and blowfilm shaping mode again, are made plastics inner by way of Macromolecular self-assembly by the present invention, form nano level micro-structural, are processed by the way that UV is photodegradative, ultimately form special porous material.By selecting different proportion designs, the particular/special requirement of medical material gas permeability can be met, the basic demand that microorganism hinders bacterium property can be met again.
Description
Technical field
It is used for disposable medical instrument or medical treatment the present invention relates to micropore medical package poromeric material, more particularly to one kind
Ventilative resistance bacterium material of consumptive material packaging and preparation method thereof.
Background technology
Conventional medical device package should meet relevant laws and regulations requirement, possess and be easy to open, and sealed reliable can be used for
Sterilizing, is provided simultaneously with hindering bacterium property.At present, sterilization of medical instrument conventional on the market packaging bag form is paper paper bag, paper plastic bag, complete
Modeling bag, aluminium plastic bag and the middle envelope with poromeric material and top bag etc..Conventional sterilization method goes out including high-temperature steam
Bacterium, hot air sterilization, irradiation sterilization, ethylene oxide sterilizing and plasma sterilization.Because different packaged forms is necessarily used for correspondence
Sterilization method, so in the selection of packing bag for medical use material, be broadly divided into two kinds, air-impermeable material and poromeric material.
Wherein, medical permeable material is medical grade paper or paster on the market, the special nonwoven cloth material of import or gluing without
Spin cloth material.For these materials, the problem being commonly encountered is：
1st, because packaging bag is made using peelable material, so due to the concussion transported, packaging bag in transportation
Edge sealing be easier phenomenon of osmosis occur；
2nd, using medical grade paper or paster because mechanical strength is relatively low, it is difficult to for the packaging of large-scale apparatus；
3rd, using the special nonwoven cloth material of import or gluing nonwoven cloth material, such as Du PontHigh cost, it is former
Material depends on import, and production and transportation turn around time is long；
4th, using the packing bag for medical use of poromeric material (area≤30%) special construction, such as middle envelope and top bag, though
So can be with cost-effective, but because vapor permeation area is less, sterilizing gas are difficult to complete in medicine equipment diffusion inside, it is not easy to
Reach aseptic result.
The content of the invention
The present invention is the above-mentioned technical problem of solution, there is provided a kind of particular/special requirement that can meet medical material gas permeability,
Micropore medical air-permeable resistance bacterium material of basic demand of microorganism resistance bacterium property and preparation method thereof can be met again.
A kind of micropore medical air-permeable resistance bacterium material proposed by the present invention, it is prepared by the raw material of following weight percents content
Form:
Medical plastic 73.2~93.7%, ketone polymer 5~20%, sensitising agent 1~5%, antioxidant 0.2~
0.8%th,
Processing aid 0.1~1%.
The present invention proposes that a kind of micropore medical air-permeable hinders the preparation method of bacterium material, comprises the following steps：
Step 1, medical plastic, ketone polymer, sensitising agent, antioxidant, processing aid are weighed by proportion speed, and
Put into high-speed mixer, at 120 DEG C of temperature of charge, mixing obtains compound in 10 minutes；
Step 2, by the compound put into double screw extruder, extruder temperature be 200~220 DEG C when extrude, squeeze
The compound for going out is granulated in being put into comminutor after water cooling, is crushed by pellet pulverizer, and granular size is controlled 5
In~10mm, after drying, vacuumized with aluminium foil film and packaged spare；
Step 3, the particle input single shaft screw rod conveyor by the compound, temperature are maintained at 160~180 DEG C, pass through
After the die head of blowfilm shaping machine, blowfilm shaping, control blow-up ratio is 1.3~2.0, and blowfilm shaping temperature is 160~180 DEG C, raw
Speed is produced at 10~30 ms/min；
Step 4, the film is carried out UV treatment in UV curing, UV optical bands are controlled in 200~280nm, power
In 80~120W/cm, irradiation distance is 80~150mm；
Step 5, UV is processed after film take-up after, isolation place 24 hours.
