CN105836240A - Tube breaking mechanism, sealed test tube assembly comprising tube breaking mechanism and application thereof - Google Patents
Tube breaking mechanism, sealed test tube assembly comprising tube breaking mechanism and application thereof Download PDFInfo
- Publication number
- CN105836240A CN105836240A CN201610143977.8A CN201610143977A CN105836240A CN 105836240 A CN105836240 A CN 105836240A CN 201610143977 A CN201610143977 A CN 201610143977A CN 105836240 A CN105836240 A CN 105836240A
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- China
- Prior art keywords
- solution
- solution conduit
- tube
- sleeve pipe
- sealing
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B69/00—Unpacking of articles or materials, not otherwise provided for
- B65B69/0033—Unpacking of articles or materials, not otherwise provided for by cutting
- B65B69/0041—Unpacking of articles or materials, not otherwise provided for by cutting by puncturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Abstract
The invention discloses a tube breaking mechanism, a sealed test tube assembly comprising the tube breaking mechanism and application of the sealed test tube assembly. The tube breaking mechanism comprises a piercing component and a supporting component. The piercing component comprises a body and a shrinking part. The outer side face of the piercing component or the outer side face of the supporting component is asymmetrically distributed relative to the center of the supporting component. The sealed test tube assembly comprises the tube breaking mechanism, a solution tube and a sleeve tube. The solution tube is embedded and inserted into the sleeve tube to form a sealed and embedded bottom space. The tube breaking mechanism is located below the bottom of the solution tube embedded in the sleeve tube and used for piercing the bottom of the solution tube. After the bottom of the solution tube is pierced, at least two gap channels are formed by the outer side face of the tube breaking mechanism and a fractured hole in the bottom of the solution tube, a solution in the solution tube can flow out of the solution tube, and air in the sleeve tube can enter the solution tube. The solution tube can be pierced quite conveniently through the tube breaking mechanism. The sealed test tube assembly does not leak, is widely applied and is good in effect.
Description
Technical field
The present invention relates to chromatographic test paper detection device, specifically a kind of Po Guan mechanism, include this broken pipe
The sealing test tube assembly of mechanism and application thereof.
Background technology
Charlton is in the Sidestream chromatography reagent paper technology (Lateral Flow, US6485982) of invention in 1988
Cause immunology diagnosis revolution, this diagnostic techniques to simplify sample by the way of chromatographic test paper and add step
Suddenly, simultaneously by the reaction of solid-phase immunity on nitrocellulose filter achieve unprecedented simple, quickly,
Accurately with cheap.Colloidal gold immune chromatography test is generalized to widely used fast medical in-vitro diagnosis subsequently
Reagent, has the most also been generalized to food safety and bio-safety field of fast detection.Other dry types simultaneously
Biochemical reagent paper also begins to use chromatographic test paper mode.In the detection project of these chromatographic test papers, part detection
Material can produce damaging effect to operator and environment, such as anthrax Pathogen test, dioxin etc..Therefore
The chromatography detecting test paper of this kind of detection object needs supporting closed detection device.
The most common chromatographic test paper typically uses hand-held test strips and plastics cartridge two kinds of forms of packaging.Hand-held
The production technology of test strips is simple, and packaging volume is little, stores convenient transportation.It has only to advise in use
In the sample solution of a fixed insertion certain depth, solution chromatography the most automatically climbs up test strips, shorter
Time showing goes out result.But after having detected, whole test strips is substantially filled with the sample solution of residual,
This residual solution may pollute environment and operator in subsequent operation.The most currently used hand-held reagent paper
Main the detecting the urine liking human or animal of immune chromatography test paper of strips, has communicable clinic
Sample is not the most adopted in this way.
The chromatographic test paper product of plastics cartridge packaging is the main flow of existing market.Three kinds are typically had in plastics cartridge
Perforate, one is sample viewing window, is used for observing the reaction result of chromatographic test paper;One is that sample solution adds
Add hole;A kind of is that air-vent is for carrying out the sample solution on rapid draing reagent paper.These three perforate may
The sample solution being added on reagent paper exposes in atmosphere, may pollute environment and operator.But compare
Hand-held test strips, has greatly reduced opportunities for contamination.
American I nverness company employ a kind of detect urine sample early pregnancy pen type plastics cartridge, should
The observation window planting cartridge is replaced by LCDs or transparent sealed plastic sheet, the added holes quilt of sample solution
Automatically, after solution absorbing rod replaces, and sample solution enters absorbing rod, this absorbing rod can be by a plastic sheath
Set connects, and can be sealed in inside plastics cartridge by sample solution completely.
During the urine that current chromatographic test paper is widely used in drug addict quickly detects.Illicit drugs inspection chromatographs
Reagent paper predominantly detect the plastics cartridge that reagent paper packaged form is plug-in type headgear.In this packaged form, layer
Analysis reagent paper all (containing observation window) can be sealed by transparent plastic sheet, and sample interpolation part is stretched out for inserting
Enter solution pipette samples, after sample has been drawn, have a plug-in type headgear by the sample interpolation part of reagent paper
Entangling, the most this kind of plastics cartridge can completely cut off sample solution containing Poison substantially to environment and operator
Pollute.
From Cetus company of the U.S. in 1985 with polymerase chain reaction (Polymerase Chain Reaction,
PCR), since realizing the specific amplification of nucleic acid, this technology is just because having high sensitivity, high specific and height
The feature of effect is widely used in epidemic disease Pathogen test field.But the high concentration cause of disease nucleotide sequence being amplified is very
Easily contaminated air, test tool and water during subsequent operation, thus result in the vacation of subsequent detection sample
Positive findings.Therefore in the penetration and promotion of detection of nucleic acids, it is also desirable to develop closed detection apparatus and method.
