CN105012049A - Print nozzle system and mixed spraying printing technology of adjustable soft hollow tube support - Google Patents
Print nozzle system and mixed spraying printing technology of adjustable soft hollow tube support Download PDFInfo
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- CN105012049A CN105012049A CN201510300556.7A CN201510300556A CN105012049A CN 105012049 A CN105012049 A CN 105012049A CN 201510300556 A CN201510300556 A CN 201510300556A CN 105012049 A CN105012049 A CN 105012049A
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Abstract
The invention provides a print nozzle system and mixed spraying printing technology of an adjustable soft hollow tube support.The print nozzle system comprises five functional parts including a pneumatic power source, a feeding device, a mixing device, sprayers and a spraying device. A hollow circular pipe is formed in such a manner that a solution A is subjected to dispensing, mixing and spraying technology under effects of a solution B, a solution C and a solution D via the sprayers. A two-layer or multi-layer structure is constructed. Under the spraying effect, connection strength between/among layers can be increased. The print nozzle system and mixed spraying printing technology of the adjustable soft hollow tube have following beneficial effects: two solutions can be completely mixed; continuous structures of hollow or solid circular pipes can be printed and accumulated in order to form different structures in order to print and manufacture hollow circular pipes similar to blood vessels; a micro-channel structure in the interior of the support can be constructed in order to transfer nutrition and other substance in tissue engineering by repair of large tissue; and the print nozzle system and mixed spraying printing technology of the adjustable soft hollow tube can be extensively applied to construction of biological tissues in all kinds.
Description
Technical field
The present invention is mechanical automation and biotechnology, organizational project crossing domain, and the mixed atomizing being specifically related to printing head system and adjustable soft hollow pipe holder prints technique.
Background technology
Organizational project by simulation natural tissues structure, utilize cell, support, somatomedin etc. three element build artificial tissue, for impaired or degenerate tissue reparation.Wherein, support is the key of space transoportation and positioning cells and somatomedin, not only need that there is certain mechanical load-bearing capability and the property of water-bearing, and in the application towards thick tissue and organ, in order to transport enough nutrition, somatomedin, oxygen to a large amount of cell, and discharging metabolic waste, making cell can grow and be fused together, form large-scale tissue and organ, but to manufacture and form the vascularization with similar blood vessel structure and blood vessel network be its manufacture difficult point.
The structure of the hydrogels such as sodium alginate is similar to the structure of the extracellular matrix of biological tissue; there is the critical natures such as good biocompatibility, biological degradability, hypotoxicity and immunoprotection; the large water gaging that its inside is rich in can effectively for cell provides growth conditions; be widely used in and prepare support, but the inner cylinder structure of the hydrogel of bulk is difficult to customization completes.
Summary of the invention
The object of the invention is to overcome above-mentioned technical deficiency, a kind of 3D print system is provided, not only while stamping ink gel stent, different cells can be printed on assigned address according to demand, and form the complex (construct) with hollow circular-tube structure stand (scaffold) or cell and support, effectively can complete structure and the function of bionical vasoganglion.The method can be widely used in the structure of various biological tissue.
Technical scheme of the present invention is achieved in that
A kind of print nozzle system, this system comprises five functional parts: pneumatic power source, pay-off, mixing arrangement, shower nozzle and sprayer unit, pneumatic power source is connected by pneumatic hose with pay-off, and pay-off is connected with mixing arrangement, and mixing arrangement is connected by pneumatic hose with shower nozzle.
Described mixing arrangement adopts reversion structure, comprises joint, the first curved pipe, and first is straight, the first U-shaped pipe, the second curved pipe, the second U-shaped pipe, the second straight tube, the 3rd straight tube; First straight tube is connected with the first curved pipe, and the first U-shaped pipe is connected with the first straight tube, and the second straight tube is connected with the first U-shaped pipe, and the second U-shaped pipe is connected with the second straight tube, and the 3rd straight tube is connected with the second U-shaped pipe, and the second curved pipe is connected with the 3rd straight tube; Inside comprises the first static agitation blade, and the second static agitation blade, wherein the first curved pipe is connected with joint.
Be provided with the first static agitation blade in first straight tube, the second straight tube, the 3rd straight tube, in the first U-shaped pipe, be provided with the second static agitation blade.
Described shower nozzle comprises shower nozzle one or shower nozzle two.
Mixing arrangement is connected with shower nozzle one or is connected with shower nozzle two.
The mixed atomizing of adjustable soft hollow pipe holder prints a technique, comprises the following steps:
1), at normal temperatures, the fluid reservoir A in pay-off is equipped with in solution A, fluid reservoir B and solution B is housed, and under the effect of the pressed gas provided in pneumatic power source, solution A and solution B are extruded by biliquid glue dispensing valve;
2) after, solution A and solution B are extruded by biliquid glue dispensing valve, enter mixing arrangement, under the effect of the pressed gas provided in pneumatic power source, solution A and solution B haptoreaction, and through the first static agitation blade, second static agitation blade, after flowing through the reversion structure of whole mixing arrangement, solution A fully mixes with solution B;
3), solution A after mixing tube fully mixes, enters shower nozzle one or shower nozzle two with solution B, in shower nozzle one or shower nozzle two exit, forms hollow or solid circular pipe structure;
4), in shower nozzle one exit, while forming hollow circular-tube structure, clamp-on solution C in the syringe needle two in shower nozzle one, solution C is contacting in shower nozzle one exit with the mixture of solution B with solution A, forms the internal structure of hollow circular-tube;
5), solution D extrudes from sprayer unit and forms atomized soln D, react, the external structure of formation hollow pipe with the surface contact of the mixture of the internal structure of the formation hollow circular-tube extruded from shower nozzle one;
6), one deck hollow circular-tube structure is namely built by above-mentioned steps, same above-mentioned steps during one deck under building, solution D is extruded from sprayer unit and is formed atomized soln D, with step 4) mixture react, namely can bonding strength between enhancement layer and layer.The hollow circular-tube structure built is two-layer or multilamellar.
The solid circular pipe structure extruded from shower nozzle two forms atomized soln D haptoreaction, generation solid circular pipe structure with extruding from sprayer unit.
The extruded velocity of solution A is 0.1-1.0ml/min, and the extruded velocity of solution B is 0.1-1.0ml/min, and the extruded velocity of solution C is 40-70ul/sec, and the extruded velocity of solution D is 300-700ul/sec.
Solution A is with sodium alginate, chitosan is the Native Gel material of representative, solution B is with calcium chloride or barium chloride, what sodium hydroxide represented can cause sodium alginate, the solution of chitosan plastic, solution C is with calcium chloride or barium chloride, what sodium hydroxide represented can cause sodium alginate, the solution of chitosan plastic, solution D is with calcium chloride or barium chloride, what sodium hydroxide represented can cause sodium alginate, the solution of chitosan plastic, the concentration of solution B is 0.2%-0.6% (m/v), the concentration of solution C is 2%-6% (m/v), the concentration of solution D is 2%-6% (m/v).
The mixed atomizing that the invention provides printing head system and adjustable soft hollow pipe holder prints technique, two kinds of solution can be made to mix completely, hollow or the solid circular pipe structure of continuous print can be printed and cumulatively form different structure, solve printing and the manufacture of the hollow circular-tubes such as similar blood vessel, and solving and repair bulk tissue in organizational project is transmit the manufacturing issue that the materials such as nutrition build internal stent micro-channel structure, can be widely used in the structure of various biological tissue.
Accompanying drawing explanation
Fig. 1 is printing head system;
1 be pneumatic power source, 2 be pay-off, 3 be mixing arrangement, 4 for shower nozzle one, 5 for shower nozzle two, 6 is sprayer unit, 7 is air compressor machine, 8 is air relief valve, 9 is biliquid glue dispensing valve, 10 is controller, 11 is fluid reservoir A, 12 is fluid reservoir B.
Fig. 2 is mixing arrangement figure.
Fig. 2 is mixing arrangement outside drawing a).
In figure, 13 is joint, and 14 is the first curved pipe, and 15 is the first straight tube, and 16 is the first U-shaped pipe, and 17 is the second curved pipe, and 18 is the second U-shaped pipe, and 19 is the second straight tube, and 20 is the 3rd straight tube.
Fig. 2 b) mixing arrangement internal mix blade figure.
21 be the first static agitation blade 1,22 is the second static agitation blade.
Fig. 3 is shower nozzle one figure,
Fig. 3 is a) shower nozzle one outline drawing,
Fig. 3 b) be shower nozzle one end partial enlarged drawing.
23 is syringe needle one, and 24 is syringe needle two, and 25 is syringe needle three.
Fig. 4 is print procedure figure.
26 is print platform, 27 hollow circular-tubes for printing;
Fig. 5 is 3D hollow cellular structure drop figure.
28 is 3D hollow cellular structure drop.
Detailed description of the invention
With reference to shown in Fig. 1, pneumatic power source 1 provides power for system.The sodium alginate of 0.2%-0.6% (m/v) is placed in fluid reservoir A 11, the calcium chloride of 2%-6% (m/v) is placed in fluid reservoir B 12, under gas pressure effect, flow through mixing arrangement 3 through pay-off 2, complete fully mixing of the sodium alginate of 0.2%-0.6% (m/v) and the calcium chloride of 2%-6% (m/v).The sodium alginate of 0.2%-0.6% (m/v) and the calcium chloride mixture of 2%-6% (m/v) are by syringe needle one (23), 2%-6% (m/v) calcium chloride is by syringe needle 2 24, to contact with the calcium chloride of 2%-6% (m/v) at the sodium alginate of shower nozzle 1 end 0.2%-0.6% (m/v) and the calcium chloride mixture of 2%-6% (m/v) and chemical reaction occurs, form hollow circular-tube internal structure.The calcium chloride of 2%-6% (m/v) sprays from sprayer unit (6), to contact with the calcium chloride mixture of 2%-6% (m/v) with the sodium alginate of 0.2%-0.6% (m/v) and chemical reaction occurs, form hollow circular-tube external structure, finally form hollow circular-tube.
With reference to shown in Fig. 2, the sodium alginate of 0.2%-0.6% (m/v) and the calcium chloride of 2%-6% (m/v) are by mixing arrangement 3, through the reversion structure of mixing arrangement 3, stir under the effect of inner first static agitation blade 21, the second static agitation blade 22 of mixing arrangement 3, complete fully mixing of the sodium alginate of 0.2%-0.6% (m/v) and the calcium chloride of 2%-6% (m/v).
With reference to shown in Fig. 3, the sodium alginate of 0.2%-0.6% (m/v) and the calcium chloride mixture of 2%-6% (m/v) are by syringe needle 1, the calcium chloride of %-6% (m/v) is by syringe needle 2 24, to contact with the calcium chloride of 2%-6% (m/v) at the sodium alginate of shower nozzle 1 end 0.2%-0.6% (m/v) and the calcium chloride mixture of 2%-6% (m/v) and chemical reaction occurs, form hollow circular-tube internal structure.
With reference to shown in Fig. 4, to contact with the calcium chloride of 2%-6% (m/v) at the sodium alginate of shower nozzle 1 end 0.2%-0.6% (m/v) and the calcium chloride mixture of 2%-6% (m/v) and chemical reaction occurs, form hollow circular-tube internal structure.The calcium chloride of 2%-6% (m/v) sprays from sprayer unit 6, to contact with the calcium chloride mixture of 2%-6% (m/v) with the sodium alginate of 0.2%-0.6% (m/v) and chemical reaction occurs, form hollow circular-tube external structure, finally form hollow circular-tube.
With reference to shown in Fig. 5, first to contact with the calcium chloride of 2%-6% (m/v) at the sodium alginate of shower nozzle 1 end 0.2%-0.6% (m/v) and the calcium chloride mixture of 2%-6% (m/v) and chemical reaction occurs, formation hollow circular-tube internal structure.The calcium chloride of 2%-6% (m/v) sprays from sprayer unit 6, to contact with the calcium chloride mixture of 2%-6% (m/v) with the sodium alginate of 0.2%-0.6% (m/v) and chemical reaction occurs, form hollow circular-tube external structure, finally form hollow circular-tube.Form the structure that one deck is made up of hollow circular-tube printing plane, when the moment that the hollow circular-tube extruded from shower nozzle 1 contacts with ground floor, the atomization calcium chloride sprayed from sprayer unit 6 carries out chemical reaction with it, form hollow circular-tube external structure, and the bonding strength strengthened between last layer and lower one deck, final formation 3D hollow cellular structure drop.
In print procedure, smooth muscle cell can be added in the sodium alginate of 0.2%-0.6% (m/v), middle mixing endotheliocyte is connect at the calcium chloride of 2%-6% (m/v), the final hollow circular-tube inner structural wall printed is made to be mixed with endotheliocyte, containing smooth muscle cell in tube wall, cultivate in culture fluid, finishing smooth myocyte and endotheliocyte Dual culture, solve the manufacturing issue repaired bulk soft tissue structure and need class blood vessel structure in organizational project.
Claims (10)
1. a print nozzle system, this system comprises five functional parts: pneumatic power source (1), pay-off (2), mixing arrangement (3), shower nozzle and sprayer unit (6), it is characterized in that, pneumatic power source (1) is connected by pneumatic hose with pay-off (2), pay-off (2) is connected with mixing arrangement (3), and mixing arrangement (3) is connected by pneumatic hose with shower nozzle.
2. printing head system according to claim 1, it is characterized in that, described mixing arrangement (3) adopts reversion structure, comprises joint (13), the first curved pipe (14), first straight tube (15), first U-shaped pipe (16), the second curved pipe (17), the second U-shaped pipe (18), second straight tube (19), the 3rd straight tube (20); First straight tube (15) is connected with the first curved pipe (14), first U-shaped pipe (16) is connected with the first straight tube (15), second straight tube (19) is connected with the first U-shaped pipe (16), second U-shaped pipe (18) is connected with the second straight tube (19), 3rd straight tube (20) is connected with the second U-shaped pipe (18), and the second curved pipe (17) is connected with the 3rd straight tube (20); Inside comprises the first static agitation blade (21), and the second static agitation blade (22), wherein the first curved pipe (14) is connected with joint (13).
3. printing head system according to claim 1, it is characterized in that, be provided with the first static agitation blade (21) in first straight tube (15), the second straight tube (19), the 3rd straight tube (20), in the first U-shaped pipe (16), be provided with the second static agitation blade (22).
4. printing head system according to claim 1, it is characterized in that, described shower nozzle comprises shower nozzle one (4) or shower nozzle two (5).
5. printing head system according to claim 1 or 4, is characterized in that, mixing arrangement (3) is connected with shower nozzle one (4) or is connected with shower nozzle two (5).
6. the mixed atomizing of adjustable soft hollow pipe holder prints a technique, it is characterized in that, comprises the following steps:
1), at normal temperatures, fluid reservoir A (11) in pay-off (2) is equipped with solution A, fluid reservoir B is equipped with solution B in (12), under the effect of the pressed gas provided in pneumatic power source (1), solution A and solution B are extruded by biliquid glue dispensing valve (9);
2) after, solution A and solution B are extruded by biliquid glue dispensing valve (9), enter mixing arrangement (3), under the effect of the pressed gas provided in pneumatic power source (1), solution A and solution B haptoreaction, and through the first static agitation blade (21), second static agitation blade (22), after flowing through the reversion structure of whole mixing arrangement (3), solution A fully mixes with solution B;
3), solution A after mixing tube fully mixes, enters shower nozzle one (4) or shower nozzle two (5) with solution B, in shower nozzle one (4) or shower nozzle two (5) exit, forms hollow or solid circular pipe structure;
4), in shower nozzle one (4) exit, while forming hollow circular-tube structure, solution C is clamp-oned in syringe needle two (24) in shower nozzle one (4), solution C is contacting in shower nozzle one (4) exit with the mixture of solution B with solution A, forms the internal structure of hollow circular-tube;
5), solution D extrudes from sprayer unit (6) and forms atomized soln D, react, the external structure of formation hollow pipe with the surface contact of the mixture of the internal structure of the formation hollow circular-tube extruded from shower nozzle one (4);
6), one deck hollow circular-tube structure is namely built by above-mentioned steps, same above-mentioned steps during one deck under building, solution D is extruded from sprayer unit (6) and is formed atomized soln D, with step 4) mixture react, namely can bonding strength between enhancement layer and layer.
7. the mixed atomizing of adjustable soft hollow pipe holder according to claim 6 prints technique, and it is characterized in that, the hollow circular-tube structure of structure is two-layer or multilamellar.
8. the mixed atomizing of adjustable soft hollow pipe holder according to claim 6 prints technique, it is characterized in that, the solid circular pipe structure extruded from shower nozzle two (5) forms atomized soln D haptoreaction, generation solid circular pipe structure with extruding from sprayer unit (6).
9. the mixed atomizing of adjustable soft hollow pipe holder according to claim 6 prints technique, it is characterized in that, the extruded velocity of solution A is 0.1-1.0ml/min, the extruded velocity of solution B is 0.1-1.0ml/min, the extruded velocity of solution C is 40-70ul/sec, and the extruded velocity of solution D is 300-700ul/sec.
10. the mixed atomizing of adjustable soft hollow pipe holder according to claim 6 prints technique, it is characterized in that, solution A is with sodium alginate, chitosan is the Native Gel material of representative, solution B is with calcium chloride or barium chloride, what sodium hydroxide represented can cause sodium alginate, the solution of chitosan plastic, solution C is with calcium chloride or barium chloride, what sodium hydroxide represented can cause sodium alginate, the solution of chitosan plastic, solution D is with calcium chloride or barium chloride, what sodium hydroxide represented can cause sodium alginate, the solution of chitosan plastic, the concentration of solution B is 0.2%-0.6% (m/v), the concentration of solution C is 2%-6% (m/v), the concentration of solution D is 2%-6% (m/v).
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CN109774118A (en) * | 2019-03-21 | 2019-05-21 | 中国科学院福建物质结构研究所 | A method of the mechanical property of enhancing FDM 3D printing product |
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Effective date of registration: 20210628 Address after: 710049 No. 28 West Xianning Road, Shaanxi, Xi'an Patentee after: XI'AN JIAOTONG University Address before: 710049 No. 28 West Xianning Road, Shaanxi, Xi'an Patentee before: XI'AN JIAOTONG University Patentee before: SHAANXI HENGTONG INTELLIGENT MACHINE Co.,Ltd. |