CN1099619A - Medicine for preventing and curing pig diarrhea and preparing method - Google Patents
Medicine for preventing and curing pig diarrhea and preparing method Download PDFInfo
- Publication number
- CN1099619A CN1099619A CN 94102184 CN94102184A CN1099619A CN 1099619 A CN1099619 A CN 1099619A CN 94102184 CN94102184 CN 94102184 CN 94102184 A CN94102184 A CN 94102184A CN 1099619 A CN1099619 A CN 1099619A
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- medicine
- polygynax
- acetic acid
- ethyl lactate
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Abstract
The invented medicine consists of (by weight) neomycin sulphate 1-20%, sodium hydrocarbonate and/or zein powder 79.8-98.9%, ethyl lactate 0.05-0.1% and acetic acid 0.05-0.1% and optional excipient containing other routine medicine. The above mentioned components are mixed thoroughly in accordance with proportion in a mixer, the product for curing and preventing pig's diarrhea is obtained.
Description
Diarrhea of pigs is the intestinal tract disease that has a strong impact on Swine Production at present, generally occurs in age of sucking and 20 kilograms of ablactational baby pig in the past.In case morbidity, except that performance diarrhoea, thereby sick pig feed desire depressed cause become thin, dehydration, poor growth, serious dies of exhaustion.This disease is given to raise pigs to produce and has been caused serious economy loss, and the control of this disease being carried out science is the key that guarantees the Swine Production economic benefit at present.
It is a lot of to cause the diarrheal reason, in Swine Production, keep environmental health, strengthen feeding and management and regularly carry out measure such as immunity prevention diarrhoea is played an important role to pig, in addition because to cause the diarrheal major reason be pathogenic microorganism breeding in a large number in intestinal, so effective method is to use antibiotic medicine that diarrhoea is prevented and treated according to characteristics and rule that pig only falls ill.Under present large scale of pig farm condition, research has very important practical significance by the technology that feedstuff interpolation antibiotic prevents whole swinery.
Neomycin is a kind of aminoglycosides antibiotics, and the product form with polygynax is used as animal drug by the approval of China pharmaceutical control and administration department at present.Clinical trial shows that this antibiotic has tangible curative effect to piglet diarrhea, and by add suitable dosage in feedstuff diarrhoea is had preventive effect, and can promote growth in piglets, is good feeding antibiotic additive.But, because very easily moisture absorption of polygynax, in feedstuff can not uniform mixing, be difficult to allow the raiser carry out the use of science, so limited the application of this antibiotic in the middle of actual.Therefore, the research screening is fit to the diluent of polygynax and makes to have the good medicament of free-running property, and science is used neomycin, brings into play it and prevents the diarrheal effect to have important practical significance in Swine Production.
Generally inappetence all of diarrheal piglet takes place, and becomes thin even dies of exhaustion thereby be directed at body.Promote this moment piglet to search for food and strengthen the immunity of self, to the adverse effect of piglet, have great importance reducing diarrhoea.Therefore we suffer from diarrhoea to control and promote the composite drug that piglet searches for food to study.
Medicine of the present invention contains polygynax, sodium bicarbonate and/or Zein powder, ethyl lactate and acetic acid.Wherein, polygynax accounts for 1～20%(weight), sodium bicarbonate and/or Zein powder account for 79.8～98.9%(weight), ethyl lactate accounts for 0.05～0.1%(weight) and acetic acid account for 0.05～0.1%(weight), and can randomly contain other conventional drug excipients.Promptly the drug products of control diarrhea of pigs after with mixing apparatus various compositions being mixed according to the above ratio.
The preferred sulfur acid neomycin of this product 2～15%(weight), contain sodium bicarbonate and/or Zein powder 79.8～97.88%(weight), contain ethyl lactate 0.06～0.08%(weight) and acetic acid 0.06～0.08%(weight), and can randomly contain other conventional drug excipients.
This product is sulfur acid neomycin 5～10%(weight more preferably), contain sodium bicarbonate and/or Zein powder 89.84～94.88%(weight), contain ethyl lactate 0.06～0.08%(weight) and acetic acid 0.06～0.08%(weight), and can randomly contain other conventional drug excipients.
This product is sulfur acid neomycin 10%(weight most preferably), contain sodium bicarbonate and/or Zein powder 89.9%(weight), contain ethyl lactate 0.05%(weight) and acetic acid 0.05%(weight), and can randomly contain other conventional drug excipients.
Polygynax plays antibacterial action in medicament, suppress pathogenic bacteria breeding in a large number in intestinal; Sodium bicarbonate and Zein powder all have the agglomerative effect of sulfuric-resisting neomycin equally, all can be used as the diluent of polygynax in medicament, and wherein first-selected sodium bicarbonate is as diluent; Ethyl lactate and acetic acid play phagostimulant in medicament, when user produces pig Olibanum flavor with this medicament with can making after feedstuff mixes in the feedstuff, thereby lure that piglet searches for food into.
Medicine of the present invention has following characteristics
1. medicine free-running property of the present invention is good, does not lump, and mix homogeneously in feedstuff has solved polygynax moisture absorption agglomeration problems in use by this medicament easily.If as diluent, this product promptly can be used as powder and is mixed in the feedstuff and also can soluble in water piglet be gavaged, and is easy to use with sodium bicarbonate.
