CN105372437A - Biochip detection machine with scrubbing function - Google Patents
Biochip detection machine with scrubbing function Download PDFInfo
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- CN105372437A CN105372437A CN201510829457.8A CN201510829457A CN105372437A CN 105372437 A CN105372437 A CN 105372437A CN 201510829457 A CN201510829457 A CN 201510829457A CN 105372437 A CN105372437 A CN 105372437A
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- biochip
- chip
- carrying platform
- article carrying
- claws
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Abstract
The invention discloses a biochip detection machine with a scrubbing function; the biochip detection machine comprises a shell, an object-bearing platform arranged in the shell and used for bearing a biochip, a chip gripper device, a collecting device used for collecting biochip information, a light shading device, a control device used for controlling operation of a biochip detector, and a chip cleaning device; the biochip object-bearing platform is provided with the biochip having a plurality of sites, the two sides of the object-bearing platform are each provided with a limit strip, and the back side of the object-bearing platform is provided with a limit block; the light shading device is a light shading device arranged at two sides of the object-bearing platform; the collection device is erected on the light shading device and comprises a CCD camera, an object lens connected to a photosensitive port of the CCD camera, and a camera power supply connected with the CCD camera, and the object lens directly faces the object-bearing platform. The biochip detection machine integrates biochip detection and chip cleaning, and has the characteristics that the structure is compact, space is saved, and use is convenient.
Description
Technical field
The present invention relates to a kind of biochip test machine with decontamination function.
Background technology
Biological chip testing technology, fluorescence, biotin or additive method is adopted to mark biomolecule (as DNA, RNA, protein molecular, antigen, the antibody etc.) target be fixed on bio-chip substrate, and marking signal is changed into the view data that can supply analyzing and processing by building some special pick-up units, to obtain and to analyze the various information such as biology, physics, chemistry of the biomolecule on biochip, the time of day of diagnostic biomolecule.
Biochip test equipment is widely used in the fields such as scientific research, medicine, health, for catching and processing the instrument of biochip image, traditional biochip supplies analysis has the following disadvantages: the handgrip function ratio of (1) chip detection instrument is more single, distance (2) checkout equipment between manual shift handgrip clamping device is needed generally to be divided into multiple chamber by dividing plate when capturing different chips, make the volume of checkout equipment larger, structure is comparatively complicated, dismounting is inconvenient, is not easy to use.(3) biochip needs are fixed after aliging with object lens again, and manual shift position is inaccurate.(4) in detecting, due to higher to the requirement for horizontality of biochip, then biochip slightly offset level position time, the easily accuracy of impact observation image.(5) there is not chip cleaning function in checkout equipment.
Summary of the invention
The invention provides a kind of biochip test machine with decontamination function, its object is to solve conventional bio-chip assay device structures complicated, volume is comparatively large, uses the problems such as comparatively inconvenience.
