CN106037988A - Multifunctional liquid-spraying dosing combination device for part of laboratory animal - Google Patents
Multifunctional liquid-spraying dosing combination device for part of laboratory animal Download PDFInfo
- Publication number
- CN106037988A CN106037988A CN201610522058.1A CN201610522058A CN106037988A CN 106037988 A CN106037988 A CN 106037988A CN 201610522058 A CN201610522058 A CN 201610522058A CN 106037988 A CN106037988 A CN 106037988A
- Authority
- CN
- China
- Prior art keywords
- liquid
- plastic
- plastics
- ear
- metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000005507 spraying Methods 0.000 title claims abstract description 17
- 241001465754 Metazoa Species 0.000 title claims abstract description 14
- 238000010171 animal model Methods 0.000 title claims abstract description 13
- 229920003023 plastic Polymers 0.000 claims abstract description 114
- 239000004033 plastic Substances 0.000 claims abstract description 105
- 239000002184 metal Substances 0.000 claims abstract description 33
- 229910052751 metal Inorganic materials 0.000 claims abstract description 33
- 241000699666 Mus <mouse, genus> Species 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 241000699670 Mus sp. Species 0.000 claims abstract description 11
- 238000007789 sealing Methods 0.000 claims description 7
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
- 239000010931 gold Substances 0.000 claims description 3
- 229910052737 gold Inorganic materials 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 19
- 240000001307 Myosotis scorpioides Species 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 206010014025 Ear swelling Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 208000005298 acute pain Diseases 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
Abstract
The invention belongs to the technical field of scientific experimental apparatuses, and in particular to a multifunctional liquid-spraying dosing combination device for a part of a laboratory animal. The combination device comprises a liquid-moving device and a mouse fixing device. The combination device is characterized in that in the liquid-moving device, the head of a micro-quantitative liquid-moving plastic tube is provided with a metal nut interface, an independent isochoric double-hole plastic hose is connected with the metal nut interface through a metal sealed two-way valve, a plastic liquid-spraying head gasket is arranged in a double-blade ear-shaped plastic liquid-spraying head, the double-blade ear-shaped plastic liquid-spraying head is connected with the independent isochoric double-hole plastic hose, the double-blade ear-shaped plastic liquid-spraying head and the independent isochoric double-hole plastic hose are in accordance with the ear shape of a mouse, uniform liquid spraying can be realized, the assembling of the mouse fixing device is simple, the head of the mouse can be well fixed, a plurality of mice can be simultaneously fixed, an operator can understand the state of the mice in time through a transparent shell, and a metal deformable buckle is easy to operate and has a fixing effect. According to the combination device, the problem of inaccurate experimental data due to non-uniform medicine application to the mice can be effectively solved.
Description
Technical field
The invention belongs to scientific experiments technique with the apparatus field, be specifically related to a kind of multifunctional spraying for laboratory animal local
Liquid is administered combination unit.
Background technology
In basic pharmacology is tested, conventional classical pharmacological experiment mice ear experiment, it is frequently present of false positive
Or false negative result.
During doing ear swelling experiment, when experimenter causes scorching with dimethylbenzene to mouse ear, generally use does
Method is to dip dimethylbenzene liquid applicator in the ear both sides of mouse with medical cotton stick or self-control cotton swab.Although so operation is convenient,
But obtained experimental data is the most inaccurate.Problem is mainly manifested in the following aspects: one, the cause inflammation effect of dimethylbenzene is strong and weak
There is dose relationship with by dimethylbenzene amount, the dimethylbenzene dipped with cotton swab goes to smear mouse ear both sides it cannot be guaranteed that smear every time
Amount the same；Two, the process every time smeared is to complete to smear with hand-held firmly cotton swab, and caused by dimethylbenzene xylene inflammation can produce acute pain,
Making mouse be in agitation, acutely hide state, so can cause smearing position and not fix, dimethylbenzene applying amount is uneven；Three, when
After having smeared dimethylbenzene, lick random rubbing owing to the pain of inflammation generation can make mouse run helter-skelter disorderly, cause dimethylbenzene drug effect also not have
Play with regard to disappearance etc..These problems can make mouse ear swelling degree size uneven, and each ear mass difference is relatively big, for rear
Continuous data process, next step experiment direction produces wrong direction etc., and time-consumingly, consumption people, effort, waste resource.
Summary of the invention
The purpose of the present invention overcomes above-mentioned deficiency exactly, it is provided that a kind of simple in construction, micro quantitative determination are accurate, easy to operate
Multifunctional liquid-spraying for laboratory animal local is administered combination unit.
