CN105361997A - Pushing and injecting device for implanting artificial retina cytoskeleton into inner eye - Google Patents
Pushing and injecting device for implanting artificial retina cytoskeleton into inner eye Download PDFInfo
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- CN105361997A CN105361997A CN201510795027.9A CN201510795027A CN105361997A CN 105361997 A CN105361997 A CN 105361997A CN 201510795027 A CN201510795027 A CN 201510795027A CN 105361997 A CN105361997 A CN 105361997A
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Abstract
The invention discloses a pushing and injecting device for implanting an artificial retina cytoskeleton into the inner eye. With the adoption of the pushing and injecting device, the artificial retina cytoskeleton can be implanted into the inner eye, the cut caused by the operation of implanting the artificial retina cytoskeleton into the inner eye can be reduced, and thus the pain of a patient suffering from the eye disease can be alleviated. The invention further aims at improving the success rate of implanting the retina cytoskeleton into the inner eye, so that the iatrogenic injury is reduced.
Description
Technical field:
The invention belongs to medical instruments field, be specifically related to eye in a kind of artificial retina cytoskeleton and implant injector.
Background technology:
Retina cell injury repairing is that cellularity impaired vision occurs, develops and lapse to common problem in science.Developing rapidly in recent years along with stem-cell research, the reparation that induced multi-potent stem cells (inducedpluripotentstemcells, iPSCs) damages for optic cell brings new hope with treatment.Due to iPSCs self replication and many differentiation potentials, cell concentration required when the donor as repairing retina cell injury not only can meet transplanting, and also iPSCs can be induced to differentiate into various different retina cell system under certain condition.Therefore, humanized iPSCs transplantation treatment retina cell damage disease is utilized to have important theory significance and good clinical treatment prospect.At present, iPSCs replacement therapy is mainly through following two approach: 1. stem cell transplantation enters subretinal space/vitreous chamber; 2. stem cell in vitro is divided into retina specific cells and is implanted into subretinal space/vitreous chamber.After research finds that iPSCs cell is grafted directly to impaired retinal tissue, the cell of more than 90% cannot replacement therapy damaged cell; And apply the differentiation-inducing retinulae of iPSCs and host retina conformability poor.Therefore, how by people iPSCs source property retina cell In vitro culture, and it being transplanted preferably and be integrated into impaired nethike embrane, is the focus that current stem-cell therapy, medical tissue engineering and field of ophthalmology are paid close attention to jointly.
People iPSCs source property retina seed cell is successfully planted on degradable poly PLGA (PLGA) support early stage by inventor, and be all kinds of retina cell by its Induction of committed differentiation, construct degradable artificial retina cell support, its organizational structure is the retina cell of circular PLGA biomaterial and the growth of adherent support.
In order to artificial retina cytoskeleton is implanted interior eye, need the retina cell stenter to implant device using particular design, this implantation device needs the cell on protective cradle not impaired in migration process, implants to reduce iatrogenic injury patient Wicresoft simultaneously.By the artificial retina cytoskeleton implantation device of this particular design, can artificial retina cytoskeleton be implanted in human eye by the micro-incision of 2mm, effectively reduce operative incision and easy to use, ensure that the success rate of support intraocular transplantation.
Summary of the invention:
The object of this invention is to provide a kind of artificial retina cytoskeleton that reduces and implant otch, alleviate persons suffering from ocular disorders misery, improve eye in artificial retina cytoskeleton and be implanted to power, in the artificial retina cytoskeleton of reduction iatrogenic injury, eye implants injector.