A kind of biochip test machine with decontamination function, comprise housing, be located in housing for carry biochip article carrying platform, for chip gripper equipment, for gather biochip information harvester and shade, for controlling control device, the device for cleaning chip of biochip supplies analysis running, the article carrying platform of described biochip arranges the biochip with multiple site; Described chip gripper equipment comprises motor mount, body frame, motor lead screw, direct current generator, bindiny mechanism, movable clamping device and pick-and-place device; Described pick-and-place device, comprise framework, be located at two claws on described framework and adjust wide assembly, described two claws are oppositely arranged, and the wide assembly of described tune is connected the distance between adjustment two claws with described claw.Described shade is for being installed on this article carrying platform both sides, and described harvester is located on this shade, and this harvester comprises CCD camera, is connected to the object lens of the photosensitive port of this CCD camera, and described object lens are right against article carrying platform, device for cleaning chip is by pedestal, first lotion pipeline, second lotion pipeline, rinse bath, wastewater outlet, described first lotion pipeline, second lotion pipeline is arranged on pedestal, the first nozzle boss and the second nozzle boss is provided with in described rinse bath, the first described lotion pipeline is communicated with liquid first nozzle boss, the second described lotion pipeline is communicated with the second nozzle boss, described first nozzle boss and the second nozzle boss are respectively equipped with the first water jet and the second water jet, described wastewater outlet is arranged on the below of rinse bath, the fluorescence that each site of described article carrying platform produces is all through the object lens of the photosensitive port corresponding to each site, these article carrying platform both sides are provided with positive stop strip, limited block is provided with on rear side of article carrying platform, described body frame is arranged on the side of motor mount, and described direct current generator is arranged in motor mount, and described activity clamping organization establishes is in body frame, and the opposite side of described motor mount is provided with optically-coupled catch and photoelectric sensor, have the guide pole that the direction along claw adjustment distance is arranged in described framework, described guide pole is arranged on two claws, and the quantity of described guide pole is two, and two guide poles are arranged in parallel, and described guide pole is connected by linear bearing with between claw, the wide assembly of described tune comprises motor, driving-belt and power wheel, described driving-belt and motor, power wheel are connected to form two parallel and traction belts that direction of motion is contrary, described two traction belts are fixedly connected with two claws respectively and the tune cross direction of direction of motion and claw is consistent, and described motor positive and inverse drives driving-belt to drive two claws relatively or deviate from motion, be provided with chip induction installation between described two claws, described chip induction installation be located to by corresponding position, the chip two ends picked up, described position induction device at least comprises the opposing motion of restriction claw and goes beyond the limit of the limit sensors dorsad of position and limit the limit sensors in opposite directions that claw move toward one another goes beyond the limit of position, also comprise the origin position sensor of instruction claw initial position, described origin position sensor at limit sensors dorsad or in opposite directions between limit sensors, and near wherein any one limit sensors, described control device is connected with a power interface and a power switch, and described control device is provided with a communication interface.
Control device is connected with a power interface and a power switch, and described control device is provided with a communication interface.Housing forms by lower house with upper shell, and described article carrying platform is located at the side in housing, the side body be connected offers a test card insert port with this article carrying platform.First water jet and the second water jet are respectively equipped with 1 ~ 10 rinse liquid outlet, wiper mechanism is provided with chip handgrip, chip handgrip is used for grab chips and is placed in by chip between two water jets, is convenient to rinse, and the distance between the first water jet and the second water jet is adjustable.
It is complicated that the object of the invention is to solve conventional bio-chip assay device structures, and volume is comparatively large, uses comparatively inconvenience, also can not damage material to be detected on chip while fully being cleaned up by the residuals on chip.
Accompanying drawing explanation
Structural representation when Fig. 1 is chip handgrip grab chips of the present invention.
Fig. 2 is the pick-and-place device schematic diagram of chip handgrip of the present invention.
Fig. 3 is that inner structure of the present invention overlooks direction schematic diagram.
Fig. 4 is device for cleaning chip schematic diagram of the present invention.
In Fig. 1,21-motor mount, 22-direct current generator, 14-motor lead screw, 25 are pick-and-place device, 26 is bindiny mechanism, 17 be optically-coupled catch, 18 be photoelectric sensor, 19,20 be movable clamping device, 21,22 be pick-and-place device, 28 be left jaw, 29 be right jaw, 27 be retaining collar, 23 for body frame.
In Fig. 2,202-pallet connecting portion, 204-framework, 205-left jamming claw, 206-right jamming claw, 208-adjust wide assembly, 210-guide pole, 212-linear bearing, 214-chip induction installation, 282-stepper motor, 284-power wheel, 285-traction belt, 286-traction belt, 252-breach, 216-limit sensors, 220-origin position sensor
In Fig. 3,10-housing, 12-article carrying platform, 120-positive stop strip, 121-limited block, 13-shade, 15-control device, 150-power interface, 151-power switch, 16-harvester, 160-communication interface, 111-device for cleaning chip, 222-chip gripper equipment
In Fig. 4,1-pedestal, 2-first lotion pipeline, 3-second lotion pipeline, 4-rinse bath, 5-wastewater outlet, 6-first nozzle boss, 7-second nozzle boss, 8-first water jet, 9-second water jet, 10-biochip, 11-chip handgrip.