The technical solution adopted for the present invention to solve the technical problems is: a kind of multifunctional spraying for laboratory animal local
Liquid is administered combination unit, and including liquid-transfering device and mouse fixing, liquid-transfering device includes that micro quantitative determination moves liquid plastic tube 1, micro-
Measure the appearance diplopore plastic hoses 5 such as quantitative pipet plastics catch bar 2, metal sealing two-way valve 3, metal nuts interface 4, independence,
Bilobate ear plastics jet head 6 and the plastics hydrojet headrest 7, micro quantitative determination pipet plastics catch bar 2 can move liquid at micro quantitative determination
Moving in plastic tube 1, micro quantitative determination moves liquid plastic tube 1 head and is provided with metal nuts interface 4, and independence etc. holds diplopore plastic hose 5
Being connected with metal nuts interface 4 by metal sealing two-way valve 3, the plastics hydrojet headrest 7 is placed in bilobate ear plastics jet head 6
In, bilobate ear plastics jet head 6 is held diplopore plastic hose 5 with independence etc. and is connected；The fixing dress of often set in mouse fixing
Put and include plastic bottom board 8, independent transparent oval plastic tube 9, plastics door closure 10, plastics catch bar 11, plastic septum 12 is transparent
Plastic dam 13 and metal variable shape buckle 14, independent transparent oval plastic tube 9 is fixed on plastic bottom board 8, and it is near tail
Being provided with opening at portion, plastics door closure 10 is placed on this opening part, and transparent plastic baffle plate 13 is located at independent transparent oval plastic tube 9
Portion, plastics catch bar 11 inserts from independent transparent oval plastic tube 9 afterbody and can within it move back and forth, metal variable shape card
Button 14 is fixed on transparent plastic baffle plate 13, and every sleeve fixture mechanism separates with plastic septum 12 respectively.
The invention has the beneficial effects as follows, the present invention can solve the experimental data that causes because of uneven to mice coating not
Problem accurately, two separate liquid-transfering devices of independence and mouse fixing simple in construction, micro quantitative determination precisely, operation side
Just, many animals can be met and synchronize fixing and hydrojet administration.Liquid-transfering device seal is good, it is possible to allow medicine quantitative accurate and
Can be used for multiple times, bilobate ear plastics jet head and independent etc. is held diplopore plastic hose and is met mouse ear shape and can be real
Existing hydrojet is uniform；Mouse fixing assembles simple, it is possible to the head of the most fixing mice, transparent outer cover can allow operator and
Time to understand mice dynamic, metal variable shape buckle easily operates and has fixing effect.
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
Accompanying drawing explanation
Fig. 1 is the knot that a kind of multifunctional liquid-spraying for laboratory animal local of the present invention is administered the liquid-transfering device of combination unit
Structure schematic diagram；
Fig. 2 is the mouse fixing that a kind of multifunctional liquid-spraying for laboratory animal local of the present invention is administered combination unit
Structural representation；
Fig. 3 is the bilobate ear plastics that a kind of multifunctional liquid-spraying for laboratory animal local of the present invention is administered combination unit
The structural representation of jet head 6；
Fig. 4 is the mouse fixing that a kind of multifunctional liquid-spraying for laboratory animal local of the present invention is administered combination unit
In amplify at 13,14 after structural representation.
In figure:
1, micro quantitative determination moves liquid plastic tube, and 2, micro quantitative determination pipet plastics catch bar, 3, metal sealing two-way valve, 4, gold
Belong to nut interface, 5, the diplopore plastic hose that holds such as independent, 6, bilobate ear plastics jet head, 7, the plastics hydrojet headrest, 8, plastics
Base plate, 9, the most transparent independent oval plastic tube, 10, plastics door closure, 11, plastics catch bar, 12, plastic septum, 13, transparent plastic
Baffle plate, 14, metal variable shape buckle.
