CN105105863A - Laboratory animal vascular intimal injury experimental facility - Google Patents
Laboratory animal vascular intimal injury experimental facility Download PDFInfo
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- CN105105863A CN105105863A CN201510452251.8A CN201510452251A CN105105863A CN 105105863 A CN105105863 A CN 105105863A CN 201510452251 A CN201510452251 A CN 201510452251A CN 105105863 A CN105105863 A CN 105105863A
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- shank
- fixation kit
- brush portion
- laboratory animal
- support bar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
Abstract
The invention relates to the field of medical experimental equipment and particularly relates to a laboratory animal vascular intimal injury experimental facility. The laboratory animal vascular intimal injury experimental facility comprises a brush part and a handle part, wherein the brush part comprises a fixed assembly and bristles arranged on the outer peripheral surface of the fixed assembly or brush teeth arranged on the fixed assembly; the fixed assembly is connected with one end of the handle part; a diameter of the brush part is greater than or equal to an inner diameter of a vessel lumen of a laboratory animal and cannot be greater by 10 percent of the inner diameter of the vessel lumen of the animal at most. The laboratory animal vascular intimal injury experimental facility provided by the invention has a simple structure and is high in pertinence on an injured position; due to the case that the diameter of the brush part is slightly greater than or equal to the inner diameter of the vessel lumen, in the process that the brush part brushes back and forth inside the blood vessels, the bristles cannot damage a vascular intimal layer and hardly cause damage to a smooth muscle layer, so that interference of the smooth muscle layer to an experimental result is reduced.
Description
Technical field
The present invention relates to medical experiment apparatus field, in particular to a kind of laboratory animal blood vessel internal membrane damage experimental provision.
Background technology
Along with the development of China's economic level and the continuous prolongation of the average life span, cardiovascular and cerebrovascular disease has surmounted cancer becomes the first killer threatening human health, atherosclerosis is the principal pathogenetic reason of cardiovascular and cerebrovascular disease, and inner film injury is the important pathogenesis of atheromatosis.At present, in the Related Experimental Study of blood vessel internal membrane damage, researcher needs by the tunica intima people of laboratory animal for causing damage, and then carry out the research of relevant vascular diseases mechanism, said process is the making of laboratory animal blood vessel internal membrane damage model.
Blood vessel wall forms primarily of three-decker, is followed successively by from inside to outside: theca interna, smooth muscle layer and theca externa.At present, most of medical science correlational study mainly adopts sacculus as the experimental provision making blood vessel internal membrane damage animal model.In the inside of sacculus, be provided with a cavity, cavity communicates with outside conduit, in the process that sacculus uses, first sacculus to be placed on laboratory animal Endovascular, then by the conduit that communicates with cavity to water filling in the cavity of sacculus, make inflation, when inflation can be born at utmost to blood vessel, the inner membrance of blood vessel just can be cracked.
But, theca interna and smooth muscle layer due to blood vessel itself are closely be connected, when theca interna is cracked, smooth muscle layer also can be subject to certain mechanical damage simultaneously, this mechanical damage will certainly cause experimental result and mix, and is difficult to observe the experimental effect caused by blood vessel internal membrane damage separately.
Summary of the invention
In view of this, the object of the embodiment of the present invention is to provide a kind of laboratory animal blood vessel internal membrane damage experimental provision, this laboratory animal blood vessel internal membrane damage experimental provision can while arterial intima layer, farthest can reduce the damage to vascular smooth muscle, and then the vascular smooth muscle reducing damage causes interference to experimental result.
The laboratory animal blood vessel internal membrane damage experimental provision that the embodiment of the present invention provides comprises: comprising: brush portion and shank;
Described brush portion comprises: fixation kit, and the bristle be arranged on described fixation kit or the brush teeth be arranged on described fixation kit;
Wherein, described fixation kit is connected with one end of described shank; The diameter of described brush portion is greater than or equal to the internal diameter of laboratory animal lumen of vessels, can not exceed 10% of animal blood lumen diameter at the most.
In conjunction with above-described embodiment, embodiments provide the first possible embodiment of above-described embodiment, described fixation kit is cylinder;
Described shank is fixed on one end of described cylindrical fixation kit;
Described bristle or described brush teeth are arranged on the outer peripheral face of described cylinder fixation kit, and form cylindrical brush portion.
In conjunction with above-described embodiment, embodiments provide the embodiment that the second of above-described embodiment is possible, described fixation kit is hemispherical;
Described shank is fixed on inside the cambered surface of described hemispheric fixation kit;
Described bristle or described brush teeth are arranged on the edge of described hemispherical fixation kit.
In conjunction with above-described embodiment, embodiments provide the third possible embodiment of above-described embodiment, described fixation kit is elliposoidal;
The fixation kit inner hollow of described elliposoidal;
Described shank through the sidewall of one end of the fixation kit major axis of described elliposoidal, and gos deep into the inside to described elliposoidal, and is connected with the sidewall of the other end of major axis;
Described bristle or described brush teeth are arranged on the outer peripheral face of described elliposoidal fixation kit.
In conjunction with above-described embodiment, embodiments providing the 4th kind of possible embodiment of above-described embodiment, also comprising for described fixation kit being strutted or closed open-and-close mechanism.
Described open-and-close mechanism comprises:
Be enclosed within described shank and the stretch ring be slidably connected with described shank;
Be fixedly connected with described stretch ring, and along the axially extended pull bar of described shank;
Described stretch ring is also provided with many first support bars; One end of first support bar described in every root is all rotationally connected with described stretch ring, and the other end and described fixation kit are rotationally connected;
The axis that the two ends of the first support bar described in every root are rotated is parallel to each other.
In conjunction with above-described embodiment, embodiments provide the 5th kind of possible embodiment of above-described embodiment, described open-and-close mechanism also comprises: many second support bars;
Second support bar described in every root is all rotationally connected with first support bar one end away from described stretch ring, and described second support bar is rotationally connected away from one end of described first support bar and described shank;
The pivot center of the pivot center of the pivot center of the first support bar and described stretch ring, described first support bar and described second support bar, described second support bar and described shank is parallel to each other.
In conjunction with above-described embodiment, embodiments provide the 6th kind of possible embodiment of above-described embodiment, be provided with cavity in described shank, and described cavity communicates with the external world in described shank one end away from described brush portion;
Described pull bar is arranged on described cavity inside, and pull bar is exposed at the outside of described shank away from one end of described stretch ring;
The sidewall of described cavity is also provided with the external world communicates, and along the axially extended connecting hole of shank;
Described pull bar is formed with connector, and described connector is connected with described stretch ring through described connecting hole.
In conjunction with above-described embodiment, embodiments provide the 7th kind of possible embodiment of above-described embodiment, it is protruding that described shank is also provided with multiple scale; The protruding axial arranging along described shank of multiple described scale, and distance between two often adjacent scale projections is all equal;
Described stretch ring is provided with fastener; Described fastener is conflicted in described scale projection or between described scale projection;
Described stretch ring is when described shank slides, and described fastener slides in described scale projection and between scale projection.
In conjunction with above-described embodiment, embodiments provide the 8th kind of possible embodiment of above-described embodiment, described shank is also carved with scale;
And/or described shank is also provided with the Handheld Division for controlling described shank away from one end of described brush portion;
And/or, be also provided with tapering; Described tapering is arranged on described brush portion one end away from described shank, or is arranged on described shank one end near described brush portion.
In conjunction with above-described embodiment, embodiments provide the 9th kind of possible embodiment of above-described embodiment, also comprise: with the seal wire of described shank, the equal physical separation of brush portion, puncture needle and vagina vasorum;
Wherein, physical separation between described seal wire, described puncture needle, described vagina vasorum;
Described seal wire, described puncture needle and/or described vagina vasorum are carved with scale.