Embodiment
Below in conjunction with the drawings and specific embodiments, the invention will be further described:
A kind of biochip test machine with decontamination function, comprise housing 10, be located in housing for carry biochip article carrying platform 12, for chip gripper equipment 222, for gather biochip information harvester 16 and shade 13, for controlling control device 15, the device for cleaning chip 111 of biochip supplies analysis running, the article carrying platform 12 of described biochip arranges the biochip with multiple site; Described chip gripper equipment 222 comprises motor mount 21, body frame 23, motor lead screw 14, direct current generator 23, bindiny mechanism 26, movable clamping device 19,20 and pick-and-place device 21,22; Described pick-and-place device 21,22; Described pick-and-place device 21,22, comprise framework 204, be located at two claws 205,206 on described framework and adjust wide assembly 208, described two claws are oppositely arranged, the wide assembly of described tune 208 is connected the distance between adjustment two claws with described claw, described shade 13 is for being installed on this article carrying platform 12 both sides, described harvester 16 is set up on this shade 13, this harvester 16 comprises CCD camera, be connected to the object lens of the photosensitive port of this CCD camera, and the camera power supply to be connected with this CCD camera, described object lens are right against article carrying platform; Device for cleaning chip is by pedestal 1, first lotion pipeline 2, second lotion pipeline 3, rinse bath 4, wastewater outlet 5, described first lotion pipeline 2, second lotion pipeline 3 is arranged on pedestal 1, the first nozzle boss 6 and the second nozzle boss 7 is provided with in described rinse bath, the first described lotion pipeline 2 is communicated with liquid first nozzle boss 6, the second described lotion pipeline 3 is communicated with the second nozzle boss 7, described first nozzle boss 6 and the second nozzle boss 7 are respectively equipped with the first water jet 8 and the second water jet 9, and described wastewater outlet 5 is arranged on the below of rinse bath 4; The fluorescence that described each site of article carrying platform 12 produces is all through the object lens of the photosensitive port corresponding to each site, and these article carrying platform 12 both sides are provided with positive stop strip 120, are provided with limited block 121 on rear side of article carrying platform 12; Described body frame 23 is arranged on the side of motor mount 21, described direct current generator 22 is arranged in motor mount 21, described movable clamping device 19,20 is arranged in body frame 23, and the opposite side of described motor mount 21 is provided with optically-coupled catch 17 and photoelectric sensor 18; The guide pole 210 that the direction along claw adjustment distance is arranged is had in described framework 204, described guide pole 210 is arranged on two claws, the quantity of described guide pole 210 is two, and two guide poles are arranged in parallel, and described guide pole is connected by linear bearing 212 with between claw; The wide assembly 208 of described tune comprises motor 282, driving-belt 285 and power wheel 284, described driving-belt 285 and motor 282, power wheel 284 are connected to form two parallel and traction belts 286 that direction of motion is contrary, described two traction belts 286 are fixedly connected with two claws respectively and the tune cross direction of direction of motion and claw is consistent, and described motor positive and inverse drives driving-belt to drive two claws relatively or deviate from motion; Be provided with chip induction installation 214 between described two claws, described chip induction installation 214 be located to by corresponding position, the chip two ends picked up; Also comprise the position induction device be located on framework, described position induction device at least comprises the opposing motion of restriction claw and goes beyond the limit of the limit sensors dorsad of position and limit the limit sensors in opposite directions that claw move toward one another goes beyond the limit of position, also comprise the origin position sensor 220 of instruction claw initial position, described origin position sensor 220 at limit sensors 216 dorsad or in opposite directions between limit sensors 216, and near wherein any one limit sensors 216; Described control device 15 is connected with power interface 150 and a power switch 151, described control device 15 is provided with a communication interface 160, described housing 10 forms by lower house with upper shell, described article carrying platform 12 is located at the side in housing, the side body be connected with this article carrying platform 12 offers a test card insert port, the first described water jet 8 and the second water jet 9 are respectively equipped with 1 ~ 10 rinse liquid outlet, the distance that described wiper mechanism is provided with between chip handgrip 11, first water jet 8 and the second water jet 9 is adjustable.
