CN1061262C - Eye drops for treating conjunctivitis and preparing process thereof - Google Patents
Eye drops for treating conjunctivitis and preparing process thereof Download PDFInfo
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- CN1061262C CN1061262C CN98116929A CN98116929A CN1061262C CN 1061262 C CN1061262 C CN 1061262C CN 98116929 A CN98116929 A CN 98116929A CN 98116929 A CN98116929 A CN 98116929A CN 1061262 C CN1061262 C CN 1061262C
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- conjunctivitis
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Abstract
The present invention relates to an eye drop for treating conjunctivitis, which is a Chinese medicinal preparation for treating the eye diseases of conjunctivitis, keratoconjunctivitis, blepharitis, hordeolum, etc. with the symptoms of red eyes, eye screen, swelling, pain, etc. The eye drop is prepared from eight traditional Chinese medicines of heartleaf houttuynia herb, honeysuckle flower, bear gall powder, cape jasmine fruit, isatis root, ephedra, pearl powder and borneol. The eye drop has the efficacy of clearing heat and toxic materials, dispersing swelling, alleviating pain, etc. Through clinical observation of over 8000 cases in six years, the total effective rate reaches 96.66%.
Description
The present invention relates to a kind of Chinese medicine preparation, particularly a kind ofly be used for the treatment of the conjunctival congestion cataracta, the Chinese medicine preparation eye drop of conjunctivitis such as swell and ache and preparation method thereof.
Conjunctivitis is commonly encountered diseases, the frequently-occurring disease of ophthalmology, and its sickness rate accounts for the first place of ophthalmology various diseases, if show effect repeatedly, do not heal for a long time, conjunctival tissue is wrecked, and forms conjunctival xerosis, causes lifelong misery.At present, the treatment of conjunctivitis still there is not specific short, generally based on topical antibiotics and antiviral medicament for the eyes.But because the most non-antibacterials of primary disease, due to virus is direct, thereby use often unsatisfactory curative effect of antibiotic and antiviral drugs merely, and this type of medicine of prolonged application also can cause the dysbacteriosis of conjunctiva, make antibacterial, virus is to antibiotic, antiviral agents deposits yields drug resistance, the side effect of medicine itself in addition, the also influential and destruction to normal structure, because antibacterial nucleoprotein is similar to mitochondrial nucleoprotein in the mammalian cell, so antibiotic and antiviral medicament for the eyes such as gentamycin, chloromycetin etc., in suppressing the synthetic process of bacterioprotein, the albumen that has also influenced human body cell line body is synthetic.Some antiviral drugs are suppressing the synthetic while of viral nucleic acid, also influenced the permeability of human body cell, thereby cytoclasis have also influenced the treatment of protopathy.
The object of the present invention is to provide a kind of effective Chinese medicine preparation eye drop of safe ready of killing and wounding with inhibitory action and host's conjunctiva, cornea tissue being had no side effect and preparation method thereof that antibacterial, virus are had.
Its prescription of Chinese medicine preparation eye drop provided by the invention is by Chinese medicine: Herba Houttuyniae, Flos Lonicerae, Fel Ursi powder, Fructus Gardeniae, Radix Isatidis, Herba Ephedrae, Margarita powder and Borneolum Syntheticum are made eye drop.The weight ratio of their each components is: Herba Houttuyniae 10-150g, Flos Lonicerae 5-80g, Fel Ursi powder 0.3-10g, Fructus Gardeniae 5-80g, Radix Isatidis 5-80g, Herba Ephedrae 1-50g, Margarita powder 0.1-20g, Borneolum Syntheticum 0.05-0.2g, more than eight flavor Chinese medicines adopt water alcohol methods to extract the Chinese medicine eye drop 1000ml of preparation, concentration 2.6~47%.Preparation technology of the present invention sees accompanying drawing 1, more than eight the flavor Chinese medicines except that Fel Ursi powder, Borneolum Syntheticum powder be broken into fine powder standby, Six-elements such as all the other Herba Houttuyniae decoct with water 3 times by the pharmacopeia rules, each each 40 minutes, collecting decoction filters, and filtrate is concentrated into syrupy shape, is 1.20~1.25 thick paste 80-90 ℃ of following relative density, add 95% ethanol, make to contain alcohol amount and reach 60%, stir evenly static 24 hours, filter filtrate recycling ethanol.The reuse Ethanol Treatment is 2 times as stated above, makes to contain alcohol amount and reach 70%, 80% respectively, reclaims ethanol and does not end to there being the alcohol flavor; Above-mentioned medicinal liquid is added aquae destillata to 800ml, and cold preservation was filtered in 24 hours.Above-mentioned standby medicated powder is added in the filtrate, fully stir and make its dissolving.Other gets sodium chloride 8g, sorbic acid 1.5g, add low amounts of water and make its dissolving, add in the medicinal liquid, stir evenly, adding the 1ml tween 80 again stirs well even, regulating pH value with NaOH is 7-8, places 24 hours, filters, on filter, add aquae destillata to 1000ml, shake up sealing, with 100 ℃ of flowing steam sterilizations 30 minutes, promptly aseptic subpackaged.
Conjunctivitis belongs to the traditional Chinese medical science " subconjunctival capillaries arteries and veins " and reaches " acute and chronic conjunctivitis ", and pyretic toxicity pents up in order, and the order warp of burning sees that then conjunctival congestion, photophobia, eyelid fester.It is treated based on heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Herba Houttuyniae, Flos Lonicerae are principal agent with the heat-clearing and toxic substances removing in the prescription, being aided with Fel Ursi, Fructus Gardeniae, Radix Isatidis helps principal agent with heat-clearing and toxic substances removing altogether, but wherein Flos Lonicerae, Fel Ursi, Fructus Gardeniae again removing heat from blood with the conjunctival congestion of dispelling, the assistant with Herba Ephedrae with its warm nature in case major-minor medicine bitter cold too, Margarita, the pain relieving of Borneolum Syntheticum clearing heat for detumescence.So eye drop of the present invention has the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain to conjunctivitis.
After the present invention succeeded in developing, through the audit of Harbin City health bureau, the institute for drug control, Harbin City was detected, and by the pharmaceutical factory trial-production of Heilongjiang Province university of TCM, was applied to clinical trial.
The Chinese medicine preparation eye drop splashes into interior 1 1-2 of eyelid and drips during use, and 4-6 time on the one, acute stage per hour 1 time.
The present invention through over 6 years to routine persons suffering from ocular disorders clinical observation surplus 8000, confirm that it has following advantage and good effect:
1, instant effect, cure rate height, stable curative effect, applied range.Promptly took effect in about 20 minutes after the general medication, congested and eye sense of discomfort alleviates, through observing contrast, total effective rate 96.66%, obvious effective rate reaches 75.24%, except that acute and chronic and painful conjunctivitis are had the tangible curative effect, conjunctival congestion cataracta, keratoconjunctivitis, blepharitis, hordeolum, trachoma etc. such as swell and ache is also had curative effect preferably, use the patient that the present invention cures, not finding has rebound phenomenon after the drug withdrawal.
2, nonirritant, have no drug resistance and have no side effect.Eye drop splashes into ophthalmic corneal, conjunctiva nonirritant, does not have uncomfortable sensation, and the prolonged and repeated application of patient finds no toxic and side effects and drug resistance.
3, have chemical sproof conjunctivitis patient to using antibiotic, the antiviral collyrium sold on the market, still effective behind the Chinese medicine eye drop of application of treatment conjunctivitis.
Embodiment:
Preparation technology of the present invention:
Get Herba Houttuyniae 80g, Flos Lonicerae 40g, Fel Ursi powder 8g, Fructus Gardeniae 24g, Radix Isatidis 24g, Herba Ephedrae 10g, Margarita powder 8g, Borneolum Syntheticum 0.1g eight flavor Chinese medicines, make 1000ml by as above technological process and live and treat the Chinese medicine eye drop of conjunctivitis.
Claims (2)
1, a kind of Chinese medicine eye drop for the treatment of conjunctivitis is characterized in that it is to be made by the raw material of following consumption:
Herba Houttuyniae 10~150g Flos Lonicerae 5~80g
Fel Ursi powder 0.3~10g Fructus Gardeniae 5~80g
Radix Isatidis 5~80g Herba Ephedrae 1~50g
Margarita powder 0.1~20g Borneolum Syntheticum 0.05~0.2g
2, the Chinese medicine eye drop of treatment conjunctivitis according to claim 1 is characterized in that its preparation method is:
A, with Herba Houttuyniae, Flos Lonicerae, Fructus Gardeniae, Radix Isatidis, Herba Ephedrae, Margarita powder decocting 3 times each 40 minutes, collecting decoction filtering and concentrating one-tenth is 1.2~1.25 thick paste 80~90 ℃ of following relative densities, the ethanol that adds 95% concentration, make to contain alcohol amount and reach 60%, 70% and 80% successively, leave standstill fully and reclaim ethanol after 24 hours and do not end to there being the alcohol flavor;
B, in above-mentioned medicinal liquid A, add distilled water to 800ml, cold preservation was filtered the back in 24 hours and is added Fel Ursi, Borneolum Syntheticum fine powder, fully dissolving back adding sodium chloride 8g, sorbic acid 1.5g stir evenly and add 1ml soil temperature-80 again, and regulating pH value with NaOH is 7-8, filter in static 24 hours;
C, above-mentioned medical liquid B is added distilled water to 1000ml, shake up sealing, aseptic subpackaged after 30 minutes with 100 ℃ of flowing steam sterilizations.
Priority Applications (1)
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CN98116929A CN1061262C (en) | 1998-08-19 | 1998-08-19 | Eye drops for treating conjunctivitis and preparing process thereof |
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CN98116929A CN1061262C (en) | 1998-08-19 | 1998-08-19 | Eye drops for treating conjunctivitis and preparing process thereof |
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CN1207322A CN1207322A (en) | 1999-02-10 |
CN1061262C true CN1061262C (en) | 2001-01-31 |
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Cited By (24)
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CN1311842C (en) * | 2005-08-18 | 2007-04-25 | 北京市眼科研究所 | Medicine for treating chronic conjunctivitis |
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US8240140B2 (en) | 2008-04-09 | 2012-08-14 | Sustainx, Inc. | High-efficiency energy-conversion based on fluid expansion and compression |
US8240146B1 (en) | 2008-06-09 | 2012-08-14 | Sustainx, Inc. | System and method for rapid isothermal gas expansion and compression for energy storage |
US8250863B2 (en) | 2008-04-09 | 2012-08-28 | Sustainx, Inc. | Heat exchange with compressed gas in energy-storage systems |
US8448433B2 (en) | 2008-04-09 | 2013-05-28 | Sustainx, Inc. | Systems and methods for energy storage and recovery using gas expansion and compression |
US8474255B2 (en) | 2008-04-09 | 2013-07-02 | Sustainx, Inc. | Forming liquid sprays in compressed-gas energy storage systems for effective heat exchange |
US8479505B2 (en) | 2008-04-09 | 2013-07-09 | Sustainx, Inc. | Systems and methods for reducing dead volume in compressed-gas energy storage systems |
US8495872B2 (en) | 2010-08-20 | 2013-07-30 | Sustainx, Inc. | Energy storage and recovery utilizing low-pressure thermal conditioning for heat exchange with high-pressure gas |
US8539763B2 (en) | 2011-05-17 | 2013-09-24 | Sustainx, Inc. | Systems and methods for efficient two-phase heat transfer in compressed-air energy storage systems |
US8578708B2 (en) | 2010-11-30 | 2013-11-12 | Sustainx, Inc. | Fluid-flow control in energy storage and recovery systems |
US8667792B2 (en) | 2011-10-14 | 2014-03-11 | Sustainx, Inc. | Dead-volume management in compressed-gas energy storage and recovery systems |
US8677744B2 (en) | 2008-04-09 | 2014-03-25 | SustaioX, Inc. | Fluid circulation in energy storage and recovery systems |
US8733095B2 (en) | 2008-04-09 | 2014-05-27 | Sustainx, Inc. | Systems and methods for efficient pumping of high-pressure fluids for energy |
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CN1296067C (en) * | 2004-01-13 | 2007-01-24 | 吴占亨 | Drink for protecting eye |
CN101987166B (en) * | 2010-08-27 | 2012-07-25 | 葛德钜 | Medicament for treating stye and preparation method thereof |
CN102895330B (en) * | 2012-09-07 | 2016-10-05 | 富阳宏成科技咨询有限公司 | A kind of eye drip medicine treating conjunctivitis |
CN104667000A (en) * | 2015-03-10 | 2015-06-03 | 王延飒 | Traditional Chinese medicine preparation for treating hordeolum |
CN105055943A (en) * | 2015-07-30 | 2015-11-18 | 青岛海之星生物科技有限公司 | Eye ointment for treating hordeolum and preparation method thereof |
CN108653429B (en) * | 2018-07-19 | 2020-11-20 | 上海市第七人民医院 | Traditional Chinese medicine composition for treating hordeolum disease and application thereof |
CN114869947A (en) * | 2022-04-29 | 2022-08-09 | 四川一只老鹰集团股份有限公司 | Eye drop for treating conjunctivitis caused by bacteria and preparation method thereof |
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CN1126076A (en) * | 1995-03-11 | 1996-07-10 | 苏州市水产研究所 | Pearl liquid for improving eyesight |
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CN1126076A (en) * | 1995-03-11 | 1996-07-10 | 苏州市水产研究所 | Pearl liquid for improving eyesight |
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US8240140B2 (en) | 2008-04-09 | 2012-08-14 | Sustainx, Inc. | High-efficiency energy-conversion based on fluid expansion and compression |
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