Conventional medical-grade plastics using granulation and blowfilm shaping mode again, are made plastics inner pass through macromolecular by the present invention
The mode of self assembly, forms nano level micro-structural, is processed by the way that UV is photodegradative, ultimately forms special porous material.
By selecting different proportion designs, the particular/special requirement of medical material gas permeability can be met, microorganism resistance bacterium property can be met again
Basic demand.
Existing poromeric material, it usually needs the gluing on material, then sealed with thermoplastic.Therefore, borrow
By the present invention is to the processing of traditional air-impermeable material and uses, the use of the gas permeable material in product design can be removed from, kept away
Exempt from sterilizing gas and incomplete harm is spread in medicine equipment, while avoiding two kinds of heat-sealings of unlike material material, reduce
The risk that heat seal process is brought.Present inventive concept is novel, easy to use, both ensure that dialysis and the resistance bacterium performance of original packing bag,
The Edge strength of packaging bag is increased again, and can enrich the form of packaging.
Specific implementation method
With reference to specific embodiment, the present invention is described in detail, and following examples will be helpful to the technology of this area
Personnel further understand the present invention, but the invention is not limited in any way.
Micropore medical permeable material proposed by the present invention, it is formulated by the raw material of following weight percents content:
Medical plastic 73.2~93.7%, ketone polymer 5~20%, sensitising agent 1~5%, antioxidant 0.2~
0.8%th,
Processing aid 0.1~1%.
Wherein, the medical plastic for being used can be at least polyethylene, polypropylene, ethylene-vinyl acetate copolymer (EVA)
One kind, molecular weight is 1000-100000.Ketone polymer can be methyl vinyl ketone polymer, ethenylphenyl
The polymer of ketone or one kind of polysulfones, the polymerizable molecular amount of ketone polymer is 500~10000, and polyethylene melting therein refers to
Number is 2~7g/10min, and density is 0.910~0.925g/cm3；Polypropylene melt index is 0.5~10g/10min, and density is
0.89-0.91g/cm3；Ethylene-vinyl acetate copolymer (EVA) melt index is 2-10g/10min, and density is 0.910-
0.935g/cm3.Sensitising agent can be ferric acetyl acetonade, ferric stearate, ferric dialky dithiocarbamatc one kind therein.
Processing aid is the one kind in PE waxes, erucyl amide, oleamide and sorbic acid acid amides.Antioxidant is preferably：Hinered phenols
Antioxidant, such as, four-[β-(the monohydroxy phenyl of 3,5- di-t-butyl -4) propionic acid], pentaerythritol ester；Phosphorous acid esters are anti-oxidant
Agent, such as, (2,4- di-tert-butyl-phenyl), tris phosphite.
The specific embodiment of micropore medical permeable material of the present invention is as follows：
Embodiment 1：Raw material weight percentage is prepared：
Polyethylene -93.7%, ketone polymer -5%, sensitising agent -1%, antioxidant 0.2%, PE waxes 0.1%.
Embodiment 2：Raw material weight percentage is prepared：
Polyethylene -83.45%, ketone polymer -12.5%, sensitising agent -2.55%, antioxidant 0.5%, PE waxes 1%.
Embodiment 3：Raw material weight percentage is prepared：
Polyethylene -73.2%, ketone polymer -20%, sensitising agent -5%, antioxidant 0.8%, PE waxes 1%.
Embodiment 4：Raw material weight percentage is prepared：
Polypropylene -85.95%, ketone polymer -10%, sensitising agent -3%, antioxidant 0.5%, erucyl amide
0.55%.
Embodiment 5：Raw material weight percentage is prepared：
Polypropylene -84.4%, ketone polymer -12%, sensitising agent -3%, antioxidant 0.2%, erucyl amide 0.4%.
Embodiment 6：Raw material weight percentage is prepared：
Polypropylene -80.5%, ketone polymer -15%, sensitising agent -4%, antioxidant 0.4%, erucyl amide 0.1%.
Embodiment 7：Raw material weight percentage is prepared：
Polyethylene -86.8%, EVA-6%, ketone polymer -5%, sensitising agent -1%, antioxidant 0.2%, sorbic acid
Acid amides 1%.
