CN104940998A - Soft tissue filling material and preparation method thereof - Google Patents
Soft tissue filling material and preparation method thereof Download PDFInfo
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- CN104940998A CN104940998A CN201510308687.XA CN201510308687A CN104940998A CN 104940998 A CN104940998 A CN 104940998A CN 201510308687 A CN201510308687 A CN 201510308687A CN 104940998 A CN104940998 A CN 104940998A
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- filling material
- tissue filling
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Abstract
The invention discloses a soft tissue filling material and a preparation method thereof. The material comprises the following components in parts by weight: 36-51 parts of polyvinyl alcohol, 12-28 parts of polyacrylamide, 13-23 parts of hyaluronic acid, 3-11 parts of sodium sulfite, 2-9 parts of BBP, 9-17 parts of dimethylacetamide, 1-14 parts of polyvinyl pyrrolidine, and 3-13 parts of carbodiimide. The soft tissue filling material prepared by the invention has good biocompatibility, and is suitable for aesthetic and plastic surgery soft tissue filling such as facelift and sunken part filling.
Description
Technical field
The invention belongs to field of medical materials, be specifically related to a kind of soft tissue filling material and preparation method thereof.
Background technology
Soft tissue refers to skin, subcutaneous tissue, muscle, tendon, ligament, joint capsule, the synovial bursae of human body, nerve, blood vessel etc.Soft tissue filling material, by implantable bioartificial body, occupies cavity and defect that soft tissue injury or pathological changes cause, substitutes and exercise or strengthen its original function, thus having extensive and important application in field of orthopedic surgery.Repair in tissue injury, improve in the treatment of face and body contour, desirable effect can be reached by soft tissue filling material.
Along with the increase at age, the evidence for senescence of people is obvious gradually, and the face as a lot of people can occur depression in various degree because of the loss of fat, thus have impact on the attractive in appearance of face, people also seems wan and sallow does not have spirit, and therefore implantable packing material reaches the effect of rejuvenation.But existing soft tissue filling material biocompatibility is poor, the side effect produced after implanting is more, as there is skin bruise, zest, inflammation, migration etc., the health of serious harm face-lifting crowd.
Summary of the invention
In order to overcome above the deficiencies in the prior art, the invention provides a kind of soft tissue filling material and preparation method thereof, obtained material has good biocompatibility, is applicable to drainer for plastic surgery Soft-tissue operation, as face crinkle-removing, depression are filled.
The technical solution used in the present invention is: a kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 36-51 part, polyacrylamide 12-28 part, hyaluronic acid 13-23 part, sodium sulfite 3-11 part, BBP2-9 part, dimethyl acetylamide 9-17 part, polyvinylpyrrolidine 1-14 part, carbodiimides 3-13 part.
Preferably, a kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 39-47 part, polyacrylamide 15-23 part, hyaluronic acid 17-21 part, sodium sulfite 5-10 part, BBP3-7 part, dimethyl acetylamide 12-15 part, polyvinylpyrrolidine 3-11 part, carbodiimides 5-12 part.
Preferred, a kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 43 parts, polyacrylamide 19 parts, hyaluronic acid 20 parts, sodium sulfite 7 parts, BBP6 part, dimethyl acetylamide 13 parts, polyvinylpyrrolidine 8 parts, carbodiimides 8 parts.
A preparation method for soft tissue filling material, comprises the following steps:
(1) by above-mentioned mass parts, polyvinyl alcohol, polyacrylamide, hyaluronic acid, sodium sulfite, BBP, dimethyl acetylamide, polyvinylpyrrolidine, carbodiimides are placed in reactor, mix homogeneously at 80-100 DEG C of temperature, be heated to 110-150 DEG C and keep 30-50min, obtain compound;
(2) step (1) gained compound is placed in mixing roll mixing, after cooling, oxirane sterilization, namely obtains described soft tissue filling material.