Solve the nucleic acid amplification product pollution problem when detection, mainly have two kinds of strategies.The first is in inspection
Airtight environment is built, such as: electrophoresis is carried out in airtight negative pressure room during surveying nucleic acid amplification product,
The overall process of real-time fluorescence PCR is not switched on reaction tube, but these methods are required for strict experiment condition and hold high
Expensive experimental facilities, is not suitable for being popularized for basic unit user.The second is incorporation dUTP in nucleic acid amplification reaction,
Use UNG ferment treatment test tool and environment with before nucleic acid amplification next time after having reacted, but this method is grasped
Make loaded down with trivial details, and there is certain contamination probability, limit the application of this strategy.
Sidestream chromatography technology is applied to the detection of nucleic acid amplification product by Gerdes etc. (US2004/0110167)
In, bring hope to detection of nucleic acids in basic unit's application.In order to avoid producing during nucleic acid Sidestream chromatography
Polluting, optimal selection is to use device to be closed by chromatography process.Look after one's family and forever wait (CN1888902)
Having invented a kind of closed nucleic acid Sidestream chromatography detection device, its structure includes shell and inner box, wraps in inner box
Include chromatography diluent, nucleic acid amplification product and chromatograph test strip, the blade in inner box while shell is closed
Puncture diluted liquid tube and nucleic acid amplification pipe, after two kinds of liquid mixing, be imported into the sample pad of chromatograph test strip, real
Existing immunochromatography chromogenic reaction.But the shortcoming of this device is: 1, device volume is big, is not suitable for the rule of finished product
Mould produces and transport;2, the test strips in device installs complexity, is not suitable for the reagent paper Assembling Production of scale;
3, after this device restarts use, the most simply and can not reopened with there is no vestige, be therefore
Relatively achieve the closing of nucleic acid amplification product, if be not intended to open the device reacted by people, amplification
The pollution of product is the most inevitable;4, this device can be only done the detection of single reactant liquor, and cannot
Detect multiple reactant liquor, i.e. in the way of multiple reactant liquors, multiple sample cannot be completed in a test strips
Detection.
Chinese invention patent application CN103529201A discloses a kind of enclosed chromatographic test paper detection dress
Putting, this device can realize completely enclosed, can block completely the sample of chromatographic test paper to the harm of operator and
The pollution of environment.But the shortcoming that this device exists has: 1, when solution conduit caliber is less, solution conduit
It is difficult at the bottom of pipe be opened;2, the gas in connecting tube is not easily accessed solution conduit, in causing connecting tube
Gas pressure will raise;If the gas pressure in connecting tube exceedes the air pressure outside pipe, and this pressure differential surpasses
Having crossed the bearing value sealing structure, the gas in pipe still can outwards be drained, when there being solution in pipe, molten
Liquid also can produce leakage under the driving of gas.
Summary of the invention
The purpose of this part is summarize some aspects of embodiments of the invention and briefly introduce some relatively
Good embodiment.This part and the description of the present application make a summary and denomination of invention may be done a little simplify or
Omit to avoid making the purpose of this part, specification digest and denomination of invention to obscure, and this simplification or omission
Cannot be used for limiting the scope of the present invention.
In view of above-mentioned and/or problems of the prior art, it is proposed that the present invention.
Therefore, one of them purpose of the present invention is to provide a kind of Po Guan mechanism easily punctured bottom solution conduit.
For solving above-mentioned technical problem, according to an aspect of the present invention, the invention provides following technical side
Case: a kind of Po Guan mechanism, including rupture component and holding components;Described rupture component includes body and setting
Portion is reduced in described body one end;Described holding components clamps the basis of described rupture component from bottom to top
Body, and described holding components to the portion that reduces of described rupture component in the shape gradually drawn in;Described puncture
The lateral surface of parts or described holding components includes at least two planes, and this lateral surface is relative to holding components
Center be mal-distribution.
As a preferred embodiment of the present invention, wherein: the bottom of described holding components is provided with fitting connection
Structure, the bottom of described fitting connection structure uses hollow post holes upwards or downward protruding post;Described
Holding components and described fitting connection structural integrity molding;The hardness of described rupture component material is not less than described
The hardness of holding components material;The portion that reduces of described rupture component uses blade or pointed body.
Another object of the present invention is to provide the close of a kind of Po Guan mechanism including easily puncturing bottom solution conduit
Envelope property test tube assembly.
For solving above-mentioned technical problem, according to an aspect of the present invention, the invention provides following technical side
Case: a kind of sealing test tube assembly including Po Guan mechanism, described sealing test tube assembly includes described broken
Pipe mechanism, solution conduit and the sleeve pipe chimeric with the sealing of described solution conduit, described solution conduit is chimeric inserts described set
Being formed in pipe and seal chimeric bottom space, described Po Guan mechanism is positioned at the bottom of the solution conduit chimeric with described sleeve pipe
Below portion and for puncturing the bottom of described solution conduit;After being punctured bottom described solution conduit, Po Guan mechanism
The hole ruptured bottom lateral surface and solution conduit at least forms two interstitial channels, and the solution in solution conduit is permissible
Flowing out in described solution conduit, the air in sleeve pipe can enter in described solution conduit;Described Po Guan mechanism is embedding
It is interior or one-body molded with described sleeve pipe that conjunction is fixed on described sleeve pipe.