Embodiment 8：Raw material weight percentage is prepared：
Polyethylene -73.2%, EVA-6%, ketone polymer -18%, sensitising agent -2%, antioxidant 0.3%, oleic acid acyl
Amine 0.5%.
Present invention production thickness is 55-170 μm of breathable film, and medical plastic is linear pellet, granular size about 3-
5mm, purity is more than 95%；Ketone polymer molecular weight is 500-10000；In order to reach well mixed effect, must be by corresponding
Ratio granulated again.
A kind of micropore medical air-permeable proposed by the present invention hinders the preparation method of bacterium material, and step is as follows：
Step 1, medical plastic, ketone polymer, sensitising agent, antioxidant, processing aid are weighed by proportion speed, and
Put into 300 liters of high-speed mixer, at 120 DEG C of temperature of charge, mixing obtains compound in 10 minutes；
Step 2, by the compound put into double screw extruder, extruder temperature be 200~220 DEG C, engine speed
It is 250rpm, is extruded when feeding rotating speed is 50rpm, the compound of extrusion is granulated in being put into comminutor after water cooling,
Crushed by pellet pulverizer again, granular size is controlled in 5~10mm, after drying, vacuumized with aluminium foil film and packaged spare；
Step 3, the particle input single shaft screw rod conveyor by the compound, temperature are maintained at 160~180 DEG C, pass through
After the die head of blowfilm shaping machine, blowfilm shaping, control blow-up ratio is 1.3~2.0, and blowfilm shaping temperature is 160~180 DEG C, raw
Speed is produced at 10~30 ms/min；
Step 4, the film is carried out UV treatment in UV curing, UV optical bands are controlled in 200~280nm, power
In 80~120W/cm, irradiation distance is 80~150mm；
Step 5, UV is processed after film take-up after, isolation place 24 hours.Then the cylinder material after shaping is divided
It is cut into corresponding size.
In technique compared with prior art, the selection that the present invention passes through medical plastic and light degradation auxiliary agent, it is not only full
The resistance bacterium gas permeability of sufficient medical material, and production cost can be reduced.Processed by rational post-processing, using economic work
Skill route so that the gas permeable material even aperture distribution.
The medical permeable material obtained by above-mentioned 8 embodiments is taken, air permeability (Xiao Baierfa) test, vapor is carried out
Transmitance, tensile strength and agar contact challenge trial, are contrasted with import gas permeability (non-woven fabrics) material.
Specific implementation example performance data such as following table：
Contrasted by data above, the resistance bacterium gas permeability that the present invention possesses meets domestic and international professional standard.
Specific embodiment of the invention is described above.It is to be appreciated that the invention is not limited in above-mentioned
Specific implementation method, those skilled in the art can within the scope of the claims make various deformations or amendments, and this is not
Influence substance of the invention.
Claims (8)
1. a kind of micropore medical air-permeable hinders bacterium material, it is characterised in that it is formulated by the raw material of following weight percentage:
Medical plastic 73.2 ~ 93.7%, ketone polymer 5 ~ 20%, sensitising agent 1 ~ 5%, antioxidant 0.2 ~ 0.8%,
Processing aid 0.1 ~ 1%；
The micropore medical air-permeable resistance bacterium material is to granulate and blowfilm shaping described raw material again, forms nano level micro- knot
Structure, is processed by ultraviolet degradation, ultimately forms special porous material.
2. micropore medical air-permeable as claimed in claim 1 hinders bacterium material, it is characterised in that the medical plastic is at least poly- second
One kind in alkene, polypropylene, ethylene-vinyl acetate copolymer, the molecular weight of medical plastic is 1000 ~ 100000.