In above-mentioned steps (2), mixing time is 3-8min, and temperature is 200-250 DEG C.
Beneficial effect: the soft tissue filling material that the present invention obtains is by the synergism between component, cytotoxicity, anaphylaxis, heat source response, heavy metal are all undetected, have and there is good biocompatibility, be applicable to drainer for plastic surgery Soft-tissue operation, as face crinkle-removing, depression are filled.
Detailed description of the invention
Embodiment 1
A kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 36 parts, polyacrylamide 12 parts, hyaluronic acid 13 parts, sodium sulfite 3 parts, BBP2 part, dimethyl acetylamide 9 parts, polyvinylpyrrolidine 1 part, carbodiimides 3 parts.
Preparation method:
(1) by above-mentioned mass parts, polyvinyl alcohol, polyacrylamide, hyaluronic acid, sodium sulfite, BBP, dimethyl acetylamide, polyvinylpyrrolidine, carbodiimides are placed in reactor, mix homogeneously at 80 DEG C of temperature, is heated to 110 DEG C and keeps 30min, obtain compound;
(2) step (1) gained compound is placed in mixing roll mixing, mixing time is 3min, and temperature is 200 DEG C, namely obtains described soft tissue filling material after cooling, oxirane sterilization.
Embodiment 2
A kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 51 parts, polyacrylamide 28 parts, hyaluronic acid 23 parts, sodium sulfite 11 parts, BBP9 part, dimethyl acetylamide 17 parts, polyvinylpyrrolidine 14 parts, carbodiimides 13 parts.
Preparation method:
(1) by above-mentioned mass parts, polyvinyl alcohol, polyacrylamide, hyaluronic acid, sodium sulfite, BBP, dimethyl acetylamide, polyvinylpyrrolidine, carbodiimides are placed in reactor, mix homogeneously at 100 DEG C of temperature, is heated to 150 DEG C and keeps 50min, obtain compound;
(2) step (1) gained compound is placed in mixing roll mixing, mixing time is 8min, and temperature is 250 DEG C, namely obtains described soft tissue filling material after cooling, oxirane sterilization.
Embodiment 3
A kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 39 parts, polyacrylamide 15 parts, hyaluronic acid 17 parts, sodium sulfite 5 parts, BBP3 part, dimethyl acetylamide 12 parts, polyvinylpyrrolidine 3 parts, carbodiimides 5 parts.
Preparation method:
(1) by above-mentioned mass parts, polyvinyl alcohol, polyacrylamide, hyaluronic acid, sodium sulfite, BBP, dimethyl acetylamide, polyvinylpyrrolidine, carbodiimides are placed in reactor, mix homogeneously at 85 DEG C of temperature, is heated to 120 DEG C and keeps 35min, obtain compound;
(2) step (1) gained compound is placed in mixing roll mixing, mixing time is 4min, and temperature is 210 DEG C, namely obtains described soft tissue filling material after cooling, oxirane sterilization.
Embodiment 4
A kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 47 parts, polyacrylamide 23 parts, hyaluronic acid 21 parts, sodium sulfite 510 parts, BBP7 part, dimethyl acetylamide 15 parts, polyvinylpyrrolidine 11 parts, carbodiimides 12 parts.
Preparation method:
(1) by above-mentioned mass parts, polyvinyl alcohol, polyacrylamide, hyaluronic acid, sodium sulfite, BBP, dimethyl acetylamide, polyvinylpyrrolidine, carbodiimides are placed in reactor, mix homogeneously at 90 DEG C of temperature, is heated to 140 DEG C and keeps 45min, obtain compound;
(2) step (1) gained compound is placed in mixing roll mixing, mixing time is 6min, and temperature is 240 DEG C, namely obtains described soft tissue filling material after cooling, oxirane sterilization.
Embodiment 5
A kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 43 parts, polyacrylamide 19 parts, hyaluronic acid 20 parts, sodium sulfite 7 parts, BBP6 part, dimethyl acetylamide 13 parts, polyvinylpyrrolidine 8 parts, carbodiimides 8 parts.
