CN1096694A

CN1096694A - Tooth-strengthening chewing-gum and preparation method thereof

Info

Publication number: CN1096694A
Application number: CN 93111461
Authority: CN
Inventors: 赵绪元; 黄波; 许树梧; 陈孝治
Original assignee: Medical Technology Development Co Of No2 Hospital Attached To Hunan Medical Un
Current assignee: Medical Technology Development Co Of No2 Hospital Attached To Hunan Medical Un
Priority date: 1993-06-23
Filing date: 1993-06-23
Publication date: 1994-12-28

Abstract

Tooth-strengthening chewing-gum is to select that oral cavity anaerobium is had remarkable inhibiting Western medicine metronidazole or chlorhexidine salt and Chinese medicine Radix Zanthoxyli or Radix Zanthoxyli is active ingredient for use, adds the adjuvant of being made up of sugar, edible glue nurse etc. in right amount simultaneously, adopts certain method to be made.Clinic trial proof this product is obvious to alleviating oral inflammation, cleaning oral cavity, reduction dental plaque effect, especially residual root of teeth, missing tooth person, halitosis patient are acted on significantly, simultaneously dental caries also there is certain preventive and therapeutic effect, clinical prevention and the treatment that mainly is applicable to the oral disease (gingivitis, periodontitis, halitosis) of each stratum is a kind of popular novel healthy food at age.

Description

Tooth-strengthening chewing-gum and preparation method thereof

The invention provides a kind of tooth-strengthening chewing-gum and preparation method thereof.

Along with human living standard's raising, the softening of eating patterns, refine, acidification, people's masticatory function weakens day by day, jawbone, tooth

System degenerates day by day.And in this degenerative process, last mandibular bone, tooth are not that balanced synchronization is carried out, thereby produced the common dentognathic system of modern and carried out syndrome-malocclusion, gingivitis, periodontal disease, dental caries etc., become one of the highest disease of modern's sickness rate, especially with old man, children for very.For this class disease, still there is not ideal Drug therapy at present.At present the main method of tooth protection mostly is that the mechanicalness oral cavity is cleaned-brushed teeth, scaling, scrapes and control, transfer

Deng, these methods have tangible limitation, as brush teeth and hold time short and property at any time not, scaling, scrape method such as control at present can't be as a kind of general tooth protection method of socialization; Medicine tooth protection aspect, there once had periodontal health tablet, the peaceful solution of periodontal to be used for to be clinical, and the former is difficult to reach medicine concentration in the part, because of being the whole body administration, easily have side effects; The latter uses inconvenience.

The object of the invention is intended to tooth-strengthening chewing-gum that provides a kind of taking convenience at falling ill periodontal widely, popularizes easily and preparation method thereof, make people when chewing chewing gum, strengthen oral hygiene, the growth of dental plaque in the control oral cavity, particularly suppress anaerobe in intraoral breeding, thereby reach the purpose of cleaning oral cavity, alleviation oral inflammation and tooth protection, strong tooth.

Choosing side of the present invention medication takes into account 3 points: (1) is mainly anaerobic infection because of the infection in the oral cavity, thus selected that anaerobe is had unique inhibiting medicine, as metronidazole, chlorhexidine salt etc.; (2) the oral cavity dental caries is mainly due to the Streptococcus mutans, thus selected to have the Chinese medicine of unique anticaries action, as Radix Zanthoxyli, Cortex Magnoliae Officinalis, Flos Lonicerae etc.; (3) subjective symptoms behind the patient infection is exactly an inflammation pain, so selected the Chinese medicine of extensive use such as Radix Zanthoxyli etc., is used for analgesia.

Technical solution of the present invention is, with medicine for its active ingredient and be equipped with appropriate amount of auxiliary materials and be made, characteristic distributions according to anaerobe in the oral cavity, selected have remarkable inhibiting medicine to anaerobe, can be Western medicine such as metronidazole, chlorhexidine salt, also Chinese medicine such as Radix Zanthoxyli, people ground Taurus etc. are effective ingredient, are equipped with appropriate amount of auxiliary materials again, are made by certain method.According to the antibacterial onset concentration of medicine to anaerobe, simulation oral cavity drug release rate design drug dose, and by testing definite ratio range of the present invention repeatedly, in this ratio range, can guarantee saliva Chinese medicine concentration effectively (in Western medicine, greater than 2ug/ml), the side effect that can avoid the whole body administration to bring again (serve on 20 of this product, can not detect the existence of medicine in the blood), its ratio range is:

1～5 part of metronidazole or chlorhexidine salt (weight, down together)

1500～5000 parts of Radix Zanthoxyli or Radix Zanthoxyli

2500～4500 parts of adjuvants

Adjuvant of the present invention mainly plays a part to regulate product color and viscosity, and it basic composition is (weight %):

Sugar 68～78%

Edible glue nurse 22～32%

Flavorant 0～0.5%

Sugar can adopt sucrose or glucose, and the viewport sense needs to add an amount of glycerol and makes lubricant.