3. micropore medical air-permeable as claimed in claim 2 resistance bacterium material, it is characterised in that described polyethylene melt index is
2 ~ 7g/10min, density is 0.910 ~ 0.925g/cm3；Described polypropylene melt index is 0.5 ~ 10g/10min, and density is
0.89~0.91g/cm³；Described ethylene-vinyl acetate copolymer melt index be 2 ~ 10g/10min, density be 0.910 ~
0.935g/cm³。
4. micropore medical air-permeable as claimed in claim 1 hinders bacterium material, it is characterised in that the ketone polymer is methyl second
One kind in the polymer of alkenyl ketone, the polymer of ethenylphenyl ketone or polysulfones, the polymerizable molecular amount of ketone polymer is 500
~10000。
5. micropore medical air-permeable as claimed in claim 1 hinders bacterium material, it is characterised in that the sensitising agent is acetylacetone,2,4-pentanedione
One kind in iron, ferric stearate, ferric dialky dithiocarbamatc.
6. micropore medical air-permeable as claimed in claim 1 hinders bacterium material, it is characterised in that the antioxidant is Hinered phenols
Antioxidant or phosphite antioxidant.
7. micropore medical air-permeable as claimed in claim 1 hinders bacterium material, it is characterised in that the processing aid is PE waxes, mustard
One kind in sour acid amides, oleamide and sorbic acid acid amides.
8. a kind of micropore medical air-permeable as claimed in claim 1 hinders the preparation method of bacterium material, it is characterised in that including as follows
Step：
Step 1, medical plastic, ketone polymer, sensitising agent, antioxidant, processing aid are weighed by proportion speed, and put into
To in high-speed mixer, at 120 DEG C of temperature of charge, mixing obtains compound in 10 minutes；
Step 2, the compound is put into double screw extruder, is extruded when extruder temperature is 200 ~ 220 DEG C, extrusion it is mixed
Close material to be granulated in being put into comminutor after water cooling, crushed by pellet pulverizer, granular size is controlled in 5 ~ 10mm
It is interior, after drying, vacuumized with aluminium foil film and packaged spare；
Step 3, the particle input single shaft screw rod conveyor by the compound, temperature is maintained at 160 ~ 180 DEG C, by die head
Afterwards, blowfilm shaping, 1.3 ~ 2.0, blowfilm shaping temperature is 160 ~ 180 DEG C to control blow-up ratio, and speed of production is at 10 ~ 30 ms/min
Clock；
Step 4, the film is carried out UV treatment in UV curing, the control of UV optical bands in 200 ~ 280nm, power 80~
120W/cm, irradiation distance is 80 ~ 150mm；
Step 5, UV is processed after film take-up after, isolation place 24 hours.
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| CN105694478A (en) * | 2016-03-31 | 2016-06-22 | 青岛百瑞吉生物工程有限公司 | Preparation method of degradable biological medical composite material |
| CN107057187A (en) * | 2017-04-12 | 2017-08-18 | 芜湖扬展新材料科技服务有限公司 | A kind of medical antibacterial packaging bag |
| CN107501624A (en) * | 2017-09-14 | 2017-12-22 | 南通荣成医药化工有限公司 | A kind of pharmaceutical packaging bag |
| CN107936416A (en) * | 2017-12-21 | 2018-04-20 | 宁波爱克创威新材料科技有限公司 | A kind of medical antibacterial thin-film material and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4247498A (en) * | 1976-08-30 | 1981-01-27 | Akzona Incorporated | Methods for making microporous products |
| CN1789317A (en) * | 2004-12-17 | 2006-06-21 | 上海三成化工有限公司 | Antibacterial, ventilating, waterproof plastic granular materials for membrane and manufacturing method thereof |
| CN102731908A (en) * | 2012-06-27 | 2012-10-17 | 新乡市中科科技有限公司 | Method for continuous hydrophilic modification of polypropylene microporous membrane |
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| DE102009004848B3 (en) * | 2009-01-16 | 2010-04-15 | Sartorius Stedim Biotech Gmbh | Electron beam-induced modification of membranes by polymers |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247498A (en) * | 1976-08-30 | 1981-01-27 | Akzona Incorporated | Methods for making microporous products |
| CN1789317A (en) * | 2004-12-17 | 2006-06-21 | 上海三成化工有限公司 | Antibacterial, ventilating, waterproof plastic granular materials for membrane and manufacturing method thereof |
| CN102731908A (en) * | 2012-06-27 | 2012-10-17 | 新乡市中科科技有限公司 | Method for continuous hydrophilic modification of polypropylene microporous membrane |
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