As a preferred embodiment of the present invention, wherein: described solution conduit outer wall uses with described internal surface of sleeve pipe
The conical surface or the face of cylinder coordinate and are provided with at least one pair of back-off at the composition surface of the described conical surface or face of cylinder cooperation
Embedded structure;Described back-off embedded structure includes bulge loop and the groove matched;When described solution conduit inserts institute
After stating sleeve pipe, described bulge loop forms back-off with described groove and mates, and causes described solution conduit to be difficult to from described set
Extract in pipe.
As a preferred embodiment of the present invention, wherein: described solution conduit outer wall uses with described internal surface of sleeve pipe
The conical surface or the face of cylinder coordinate and are provided with at least one sealing at the composition surface of the described conical surface or face of cylinder cooperation
Coupling circle;The described coupling circle that seals at least includes a bulge loop, another face formation one that bulge loop is matched
Quantitative interference fit, thus play sealing function;Described sealing is mated at circle or is provided with on described sleeve pipe
Exhaust gear;When described solution conduit inserts described sleeve pipe, described exhaust structure is by the sky inside and outside described sleeve pipe
Gas connects, to maintain the suitable gas pressure of described cannula cavity;Described exhaust gear includes being arranged on described
The vertical groove on the downside of mating circle with the interference of the tube side wall that bulge loop mates in circle is mated in sealing topmost, should
Certain distance is had between two ends up and down and the interference fit circle of vertical groove.
As a preferred embodiment of the present invention, wherein: described solution conduit be internally provided with vertical partition wall,
The inside of described solution conduit is divided into two cavitys by described partition wall.
As a preferred embodiment of the present invention, wherein: the bottom of described solution conduit sets effigurate cutting
Trace, it is simple to the portion that reduces of Po Guan mechanism punctures the bottom of described solution conduit.
As a preferred embodiment of the present invention, wherein: the bottom of described solution conduit is chimeric to be had outside another
Edge is not more than the solution container of external diameter bottom solution conduit, when thorn upwards pushes up in Po Guan mechanism, first punctures described molten
The upper lower wall of liquid container, then punctures the bottom of solution conduit, the solution of the most described solution container and solution conduit
Solution flow out and mix.
As a preferred embodiment of the present invention, wherein: described solution conduit includes body and lid;Described lid
After son press-in solution conduit body, solution conduit inboard wall of tube body and lid outer wall are formed to seal and combine;Described solution conduit
Inboard wall of tube body uses the conical surface or the face of cylinder to coordinate with lid outer wall;The composition surface that the described conical surface or the face of cylinder coordinate
Place is provided with at least one pair of back-off embedded structure;Described back-off structure includes bulge loop and the groove matched;When
After lid inserts solution conduit body, described bulge loop forms back-off with described groove and mates, and causes described lid very
Difficulty is extracted in solution conduit body.
As a preferred embodiment of the present invention, wherein: described solution conduit inboard wall of tube body uses with lid outer wall
The conical surface or the face of cylinder coordinate;At least one sealing it is provided with at the composition surface that the described conical surface or the face of cylinder coordinate
Join circle;The described coupling circle that seals at least includes a bulge loop, and matched another face of bulge loop is formed necessarily
The interference fit of amount, thus play sealing function.
As a preferred embodiment of the present invention, wherein: described sleeve pipe includes connecting tube and matched length
Pipe, described connecting tube uses the conical surface or the face of cylinder to coordinate with described long tube, and the described conical surface or the face of cylinder coordinate
It is provided with at least one pair of back-off embedded structure at chimeric composition surface or at least one seals coupling circle;Described fall
Button embedded structure includes bulge loop and the groove matched, after described long tube inserts described connecting tube, described convex
Ring forms back-off with described groove and mates, and causes described long tube to be difficult to extract in described connecting tube;Described close
Envelope coupling circle at least includes a bulge loop, and matched another face of bulge loop forms a certain amount of interference and joins
Close, thus play sealing function;It is provided with exhaust gear on described long tube;When described solution conduit is inserted described
During connecting tube, described exhaust structure is by the air communication inside and outside described connecting tube, in maintaining described connecting tube
The suitable gas pressure in chamber.
As a preferred embodiment of the present invention, wherein: described exhaust gear includes being arranged on described long tube
A threaded endoporus and one can be by the screw of this threaded interior hole screwing hermetic;Described screw comprises spiral shell
Silk head and screw cylinder, when the revolving force that this screw terminal is exceeded certain torsion torch screws, screw terminal and screw
Cylinder fracture departs from, and screw column delay is fixed in the threaded interior hole sealed up.
As a preferred embodiment of the present invention, wherein: described exhaust gear includes being arranged on described long tube
Band seal the endoporus of back-off structure and a plastic closure that this endoporus can be carried out back-off sealing;When
After plastic closure is inserted endoporus, this endoporus is sealed by back-off.
Another object of the present invention is to provide the application of a kind of sealing test tube assembly.
For solving above-mentioned technical problem, according to an aspect of the present invention, the invention provides following technical side
Case: the application of a kind of sealing test tube assembly, comprises in described sleeve pipe and absorbs described solution conduit release solution
Medium, in described solution conduit, the solution of release can occur biochemical reaction on the medium further, presents anti-
Induction signal;Described medium uses immune chromatography test paper, the biochemical reagent paper of dry type, certain life dried
Change the one in reacted constituent or special bio-chemical solution.
As a preferred embodiment of the present invention, wherein: described long tube comprises particular medium, described medium
Absorb the solution of release in described solution conduit, biochemical reaction occurs the most further, presents reaction
Signal;Described medium uses immune chromatography test paper, the biochemical reagent paper of dry type, certain biochemistry dried
One in reacted constituent or particularly bio-chemical solution.