In the laboratory animal blood vessel internal membrane damage experimental provision that the embodiment of the present invention provides, shank is generally more elongated and has the rod shape of certain deformability, experimenter can hand-held shank, brush portion is deep in the blood vessel of laboratory animal, general, brush portion comprises two parts: fixation kit, and the bristle be arranged on fixation kit or brush teeth.Wherein fixation kit is connected with shank, and bristle or brush teeth are arranged on fixation kit, and the diameter of final formed brush portion is greater than or equal to the internal diameter of laboratory animal lumen of vessels, but can not exceed 10% of animal blood lumen diameter at the most.Usually, in order to bristle or brush teeth by blood vessel internal membrane damage, and can reduce the damage to smooth muscle layer as far as possible.This laboratory animal blood vessel internal membrane damage experimental provision, when in use, brush portion is inserted the Ink vessel transfusing of laboratory animal, then shank is pulled, brush portion is swiped back and forth in laboratory animal internal blood vessel, in the process that bristle or brush teeth swipe back and forth in brush portion, can by the inner film injury of blood vessel, and in this process, diameter due to brush portion equals or micro-internal diameter being greater than the lumen of vessels of laboratory animal, and simultaneously, bristle or brush teeth generally all have larger elasticity, therefore bristle or brush teeth are when the blood vessel internal membrane damage making to contact with it, the reduction that can try one's best is to the damage of smooth muscle layer.Therefore laboratory animal blood vessel internal membrane damage experimental provision provided by the present invention can reduce the damage to smooth muscle layer, and the smooth muscle layer reducing damage causes interference to experimental result.
For making above-mentioned purpose of the present invention, feature and advantage become apparent, preferred embodiment cited below particularly, and coordinate appended accompanying drawing, be described in detail below.
Accompanying drawing explanation
In order to be illustrated more clearly in the technical scheme of the embodiment of the present invention, be briefly described to the accompanying drawing used required in embodiment below, be to be understood that, the following drawings illustrate only some embodiment of the present invention, therefore the restriction to scope should be counted as, for those of ordinary skill in the art, under the prerequisite not paying creative work, other relevant accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 shows the laboratory animal blood vessel internal membrane damage experimental provision structural representation that the embodiment of the present invention provides;
Fig. 2 shows the another kind of laboratory animal blood vessel internal membrane damage experimental provision structural representation that the embodiment of the present invention provides;
Fig. 3 shows the another kind of laboratory animal blood vessel internal membrane damage experimental provision structural representation that the embodiment of the present invention provides;
Fig. 4 shows in the another kind of laboratory animal blood vessel internal membrane damage experimental provision that the embodiment of the present invention provides and drives the structural representation with mechanism;
Fig. 5 shows the partial structurtes schematic diagram of open-and-close mechanism in the another kind of laboratory animal blood vessel internal membrane damage experimental provision that the embodiment of the present invention provides;
Reference numeral:
101-brush portion; 102-shank; 103-fixation kit; 104-bristle; 105-brush teeth; 106-open-and-close mechanism; 107-stretch ring; 108-pull bar; 109-first support bar; 110-second support bar; 111-Handheld Division; 112-tapering; 113-cavity; 114-connecting hole; 115-connector; 116-scale is protruding; 117-fastener.
Detailed description of the invention
Below in conjunction with accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.The assembly of the embodiment of the present invention describing and illustrate in usual accompanying drawing herein can be arranged with various different configuration and design.Therefore, below to the detailed description of the embodiments of the invention provided in the accompanying drawings and the claimed scope of the present invention of not intended to be limiting, but selected embodiment of the present invention is only represented.Based on embodiments of the invention, the every other embodiment that those skilled in the art obtain under the prerequisite not making creative work, all belongs to the scope of protection of the invention.
In the experimentation of existing blood vessel internal membrane damage, the experimental provision used is sacculus, when use, sacculus can be placed on the Ink vessel transfusing of laboratory animal, then to sacculus water filling, until inflation, crack tunica intima.But when sacculus cracks tunica intima, also can cause damage to the smooth muscle layer of blood vessel simultaneously, the smooth muscle layer of damage can cause experimental result and mix, based on this, the invention provides a kind of laboratory animal blood vessel internal membrane damage experimental provision, cause in the process of damage artificial to tunica intima, farthest reduce the damage to smooth muscle layer, avoid the smooth muscle layer damaged to cause interference to experimental result.The laboratory animal blood vessel internal membrane damage experimental provision that inventing provides generally is used in it the laboratory animals such as mice, rat, rabbit, in view of laboratory animal difference, injured blood vessel and pipe diameter size thereof are different, therefore experimental provision provided by the present invention divides multiple large ting model.
Shown in Figure 1, embodiments provide a kind of laboratory animal blood vessel internal membrane damage experimental provision, in the present embodiment, the structure of the device provided by the present invention of explanation conveniently, therefore only for bristle 104, but it should be noted that in the present embodiment, also bristle 104 can be replaced with brush teeth.The device that the present embodiment provides comprises: brush portion 101 and shank 102; Described brush portion 101 comprises: fixation kit 103, and is arranged on the bristle 104 on described fixation kit 103;
Wherein, described fixation kit 103 is connected with one end of described shank 102; The diameter of described brush portion 101 is greater than or equal to the internal diameter than laboratory animal lumen of vessels, but can not exceed 10% of animal blood lumen diameter at the most.
When specific implementation, shank is generally more elongated and has the rod shape of certain deformability, experimenter can hand-held shank, brush portion is deep in the blood vessel of laboratory animal, general, brush portion 101 comprises two parts: fixation kit, and the bristle be arranged on fixation kit or brush teeth.Wherein fixation kit is connected with shank, and bristle or brush teeth are arranged on fixation kit, and the diameter of final formed brush portion is greater than or equal to the internal diameter of laboratory animal lumen of vessels, but can not exceed 10% of animal blood lumen diameter at the most.Usually, in order to bristle or brush teeth can by blood vessel internal membrane damage, and the damage as far as possible reduced smooth muscle layer, this laboratory animal blood vessel internal membrane damage experimental provision when in use, brush portion 101 is inserted the Ink vessel transfusing of laboratory animal, then shank 102 is pulled, brush portion 101 is swiped back and forth in laboratory animal internal blood vessel, in the process that bristle 104 swipes back and forth in brush portion 101, can by the inner film injury of blood vessel, and in this process, diameter due to brush portion 101 equals or is micro-ly greater than the internal diameter of the lumen of vessels of laboratory animal, and simultaneously, bristle generally all has larger elasticity, therefore bristle 104 is when the blood vessel internal membrane damage making to contact with it, farthest can reduce the damage to smooth muscle layer.Therefore laboratory animal blood vessel internal membrane damage experimental provision provided by the present invention can reduce the damage to smooth muscle layer, and then the smooth base layers reducing damage causes interference to experimental result.
In the above-described embodiments, can to advance damage exposed vessel, incision, under direct-view, this experimental provision is sent into advance damage Ink vessel transfusing, this situation is mainly used in body surface and can not touches in the tunica intima of vein damage that blood flow beats, can certainly be applied in Artery injury, this will experimentally personnel specific experiment design.。In addition, this feature of arteriopalmus can be touched in order to make full use of animal body surface, the device that the present embodiment provides, also comprising: with the seal wire of shank, the equal physical separation of brush portion, puncture needle and vagina vasorum.By seal wire, puncture needle and vagina vasorum, this experimental provision can be sent into advance damage Endovascular, avoid the interference of open surgery to experimental result, this situation can be used for laboratory animal Artery injury.Certainly, directly can also apply this laboratory animal blood vessel internal membrane damage experimental provision in open surgery, now then not need by means of with the seal wire of shank, the equal physical separation of brush portion, puncture needle and vagina vasorum.Below the specific implementation method of this laboratory animal blood vessel internal membrane damage experimental provision is applied under then stressing Wicresoft's condition.
Wherein, physical separation between described seal wire, described puncture needle, described vagina vasorum.
When in use, puncture needle is first used to thrust the blood vessel of laboratory animal.Puncture needle is provided with through hole, by this through hole, seal wire is inserted after in blood vessel, puncture needle is pulled out, then, by vagina vasorum along seal wire, insert the blood vessel of laboratory animal; Vagina vasorum is provided with through hole, and when inserting vagina vasorum, seal wire is in the through hole of vagina vasorum; Subsequently, seal wire is extracted out from the through hole vagina vasorum, then from the through hole of vagina vasorum, laboratory animal blood vessel internal membrane damage experimental provision provided by the present invention is inserted in blood vessel.Artificial damage is caused to tunica intima in, can hand-held vagina vasorum, pull shank 102, brush portion 101 swiped back and forth in internal blood vessel.In this process, the through hole that vagina vasorum is exposed at one end of extravascular is closed, and the diameter of shank generally can be smaller, directly passes from the position closed, can not affect the closure of vagina vasorum.Blood in operation process can be reduced like this flow out from the opening part of vagina vasorum.Meanwhile, in the process pulling shank 102, due to friction can not be caused with the opening of blood vessel, the misery that laboratory animal is brought can be reduced to a certain extent.
Consider the degree of depth in order to the intravasations such as seal wire, vagina vasorum, puncture needle can be monitored at any time, scale can be carved with on seal wire, vagina vasorum, puncture needle, by scale, the degree of depth of seal wire, vagina vasorum or puncture needle intravasation can be observed easily.
Under the assistance of the vascular puncture equipment such as vagina vasorum, puncture needle, seal wire, laboratory animal blood vessel internal membrane damage experimental provision provided by the present invention is utilized to make in the process of animal blood vessels inner film injury model, effectively can avoid open surgery, and only carry out Minimally Invasive Surgery, and then the interference of open surgery to experimental result can be reduced.
In addition, consider in order to the degree of depth that brush portion 102 gos deep into blood vessel can be monitored at any time, shank 102 is also carved with scale, by the scale carved on shank 102 and vagina vasorum, brush portion can be observed easily and go deep into the degree of depth of blood vessel and determine to be about to the scope to blood vessel injury.
In addition, consider that shank can extend into the Ink vessel transfusing of laboratory animal, therefore shank is very thin, especially for the laboratory animal that mice, rat, rabbit equal-volume are smaller, needs the diameter of shank to be less than the internal diameter of these laboratory animal lumen of vessels.But the one end needing hand-held shank to be exposed at laboratory animal external due to experimenter again swipes back and forth, and meticulous shank is not easy by the hand-held associative operation that carries out of experimenter, therefore, Handheld Division 111 is also formed with away from one end of brush portion at shank, the size of Handheld Division 111 can specifically be determined according to actual needs, such as Handheld Division can be set to point thickness, facilitate experimenter hand-held.
In the above-described embodiments, shank 102 and brush portion 101 can be fixedly connected with, and also can be dismountable connections.Because the thickness of shank 102 is generally all relatively fixed, the diameter of brush portion 101 then needs selecting as the case may be, when being fixedly connected with brush portion 101 by shank 102, makes disposable device by whole experimental provision.And by shank 102 and the dismountable connection of brush portion 101, the brush portion 102 diameter can being selected suitable according to practical situation is tested.
The concrete structure of laboratory animal tunica intima experimental provision provided by the present invention can have several as follows:
1, specifically shown in Figure 1, fixation kit 103 is cylinder, and shank 102 is fixed on one end of cylinder fixation kit, and bristle 104 is arranged on the outer peripheral face of cylinder fixation kit 103, forms cylindrical brush portion 101.
When specific implementation, because blood vessel itself is approximate circle tubulose, therefore brush portion 101 is cylinder, bristle 104 set on cylindrical fixation kit 103 outer peripheral face fully can touch with tunica intima, when the hand-held shank of operator is exerted oneself uneven about Ink vessel transfusing swipes back and forth time, also can ensure that brush portion can contact with tunica intima fully.It should be noted that, above-mentioned this kind of situation is when bristle 104 length is consistent, and bristle lengths can inconsistent in, fixation kit 103 is that all it doesn't matter for what shape, as long as the shape ensureing final formed brush portion 101 is that cylinder just can.
2, specifically shown in Figure 2, described fixation kit 103 is hemispherical;
Described shank 102 is fixed on inside the cambered surface of described hemispheric fixation kit 103;
Described bristle is arranged on the edge of described hemispherical fixation kit.
When specific implementation, hemispheric fixation kit 103 is similar to the shape of drawing pin or umbrella cover, and the material for making fixation kit 103 is generally have elastic, is compressed when fixation kit 103 can be made to walk in vagina vasorum.Like this, brush portion 101 can be made to walk in vagina vasorum more convenient.
Meanwhile, it should be noted that and also fixation kit 103 can not be set to hemispherical, but be set to round sheet (namely highly smaller cylinder), effect same as the previously described embodiments can be reached equally.
3, specifically shown in Figure 3, described fixation kit 103 is elliposoidal;
Fixation kit 103 inner hollow of described elliposoidal;
Described shank 102 through the sidewall of one end of fixation kit 103 major axis of described elliposoidal, and gos deep into the inside of the fixation kit 103 to described elliposoidal, and is connected with the sidewall of the other end of the major axis of the fixation kit 103 of elliposoidal;
Described brush teeth 105 is arranged on the outer peripheral face of the fixation kit of described elliposoidal.
When specific implementation, being generally have elastic for making the material of fixation kit 103, when fixation kit 103 can be made to walk in vagina vasorum internally, fixation kit 103 can being walked in vagina vasorum smoothly.Simultaneously, the fixation kit 103 of hollow is more prone to produce deformation under external force, namely brush portion 101 can fully be contacted with the inner membrance of blood vessel, damage is caused to inner membrance, be not easy again to crack smooth muscle layer simultaneously, further minimizing is to the damage of smooth muscle layer, and the smooth muscle layer reducing damage damages the impact caused experimental result.
It should be noted that, in the concrete structure of above-mentioned three laboratory animal tunica intima experimental provisions, the concrete structure of the device provided by the present invention of explanation conveniently, therefore only for bristle 104 or brush teeth 105, but in fact, bristle 104 and brush teeth 105 all can be used in above-mentioned three embodiments, repeats no more in the description.
In addition, consider the fixation kit 103 of above-mentioned hemispheric fixation kit 103 or elliposoidal, it will walk in thinner vagina vasorum, after experiment terminates, it is also needed to release in vagina vasorum, and the structure of vagina vasorum is pyramidal structure, namely endovascular position diameter is deep into little, and be less than the diameter of blood vessel, be exposed at EV position diameter large, and the diameter of brush portion 101 will equal or micro-internal diameter being greater than lumen of vessels, time this just causes and is released in vagina vasorum by fixation kit 103, brush portion 101 is easily by the edge card master of vagina vasorum, therefore, present invention also offers another embodiment to solve the problem, shown in Figure 2, the device that another embodiment of the present invention provides also comprises: open-and-close mechanism 106,
Described open-and-close mechanism 106 comprises:
Be enclosed within described shank 102 and the stretch ring 107 be slidably connected with described shank 102;
Be fixedly connected with described stretch ring 107, and along the axially extended pull bar 108 of described shank 102;
Described stretch ring 107 is also provided with multiple first support bar 109; One end of described first support bar 109 is all rotationally connected with described stretch ring 107, and the other end and described fixation kit 103 are rotationally connected;
The axis that the two ends of the first support bar 109 described in every root are rotated is parallel to each other.
When specific implementation, if fixation kit 103 is hemispheric fixation kits, shown in Figure 5, so the first support bar 109 is connected to inside the cambered surface of fixation kit.This device when in use, can pull railing 108, thus drives stretch ring 107 to move back and forth on shank 102.Because one end of the first support bar 109 is rotationally connected with stretch ring 107, and be rotationally connected inside the cambered surface of the other end and hemispheric fixation kit.When towards time near the direction pushing drawing rod 108 of brush portion 101, stretch ring 107 slides along shank 102 towards near the direction of brush portion 101 thereupon, and the first support bar 109 rotates thereupon, thus the cambered surface of fixation kit is supported; And when pulling pull bar 108 towards the direction away from brush portion 101, stretch ring 107 slides along shank 102 towards the direction away from brush portion 101, and the first support bar 109 also rotates, thus the cambered surface of fixation kit is regained thereupon thereupon.
If fixation kit 103 is fixation kits of elliposoidal, its structure is also similar to above-mentioned situation, does not repeat them here.
In addition, shown in 3, the embodiment of the present invention also provides another kind of open-and-close mechanism, and described open-and-close mechanism is except including the structure of the open-and-close mechanism provided in above-described embodiment in the present embodiment, also comprises:
Many second support bars 110;
Second support bar 110 described in every root is all rotationally connected with first support bar 109 one end away from described stretch ring 107, and described second support bar 110 is rotationally connected away from one end of described first support bar 109 and described shank 102;
First support bar 109 is parallel to each other with the pivot center of described shank 102 with the pivot center of described second support bar 110, described second support bar 110 with the pivot center of described stretch ring 107, described first support bar 109.
In addition, in another embodiment provided by the present invention, shown in Figure 4, additionally provide another kind of open-and-close mechanism.In the present embodiment, in described shank 102, be provided with cavity 113, and described cavity 113 communicates with the external world in described shank one end away from described brush portion 101;
It is inner that described pull bar 108 is arranged on described cavity 113, and pull bar 108 is exposed at the outside of described shank 102 away from one end of described stretch ring 107;
The sidewall of described cavity 113 is also provided with the external world communicates, and along the axially extended connecting hole 114 of shank 102;
Described pull bar is formed with connector 115, described connector 115 is connected with described stretch ring 107 through described connecting hole 114.
Like this, pull bar 108 is arranged in the cavity 113 of shank 102, directly on pull bar 108, form connector 115, through the connecting hole 114 communicated with cavity 113 set on shank 102, couple together with stretch ring 107, when experiment, pull bar 108 can be pulled from the end of shank 102, thus control the folding of brush portion 101, make overall structure more compact.
When specific implementation, the action principle of the open-and-close mechanism that the present embodiment provides and effect similar to the above embodiments, therefore do not repeat them here.
In addition, in the above-described embodiments, in one end of brush portion 101 being provided with Handheld Division 111 at shank 102, the through hole that cavity 113 communicates can be arranged on Handheld Division 111, pull bar 108 can pass this through hole away from one end of stay cord ring 107, communicates with the external world.
In addition, in several of the above embodiments where, consider in the process of experiment, control brush portion enters into blood vessel inside along the trend of blood vessel, and control brush portion 101 to move reciprocatingly at laboratory animal Ink vessel transfusing, if an end margin of shank 102 intravasation is too sharp-pointed, namely have corner angle to exist, the friction between shank 102 edge and tunica intima is easily caused in side in the process sending into blood vessel, thus causes brush portion 101 to be not easily admitted in blood vessel.Therefore see shown in Fig. 1-Fig. 3, tapering 112 is also provided with; Described tapering 112 is arranged on described brush portion 101 one end away from described shank 102, or is arranged on described shank 102 one end near described brush portion 101.This tapering is fillet away from one end of brush portion 101, is similar to bullet type, and be thus not easy to cause friction between tunica intima, brush portion more easily sends into blood vessel.
In addition, consider after brush portion will being inserted the blood vessel of laboratory animal, propping up or regaining of the fixation kit of hemispherical or elliposoidal is controlled again by open-and-close mechanism, when fixation kit is propped up, the diameter of brush portion 101 is large than the lumen of vessels internal diameter of laboratory animal, and the blood vessel thickness of each laboratory animal is different, even and same laboratory animal, the blood vessel thickness of its different parts is also different, therefore need according to different situations, decide to drive the concrete size propped up by fixation kit with mechanism.Therefore the structure of another laboratory animal blood vessel internal membrane damage experimental provision is additionally provided in an alternative embodiment of the invention, in the present embodiment, the Local map of a generator.Shown in Figure 5: to be also provided with multiple scale projection 116 at shank 102; Convex 116 axial arrangings along described shank 102 of multiple described scale, and distance between two often adjacent scale projections 116 is all equal;
Described stretch ring 107 is provided with fastener 117; Described fastener 117 is conflicted in described scale projection 116 or between described scale projection 116;
Described stretch ring 107 is when described shank 102 slides, and described fastener 117 slides in described scale projection 116 and between scale projection 116.
When specific implementation, distance between scale projection 116 can carry out concrete setting according to the actual needs, such as if the builds such as mice, rat, rabbit are less, the comparatively thin shorter laboratory animal of blood vessel, the distance between scale projection 116 can be set to 0.5mm-2mm; If the build such as pig, cattle is comparatively large, the comparatively thick longer laboratory animal of blood vessel, distance between scale projection 116 can be set to 5mm-10mm etc., it should be noted that, here the distance between scale projection 116 does not do any constraint, can carry out concrete setting according to the laboratory animal of reality.When fixation kit 103 is propped up by the first support bar 109 by needs time, need to prop up how many, the sliding distance of stretch ring 107 on shank 102 can be converted into, and fastener 117 is arranged on stretch ring 107, can slide above scale projection 116 along with the slip of stretch ring 107, scale projection 116 often slips over a scale projection, shank 102 outer wall between capital and scale projection 116 touches, and the vibrations of operator when can feel that shank 102 stuck part 117 touches, thus can perception fastener 117 position of sliding in scale projection 116, thus judge the height that the first support bar 109 is propped up.
The above; be only the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; change can be expected easily or replace, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should described be as the criterion with the protection domain of claim.
Claims (10)
1. a laboratory animal blood vessel internal membrane damage experimental provision, is characterized in that, comprising: brush portion and shank;
Described brush portion comprises: fixation kit, and the bristle be arranged on described fixation kit or the brush teeth be arranged on described fixation kit;
Wherein, described fixation kit is connected with one end of described shank; The diameter of described brush portion is greater than or equal to the internal diameter of laboratory animal lumen of vessels, can not exceed 10% of animal blood lumen diameter at the most.
2. device according to claim 1, is characterized in that, described fixation kit is cylinder;
Described shank is fixed on one end of described cylindrical fixation kit;
Described bristle or described brush teeth are arranged on the outer peripheral face of described cylinder fixation kit, and form cylindrical brush portion.
3. device according to claim 1, is characterized in that, described fixation kit is hemispherical;
Described shank is fixed on inside the cambered surface of described hemispheric fixation kit;
Described bristle or described brush teeth are arranged on the edge of described hemispherical fixation kit.
4. device according to claim 1, is characterized in that, described fixation kit is elliposoidal;
The fixation kit inner hollow of described elliposoidal;
Described shank through the sidewall of one end of the fixation kit major axis of described elliposoidal, and gos deep into the inside to described elliposoidal, and is connected with the sidewall of the other end of major axis;
Described bristle or described brush teeth are arranged on the outer peripheral face of described elliposoidal fixation kit.
5. the device according to claim 3 or 4, is characterized in that, also comprises for being strutted by described fixation kit or closed open-and-close mechanism.
Described open-and-close mechanism comprises:
Be enclosed within described shank and the stretch ring be slidably connected with described shank;
Be fixedly connected with described stretch ring, and along the axially extended pull bar of described shank;
Described stretch ring is also provided with many first support bars; One end of first support bar described in every root is all rotationally connected with described stretch ring, and the other end and described fixation kit are rotationally connected;
The axis that the two ends of the first support bar described in every root are rotated is parallel to each other.
6. device according to claim 5, is characterized in that, described open-and-close mechanism also comprises: many second support bars;
Second support bar described in every root is all rotationally connected with first support bar one end away from described stretch ring, and described second support bar is rotationally connected away from one end of described first support bar and described shank;
The pivot center of the pivot center of the pivot center of the first support bar and described stretch ring, described first support bar and described second support bar, described second support bar and described shank is parallel to each other.
7. the device according to claim 5 or 6, is characterized in that, is provided with cavity in described shank, and described cavity communicates with the external world in described shank one end away from described brush portion;
Described pull bar is arranged on described cavity inside, and pull bar is exposed at the outside of described shank away from one end of described stretch ring;
The sidewall of described cavity is also provided with the external world communicates, and along the axially extended connecting hole of shank;
Described pull bar is formed with connector, and described connector is connected with described stretch ring through described connecting hole.
8. device according to claim 7, is characterized in that, it is protruding that described shank is also provided with multiple scale; The protruding axial arranging along described shank of multiple described scale, and distance between two often adjacent scale projections is all equal;
Described stretch ring is provided with fastener; Described fastener is conflicted in described scale projection or between described scale projection;
Described stretch ring is when described shank slides, and described fastener slides in described scale projection and between scale projection.
9. the device according to claim 1-5 any one, is characterized in that, described shank is also carved with scale;
And/or described shank is also provided with the Handheld Division for controlling described shank away from one end of described brush portion;
And/or, be also provided with tapering; Described tapering is arranged on described brush portion one end away from described shank, or is arranged on described shank one end near described brush portion.
10. the device according to any opposite sex of claim 1-5, is characterized in that, also comprise: with the seal wire of described shank, the equal physical separation of brush portion, puncture needle and vagina vasorum;
Wherein, physical separation between described seal wire, described puncture needle, described vagina vasorum;
Described seal wire, described puncture needle and/or described vagina vasorum are carved with scale.
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| CN201510452251.8A CN105105863B (en) | 2015-07-28 | 2015-07-28 | Experimental animal blood vessel inner film injury experimental provision |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109009537A (en) * | 2018-06-27 | 2018-12-18 | 新乡医学院 | A kind of animal blood vessels inner film injury experimental provision |
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| CN105105863B (en) | 2017-11-24 |
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