CN1067279A - The method for making of medical non-woven cloth with organism function and goods thereof - Google Patents
The method for making of medical non-woven cloth with organism function and goods thereof Download PDFInfo
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- CN1067279A CN1067279A CN 92105611 CN92105611A CN1067279A CN 1067279 A CN1067279 A CN 1067279A CN 92105611 CN92105611 CN 92105611 CN 92105611 A CN92105611 A CN 92105611A CN 1067279 A CN1067279 A CN 1067279A
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- chitin
- alginate
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Abstract
The invention provides a kind of manufacture method and goods thereof of medical adhesive-bonded fabric of Biofunctional fiber.It is characterized in that adopting the chitin fiber and the alginate fiber of gained after improving technology is material composition, is processed into medical adhesive-bonded fabric through wet processing.The inventive method technology is easy, yield rate is high, processing cost is low.These goods have hemostasis, ease pain, protect from infection, promote the effect of healing.Because its good biocompatibility and living body absorbability make epidermal cell be convenient to grow into, scar is left over few.And it is good to have suction and oxygen permeability, and dissolubility resistent is strong, more the NA advantage in back.
Description
The present invention relates to wound and use the dressing field, particularly method for making of medical non-woven cloth with organism function and products thereof.
Chitin is the product that makes from natural materials, has good affinity to giving birth to body, is suitable for use as the protective material of skin trauma.Qingdao Marine University succeeded in developing chitnous membrane in 1988, once obtained the international invention award of eureka, was known as " artificial skin ".This school is dissolved in chitan and is mixed with solution in the spirit of vinegar with the The tape casting film forming.This film is crisp and stiff, and having a good sweat property is poor, and wet strength is very low, can not be used for needing sutured
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Qingdao Marine University succeeded in developing the freeze-dried body of chitin again in 1991, be called " styptic sponge ".Its method for making is that chitin is dissolved in dimethylacetylamide-lithium chloride solution, freeze-dried then one-tenth frozen bean curd shape.The plastic property and the heat and moisture preserving of the freeze-dried body of this chitin are relatively poor.
Japanese Patent Application Laid-Open clear 170254 discloses the method for system chitin nonwoven fabric, this method is dissolved in chitan makes spinning solution in the spirit of vinegar, with alkaline aqueous solution as coagulating agent spin chitosan fibers, with this fiber to contain the acetic anhydride dipping of methyl alcohol etc., is bonding composition with this silk with the vinal short fiber, utilizes the machine hand to plant again and makes wet nonwoven fabrics; Chitan or chitin fiber that the clear 62-97557 of Japanese Patent Application Laid-Open will handle are made into cloth, and the former improves the resistance to water of chitin cloth through post processing, but the two yield rate is low, the processing cost height.
The object of the invention is: a kind of medical adhesive-bonded fabric method for making and goods thereof are provided, and the good permeability of said nonwoven fabric, plastic property is good, and heat and moisture preserving is strong, and living body adaptability energy excellence has concurrently and urgees more, anastalsis; Preparation process is easy, reasonable, and cost is low.
The present invention seeks to reach like this: with the Crustaceans shell is raw material, pulverize back decalcification in hydrochloric acid solution, deproteinization in sodium hydroxide solution, this chitin is dissolved in to make in the dimethylacetamide solution that contains lithium chloride contains chitinous spinning solution, through deaeration, extrude the back in moisture 20~50(weight) solidified forming in the dimethylacetamide solution solidifying body of % etc., after tow is derived with 10 meters/minute speed, 1.4 times of drawing-offs, through fully getting chitin fiber after the washing, with fiber number be 1~4 but the alginate fiber and after chitin fiber is cut into 3~10 millimeters respectively, than the ratio that is 85/15~15/85 mixing that in water, suspends, compressed again dewater vacuumize with chitin fiber and alginate fibre weight, obtain nonwoven fabric, thereby the object of the invention has just reached fully.
The present invention is described in detail below in conjunction with embodiment.