Preparation method:
(1) by above-mentioned mass parts, polyvinyl alcohol, polyacrylamide, hyaluronic acid, sodium sulfite, BBP, dimethyl acetylamide, polyvinylpyrrolidine, carbodiimides are placed in reactor, mix homogeneously at 90 DEG C of temperature, is heated to 130 DEG C and keeps 40min, obtain compound;
(2) step (1) gained compound is placed in mixing roll mixing, mixing time is 5min, and temperature is 220 DEG C, namely obtains described soft tissue filling material after cooling, oxirane sterilization.
Comparative example 1
Do not add hyaluronic acid with the difference of embodiment 5.
A kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 43 parts, polyacrylamide 19 parts, sodium sulfite 7 parts, BBP6 part, dimethyl acetylamide 13 parts, polyvinylpyrrolidine 8 parts, carbodiimides 8 parts.
Preparation method:
(1) by above-mentioned mass parts, polyvinyl alcohol, polyacrylamide, sodium sulfite, BBP, dimethyl acetylamide, polyvinylpyrrolidine, carbodiimides are placed in reactor, mix homogeneously at 90 DEG C of temperature, is heated to 130 DEG C and keeps 40min, obtain compound;
(2) step (1) gained compound is placed in mixing roll mixing, mixing time is 5min, and temperature is 220 DEG C, namely obtains described soft tissue filling material after cooling, oxirane sterilization.
Comparative example 2
Do not add dimethyl acetylamide with the difference of embodiment 5.
A kind of soft tissue filling material, is made up of each component of following mass parts: polyvinyl alcohol 43 parts, polyacrylamide 19 parts, hyaluronic acid 20 parts, sodium sulfite 7 parts, BBP6 part, polyvinylpyrrolidine 8 parts, carbodiimides 8 parts.
Preparation method:
(1) by above-mentioned mass parts, polyvinyl alcohol, polyacrylamide, hyaluronic acid, sodium sulfite, BBP, polyvinylpyrrolidine, carbodiimides are placed in reactor, mix homogeneously at 90 DEG C of temperature, are heated to 130 DEG C and keep 40min, obtain compound;
(2) step (1) gained compound is placed in mixing roll mixing, mixing time is 5min, and temperature is 220 DEG C, namely obtains described soft tissue filling material after cooling, oxirane sterilization.
Performance test:
Adopt the packing material of embodiment 1-5 to carry out clinical trial, sample is 100 people, is divided into 5 groups, often organizes 10 male 10 female, does not all occur side effect.
The performance test of the soft tissue filling material that embodiment 1-5 and comparative example 1-2 obtains is as shown in the table:
| Cytotoxicity | Anaphylaxis | Heat source response | Heavy metal | |
| Embodiment 1 | Nothing | Nothing | Nothing | Do not detect |
| Embodiment 2 | Nothing | Nothing | Nothing | Do not detect |
| Embodiment 3 | Nothing | Nothing | Nothing | Do not detect |
| Embodiment 4 | Nothing | Nothing | Nothing | Do not detect |
| Embodiment 5 | Nothing | Nothing | Nothing | Do not detect |
| Comparative example 1 | Nothing | Have | Have | Do not detect |
| Comparative example 2 | Have | Nothing | Have | Do not detect |
As can be seen from the above table: the obtained soft tissue filling material cytotoxicity of embodiment 1-5, anaphylaxis, heat source response, heavy metal are all undetected; Do not add hyaluronic acid in comparative example 1, have the concurrent raw heat source response of allergic phenomena; Do not add dimethyl acetylamide in comparative example 2, have the concurrent raw heat source response of cytotoxicity.It can thus be appreciated that, the soft tissue filling material that the present invention obtains is by the synergism between component, cytotoxicity, anaphylaxis, heat source response, heavy metal are all undetected, have and there is good biocompatibility, be applicable to drainer for plastic surgery Soft-tissue operation, as face crinkle-removing, depression are filled.