In artificial retina cytoskeleton of the present invention, eye implants injector, it is characterized in that, comprise the sleeve of hollow tubular, the Vitreous cavity head be made up of flexible material, spring, stenter to implant bar, contiguous block and inject bar, described sleeve comprise fore-aft travel connect inject head and bolus tube, annular stop block is provided with at the middle part of the hollow pipe of bolus tube, the hole passed for stenter to implant bar is provided with in the middle part of annular stop block, the right-hand member inwall of bolus tube is provided with fixture block, described injects bar, contiguous block, stenter to implant bar and Vitreous cavity head order are fixedly linked, groove is had in the middle part of described contiguous block, the draw-in groove corresponding with fixture block is provided with near the edge of stenter to implant bar side at groove, draw-in groove is connected with maintenance slide plate near the edge of injecting bar side, the other end of this maintenance slide plate is provided with banking stop, described contiguous block, stenter to implant bar and Vitreous cavity head are positioned at the hollow pipe of sleeve, described spring is placed on stenter to implant bar, its one end props up contiguous block and is connected block stop and fixes, one end props up annular stop block and is stopped by annular stop block and fixes in addition, in the periphery ancient piece of jade, round, flat and with a hole in its centre shape size of described contiguous block and bolus tube right-hand member, hollow pipe shape adapts, draw-in groove on contiguous block props up with maintenance slide plate is corresponding with the fixture block on the right-hand member inwall of bolus tube, the front end of described Vitreous cavity head is provided with can place the cytoskeletal placement groove of artificial retina.
Preferably, the described Vitreous cavity head be made up of flexible material is the Vitreous cavity head be made up of silica gel.
Described bolus tube right-hand member outer wall is preferably also provided with a pair relative handle of upper and lower both sides.
Described head of injecting is connected preferably by cutting ferrule with bolus tube, injects head and snaps in the hollow pipeline of bolus tube.
In artificial retina cytoskeleton of the present invention, eye implants injector is use like this: take off and inject head, artificial retina cytoskeleton is put in the placement groove of the front end of Vitreous cavity head that (the Vitreous cavity head of flexible material can make when contact eyes to be flexible, not damaged), then set up and inject head, move to drawing axis (in the process, inject head and can protect artificial retina cytoskeleton, avoid in migration process impaired, patient Wicresoft is implanted to reduce iatrogenic injury) simultaneously, hold handle, inject bar, Compress Spring, fixture block skids off and enters maintenance slide plate from draw-in groove, Vitreous cavity head stretches out from injecting head, continue to inject bar, fixture block is made to prop up banking stop on maintenance slide plate, Vitreous cavity head has just reached assigned address, then eye in the artificial retina cytoskeleton of the placement groove of the front end of Vitreous cavity head being implanted by the micro-incision of 2mm, so just effectively can reduce operative incision and easy to use, ensure that the success rate of support intraocular transplantation.Fixture block, draw-in groove and maintenance slide plate can limit the displacement of Vitreous cavity head, have limit and push away effect, thus can be good at artificial retina cytoskeleton to implant interior eye.After implantation, unclamp and inject bar, under the action of the spring, Vitreous cavity head, stenter to implant bar, contiguous block and inject bar and shrink back, until fixture block snaps in draw-in groove.
Utilize the present invention artificial retina cytoskeleton can be implanted interior eye, in this artificial retina cytoskeleton, in eye implantation, eye can reduce retinulae stenter to implant otch, alleviates persons suffering from ocular disorders misery.And the present invention also aims to improve eye in retina cell support and be implanted to power, reduce iatrogenic injury.
Accompanying drawing illustrates:
Fig. 1 is the stereoscopic appearance figure that in artificial retina cytoskeleton of the present invention, eye implants injector;
Fig. 2 is external structure and the internal structure exploded view that in artificial retina cytoskeleton of the present invention, eye implants the solid of injector;
Fig. 3 is the sectional exploded view that in artificial retina cytoskeleton of the present invention, eye implants the sleeve (main-vision surface) of injector, and the structure main-vision surface exploded view of inside;
Fig. 4 is the sectional view that in artificial retina cytoskeleton of the present invention, eye implants injector;
Fig. 5 is contiguous block in Fig. 3 and the enlarged drawing of injecting bar;
Fig. 6 is the enlarged drawing of Vitreous cavity head;
Wherein: 1, inject head; 2, bolus tube; 3, inject bar, 4, contiguous block; 5, stenter to implant bar; 6, Vitreous cavity head; 7, draw-in groove; 8, maintenance slide plate; 9, groove; 10, annular stop block; 11, fixture block; 12, groove is placed; 13, handle; 14, hole; 15, banking stop; 16, spring.
Detailed description of the invention:
Following examples further illustrate of the present invention, instead of limitation of the present invention.
Unless special circumstances have other to limit, otherwise following definition is applicable to the term that uses in this description.
Term definition:
The term " support " used in this application refers to synthetic degradable medical biological PLGA compound (PLGA) support, and this support can sustenticular cell Growth and Differentiation.
The term " retina cell " used in this application refers to through the differentiation-inducing specific retina cell of stem cell, comprises but does not refer in particular to retinal ganglial cells, retinal pigment epithelium, retinal cones cell, retina rod cell, bipolar cell etc.
The term " retina cell support " used in this application refers to plants on synthetic degradable medical biological PLGA compound (PLGA) support by stem cell, be induced to differentiate into specific retina cell, comprise but do not refer in particular to retinal ganglial cells, retinal pigment epithelium, retinal cones cell, retina rod cell, bipolar cell etc.
Embodiment 1:
As Fig. 1, 2, 3, 4, shown in 5 and 6, in the artificial retina cytoskeleton of the present embodiment, eye implants injector, comprise the sleeve of hollow tubular, the Vitreous cavity head 6 be made up of silica gel, spring 16, (it is elongated rod-like members to stenter to implant bar 5, its diameter range is at about 1.3mm to 1.7mm, diameter in the present embodiment is about 1.5mm), contiguous block 4 and inject bar 3, what described sleeve comprised that fore-aft travel connects injects 1 and a bolus tube 2, annular stop block 10 is provided with at the middle part of the hollow pipe of bolus tube 2, the hole 14 passed for stenter to implant bar 5 is provided with in the middle part of annular stop block, the right-hand member inwall of bolus tube is provided with fixture block 11, described injects bar 3, contiguous block 4, stenter to implant bar 5 and Vitreous cavity head 6 order are fixedly linked, groove 9 is had in the middle part of described contiguous block 3, the draw-in groove 7 corresponding with fixture block is provided with near the edge of stenter to implant bar side at groove, draw-in groove is connected with maintenance slide plate 8 near the edge of injecting bar side, the other end of this maintenance slide plate is provided with banking stop 15, described contiguous block 4, stenter to implant bar 5 and Vitreous cavity head 6 are positioned at the hollow pipe of sleeve, described spring 16 is placed on stenter to implant bar 5, its one end props up contiguous block 4 and is connected block stop and fixes, one end props up annular stop block 10 and is stopped by annular stop block and fixes in addition, in the periphery ancient piece of jade, round, flat and with a hole in its centre shape size of described contiguous block and bolus tube right-hand member, hollow pipe shape adapts, draw-in groove 7 on contiguous block and maintenance slide plate 8 is corresponding with the fixture block 11 on the right-hand member inwall of bolus tube props up, the front end of described Vitreous cavity head is provided with can place the cytoskeletal placement groove 12 of artificial retina, a pair handle 13 is relatively provided with in the described upper and lower both sides of bolus tube right-hand member outer wall, described inject 1 and be connected by cutting ferrule with bolus tube 2, inject head to snap in the hollow pipeline of bolus tube.
Claims (4)
1. in an artificial retina cytoskeleton, eye implants injector, it is characterized in that, comprise the sleeve of hollow tubular, the Vitreous cavity head be made up of flexible material, spring, stenter to implant bar, contiguous block and inject bar, described sleeve comprise fore-aft travel connect inject head and bolus tube, annular stop block is provided with at the middle part of the hollow pipe of bolus tube, the hole passed for stenter to implant bar is provided with in the middle part of annular stop block, the right-hand member inwall of bolus tube is provided with fixture block, described injects bar, contiguous block, stenter to implant bar and Vitreous cavity head order are fixedly linked, groove is had in the middle part of described contiguous block, the draw-in groove corresponding with fixture block is provided with near the edge of stenter to implant bar side at groove, draw-in groove is connected with maintenance slide plate near the edge of injecting bar side, the other end of this maintenance slide plate is provided with banking stop, described contiguous block, stenter to implant bar and Vitreous cavity head are positioned at the hollow pipe of sleeve, described spring is placed on stenter to implant bar, its one end props up contiguous block and is connected block stop and fixes, one end props up annular stop block and is stopped by annular stop block and fixes in addition, in the periphery ancient piece of jade, round, flat and with a hole in its centre shape size of described contiguous block and bolus tube right-hand member, hollow pipe shape adapts, draw-in groove on contiguous block props up with maintenance slide plate is corresponding with the fixture block on the right-hand member inwall of bolus tube, the front end of described Vitreous cavity head is provided with can place the cytoskeletal placement groove of artificial retina.
2. in artificial retina cytoskeleton according to claim 1, eye implants injector, and it is characterized in that, the described Vitreous cavity head be made up of flexible material is the Vitreous cavity head be made up of silica gel.
3. in artificial retina cytoskeleton according to claim 1, eye implants injector, it is characterized in that, described bolus tube right-hand member outer wall is also provided with a pair relative handle of upper and lower both sides.
4. in artificial retina cytoskeleton according to claim 1, eye implants injector, and it is characterized in that, described head of injecting is connected by cutting ferrule with bolus tube, injects head and snaps in the hollow pipeline of bolus tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510795027.9A CN105361997B (en) | 2015-11-17 | 2015-11-17 | Eye is implanted into injector in a kind of artificial retina cytoskeleton |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510795027.9A CN105361997B (en) | 2015-11-17 | 2015-11-17 | Eye is implanted into injector in a kind of artificial retina cytoskeleton |
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| Publication Number | Publication Date |
|---|---|
| CN105361997A true CN105361997A (en) | 2016-03-02 |
| CN105361997B CN105361997B (en) | 2018-01-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510795027.9A Active CN105361997B (en) | 2015-11-17 | 2015-11-17 | Eye is implanted into injector in a kind of artificial retina cytoskeleton |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110507477A (en) * | 2019-09-27 | 2019-11-29 | 安徽国泰国瑞医疗科技有限公司 | A kind of device for the implantation of ophthalmology drainage tube |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226813A (en) * | 1996-08-02 | 1999-08-25 | 斯塔尔外科公司 | Spring biased deformable intraocular lens injecting apparatus |
| GB2408456A (en) * | 2003-11-28 | 2005-06-01 | Mohamed Naguib Abdel-Khalek | Fluid evacuation syringe |
| US20060235430A1 (en) * | 2005-04-15 | 2006-10-19 | Intralens Vision, Inc. | Corneal implant injector assembly and methods of use |
| WO2007097221A1 (en) * | 2006-02-22 | 2007-08-30 | Hoya Corporation | Intraocular lens inserter |
| CN205251823U (en) * | 2015-11-17 | 2016-05-25 | 中山大学中山眼科中心 | Infusion device is implanted to eye in artificial retina cytoskeleton |
-
2015
- 2015-11-17 CN CN201510795027.9A patent/CN105361997B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226813A (en) * | 1996-08-02 | 1999-08-25 | 斯塔尔外科公司 | Spring biased deformable intraocular lens injecting apparatus |
| GB2408456A (en) * | 2003-11-28 | 2005-06-01 | Mohamed Naguib Abdel-Khalek | Fluid evacuation syringe |
| US20060235430A1 (en) * | 2005-04-15 | 2006-10-19 | Intralens Vision, Inc. | Corneal implant injector assembly and methods of use |
| WO2007097221A1 (en) * | 2006-02-22 | 2007-08-30 | Hoya Corporation | Intraocular lens inserter |
| CN205251823U (en) * | 2015-11-17 | 2016-05-25 | 中山大学中山眼科中心 | Infusion device is implanted to eye in artificial retina cytoskeleton |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110507477A (en) * | 2019-09-27 | 2019-11-29 | 安徽国泰国瑞医疗科技有限公司 | A kind of device for the implantation of ophthalmology drainage tube |
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| Publication number | Publication date |
|---|---|
| CN105361997B (en) | 2018-01-09 |
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Address after: 510060 No. 54 martyrs South Road, Guangzhou, Guangdong, Yuexiu District Co-patentee after: Shandong baiduoan Medical Equipment Co.,Ltd. Patentee after: ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN University Address before: 510060 No. 54 martyrs South Road, Guangzhou, Guangdong, Yuexiu District Co-patentee before: Shandong Branden Medical Device Co.,Ltd. Patentee before: ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN University |
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