CN104856740A - Combined device for tumor blood capillary embolism with ultrasound micro-bubble contrast agents - Google Patents
Combined device for tumor blood capillary embolism with ultrasound micro-bubble contrast agents Download PDFInfo
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- CN104856740A CN104856740A CN201510219530.XA CN201510219530A CN104856740A CN 104856740 A CN104856740 A CN 104856740A CN 201510219530 A CN201510219530 A CN 201510219530A CN 104856740 A CN104856740 A CN 104856740A
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- Prior art keywords
- probe
- ultrasonic
- ultrasound
- contrast agent
- microbubble contrast
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0039—Ultrasound therapy using microbubbles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0043—Ultrasound therapy intra-cavitary
Abstract
A combined device for tumor blood capillary embolism with ultrasound micro-bubble contrast agents comprises an injection device of the ultrasound micro-bubble contrast agents, a type-B ultrasonic inspection probe and a type-B ultrasonic induction probe, wherein the type-B ultrasonic inspection probe and the type-B ultrasonic induction probe are combined to form a probe structure; and an ultrasound generation device of the type-B ultrasonic inspection probe is a piezoelectric ceramic chip array, the type-B ultrasonic induction probe is a round ultrasonic transducer, cross sections of probes of the piezoelectric ceramic chip array are arranged into a concave arc shape, and the round ultrasonic transducer is disposed inside the concave arc.
Description
One, technical field
The present invention relates to the combination unit that ultrasound microbubble contrast agent carries out tumor capillary embolism.
Two, background technology
Present inventor Wu Wei proposes method and the thinking that ultrasound microbubble contrast agent carries out tumor capillary embolism treatment tumor for 2003 first, disclosed patent has: 03132373.1 ultrasound microbubble contrast agent forms the purposes that capillary embolism prepares tumour medicine, the mode injected by ultrasound microbubble contrast agent is as the agent of formation capillary embolism, thus as tumour medicine, the position ultrasound wave forming capillary embolism is being needed to carry out pressing close to irradiation, selective induction forming region capillary embolism.Ultrasound microbubble contrast agent is for the formation of the method to set up of the medical treatment device of capillary embolism, produce the combination of injection device, regional positioning device and apparatus for ultrasonic therapeutic treatment by ultrasound microbubble contrast agent to form, the mode that ultrasound microbubble contrast agent injects by ultrasound microbubble contrast agent generation injection device is as the agent of formation capillary embolism, regional positioning device determines the position needing to form capillary embolism, apparatus for ultrasonic therapeutic treatment positions irradiation at this position ultrasound wave, selective induction forming region tiny blood vessels thromboembolism.
200410014367.5 spikes with targeting substance proposed or label isotope microbubble reagent and purposes, mix by ultrasound microbubble contrast agent with the spike of targeting substance or label isotope material or combine.Spike or label isotope comprise general medical-isotope; Microbubble reagent comprises fluorine carbon microbubble reagent, normal saline microbubble reagent, galactose bubble liquid, peplos bubble liquid, carbon dioxide-type generation type microbubble reagent, and comprise choose macromolecular material as ultrasound agent parcel, stick, stable and carry the carrier of bubble.Be used for low frequency with the spike of targeting substance or label isotope, the acoustic horn effect of low power ultrasound induction microvesicle to cause in the method treatment tumor of blood vessel embolism tumor region location and utilize the biological effect launching β ray isotopic ionization radiation to the radiation of tumor cell simultaneously.
Ultrasound microbubble contrast agent carries out the square Be very effective of tumor capillary embolism treatment tumor, and microbubble reagent medicine itself is harmless to human non-toxic, has good potential applicability in clinical practice and social benefit.Medicine comprises Therapeutic Method not damaged, and without general toxicity side effect, determined curative effect, is suitable for various malignant tumor by stages, the malignant tumor of the body surfaces such as the abdominal cavity except lung tumors, pelvic cavity, mammary gland, easy to operate, can repetitive therapy.
But, the present inventor uses B ultrasonic induction probe (probe that low frequency high energy ultrasonic produces and apparatus for ultrasonic therapeutic treatment) to position irradiation at tumor locus ultrasound wave, selective induction forming region tiny blood vessels thromboembolism.Knub position is detected in advance by ultrasound diagnosis probe (being generally 3.5M high frequency low-yield), the mode in advance ultrasound microbubble contrast agent injected as formation capillary embolism agent, thus as tumor (not using antitumor drug); B ultrasonic induction is popped one's head in is needing the position ultrasound wave forming capillary embolism to carry out pressing close to irradiation, selective induction forming region capillary embolism, thus the object reaching treatment tumor.
Ultrasound microbubble contrast agent carries out tumor capillary embolism and is combined with multiple detection or injection device, ultrasound diagnosis probe and B ultrasonic induction (treatment) probe are dual probe structures, even if ultrasound diagnosis probe checks that knub position can not ensure time very accurate that B ultrasonic induction (treatment) probe carries out inducing (treatment) microbubble reagent very accurately, the work of the latter is obviously more important, and yet there are no good scheme can head it off.