The present invention has following technical effect that the Po Guan mechanism in the present invention is owing to comprising asymmetrically distributed two
Individual side, can form two passages when puncturing solution conduit, makes the air pressure balance inside and outside solution conduit, therefore,
Solution conduit can be punctured easily;Sealing test tube assembly in the present invention is owing to comprising above-mentioned broken pipe machine
Structure, therefore can ensure that the air pressure balance inside and outside solution conduit, will not produce leakage;Sealing in the present invention
Test tube assembly is widely used, and is quick on the draw, effective.
Accompanying drawing explanation
In order to be illustrated more clearly that the technical scheme of the embodiment of the present invention, required in embodiment being described below
Accompanying drawing to be used is briefly described, it should be apparent that, the accompanying drawing in describing below is only the present invention's
Some embodiments, for those of ordinary skill in the art, on the premise of not paying creative work,
Other accompanying drawing can also be obtained according to these accompanying drawings.Wherein:
Fig. 1 is the perspective view of the Po Guan mechanism in the present invention.
Fig. 2 is the perspective view at another visual angle of Po Guan mechanism in the present invention.
Fig. 3 is the front view of the Po Guan mechanism in the present invention.
Fig. 4 is the A-A sectional view in Fig. 3.
Fig. 5 is the top view of Fig. 3.
Fig. 6 is the upward view of Fig. 3.
Fig. 7 is the perspective view of sealing test tube the first embodiment of assembly in the present invention.
Fig. 8 is the front view of sealing test tube the first embodiment of assembly in the present invention.
Fig. 9 is the B-B sectional view in Fig. 8.
Figure 10 is the C-C sectional view in Fig. 8.
Figure 11 is the D-D sectional view in Fig. 8.
Figure 12 is the top view of Fig. 8.
Figure 13 is the E-E sectional view in Figure 12.
Figure 14 is the structural representation sealing coupling circle in the present invention.
Figure 15 is the perspective view of the solution conduit in the present invention.
Figure 16 is the front view of the solution conduit in the present invention.
Figure 17 is the front sectional view of the solution conduit in the present invention.
Figure 18 is the left view of Figure 16.
Figure 19 is the structural representation being provided with solution container in the present invention bottom solution conduit.
Figure 20 is the perspective view of the sealing test tube assembly the second embodiment in the present invention.
Figure 21 is the front sectional view of the sealing test tube assembly the second embodiment in the present invention.
Figure 22 is the perspective view of the exhaust gear the second embodiment in the present invention.
Figure 23 is the front sectional view of Figure 22.
Figure 24 is the perspective view of the third embodiment of exhaust gear in the present invention.
Figure 25 is the front sectional view of Figure 24.In Fig. 1 Figure 19, reference is respectively as follows: Po Guan mechanism
100, rupture component 110, body 111, reduce portion 112, holding components 120, be fitting to connection structure 121,
Hollow post holes 122, sealing test tube assembly 200, solution conduit 300, lid 301, partition wall 302, pipe
Body 303, sleeve pipe 400, connecting tube 410, long tube 420, threaded endoporus 421, screw 422, band
Seal the endoporus 423 of back-off structure, lid 424, back-off embedded structure 500, bulge loop 501, groove 502,
Seal coupling circle 600, bulge loop 601, exhaust gear 700, vertical groove 701, solution container 800.
Detailed description of the invention
Understandable, below in conjunction with description for enabling the above-mentioned purpose of the present invention, feature and advantage to become apparent from
The detailed description of the invention of the present invention is described in detail by accompanying drawing.
Elaborate a lot of detail in the following description so that fully understanding the present invention, but the present invention
Other can also be used to be different from alternate manner described here implement, those skilled in the art can be not
Doing similar popularization in the case of running counter to intension of the present invention, therefore the present invention is not by following public specific embodiment
Restriction.
Secondly, " embodiment " or " embodiment " referred to herein refers to may be included in the present invention at least
Special characteristic, structure or characteristic in one implementation.Different in this manual local appearance "
In one embodiment " not refer both to same embodiment, it is not single or selective and other enforcements
The embodiment that example is mutually exclusive.
Understandable, below in conjunction with description for enabling the above-mentioned purpose of the present invention, feature and advantage to become apparent from
The detailed description of the invention of the present invention is described in detail by accompanying drawing.
Fig. 1 Fig. 6 is the embodiment representing the Po Guan mechanism 100 in the present invention.Po Guan mechanism 100 is independent
As a part.
As shown in Fig. 1 Fig. 6, a kind of Po Guan mechanism 100, including rupture component 110 and holding components 120.
The hardness of rupture component 110 material is not less than the hardness of holding components 120 material.
Rupture component 110 includes body 111 and is arranged on the portion that reduces 112 of body 111 one end.Punctured part
The portion that reduces 112 of part 110 uses blade or pointed body.
Holding components 120 clamps the body 111 of rupture component 110, and holding components 120 from bottom to top
To the portion that reduces 112 of rupture component 110 in the shape gradually drawn in.The bottom of holding components 120 is provided with
Be fitting to connection structure 121, be fitting to connection the bottom of structure 121 use hollow post holes 122 upwards or to
Under protruding post, embodiment shown in figure uses hollow post holes 122.Holding components 120 and fitting connection
Structure 121 is the most one-body molded.