Detailed description of the invention
Seeing Fig. 1-Fig. 4, the present invention proposes: a kind of multifunctional liquid-spraying for laboratory animal local is administered combination dress
Putting, including liquid-transfering device and mouse fixing, liquid-transfering device includes that micro quantitative determination moves liquid plastic tube 1, micro quantitative determination pipet
Plastics catch bar 2, metal sealing two-way valve 3, metal nuts interface 4, independence etc. holds diplopore plastic hose 5, bilobate ear plastics
Jet head 6 and the plastics hydrojet headrest 7, micro quantitative determination pipet plastics catch bar 2 can move in micro quantitative determination moves liquid plastic tube 1
Dynamic, micro quantitative determination moves liquid plastic tube 1 head and is provided with metal nuts interface 4, and independence etc. is held diplopore plastic hose 5 and passed through metal sealing
Two-way valve 3 is connected with metal nuts interface 4, and the plastics hydrojet headrest 7 is placed in bilobate ear plastics jet head 6, and bilobate ear is moulded
Material jet head 6 is held diplopore plastic hose 5 with independence etc. and is connected；Every sleeve fixture mechanism in mouse fixing includes plastic bottom board
8, independent transparent oval plastic tube 9, plastics door closure 10, plastics catch bar 11, plastic septum 12, transparent plastic baffle plate 13 and gold
Belonging to deformable buckle 14, independent transparent oval plastic tube 9 is fixed on plastic bottom board 8, and it is provided with opening at afterbody, moulds
Bin gate lid 10 is placed on this opening part, and transparent plastic baffle plate 13 is located at independent transparent oval plastic tube 9 head, plastics catch bar 11
Inserting from independent transparent oval plastic tube 9 afterbody and can within it move back and forth, metal variable shape buckle 14 is fixed on transparent
In plastic dam 13, every sleeve fixture mechanism separates with plastic septum 12 respectively.
In the present embodiment, mouse fixing is as in figure 2 it is shown, be designed to the independent fixing device of ten sets and be fixed on side by side and mould
On material base plate 8, ten mices can be fixed simultaneously, and spray medicine to them.
Preparation: first assembled as shown in accompanying drawing by each device, then checks the air-tightness of liquid-transfering device part, with
And the stability of mouse fixing.
Work process:
Step 1, product of getting it filled, in micro quantitative determination moves liquid plastic tube 1, press lightly on micro quantitative determination pipet plastics catch bar
2, till treating that in the plastics hydrojet headrest 7, bilobate ear plastics jet head 6 both sides all produce hydrojet；
Step 2, closedown metal variable shape buckle 14, open plastics door closure 10, by mouse head towards metal variable shape card
Button 14 is put in independent transparent oval plastic tube 9, is then shut off plastics door closure 10, then pushes hard 11 mices of plastics catch bar
Promote the most forward, treat mouse head contacting metal deformable buckle 14 edge, stop promoting, open metal variable shape buckle
14, after mouse head stretches out metal variable shape buckle 14, close metal variable shape buckle 14；
Step 3, the bilobate ear hydrojet plastic cap 6 in liquid-transfering device is received mouse ear, the choosing of the hydrojet plastics headrest 7
Select according to depending on laboratory animal size, promote micro quantitative determination pipet plastics catch bar 2 according to required dose, complete quantitatively to spray
Liquid；
Step 4, when drug effect play after open metal variable shape buckle 14, mice is slowly released, then carries out follow-up reality
Test.
Claims (1)
1. the multifunctional liquid-spraying for laboratory animal local is administered a combination unit, including the fixing dress of liquid-transfering device and mice
Put, it is characterised in that liquid-transfering device include micro quantitative determination move liquid plastic tube (1), micro quantitative determination pipet plastics catch bar (2),
Metal sealing two-way valve (3), metal nuts interface (4), independence etc. holds diplopore plastic hose (5), bilobate ear plastics jet head
(6) and the plastics hydrojet headrest (7), micro quantitative determination pipet plastics catch bar (2) can shifting in micro quantitative determination moves liquid plastic tube (1)
Dynamic, micro quantitative determination moves liquid plastic tube (1) head and is provided with metal nuts interface (4), independent etc. holds diplopore plastic hose (5) by gold
Belonging to sealing two-way valve (3) to be connected with metal nuts interface (4), the plastics hydrojet headrest (7) are placed in bilobate ear plastics jet head (6)
In, bilobate ear plastics jet head (6) holds diplopore plastic hose (5) with independence etc. and is connected；Often set in mouse fixing is solid