Three, summary of the invention
The present invention seeks to, the combination unit that a kind of ultrasound microbubble contrast agent carries out tumor capillary embolism is proposed, especially ultrasound diagnosis probe checks that knub position accurately can ensure that B ultrasonic induction (treatment) probe carries out inducing (treatment) microbubble reagent very accurately, thus guarantees the effect of oncotherapy.
Technical scheme of the present invention is, a kind of ultrasound microbubble contrast agent carries out the combination unit of tumor capillary embolism, comprises ultrasound microbubble contrast agent injection device, ultrasound diagnosis probe and B ultrasonic induction probe, ultrasound diagnosis probe and B ultrasonic induction probe coupling probe structure.
Further, the ultrasonic generator of ultrasound diagnosis probe is piezoelectric ceramics chip arrays, and B ultrasonic induction probe is circular ultrasonic transducer, and the cross sectional arrangements of the probe of piezoelectric ceramics chip arrays becomes concave arc shape, and in circular ultrasonic transducer concave arc shape.
Further, piezoelectric ceramics chip arrays and circular ultrasonic transducer all have electric connection line to be connected to outside.
Beneficial effect of the present invention: the present invention has developed the medical treatment device of ultrasound microbubble contrast agent for the formation of capillary embolism, produce the combination of injection device, regional positioning device and apparatus for ultrasonic therapeutic treatment by ultrasound microbubble contrast agent to form, the mode that ultrasound microbubble contrast agent injects by ultrasound microbubble contrast agent generation injection device is as the agent of formation capillary embolism, regional positioning device determines the position needing to form capillary embolism, apparatus for ultrasonic therapeutic treatment positions irradiation at this position ultrasound wave, selective induction forming region tiny blood vessels thromboembolism.Even if ultrasound diagnosis probe checks that knub position can ensure time very accurate that B ultrasonic induction (treatment) probe carries out inducing (treatment) microbubble reagent very accurately, ensure to carry out induction thromboembolism in place.
Four, accompanying drawing explanation
Fig. 1 is level cross-sectionn of the present invention structural representation;
Fig. 2 is vertical cross-section structural representation of the present invention;
Fig. 3 is the present invention's schematic diagram when using.
Five, detailed description of the invention
As shown in the figure, a kind of ultrasound microbubble contrast agent carries out the combination unit of tumor capillary embolism, comprises ultrasound microbubble contrast agent injection device, ultrasound diagnosis probe and B ultrasonic induction probe, and ultrasound diagnosis probe and B ultrasonic induction probe are coupling probe structure 1.
In coupling probe structure 1, the ultrasonic generator of ultrasound diagnosis probe is piezoelectric ceramics chip arrays 2, B ultrasonic induction probe is circular ultrasonic transducer 3, the cross sectional arrangements of the probe of piezoelectric ceramics chip arrays becomes concave arc shape, and in circular ultrasonic transducer concave arc shape, but do not contact, without any acoustical coupling material between piezoelectric ceramics chip arrays and circular ultrasonic transducer, a preferably ring-type dead slot structure.
Piezoelectric ceramics chip arrays and circular ultrasonic transducer all have electric connection line to be connected to outside.Piezoelectric ceramics chip arrays picks out B ultrasonic holding wire and drive signal line simultaneously, connects ready-made B ultrasonic main frame, and circular ultrasonic transducer has drive signal line to connect power driving power supply, and power driving power supply B ultrasonic main frame is also integrated certainly.
Claims (4)
1. ultrasound microbubble contrast agent carries out a combination unit for tumor capillary embolism, it is characterized in that comprising ultrasound microbubble contrast agent injection device, ultrasound diagnosis probe and B ultrasonic induction probe, ultrasound diagnosis probe and B ultrasonic induction probe coupling probe structure.
2. microbubble contrast agent according to claim 1 carries out the combination unit of tumor capillary embolism, it is characterized in that the ultrasonic generator that ultrasound diagnosis is popped one's head in is piezoelectric ceramics chip arrays, B ultrasonic induction probe is circular ultrasonic transducer, the cross sectional arrangements of the probe of piezoelectric ceramics chip arrays becomes concave arc shape, and in circular ultrasonic transducer concave arc shape.
3. microbubble contrast agent according to claim 1 carries out the combination unit of tumor capillary embolism, it is characterized in that piezoelectric ceramics chip arrays and circular ultrasonic transducer all have electric connection line to be connected to outside.