Claims (5)
1. a soft tissue filling material, it is characterized in that, be made up of the component of following mass parts: polyvinyl alcohol 36-51 part, polyacrylamide 12-28 part, hyaluronic acid 13-23 part, sodium sulfite 3-11 part, BBP2-9 part, dimethyl acetylamide 9-17 part, polyvinylpyrrolidine 1-14 part, carbodiimides 3-13 part.
2. a kind of soft tissue filling material according to claim 1, it is characterized in that, be made up of the component of following mass parts: polyvinyl alcohol 39-47 part, polyacrylamide 15-23 part, hyaluronic acid 17-21 part, sodium sulfite 5-10 part, BBP3-7 part, dimethyl acetylamide 12-15 part, polyvinylpyrrolidine 3-11 part, carbodiimides 5-12 part.
3. a kind of soft tissue filling material according to claim 1, it is characterized in that, be made up of the component of following mass parts: polyvinyl alcohol 43 parts, polyacrylamide 19 parts, hyaluronic acid 20 parts, sodium sulfite 7 parts, BBP6 part, dimethyl acetylamide 13 parts, polyvinylpyrrolidine 8 parts, carbodiimides 8 parts.
4. the preparation method of a kind of soft tissue filling material of claims 1 to 3 described in any one, is characterized in that: comprise the following steps:
(1) by above-mentioned mass parts, polyvinyl alcohol, polyacrylamide, hyaluronic acid, sodium sulfite, BBP, dimethyl acetylamide, polyvinylpyrrolidine, carbodiimides are placed in reactor, mix homogeneously at 80-100 DEG C of temperature, be heated to 110-150 DEG C and keep 30-50min, obtain compound;
(2) step (1) gained compound is placed in mixing roll mixing, after cooling, oxirane sterilization, namely obtains described soft tissue filling material.
5. the preparation method of a kind of soft tissue filling material according to claim 4, is characterized in that: in described (3), mixing time is 3-8min, and temperature is 200-250 DEG C.
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| CN201510308687.XA CN104940998A (en) | 2015-06-08 | 2015-06-08 | Soft tissue filling material and preparation method thereof |
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| CN201510308687.XA CN104940998A (en) | 2015-06-08 | 2015-06-08 | Soft tissue filling material and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114146219A (en) * | 2021-12-29 | 2022-03-08 | 上海璞聚生物科技有限公司 | Soft tissue filler and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101400327A (en) * | 2006-03-13 | 2009-04-01 | 凯塞拉生物药品公司 | Fluidic tissue augmentation compositions and methods |
| US20090227689A1 (en) * | 2007-03-05 | 2009-09-10 | Bennett Steven L | Low-Swelling Biocompatible Hydrogels |
| CN102284082A (en) * | 2011-07-01 | 2011-12-21 | 董萍 | Facial fibrous protein composite filled and positioned in subcutaneous soft tissues, and preparation method thereof |
-
2015
- 2015-06-08 CN CN201510308687.XA patent/CN104940998A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101400327A (en) * | 2006-03-13 | 2009-04-01 | 凯塞拉生物药品公司 | Fluidic tissue augmentation compositions and methods |
| US20090227689A1 (en) * | 2007-03-05 | 2009-09-10 | Bennett Steven L | Low-Swelling Biocompatible Hydrogels |
| CN102284082A (en) * | 2011-07-01 | 2011-12-21 | 董萍 | Facial fibrous protein composite filled and positioned in subcutaneous soft tissues, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张元龙等: "聚丙烯酰胺水凝胶在颜面软组织填充中的应用", 《实用美容整形外科杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114146219A (en) * | 2021-12-29 | 2022-03-08 | 上海璞聚生物科技有限公司 | Soft tissue filler and preparation method thereof |
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