During use, utilize chip handgrip 11 grab chips, chip is placed between two water jets, chip cleaning fluid is flowed into the first nozzle boss 6 and the second nozzle boss 7 respectively by the first lotion pipeline 2 and the second lotion pipeline 3, then cleaning fluid is from the first water jet 8 and the ejection of the second water jet 9, cleans biochip.
Claims (5)
1. the biochip test machine with decontamination function, comprise housing, be located in housing for carry biochip article carrying platform, for chip gripper equipment, for gather biochip information harvester and shade, for controlling control device, the device for cleaning chip of biochip supplies analysis running, it is characterized in that: the article carrying platform of described biochip arranges the biochip with multiple site, described chip gripper equipment comprises motor mount, body frame, motor lead screw, direct current generator, bindiny mechanism, movable clamping device and pick-and-place device, described pick-and-place device, comprise framework, be located at two claws on described framework and adjust wide assembly, described two claws are oppositely arranged, and the wide assembly of described tune is connected the distance between adjustment two claws with described claw, described shade is for being installed on this article carrying platform both sides, and described harvester is located on this shade, and this harvester comprises CCD camera, is connected to the object lens of the photosensitive port of this CCD camera, and described object lens are right against article carrying platform, device for cleaning chip is by pedestal, first lotion pipeline, second lotion pipeline, rinse bath, wastewater outlet, described first lotion pipeline, second lotion pipeline is arranged on pedestal, the first nozzle boss and the second nozzle boss is provided with in described rinse bath, the first described lotion pipeline is communicated with liquid first nozzle boss, the second described lotion pipeline is communicated with the second nozzle boss, described first nozzle boss and the second nozzle boss are respectively equipped with the first water jet and the second water jet, described wastewater outlet is arranged on the below of rinse bath, the fluorescence that each site of described article carrying platform produces is all through the object lens of the photosensitive port corresponding to each site, these article carrying platform both sides are provided with positive stop strip, limited block is provided with on rear side of article carrying platform, described body frame is arranged on the side of motor mount, and described direct current generator is arranged in motor mount, and described activity clamping organization establishes is in body frame, and the opposite side of described motor mount is provided with optically-coupled catch and photoelectric sensor, have the guide pole that the direction along claw adjustment distance is arranged in described framework, described guide pole is arranged on two claws, and the quantity of described guide pole is two, and two guide poles are arranged in parallel, and described guide pole is connected by linear bearing with between claw, the wide assembly of described tune comprises motor, driving-belt and power wheel, described driving-belt and motor, power wheel are connected to form two parallel and traction belts that direction of motion is contrary, described two traction belts are fixedly connected with two claws respectively and the tune cross direction of direction of motion and claw is consistent, and described motor positive and inverse drives driving-belt to drive two claws relatively or deviate from motion, be provided with chip induction installation between described two claws, described chip induction installation be located to by corresponding position, the chip two ends picked up, described position induction device at least comprises the opposing motion of restriction claw and goes beyond the limit of the limit sensors dorsad of position and limit the limit sensors in opposite directions that claw move toward one another goes beyond the limit of position, also comprise the origin position sensor of instruction claw initial position, described origin position sensor at limit sensors dorsad or in opposite directions between limit sensors, and near wherein any one limit sensors, described control device is connected with a power interface and a power switch, and described control device is provided with a communication interface.
2. a kind of biochip test machine with decontamination function according to claim 1, it is characterized in that: described housing forms by lower house with upper shell, described article carrying platform is located at the side in housing, the side body be connected offers a test card insert port with this article carrying platform.
3. a kind of biochip test machine with decontamination function according to claim 1, is characterized in that: the first described water jet and the second water jet are respectively equipped with 1 ~ 10 rinse liquid outlet.