4. microbubble contrast agent according to claim 1 carries out the combination unit of tumor capillary embolism, it is characterized in that it being ring-type dead slot structure between piezoelectric ceramics chip arrays and circular ultrasonic transducer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510219530.XA CN104856740A (en) | 2015-04-30 | 2015-04-30 | Combined device for tumor blood capillary embolism with ultrasound micro-bubble contrast agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510219530.XA CN104856740A (en) | 2015-04-30 | 2015-04-30 | Combined device for tumor blood capillary embolism with ultrasound micro-bubble contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104856740A true CN104856740A (en) | 2015-08-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510219530.XA Pending CN104856740A (en) | 2015-04-30 | 2015-04-30 | Combined device for tumor blood capillary embolism with ultrasound micro-bubble contrast agents |
Country Status (1)
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| CN (1) | CN104856740A (en) |
Citations (13)
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|---|---|---|---|---|
| US5694936A (en) * | 1994-09-17 | 1997-12-09 | Kabushiki Kaisha Toshiba | Ultrasonic apparatus for thermotherapy with variable frequency for suppressing cavitation |
| CN1519041A (en) * | 2003-09-01 | 2004-08-11 | 巍 吴 | Method and equipment for setting medical care device of ultrasound microbubble contrast media to form embolism in capillary vessel |
| CN2762763Y (en) * | 2005-01-29 | 2006-03-08 | 重庆福斯电子技术有限公司 | Phase array focusing supersonic closing hemostat for blood vessel |
| CN2810654Y (en) * | 2004-06-23 | 2006-08-30 | 吴巍 | Device for resulting in tumor vascular embolism by ultrasonic radiation micro-bubble reagent |
| CN1901837A (en) * | 2003-12-30 | 2007-01-24 | 利普索尼克斯股份有限公司 | Component ultrasound transducer |
| US20080221448A1 (en) * | 2007-03-07 | 2008-09-11 | Khuri-Yakub Butrus T | Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions |
| WO2009094554A2 (en) * | 2008-01-25 | 2009-07-30 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
| CN102233159A (en) * | 2010-05-06 | 2011-11-09 | 高春平 | Focused ultrasonic noninvasive sound powered tumor therapy system |
| US20130261461A1 (en) * | 2012-04-02 | 2013-10-03 | Olympus Corporation | Ultrasonic treatment apparatus |
| CN103721348A (en) * | 2012-10-16 | 2014-04-16 | 重庆海扶医疗科技股份有限公司 | Ultrasonic monitoring treatment device and ultrasonic monitoring device |
| WO2014138050A1 (en) * | 2013-03-04 | 2014-09-12 | Sunnybrook Health Sciences Centre | System and method for measuring and correcting ultrasound phase distortions induced by aberrating media |
| WO2014145926A2 (en) * | 2013-03-15 | 2014-09-18 | Ardent Sound, Inc. | Liquid-filled acoustic probe system with reservoir and loss detection means |
| WO2014156766A1 (en) * | 2013-03-29 | 2014-10-02 | オリンパス株式会社 | Ultrasonic treatment device |
-
2015
- 2015-04-30 CN CN201510219530.XA patent/CN104856740A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5694936A (en) * | 1994-09-17 | 1997-12-09 | Kabushiki Kaisha Toshiba | Ultrasonic apparatus for thermotherapy with variable frequency for suppressing cavitation |
| CN1519041A (en) * | 2003-09-01 | 2004-08-11 | 巍 吴 | Method and equipment for setting medical care device of ultrasound microbubble contrast media to form embolism in capillary vessel |
| CN1901837A (en) * | 2003-12-30 | 2007-01-24 | 利普索尼克斯股份有限公司 | Component ultrasound transducer |
| CN2810654Y (en) * | 2004-06-23 | 2006-08-30 | 吴巍 | Device for resulting in tumor vascular embolism by ultrasonic radiation micro-bubble reagent |
| CN2762763Y (en) * | 2005-01-29 | 2006-03-08 | 重庆福斯电子技术有限公司 | Phase array focusing supersonic closing hemostat for blood vessel |
| US20080221448A1 (en) * | 2007-03-07 | 2008-09-11 | Khuri-Yakub Butrus T | Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions |
| WO2009094554A2 (en) * | 2008-01-25 | 2009-07-30 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
| CN102233159A (en) * | 2010-05-06 | 2011-11-09 | 高春平 | Focused ultrasonic noninvasive sound powered tumor therapy system |
| US20130261461A1 (en) * | 2012-04-02 | 2013-10-03 | Olympus Corporation | Ultrasonic treatment apparatus |
| CN103721348A (en) * | 2012-10-16 | 2014-04-16 | 重庆海扶医疗科技股份有限公司 | Ultrasonic monitoring treatment device and ultrasonic monitoring device |
| WO2014138050A1 (en) * | 2013-03-04 | 2014-09-12 | Sunnybrook Health Sciences Centre | System and method for measuring and correcting ultrasound phase distortions induced by aberrating media |
| WO2014145926A2 (en) * | 2013-03-15 | 2014-09-18 | Ardent Sound, Inc. | Liquid-filled acoustic probe system with reservoir and loss detection means |
| WO2014156766A1 (en) * | 2013-03-29 | 2014-10-02 | オリンパス株式会社 | Ultrasonic treatment device |
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| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150826 |
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| RJ01 | Rejection of invention patent application after publication |