Determine device and include plastic bottom board (8), independent transparent oval plastic tube (9), plastics door closure (10), plastics catch bar (11), mould
Material dividing plate (12), transparent plastic baffle plate (13) and metal variable shape buckle (14), independent transparent oval plastic tube (9) is fixed on
On plastic bottom board (8), it is provided with opening at afterbody, and plastics door closure (10) is placed on this opening part, transparent plastic baffle plate (13)
Being located at independent transparent oval plastic tube (9) head, plastics catch bar (11) is inserted from independent transparent oval plastic tube (9) afterbody
Entering and can within it move back and forth, metal variable shape buckle (14) is fixed on transparent plastic baffle plate (13), every sleeve fixture mechanism
Separate with plastic septum (12) respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610522058.1A CN106037988B (en) | 2016-07-05 | 2016-07-05 | A kind of multifunctional liquid-spraying administration combination unit local for experimental animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610522058.1A CN106037988B (en) | 2016-07-05 | 2016-07-05 | A kind of multifunctional liquid-spraying administration combination unit local for experimental animal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106037988A true CN106037988A (en) | 2016-10-26 |
| CN106037988B CN106037988B (en) | 2018-01-05 |
Family
ID=57200973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610522058.1A Active CN106037988B (en) | 2016-07-05 | 2016-07-05 | A kind of multifunctional liquid-spraying administration combination unit local for experimental animal |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106037988B (en) |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037399A (en) * | 1989-07-07 | 1991-08-06 | Reichert Elmer L | Apparatus for the administration of medications to animals |
| US20030083647A1 (en) * | 1999-12-27 | 2003-05-01 | Pamela Fereira | Osmotic beneficial agent delivery system |
| WO2004007004A1 (en) * | 2002-07-10 | 2004-01-22 | Henke-Sass Wolf Gmbh | Veterinary syringe |
| CN101455588A (en) * | 2008-12-10 | 2009-06-17 | 南京医科大学第一附属医院 | Animal smoking device for experiment |
| CN101637411A (en) * | 2009-08-12 | 2010-02-03 | 大连大学 | Tiny vein injection drug delivery system on body surface of experimental animal |
| CN201831975U (en) * | 2010-11-01 | 2011-05-18 | 东北农业大学 | Gavage apparatus for poultry |
| CN202005815U (en) * | 2011-02-22 | 2011-10-12 | 山东大学 | Heat-preservation fixing table for blood-taking and injecting of blood vessels at tail of big/small mouse for experiment |
| CN202477898U (en) * | 2012-04-09 | 2012-10-10 | 黑龙江农垦职业学院 | Animal gavage feeding device capable of monitoring liquid drug temperature in real time |
| CN203001166U (en) * | 2013-01-16 | 2013-06-19 | 朱宇 | Experimental mouse fixing device for caudal intravenous administration |
| CN203634330U (en) * | 2014-01-06 | 2014-06-11 | 黑龙江省兽医科学研究所 | Veterinary multifunctional injection medicine supply apparatus |
| CN204446177U (en) * | 2015-03-04 | 2015-07-08 | 中国长江三峡集团公司中华鲟研究所 | A kind of catheter type fish syringe |
| CN205031387U (en) * | 2015-09-16 | 2016-02-17 | 张超奇 | Mouse fixing device for experiments |
-
2016
- 2016-07-05 CN CN201610522058.1A patent/CN106037988B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037399A (en) * | 1989-07-07 | 1991-08-06 | Reichert Elmer L | Apparatus for the administration of medications to animals |
| US20030083647A1 (en) * | 1999-12-27 | 2003-05-01 | Pamela Fereira | Osmotic beneficial agent delivery system |
| WO2004007004A1 (en) * | 2002-07-10 | 2004-01-22 | Henke-Sass Wolf Gmbh | Veterinary syringe |
| CN101455588A (en) * | 2008-12-10 | 2009-06-17 | 南京医科大学第一附属医院 | Animal smoking device for experiment |
| CN101637411A (en) * | 2009-08-12 | 2010-02-03 | 大连大学 | Tiny vein injection drug delivery system on body surface of experimental animal |
| CN201831975U (en) * | 2010-11-01 | 2011-05-18 | 东北农业大学 | Gavage apparatus for poultry |
| CN202005815U (en) * | 2011-02-22 | 2011-10-12 | 山东大学 | Heat-preservation fixing table for blood-taking and injecting of blood vessels at tail of big/small mouse for experiment |
| CN202477898U (en) * | 2012-04-09 | 2012-10-10 | 黑龙江农垦职业学院 | Animal gavage feeding device capable of monitoring liquid drug temperature in real time |
| CN203001166U (en) * | 2013-01-16 | 2013-06-19 | 朱宇 | Experimental mouse fixing device for caudal intravenous administration |
| CN203634330U (en) * | 2014-01-06 | 2014-06-11 | 黑龙江省兽医科学研究所 | Veterinary multifunctional injection medicine supply apparatus |
| CN204446177U (en) * | 2015-03-04 | 2015-07-08 | 中国长江三峡集团公司中华鲟研究所 | A kind of catheter type fish syringe |
| CN205031387U (en) * | 2015-09-16 | 2016-02-17 | 张超奇 | Mouse fixing device for experiments |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106037988B (en) | 2018-01-05 |
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