4. a kind of biochip test machine with decontamination function according to claim 1, is characterized in that: described wiper mechanism is provided with chip handgrip.
5. a kind of biochip test machine with decontamination function according to claim 1, is characterized in that: the distance between the first water jet and the second water jet is adjustable.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510829457.8A CN105372437A (en) | 2015-11-25 | 2015-11-25 | Biochip detection machine with scrubbing function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510829457.8A CN105372437A (en) | 2015-11-25 | 2015-11-25 | Biochip detection machine with scrubbing function |
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| Publication Number | Publication Date |
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| CN105372437A true CN105372437A (en) | 2016-03-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510829457.8A Pending CN105372437A (en) | 2015-11-25 | 2015-11-25 | Biochip detection machine with scrubbing function |
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| CN (1) | CN105372437A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106168626A (en) * | 2016-04-08 | 2016-11-30 | 深圳雷杜生命科学股份有限公司 | Biochip analysis instrument and the method for analysis |
| CN113030460A (en) * | 2021-02-26 | 2021-06-25 | 西安交通大学 | Hand-held instrument for detecting magnetic sensitive biochip signal |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020174884A1 (en) * | 2000-08-10 | 2002-11-28 | Affymetrix Inc. | Cartridge washing system and methods |
| CN1453586A (en) * | 2002-04-27 | 2003-11-05 | 公准精密工业股份有限公司 | Biochip work platform |
| US6656724B1 (en) * | 1997-11-19 | 2003-12-02 | Mwg-Biotech Ag | Apparatus for automatic implementation of chemical or biological methods |
| CN101066022A (en) * | 2007-04-03 | 2007-11-07 | 江苏大学 | Linear motor driven terminal executor of picking robot |
| CN101334402A (en) * | 2007-06-26 | 2008-12-31 | 上海裕隆生物科技有限公司 | Full-automatic biological chips detection system |
| CN201725785U (en) * | 2010-03-31 | 2011-01-26 | 深圳市大族激光科技股份有限公司 | Chip picking and placing device |
| CN102814294A (en) * | 2012-06-19 | 2012-12-12 | 江苏三联生物工程有限公司 | Cleaning and drying device for biological chip |
| CN204422530U (en) * | 2015-03-11 | 2015-06-24 | 厦门拜尔杰生物科技有限公司 | Biological chip reading apparatus |
-
2015
- 2015-11-25 CN CN201510829457.8A patent/CN105372437A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6656724B1 (en) * | 1997-11-19 | 2003-12-02 | Mwg-Biotech Ag | Apparatus for automatic implementation of chemical or biological methods |
| US20020174884A1 (en) * | 2000-08-10 | 2002-11-28 | Affymetrix Inc. | Cartridge washing system and methods |
| CN1453586A (en) * | 2002-04-27 | 2003-11-05 | 公准精密工业股份有限公司 | Biochip work platform |
| CN101066022A (en) * | 2007-04-03 | 2007-11-07 | 江苏大学 | Linear motor driven terminal executor of picking robot |
| CN101334402A (en) * | 2007-06-26 | 2008-12-31 | 上海裕隆生物科技有限公司 | Full-automatic biological chips detection system |
| CN201725785U (en) * | 2010-03-31 | 2011-01-26 | 深圳市大族激光科技股份有限公司 | Chip picking and placing device |
| CN102814294A (en) * | 2012-06-19 | 2012-12-12 | 江苏三联生物工程有限公司 | Cleaning and drying device for biological chip |
| CN204422530U (en) * | 2015-03-11 | 2015-06-24 | 厦门拜尔杰生物科技有限公司 | Biological chip reading apparatus |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106168626A (en) * | 2016-04-08 | 2016-11-30 | 深圳雷杜生命科学股份有限公司 | Biochip analysis instrument and the method for analysis |
| CN113030460A (en) * | 2021-02-26 | 2021-06-25 | 西安交通大学 | Hand-held instrument for detecting magnetic sensitive biochip signal |
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