Manufacture method of the present invention is:

1, at first prepares the dense pure liquid (saturable) of Western medicine (metronidazole or chlorhexidine salt);

2, extract Chinese medicine (Radix Zanthoxyli or Radix Zanthoxyli) repeatedly to closely colourless with pure method, reclaim ethanol to rare extractum shape;

3, under heat-retaining condition, with the dense ethanol liquid of above-mentioned Western medicine, liquid glucose is a small amount of and the Chinese medicine extract stone roller closes;

4, adjuvant such as Icing Sugar, glue nurse and said mixture are ground even, extrusion molding, cooling, packing is product of the present invention.

Chinese medicine of the present invention except that Radix Zanthoxyli, Radix Zanthoxyli, also can adopt Cortex Magnoliae Officinalis, Flos Lonicerae etc.

The invention has the advantages that:

1, taking convenience.The popular food chewing gum of liking with people on the mouthfeel is as good as, and sweet fragrance is refrigerant tasty and refreshing, anti-chewing, and glad is popular acceptance.

2, curative effect is obvious.How tame this product is on probation through hospital clinical, and the total effective rate of prove its control periodontal disease, alleviating gingivitis is greater than 90%, and the total effective rate that reduces dental plaque index is greater than 94%.Compare with commercially available chewing gum and to have tangible cleaning oral cavity, eliminate the halitosis effect, clinical prevention and the treatment that mainly is applicable to the oral disease (gingivitis, periodontitis, halitosis) of each stratum at age.

3, medicine infiltrates in the glue nurse, can make oral cavity partial keep certain drug level by chewing slow release, guarantees lasting medicine.

4, the used dosage of medicine is little than oral dose, and it is big to play a role, and is safe and reliable.

Embodiment 1:

Prescription: 1 part of metronidazole, 1500 parts of Radix Zanthoxylis, 2500 parts of adjuvants.

Method for making: get 95% ethanol percolation Radix Zanthoxyli to closely colourless.Get 95% dissolve with ethanol metronidazole and become saturated solution.

To go up two liquid and mix, fling to most ethanol, and add a little liquid glucose (so that solution thickness be degree) slightly and fully grind even.

The thick liquid that above-mentioned stone roller is even, edible glue nurse, Icing Sugar fully grind in fireless cooker and close (the softening material of pot Wen Yineng is degree), add the flavorant extrusion molding, cooling, packing, and product meets food hygienic standard after testing.

Embodiment 2:

Prescription: 5 parts of metronidazoles, 5000 parts of Radix Zanthoxyli, 4500 parts of adjuvants, method for making is the same.

Claims

1, a kind of sugar that comprises, the tooth-strengthening chewing-gum that adjuvants such as glue nurse are formed is characterized in that it comprises that also oral cavity anaerobium is had remarkable inhibiting Western medicine metronidazole or chlorhexidine salt and Chinese medicine Radix Zanthoxyli or people ground Taurus, it consists of (weight portion):

1～5 part of metronidazole or chlorhexidine salt

1500～5000 parts of Radix Zanthoxyli or people ground Taurus

2500～4500 parts of adjuvants

2, tooth-strengthening chewing-gum according to claim 1 is characterized in that used Chinese medicine is Cortex Magnoliae Officinalis, Flos Lonicerae.

3, key tooth chewing gum according to claim 1 and 2 is characterized in that adjuvant consists of (weight %)

Sugar 68～78% edible glue nurses 22～32%

Flavorant 0～0.5%

4, tooth-strengthening chewing-gum according to claim 3 is characterized in that the viewport sense need add an amount of glycerol.

5, a kind of manufacture method of tooth-strengthening chewing-gum is characterized in that:

(1), at first prepares the dense pure liquid of Western medicine;

(2), extract Chinese medicine repeatedly to closely colourless, reclaim ethanol to rare extractum shape with pure method;

(3), under heat-retaining condition, with the dense ethanol liquid of above-mentioned Western medicine, liquid glucose is a small amount of and the Chinese medicine extract stone roller closes;

(4), adjuvant and said mixture are ground even, extrusion molding, cooling, packing.