Chitin is a kind of boiomacromolecule that is made of the n acetylglucosamine n or derivatives thereof.It is the contained active ingredients of shell such as Crustaceans such as shrimp, crab, silkworm chrysalis, and this n acetylglucosamine n or derivatives thereof is also quite abundant in human body, thereby has excellent promotion healing effect; Alginate is the boiomacromolecule salt that is made of mannuronic acid salt and gulose aldehyde acid salt, be rich in calcium activated composition as main clotting factor, therefore is rich in anastalsis, simultaneously, because its extremely strong hydrophily can play the effect of the bonding composition of nonwoven fabric, as the fiber with these two kinds of compositions make nonwoven fabric then this cloth have the healing of promotion and anastalsis simultaneously.Nonwoven fabric of the present invention is made with these two kinds of fibers.
In the methods of the invention, below crust raw material pulverizing to 50 order of prior art elder generation with Crustaceans, below best 100 orders, decalcification in hydrochloric acid, deproteinization in sodium hydroxide solution then, then it is dissolved in the dicyandiamide solution of dimethylacetylamide-lithium chloride, the chitinous concentration in dissolving back is 1.5~7.5(weight) %.Air pressure with 4.5 crust after the deaeration is extruded into gear wheel metering pump, after the spray orifice of 0.06 mm dia is extruded, in moisture 20~50(weight) %, be preferably 25~35(weight) solidified forming in the dimethylacetamide solution coagulation system of %, after tow is derived with 10 meters/minute speed, 1.4 times of drawing-offs obtain chitin fiber through fully washing.
Make coagulation system with dimethylacetylamide-water and do more economical rationality of coagulation system than butanols, acetone class, it is convenient to reclaim, and is suitable for suitability for industrialized production.Mixed proportion by dimethylacetylamide-water can also be regulated setting rate, make process of setting comparatively relax (moisture many more, it is fierce more then to solidify), formed fibre section is rounding comparatively, and alleviated skin-cored structure, the gained fibre strength also increases.When the part by weight of dimethylacetylamide and water>80/20, solidify difficulty, when the moisture 50(weight of solidifying solution that surpasses) during %, it is too fierce then to solidify, and fiber quality is not good.
With fiber number is after the alginate fiber at 1~4 dawn and said chitin fiber are cut into 3~10 millimeters respectively, with chitin fiber to the alginate fibre weight than the ratio that is 85/15~15/85 mixing that in water, suspends, pass through 80 purpose copper mesh then from the bottom draining, the compression of gained deposit is dewatered, and, obtain the Biofunctional medical adhesive-bonded fabric 100 ℃ of following vacuumizes.After the γShe Xianmiejun sterilization, be used as medical dressing.
The present invention adopts fiber number 1~4d, and length is the chitin and the alginate of 3~10 millimeters staple fibre, and what mainly consider is to make made nonwoven fabric have proper physical performance and serviceability, for example the flexibility of nonwoven fabric, tearing strength and gas permeability etc.; Using length is that 3~10 millimeters staple fibre can make it be uniformly dispersed in suspension, and as improving the tearing strength that length can improve nonwoven fabric, but in process, easy entanglement is agglomerating during than the long fiber suspended dispersed.Adopt the weight ratio of chitin and alginate to select 85/15~15/85 for use, purpose is to make the alginate fiber play adhesive effect.When skin zone's position use is got in dermatoplasty, require nonwoven fabric to have the effect of stronger promotion epidermal growth, should select the higher ratio of chitin content for use, hold concurrently to be with in the strong anastalsis of needs and urge more to do the time spent, should select the higher ratio of alginate content for use.
As follows with the made nonwoven fabric of above method for making: it is material composition that this nonwoven fabric adopts the short fiber of chitin fiber and alginate fiber, make through wet method, chitin fiber is 85/15~15/85 with alginate fibre weight ratio, fibre number was 1~4 dawn, fibre length is 3~10 millimeters, and intensity is 1.5~3.5g/d.
Can obtain molecular weight height and narrow molecular weight distribution with the inventive method, the chitin of dissolubility and good spinnability, thus make the dissolubility resistent of nonwoven fabric strong, be difficult for behind the wound healing sticking together.The present invention adopts dimethylacetylamide-aqueous solution coagulation system, can prevent that big molecule is degraded in the stoste, guarantees the stable of production technology, improves the combination property of fiber, and reduces cost.
Medical adhesive-bonded fabric of the present invention combines the anastalsis of chitinous promotion healing effect and alginate, and therefore, nonwoven fabric of the present invention has hemostasis, eases pain, protects from infection, promotes the effect of Wound healing.Because its good biocompatibility and living body absorbability make epidermal cell be convenient to grow into, scar is left over few, and has suction and good permeability, and dissolubility resistent can be strong, and NA advantage heals.
Embodiment 1:
The crab shell is washed, crushed after being dried to 50 order, 10 ℃ of following decalcifications are 60 minutes in 11% hydrochloric acid solution, washing back deproteinization 4 hours under 95 ℃ of conditions in 5.5% sodium hydroxide solution, wash in neutrality and intensive drying and get pure chitin, productive rate 16%, this chitin is dissolved in is mixed with the spinning solution that contains chitin 7% in the dimethylacetamide solution that contains 8.5% lithium chloride, air pressure with 4.5bar after the deaeration is pressed out to gear pump metering and conveying, after the spray orifice of 0.06 mm dia is extruded in dimethylacetylamide-water-setting solid solution of moisture 45% solidified forming, tow is derived 1.7 times of first break draft with 10 meters/minute speed, through fully wash filament number 2.5d, the chitin fiber of intensity 1.5g/d.With water-soluble 5% spinning solution that is made into of Sodium Alginate, with with aforementioned same method extrude the back contain solidifying of 1.5% calcium chloride molten in solidified forming, tow is derived 2.2 times of first break draft with 10 meters/minute speed, through fully wash filament number 1.5d, the alginate fiber of intensity 2.9g/d.Two kinds of fibers are cut into 8 millimeters long,, pass through 80 purpose copper mesh then from the bottom draining with ratio suspension mixing in big water gaging of chitin/alginate=50/50.Gained deposit compression is dewatered and obtain nonwoven fabric in 4 minutes 100 ℃ of following vacuumizes, 3 dawn of fibre number of nonwoven fabric, 8 millimeters of fibre lengths, intensity 2.8g/d.
Embodiment 2:
With crab shell washing, crushed after being dried to 100 order, 0 ℃ of following decalcification is 30 minutes in 7.4% hydrochloric acid solution, and washing back deproteinization 3 hours under 85 ℃ of conditions in 4% sodium hydroxide solution is washed to neutral and intensive drying gets pure chitin, productive rate 15%.This chitin is dissolved in is mixed with the spinning solution that contains chitin 3.5% in the dimethylacetamide solution that contains 7% lithium chloride, air pressure with 4.5bar after the deaeration is pressed out to gear pump metering and conveying, after the spray orifice of 0.08 mm dia is extruded in dimethylacetylamide-water-setting solid solution of moisture 35% solidified forming, the silk sour jujube is derived 1.4 times of first break draft with 10 meters/minute speed, through fully wash filament number 1.5d, the chitin fiber of intensity 2.8g/d.After will being cut into 8 millimeters than the alginate fiber among chitin fiber and the embodiment 1, suspending in big water gaging with the ratio of chitin/algae depickling salt=40/60 and to mix, and make nonwoven fabric with method similarly to Example 1.2.9 dawn of fibre number of nonwoven fabric, 8 millimeters of fibre lengths, intensity 3g/d.
Embodiment 3:
With crab shell washing, crushed after being dried to 200 order ,-10 ℃ of following decalcifications are 15 minutes in 4% hydrochloric acid solution, and washing back deproteinization 2 hours under 75 ℃ of conditions in 2.5% sodium hydroxide solution is washed to neutral and intensive drying gets pure chitin, productive rate 13%.This chitin is dissolved in is mixed with the spinning solution that contains chitin 2% in the dimethylacetamide solution that contains 4% lithium chloride, air pressure with 4.5bar after the deaeration is pressed out to gear pump metering and conveying, after the spray orifice of 0.12 mm dia is extruded in dimethylacetylamide-water-setting solid solution of moisture 25% solidified forming, tow is derived 1.2 times of first break draft with 6 meters/minute speed, through fully wash filament number 2d, the chitin fiber of intensity 3.1g/d.To be cut into after 8 millimeters ratio with chitin/alginate=15/85 than chitin fiber and alginate fiber among the embodiment 1 and in big water gaging, suspend and mix, and make nonwoven fabric with method similarly to Example 1.
Embodiment 4:
Gained fiber among the embodiment 2 is cut into behind 60 millimeters short fibers mixed with chitin/alginate=85/15, be placed in the aqueous solution that contains 1% Sodium Alginate through combing-lapping-acupuncture, pass through 80 purpose copper mesh then from the bottom draining, obtained nonwoven fabric in 4 minutes 100 ℃ of following vacuumizes after compression dewaters.
Embodiment 5:
Sample after combing-lapping-acupuncture among the embodiment 4 is placed the water slurry that contains 2% alginate fiber (3 millimeters long), use with the quadrat method draining, dewater, obtain nonwoven fabric after the drying.
Claims (3)
1, the method for making of medical non-woven cloth with organism function, with the Crustaceans shell is raw material, pulverize back decalcification in hydrochloric acid solution, deproteinization in sodium hydroxide solution, this chitin is dissolved in to make in the diformazan left side acetamide solution that contains lithium chloride contains chitinous spinning solution, obtain chitin fiber through solidified forming, it is characterized in that: after said spinning solution deaeration, air pressure with 4.5 crust is pressed out to the gear pump metering, after the spray orifice of 0.06 mm dia is extruded in the dimethylacetamide solution coagulation system of moisture 20-50 (weight) % solidified forming, after tow is derived with 10 meters/minute speed, 1.4 times of drawing-offs, through fully wash chitin fiber, with fiber number is after the alginate fiber at 1~4 dawn and chitin fiber are cut into 3~10 millimeters respectively, with chitin fiber to the alginate fibre weight than the ratio that is 85/15~15/85 mixing that in water, suspends, then by 80 purpose copper mesh from the bottom draining, gained deposit compression dewatered and obtain nonwoven fabric 100 ℃ of following vacuumizes.
2, according to the method for making of the described nonwoven fabric of claim 1, it is characterized in that: the moisture 25~35(of being weight in said dimethylacetylamide-aqueous solution coagulation system) %.
3, according to the resulting medical adhesive-bonded fabric of the method for claim 1, it is characterized in that: it is material composition that said nonwoven fabric adopts the short fiber of chitin fiber and alginate fiber, make through wet method, chitin fiber is 85/15~15/85 to the alginate fiber weight ratio, fibre number was 1~4 dawn, fibre length is 3~10 millimeters, and intensity is 1.5~3.5g/d.
Priority Applications (1)
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CN 92105611 CN1027599C (en) | 1992-07-14 | 1992-07-14 | Process for producing medical non-woven cloth with organism function and products thereof |
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CN 92105611 CN1027599C (en) | 1992-07-14 | 1992-07-14 | Process for producing medical non-woven cloth with organism function and products thereof |
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CN1067279A true CN1067279A (en) | 1992-12-23 |
CN1027599C CN1027599C (en) | 1995-02-08 |
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CN 92105611 Expired - Fee Related CN1027599C (en) | 1992-07-14 | 1992-07-14 | Process for producing medical non-woven cloth with organism function and products thereof |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100500413C (en) * | 2003-07-11 | 2009-06-17 | 株式会社神户制钢所 | Metering feeder, kneading and extruding equipment |
US7951237B2 (en) | 2000-02-21 | 2011-05-31 | Smartfiber Ag | Polymer composition and molded articles produced therefrom |
CN110241481A (en) * | 2019-05-28 | 2019-09-17 | 福建美可纸业有限公司 | A kind of superabsorbent water composite fibre and preparation method thereof |
-
1992
- 1992-07-14 CN CN 92105611 patent/CN1027599C/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7951237B2 (en) | 2000-02-21 | 2011-05-31 | Smartfiber Ag | Polymer composition and molded articles produced therefrom |
US8496748B2 (en) | 2000-02-21 | 2013-07-30 | Smartfiber Ag | Polymer composition and molded articles produced therefrom |
CN100500413C (en) * | 2003-07-11 | 2009-06-17 | 株式会社神户制钢所 | Metering feeder, kneading and extruding equipment |
CN110241481A (en) * | 2019-05-28 | 2019-09-17 | 福建美可纸业有限公司 | A kind of superabsorbent water composite fibre and preparation method thereof |
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CN1027599C (en) | 1995-02-08 |
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