The lateral surface of rupture component 110 or holding components 120 includes at least two planes, such as in Fig. 4
First shown A and second B, and the two face A with B relative to holding components 120 center in
Mal-distribution, say, that the two face A Yu B projection of shape on the top view shown in Fig. 5 with
Area is unequal, thus when puncturing solution conduit 300, forms size based on two asymmetric both sides
Two passages not waited, as shown in Figure 13.
Fig. 7 Figure 13 is the reality representing a kind of sealing test tube assembly 200 using above-mentioned Po Guan mechanism 100
Execute example.
As shown in Fig. 7 Figure 13, sealing test tube assembly 200 includes Po Guan mechanism 100, solution conduit 300
And seal chimeric sleeve pipe 400 with solution conduit 300.
As shown in Figure 15 Figure 18, solution conduit 300 includes body 303 and lid 301.Solution conduit body
Connected by connection strap between 303 and lid 301.Solution conduit body 303 is divided into bottom, bottom and top,
The diameter on solution conduit body 303 top is more than the diameter of solution conduit body 303 bottom.Solution conduit body 303
Lower, outer perimeter is provided with solution conduit exterior groove 502 or bulge loop, and solution conduit body 303 upper inside wall circumference sets
There are solution conduit interior grooves 502 or bulge loop;It is convex that the periphery of solution conduit lid 301 is provided with solution conduit lid periphery
Ring 501 or groove.Solution conduit body 303 includes solution conduit exterior groove 502 or bulge loop, molten from bottom to up
Liquid pipe interior grooves 502 or bulge loop.
As shown in figure 17, bottom solution conduit body 303, it is provided with solution conduit polycrystalline substance, in the present embodiment,
This solution conduit polycrystalline substance is set to the planar structure closed.The bottom of solution conduit 300 is also provided with a setting
The cut channel of shape, it is simple to the portion that reduces 112 of Po Guan mechanism 100 punctures the bottom of solution conduit 300.This cut channel shape
Shape both can be ring or abnormity Guan Bi circle, it is also possible to is ring or the abnormity Guan Bi circle of breach, also may be used
To be the groove of strip.
Some special biochemical reaction is required there are two solution cavitys, for reaching this purpose, in solution conduit
300 be internally provided with vertical partition wall 302, as shown in figure 13, partition wall 302 is by solution conduit 300
Inside is divided into two cavitys.After completion of the reaction, can molten by two cavitys by rocking of solution conduit 300
Liquid mixes;The molten of two cavitys can also be made when rupture component 110 cuts through bottom solution conduit 300
It is mixed together when liquid discharges simultaneously.
Use partition wall 302 formed two cavitys in solution be conjuncted after all, in course of reaction certain
A little reaction conditions cannot independently apply.Therefore, as shown in figure 19, the bottom in solution conduit 300 is all right
The chimeric solution container 800 having another outward flange to be not more than external diameter bottom solution conduit 300, when Po Guan mechanism
100 upwards top thorn time, first puncture the upper lower wall of solution container 800, then puncture the bottom of solution conduit 300,
Hereafter the solution of solution container 800 flows out with the solution of solution conduit 300 and mixes.
As shown in Figure 12,13, sleeve pipe 400 is provided with a counterbore shape interface mated with solution conduit 300,
Being provided with bulge loop or groove in this counterbore shape interface, this bulge loop or groove can be with the solution conduit inserting counterbore shape interface
Exterior groove or bulge loop coordinate fixing formation back-off embedded structure, form sealed environment and can not be opened.
Po Guan mechanism 100 is positioned at solution conduit 300 bottom part down chimeric with sleeve pipe 400 and for puncturing solution
The bottom of pipe 300.Po Guan mechanism 100 by be fitting to connection structure 121 be fitted and fixed with in sleeve pipe 400 or
Person is one-body molded with sleeve pipe 400.
After being punctured bottom solution conduit 300, the lateral surface of Po Guan mechanism 100 ruptures bottom solution conduit 300
Hole formed at least two interstitial channels, the solution in solution conduit 300 by one of them interstitial channels can
To flow out in solution conduit 300, the air in sleeve pipe 400 can be entered by other in which interstitial channels
In solution conduit 300.
Solution conduit 300 is chimeric inserts the bottom space that sleeve pipe 400 interior formation sealing is chimeric, outside solution conduit 300
Wall uses the conical surface or the face of cylinder to coordinate with sleeve pipe 400 inwall.
A kind of embodiment at composition surface that the conical surface or the face of cylinder coordinate is provided with at least one pair of back-off and is fitted together to
Structure 500, such as Fig. 9, shown in 13.Back-off embedded structure 500 includes bulge loop 501 and the groove matched
502.After solution conduit 300 inserts sleeve pipe 400, bulge loop 501 forms back-off with groove 502 and mates, and causes
Solution conduit 300 is made to be difficult to extract in sleeve pipe 400.
The another kind of embodiment at composition surface that the conical surface or the face of cylinder coordinate is provided with at least one sealing
Join circle 600, as shown in figure 14.Seal coupling circle 600 and at least include a bulge loop 601, bulge loop 601 with
Another face of its coupling forms a certain amount of interference fit, thus plays sealing function.
Seal and be provided with exhaust gear 700 at coupling circle 600.When solution conduit 300 inserts sleeve pipe 400,
Exhaust structure 700 is by the air communication inside and outside sleeve pipe 400, to maintain sleeve pipe 400 inner chamber suitable gas pressure
Power.
The first embodiment of exhaust gear 700, including in the sealing coupling circle 600 being arranged on topmost with
Vertical groove 701 on the downside of the interference coupling circle of the tube side wall of bulge loop 601 coupling, this vertical groove 701
Certain distance is had up and down between two ends and interference fit circle.
As shown in figure 17, solution conduit body 303 upper inside wall circumference be provided with upper and lower two grooves 502 or
Bulge loop, is internal first groove of solution conduit or bulge loop, internal second groove of solution conduit or bulge loop, solution respectively
The periphery of lid 301 is provided with bulge loop 501 or groove, this solution conduit lid periphery bulge loop 501 or groove with
Internal first groove of solution conduit or bulge loop, internal second groove of solution conduit or bulge loop can fitted seal.See
Figure 13, solution conduit lid periphery bulge loop or groove coordinate fixing with solution conduit interior grooves or bulge loop.Work as solution
When being groove 502 on pipe body 303 upper inside wall circumference, then the periphery of solution conduit lid 301 is bulge loop
501;Otherwise, when being bulge loop 501 groove 502 on solution conduit body 303 upper inside wall circumference, the most molten
The periphery of liquid lid 301 is groove 502.Solution conduit lid 301 is during covering outside solution conduit lid
All bulge loops or groove first first groove internal with solution conduit or bulge loop coordinate, solution conduit lid after second time pressing
301 can also press internal second groove of LAP and solution conduit or bulge loop coordinates again, finally cover state in
Can not extract and sealing state (internal liquid will not occur leakage phenomenon).Internal first groove of solution conduit or
Bulge loop can allow solution conduit lid 301 to repeat to open, internal second groove of solution conduit or bulge loop then reverse barb
Live solution conduit lid 301 so that it is after being disposably pressed into position, form enclosed environment, it is impossible to be opened again.
Solution conduit body 303 inwall uses the conical surface or the face of cylinder to coordinate with lid 301 outer wall.Lid 301 is pressed
After entering solution conduit body 303, solution conduit body 303 inwall and lid 301 outer wall are formed to seal and combine.
In some applications, it is desirable to the solution in solution conduit 300 is after bottom is discharged into sleeve pipe 400, molten
Liquid pipe 300 and sleeve pipe 400 still maintain one to seal cavity, therefore it is required that solution conduit 300 and its lid 301
Sealing back-off structure to be formed.
A kind of embodiment sealing back-off structure is: be provided with at the composition surface that the conical surface or the face of cylinder coordinate
At least one pair of back-off embedded structure 500;Back-off structure 500 includes bulge loop 501 and the groove 502 matched;
After lid 301 inserts solution conduit body 303, bulge loop 501 forms back-off with groove 502 and mates, and causes
Lid 301 is difficult to extract in solution conduit body 303.
The another embodiment sealing back-off structure is: be provided with at the composition surface that the conical surface or the face of cylinder coordinate
At least one seals coupling circle 601, as shown in figure 14.Seal coupling circle 601 and at least include a bulge loop
601, matched another face of bulge loop 601 forms a certain amount of interference fit, thus plays sealing and make
With.
As shown in Figure 20, Figure 21, sleeve pipe 400 includes connecting tube 410 and matched long tube 420.
Connecting tube 410 is provided with a counterbore shape interface mated with solution conduit 300, is provided with in this counterbore shape interface
Bulge loop or groove, this bulge loop or groove can coordinate fixing shape with the solution conduit exterior groove inserting interface or bulge loop
Become back-off embedded structure, form sealed environment and can not be opened.
Counterbore shape interface inner bottom part is provided with Po Guan mechanism 100, and for discharging the solution in solution conduit, it is to molten
The specific function power that gives liquid pipe polycrystalline substance can be ruptured disengaging, and solution discharges from solution conduit.Heavy
The inner bottom part of hole shape interface is provided with solution channel, and the liquid that solution conduit discharges will flow to through solution channel
The sample solution reception area of the chromatographic test paper in long tube 420.In the present embodiment, Po Guan mechanism 100 inserts also
It is entrenched in the pit of connecting tube 410 counterbore shape interface inner bottom part.
It is additionally provided with an interface mated with long tube 420 in connecting tube 410, in this interface, is provided with bulge loop or recessed
Groove, this bulge loop or groove coordinate fixing with long tube 420 exterior groove or bulge loop, form back-off and seal structure,
It is inserted into after making stress and forms sealed environment after the long tube 420 of connecting tube 410 enters position and can not be opened.
Long tube 420 is the hollow tube of one end open.Position is mated at the long tube 420 inserting connecting tube 410
On be additionally provided with exterior groove or bulge loop, this exterior groove or bulge loop are joined with the bulge loop in connecting tube 410 or groove
Closing fixing, reagent paper is inserted by long tube 420 opening part.
Connecting tube 410 uses the conical surface or the face of cylinder to coordinate with long tube 420, and it is chimeric that the conical surface or the face of cylinder coordinate
It is provided with at least one pair of back-off embedded structure 500 at composition surface or at least one seals coupling circle 601.
Back-off embedded structure 500 includes bulge loop 501 and the groove 502 matched, when long tube 420 inserts even
After adapter 410, bulge loop 501 forms back-off with groove 502 and mates, and causes long tube 420 to be difficult to from connecting tube
Extract in 410.
Seal coupling circle 601 and at least include a bulge loop 601, another face shape that bulge loop 601 is matched
Become a certain amount of interference fit, thus play sealing function, as shown in figure 14.
Exhaust gear 700 it is provided with on long tube 420;When solution conduit 300 inserts connecting tube 410, aerofluxus
Structure 700 is by the air communication inside and outside connecting tube 410, to maintain connecting tube 410 inner chamber suitable gas pressure
Power.
The second embodiment of exhaust gear 700, threaded interior including be arranged on long tube 420
Hole 421 and one can be by the screws 422 of this threaded interior hole 421 screwing hermetic;Screw thread comprises screw terminal and spiral shell
Filament cylinder, when the revolving force that this screw terminal is exceeded certain torsion torch screws, screw terminal ruptures with screw cylinder
Departing from, screw column delay is fixed in the threaded interior hole sealed up.
The third embodiment of exhaust gear 700, seals back-off including the band being arranged on long tube 420
The endoporus 423 of structure and a plastic closure 424 that this endoporus 423 can be carried out back-off sealing;When moulding
After material lid 424 inserts endoporus 423, this endoporus 423 is sealed by back-off.
As a kind of application of sealing test tube assembly, sleeve pipe 400 comprises absorbent solution pipe 300 and discharges molten
The medium of liquid, in solution conduit 300, the solution of release can occur biochemical reaction on the medium further, presents
Go out reaction signal.
As the another kind of application of sealing test tube assembly, long tube 420 comprises particular medium, Absorption of Medium
In solution conduit 300, there is biochemical reaction, present reaction signal in the solution of release the most further.
In above two application, medium uses immune chromatography test paper, the biochemical reagent paper of dry type, dried
Certain biochemical reaction composition or the special one in bio-chemical solution.
It should be noted that above example only in order to technical scheme to be described and unrestricted, although ginseng
According to preferred embodiment, the present invention is described in detail, it will be understood by those within the art that, can
Technical scheme is modified or equivalent, without deviating from the essence of technical solution of the present invention
God and scope, it all should be contained in the middle of scope of the presently claimed invention.
Claims (15)
1. a Zhong Poguan mechanism (100), it is characterised in that: include rupture component (110) and holding components (120);
Described rupture component (110) include body (111) and be arranged on described body (111) one end reduce portion
(112);Described holding components (120) clamps the body (111) of described rupture component (110) from bottom to top,
And described holding components (120) to the portion that reduces (112) of described rupture component (110) in gradually drawing in
Shape;The lateral surface of described rupture component (110) or described holding components (120) includes at least two
Individual plane, and this lateral surface is mal-distribution relative to the center of holding components (120).
2. Po Guan mechanism (100) as claimed in claim 1, it is characterised in that: described holding components (120)
Bottom be provided with fitting connection structure (121), the bottom of described fitting connection structure (121) uses upwards
Hollow post holes (122) or downward protruding post;Described holding components (120) is fitting to connection knot with described
Structure (121) can be one-body molded;The hardness of described rupture component (110) material is not less than described holding components (120)
The hardness of material, the portion that reduces (112) of described rupture component (110) uses blade or pointed body.
3. the sealing comprised just like the Po Guan mechanism (100) according to any one of claim 1,2
Test tube assembly (200), described sealing test tube assembly (200) includes described Po Guan mechanism (100), solution
Pipe (300) and the sleeve pipe (400) chimeric with described solution conduit (300) sealing, it is characterised in that: described
Solution conduit (300) is fitted together in inserting described sleeve pipe (400) to be formed and seals the bottom space being fitted together to, described broken
Pipe mechanism (100) is positioned at solution conduit (300) bottom part down chimeric with described sleeve pipe (400) and is used for stinging
The bottom of broken described solution conduit (300);After described solution conduit (300) bottom is punctured, Po Guan mechanism (100)
The hole that ruptures, lateral surface and solution conduit (300) bottom at least form two interstitial channels, solution conduit (300)
Interior solution can flow out in described solution conduit (300), and the air in sleeve pipe (400) can enter institute
State in solution conduit (300);Described Po Guan mechanism (100) be fitted and fixed with in described sleeve pipe (400) or
One-body molded with described sleeve pipe (400).
4. sealing test tube assembly as claimed in claim 3, it is characterised in that: described solution conduit (300)
Outer wall and described sleeve pipe (400) inwall use the conical surface or the face of cylinder coordinates and the described conical surface or face of cylinder cooperation
At least one pair of back-off embedded structure (500) it is provided with at composition surface;Described back-off embedded structure (500) includes
The bulge loop (501) matched and groove (502);When described solution conduit (300) inserts described sleeve pipe (400)
After, described bulge loop (501) forms back-off with described groove (502) and mates, and causes described solution conduit (300)
It is difficult to extract in described sleeve pipe (400).
5. sealing test tube assembly as claimed in claim 3, it is characterised in that: described solution conduit (300)
Outer wall and described sleeve pipe (400) inwall use the conical surface or the face of cylinder coordinates and the described conical surface or face of cylinder cooperation
It is provided with at least one at composition surface and seals coupling circle (600);Described coupling circle (600) that seals at least includes
One bulge loop (601), matched another face of bulge loop (601) forms a certain amount of interference fit, from
And play sealing function;Described sealing is provided with exhauster on coupling circle (600) place or described sleeve pipe (400)
Structure (700);When described solution conduit (300) inserts described sleeve pipe (400), described exhaust structure (700)
By the air communication inside and outside described sleeve pipe (400), to maintain the suitable gas of described sleeve pipe (400) inner chamber
Pressure;Described exhaust gear (700) include being arranged in sealing coupling circle (600) of described the top with
Vertical groove (701) on the downside of the interference coupling circle of the tube side wall that bulge loop (601) mates, this vertical groove (701)
Two ends up and down and interference fit circle between have certain distance.
6. sealing test tube assembly as claimed in claim 3, it is characterised in that: described solution conduit (300)
Be internally provided with vertical partition wall (302), described partition wall (302) is by described solution conduit (300)
Inside is divided into two cavitys.
7. sealing test tube assembly as claimed in claim 3, it is characterised in that: described solution conduit (300)
Bottom set effigurate cut channel, it is simple to the portion that reduces (112) of Po Guan mechanism (100) punctures described
The bottom of solution conduit (300).
8. sealing test tube assembly as claimed in claim 3, it is characterised in that: described solution conduit (300)
The chimeric solution container (800) having another outward flange to be not more than solution conduit (300) bottom external diameter in bottom,
When thorn upwards pushes up in Po Guan mechanism (100), first puncture the upper lower wall of described solution container (800), then
Puncture the bottom of solution conduit (300), the solution of the most described solution container (800) and solution conduit (300)
Solution flow out and mix.
9. sealing test tube assembly as claimed in claim 3, it is characterised in that: described solution conduit (300)
Including body (303) and lid (301);After described lid (301) press-in solution conduit body (303),
Solution conduit body (303) inwall and lid (301) outer wall are formed to seal and combine;Described solution conduit body (303)
Inwall uses the conical surface or the face of cylinder to coordinate with lid (301) outer wall;The joint that the described conical surface or the face of cylinder coordinate
At least one pair of back-off embedded structure (500) it is provided with at face;Described back-off structure (500) includes matching
Bulge loop (501) and groove (502);After lid (301) inserts solution conduit body (303), described convex
Ring (501) forms back-off with described groove (502) and mates, and causes described lid (301) to be difficult to from solution
Pipe body is extracted in (303).
10. sealing test tube assembly as claimed in claim 9, it is characterised in that: described solution conduit body
(303) inwall uses the conical surface or the face of cylinder to coordinate with lid (301) outer wall;The described conical surface or the face of cylinder coordinate
Composition surface at be provided with at least one seal coupling circle (601);Described coupling circle (601) that seals at least is wrapped
Including a bulge loop (601), matched another face of bulge loop (601) forms a certain amount of interference fit,
Thus play sealing function.
11. sealing test tube assemblies as claimed in claim 3, it is characterised in that: described sleeve pipe (400)
Including connecting tube (410) and matched long tube (420), described connecting tube (410) and described long tube
(420) use the conical surface or the face of cylinder to coordinate, be provided with at the chimeric composition surface that the described conical surface or the face of cylinder coordinate
At least one pair of back-off embedded structure (500) or at least one sealing coupling circle (601);Described back-off is fitted together to
Structure (500) includes bulge loop (501) and the groove (502) matched, when described long tube (420) inserts
After described connecting tube (410), described bulge loop (501) forms back-off with described groove (502) and mates, and causes
Described long tube (420) is made to be difficult to extract in described connecting tube (410);The described coupling that seals encloses (601)
At least including a bulge loop (601), matched another face of bulge loop (601) forms a certain amount of interference
Coordinate, thus play sealing function;Exhaust gear (700) it is provided with on described long tube (420);When described
When solution conduit (300) inserts described connecting tube (410), described exhaust structure (700) is by described connecting tube
(410) air communication inside and outside, to maintain the suitable gas pressure of described connecting tube (410) inner chamber.
12. sealing test tube assemblies as claimed in claim 11, it is characterised in that: described exhaust gear
(700) include that a threaded endoporus (421) being arranged on described long tube (420) and one can be by
The screw (422) of this threaded interior hole (421) screwing hermetic;Described screw (422) comprises screw terminal and spiral shell
Filament cylinder, when the revolving force that this screw terminal is exceeded certain torsion torch screws, screw terminal ruptures with screw cylinder
Departing from, screw column delay is fixed in the threaded interior hole (421) sealed up.
13. sealing test tube assemblies as claimed in claim 11, it is characterised in that: described exhaust gear (700)
Endoporus (423) and one including the band sealing back-off structure being arranged on described long tube (420) can
This endoporus (423) is carried out the plastic closure (424) of back-off sealing;When plastic closure (424) is inserted
After endoporus (423), this endoporus (423) is sealed by back-off.
The application of 14. 1 kinds of sealing test tube assemblies as according to any one of claim 3-9, its feature exists
In: described sleeve pipe (400) comprises the medium absorbing described solution conduit (300) release solution, described molten
In liquid pipe (300), the solution of release can occur biochemical reaction on the medium further, presents reaction signal;
Described medium uses immune chromatography test paper, the biochemical reagent paper of dry type, certain biochemical reaction dried to become
Point or the special one in bio-chemical solution.
The application of the 15. sealing test tube assemblies as according to any one of claim 10-13, its feature exists
In: described long tube (420) also can comprise particular medium, solution conduit (300) described in described Absorption of Medium
, there is biochemical reaction the most further, present reaction signal in the solution of middle release;Described medium is adopted
With immune chromatography test paper, the biochemical reagent paper of dry type, dried certain biochemical reaction composition or spy
One in other bio-chemical solution.
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CN106434320A (en) * | 2016-11-15 | 2017-02-22 | 上海快灵生物科技有限公司 | Micro-solution reactor |
CN107102000A (en) * | 2017-05-31 | 2017-08-29 | 苏州点晶生物科技有限公司 | A kind of nucleic acid detection apparatus |
CN109061130A (en) * | 2018-08-06 | 2018-12-21 | 张岩锐 | A kind of device with urinalysis test strips |
CN109425573A (en) * | 2017-08-31 | 2019-03-05 | 北京金诺美生物技术有限公司 | A kind of solution detection device and detection method |
WO2020173445A1 (en) * | 2019-02-25 | 2020-09-03 | 上海快灵生物科技有限公司 | Biochemical reaction test tube and use method therefor, and gene amplification kit |
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