2. medicine of the present invention has therapeutical effect to diarrhea of pigs, when adding by a certain percentage in feedstuff diarrhea of pigs is had preventive effect, medium-term and long-term interpolation of feedstuff pig is not only produced any toxic side effects.
3. medicine of the present invention has the food calling effect to piglet, the malnutrition that causes because of off feed in the time of can alleviating diarrhoea in the control piglet diarrhea.
Embodiment 1
Take by weighing polygynax 500 grams, sodium bicarbonate 4495 grams, ethyl lactate 2.5 grams, acetic acid 2.5 grams, mix homogeneously in mixer, packing.
Embodiment 2
Take by weighing polygynax 250 grams, Zein powder 4744 grams, ethyl lactate 3 grams, acetic acid 3 grams mix homogeneously in mixer, packing.
Embodiment 3
Take by weighing polygynax 100 grams, sodium bicarbonate and Zein powder 4890 grams, ethyl lactate 5 gram acetic acid 5 grams, mix homogeneously in mixer, packing.
Adopt the product of embodiment 1 to descend routine clinical trial:
Select the piglet (generally showing as yellow scour of piglet) with obvious symptom of diarrhea in the swinery of Red Star pig farm, Yuncheng County, Shandong, the dosage of pressing every every day the 10-20 gram mixes in feedstuff, allows pig free choice feeding feedstuff, adds up the therapeutic outcome in three days.Result by 200 piglet clinical trials of accumulative total shows that this medicine is to diarrheal cure rate average out to 99%.The piglet of laxativeness was cured in one day, and heavier person cured in three days.The piglet of curing does not have in growth significantly slows down phenomenon, no cad pig appearance, and every pig mean treatment cost is the highest to be no more than 6 yuans.By above-mentioned evidence, piglet peace has the effect of strong treatment piglet diarrhea, and it is low to have a cost, promotes the effect that piglet growth is grown.With regard to this result of practical application measuring and calculating, every pig nearly 5-10 unit of on average cutting down expenses.Annual nearly ten thousand yuan of the economic losses that reduce of the whole audience.
Claims (6)
1, control diarrhea of pigs medicine, this medicine contains
Polygynax 1～20% (weight),
Sodium bicarbonate and/or Zein powder 79.8～98.9% (weight),
Ethyl lactate 0.05～0.1% (weight),
Acetic acid 0.05～0.1% (weight).
2, according to the medicine of claim 1, wherein contain
Polygynax 2～15%(weight),
Sodium bicarbonate and/or Zein powder 79.8～97.88%(weight),
Ethyl lactate 0.06～0.08%(weight),
Acetic acid 0.06～0.08%(weight).
3, according to the medicine of claim 2, wherein contain
Polygynax 5～10%(weight),
Sodium bicarbonate and/or Zein powder 89.84～94.88%(weight),
Ethyl lactate 0.06～0.08%(weight),
Acetic acid 0.06～0.08%(weight).
4, according to the medicine of claim 3, wherein contain
Polygynax 10%(weight),
Sodium bicarbonate and/or Zein powder 89.9%(weight),
Ethyl lactate 0.05%(weight),
Acetic acid 0.05%(weight).
5, according to the medicine of claim 4, wherein contain
Polygynax 10%(weight),
Sodium bicarbonate 0.1～88.9%(weight),
Zein powder 1～89.9%(weight),
Ethyl lactate 0.05%(weight),
Acetic acid 0.05%(weight).
6, the method for preparing control diarrhea of pigs medicine, this method comprise with
Polygynax 1～20%(weight),
Sodium bicarbonate and/or Zein powder 79.8～98.9%(weight),
Ethyl lactate 0.05～0.1%(weight),
Acetic acid 0.05～0.1%(weight).
And can randomly contain other conventional drug excipients, mix with mixing apparatus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94102184 CN1099619A (en) | 1994-03-08 | 1994-03-08 | Medicine for preventing and curing pig diarrhea and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94102184 CN1099619A (en) | 1994-03-08 | 1994-03-08 | Medicine for preventing and curing pig diarrhea and preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1099619A true CN1099619A (en) | 1995-03-08 |
Family
ID=5030544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94102184 Pending CN1099619A (en) | 1994-03-08 | 1994-03-08 | Medicine for preventing and curing pig diarrhea and preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1099619A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2261664A3 (en) * | 1999-08-11 | 2011-11-02 | Cedars Sinai Medical Center | Methods of treating bloating, abdominal pain and diarrhea |
| US8388935B2 (en) | 1999-08-11 | 2013-03-05 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
-
1994
- 1994-03-08 CN CN 94102184 patent/CN1099619A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2261664A3 (en) * | 1999-08-11 | 2011-11-02 | Cedars Sinai Medical Center | Methods of treating bloating, abdominal pain and diarrhea |
| US8197805B2 (en) | 1999-08-11 | 2012-06-12 | Cedars-Sinai Medical Center | Methods of treating autoimmune diseases caused by small intestinal bacterial overgrowth |
| US8388935B2 (en) | 1999-08-11 | 2013-03-05 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |