CN1126085A - Chinese medicinal preparation for prevention and treatment of CHD and angina pectoris - Google Patents

Abstract

The Chinese patent medicine in the form of oral liquid or capsule for curing coronary heart disease and angina pectoris with better curative effect, no toxic by-effect is prepared from ginseng, cinammon twigs, leech, trichosanthes fruit and tuckahoe through alcohol extraction, decoction in water, concentration and alcohol deposition.

Description

A kind of coronary heart disease, anginal Chinese medicine preparation prevented and treated

The invention belongs to a kind of Chinese medicine preparation of preventing and treating cardiovascular disease such as coronary heart disease, angina pectoris.

Cardiovascular disease such as coronary heart disease, angina pectoris is one of important diseases that influences middle-aged and elderly people health, and along with the increase of middle-aged and elderly people, preventing and treating these cardiovascular disease has become the problem that the whole society extremely is concerned about.The Chinese and western drugs that has occurred at present many treatment this respect diseases, but it is too expensive that these medicines have, and the untoward reaction that has is more and heavy, and controlling of having can not be prevented, the curative effect that also has is not ideal enough or use is convenient inadequately, and old friends are still making great efforts the better medicine newly of research and development.

The purpose of this invention is to provide a kind of to prevent and treat coronary heart disease, angina pectoris has produce effects and the few and light Chinese medicine preparation of untoward reaction.

The present invention realizes its purpose as follows:

The composition of raw materials scope of each Chinese medicine of this Chinese medicine preparation is: 1-3 parts of 2-5 parts of Ramulus Cinnamomi of 1-3 parts of Poria of 2-6 parts of Hirudos of 1-4 parts of Fructus Trichosanthis of (parts by weight) Radix Ginseng

The preparation method of this Chinese medicine preparation is:

Radix Ginseng in the prescription is extracted active ingredient separately with ethanol, reclaim and to be made into aqueous solution behind the ethanol or dry extract is standby; Ramulus Cinnamomi earlier after hydrodistillation extracts the volatile oil Aromatic water, with remaining medicinal residues and medicinal liquid and ginseng residue and other three flavors medicine mixes or separately with decocting in water, concentrated, precipitate with ethanol is refined into aqueous solution or dry extract is standby; Each aqueous solution be mixed in proportion and add sweeting agent, antiseptic can be made into oral liquid; Each dry extract is pulverized the back by the formula proportion mixing and add adjuvants such as dextrin, starch and promptly can be made into capsule.

Pharmacological actions such as Chinese medicine preparation of the present invention has resisting myocardial ischemia, reduces myocardial oxygen consumption, improves cardiac function, anticoagulant, it is good to prevent and treat disease effects such as coronary heart disease, angina pectoris, safe without toxic side effect, and it is easy to use, preparation cost is low, is a kind of good medicine of cardiovascular system diseases.

In the prescription of Chinese medicine preparation of the present invention, Radix Ginseng is the dry root of Araliaceae Radix Ginseng Panax ginseng C.A.Mey, Gan Wen, and strongly invigorating primordial QI is calmed the nerves in the accent, is monarch drug; Ramulus Cinnamomi is the dry tender skill of canella Cortex Cinnamomi Cin-namomum cassia Presl, and is hot sweet warm in nature, warming the meridian promoting the circulation of blood, beneficial heart and inducing arteries and veins; Poria is the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw) Wolf, and sweet light property is flat, spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming; Ramulus Cinnamomi and Poria are ministerial drug altogether; Fructus Trichosanthis is that cucurbitaceous plant is drawn together building Trichosanthes kirilowiiMaxim, or and the bilateral dry mature fruit of drawing together building Trichosanthes rosthornii Harms of equal plant, sweet cold, the chest stuffiness relieving promoting the circulation of QI, dissipating phlegm and resolving masses; Hirudo is the dry body of Hirudinidae animal whitmania Whitmania pigra Whit-man, Hirudo Hirude nipponica Whitman or Folium Salicis Babylonicae Hirudo Whitmania acranulata Whit-man, becomes bitterness flat, removing blood stasis, the eliminating stagnation of stimulating the menstrual flow; Fructus Trichosanthis and Hirudo are adjuvant drug altogether.Close the side of forming, have QI invigorating activate yang, reduce phlegm invigorate blood circulation, effect that mind calming is promoted blood circulation, therefore preparation of the present invention is applicable to that coronary heart disease, angina pectoris etc. belong to the deficiency in origin and excess in superficiality person of " heart deficiency of spleen-QI, the internal resistance of the expectorant stasis of blood ".Radix Panacis Quinquefolii (for the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinquefolium L) has the effect of being equal to Radix Ginseng, and the Radix Panacis Quinquefolii of available equivalent replaces Radix Ginseng or the two haves both at the same time; Also the Radix Codonopsis that quantity available is bigger (being the dry root of campanulaceae plant Radix Codonopsis Codonop-sis pilosula (Franch.) Nannf., plain flower Radix Codonopsis C.Pilosula Nannf.Var.modesta (Nan-nf) L.T.shen or radix codonpsis tangshen C.tangshen Oliv) substitutes Radix Ginseng.Medicinal function and the Hirudo of Pheretima (dry body of huge earthworm animal Pheretima aspergillum Pheretima aspergillum of section (Perrier) or Allolobophora caliginosa trapezoides Allolobophora caliginosa (Savigny) trapezoides (Ant Duges)) have similarity, are used as medicine so the bigger Pheretima of quantity available substitutes Hirudo.

In preparation during Chinese medicine preparation of the present invention, the Radix Ginseng in the prescription with conventional pure extracting method separately with being made into aqueous solution behind its medicinal ingredient of alcohol extraction, the recovery ethanol or dry extract is standby.Ramulus Cinnamomi in the prescription is earlier after hydrodistillation extracts the volatile oil Aromatic water, all the other medicinal residues and medicinal liquid can with conventional method with ginseng residue and excess-three thereof flavor medicine merge decocting in water, concentrate, precipitate with ethanol is refined into aqueous solution or dry extract, also can with conventional method with each flavor prescription only decocting in water, concentrate, precipitate with ethanol is refined into aqueous solution or dry extract, press formula proportion again panax ginseng extractum controlling the water circulation solution mixed with all the other four medicines (independent or blended) Purified Water solution and Ramulus Cinnamomi Aromatic water, add sweeting agent, antiseptic be made into oral liquid fill, sterilization, check the oral liquid finished product; Perhaps each Chinese medicine is pulverized after extraction is refined into dry extract and added dextrin or become oral capsule with auxiliary materials and mixing fills such as starch.

Pharmacy quality standard of the present invention meets that " each related item standard under Chinese pharmacopoeia (90 years versions) oral liquid and the capsule item: oral liquid is brownish black, clear liquid, the sweet band of distinguishing the flavor of is slightly pained, the peculiar aromatic odor of Ramulus Cinnamomi is arranged, storage for a long time has small amount of precipitate separates out, and content of ginsenoside is more than or equal to 1.0mg/ml in the finished product; Capsule 's content is a brown-black powder, and bitter in the mouth has the distinctive aromatic odor of Ramulus Cinnamomi, and the thin layer chromatography inspection has the distinctive speckle of ginsenoside, and content of ginsenoside is more than or equal to 15.0mg/g (powder) or 5mg/ grain (capsule) in the finished product.

Embodiment 1:

Prescription:

Radix Ginseng Rubra 1kg Fructus Trichosanthis 2kg Hirudo 1kg Poria 2kg Ramulus Cinnamomi 0.8kg white sugar 1kg sorbic acid 20g adding distil water is made into 10 liters.

Preparation technology:

1. red ginseng powder is broken to 10 orders, with 10 times of amount 70% ethanol heating and refluxing extraction medicinal ingredient at twice, each 5 hours, filter, collect filtrate; Filtering residue boils and boils three times, add 5 times of amounts of water at every turn, boil and boil 2 hours, filter, filtrate merging is concentrated into 100% (crude drug g/ml, as follows), add 3 times of amounts of 95% ethanol and stir standing over night, filter, filtrate and above-mentioned alcohol reflux filtrate merge, and reclaim and wave most ethanol, are made into distilled water that to contain crude drug 50% medicinal liquid standby;

2. get the Ramulus Cinnamomi decoction pieces and add 10 times of amounts of water, water distillation is altogether collected distillate and is about 5 times of amounts of crude drug amount, remainder adds Fructus Trichosanthis, the Poria azeotropic boils three times, adds water to 10 times of crude drug amounts first, 6 times of each times later on, boiled 2 hours at every turn, filter, filtrate merging is concentrated into 100%, adds 3 times of amounts of 95% ethanol and stirs, standing over night, filter, filtrate recycling ethanol is waved and is added above-mentioned Ramulus Cinnamomi distillate behind the most ethanol to be made into aqueous solution standby;

3. Hirudo powder is broken to 10 orders and boils and boil three times, add 5 times of amounts of water at every turn, boil and boil 2 hours, filter, filtrate merging is concentrated into 100%, adds 3 times of amounts of 95% ethanol and stirs standing over night, filter, filtrate recycling ethanol, it is standby to be made into every milliliter of aqueous solution that contains crude drug 0.5g;

4. with above-mentioned 1., 2., 3. each reserve liquid of gained merges, and filters, it is standby to get clear filtrate;

5. white sugar, sorbic acid are added in 2 liters of the distilled water, boil dissolving, filter, syrup is standby;

6. will be 4. and 5. liquid merge, adding distil water is joined 10 liters of mixings of foot, fill is sealed, sterilization, check, the packing oral liquid that gets product.

The every standard of this end product quality meets " each pertinent regulations under Chinese pharmacopoeia (90 years versions) the oral liquid item.

Embodiment 2:

Prescription:

Radix Panacis Quinquefolii 1kg Fructus Trichosanthis 3kg Hirudo 1kg Poria 3kg Ramulus Cinnamomi 1kg white sugar 1kg stevioside powder 1g sorbic acid 10g distilled water is an amount of, is made into the 15kg oral liquid, or adds dextrin to being made into the 1.2kg powder for 3000 of fill capsules.

Preparation method:

1. Radix Panacis Quinquefolii powder is broken into 20 order coarse powder, and add 10 times of amount 75% ethanol and divide heating and refluxing extraction three times, each 3 hours, filter, merge alcohol extract, reclaim ethanol, it is standby to be made into 50% aqueous solution;

2. Ramulus Cinnamomi adds 8 times of amounts of water, and 3 liters of Aromatic water of water distillation recovery are standby altogether;

3. 1. its excess-three flavor Chinese medicine add, 2. the surplus medicinal residues of institute and medicinal liquid azeotropic boil 2 times, head adds water to 8 times of doses, 6 times of the second time, each 2 hours, to filter, merging is concentrated into 100% concentration, adding 2 times of amounts of 95% ethanol stirs, staticly settled 48 hours, and filtered filtrate recycling ethanol, wave most ethanol, adding 2., gained Aromatic water and distilled water are made into 10 premium on currency solution;

4. incite somebody to action 1. and 3. gained liquid merging, add white sugar, stevioside powder, sorbic acid and distilled water are made into 15 liters, filter, and packing, sterilization, check, labeling get the oral liquid finished product.

If need make capsule, will be 1. the gained alcohol extract and 3. gained contain pure filtrate (but not adding 2. gained Aromatic water and distilled water) merging, reclaim ethanol, concentrate, vacuum drying or spray drying get dry extract, will be 2. the gained Aromatic water be refined into volatile oil and add and add dextrin again after dry extract absorbs it and join foot to 1.2kg as auxiliary shape agent in right amount, the fill capsule promptly gets the capsule finished product.

The prepared finished product of this law (or semi-finished product), quality inspection of finished products meet " each related item standard under Chinese pharmacopoeia (90 years versions) oral liquid and the capsule item.

Embodiment 3:

Prescription:

Radix Ginseng 1.5kg Poria 1.5kg Hirudo 1.5kg Fructus Trichosanthis 1.0kg Ramulus Cinnamomi 1.2kg white sugar 1kg stevioside 1g sorbic acid 10g distilled water is made into 15 liters in right amount.(or add starch be made into 3000 of 1.20 fill capsules in right amount).

Preparation method

1. the Radix Ginseng coarse powder adds 9 times of amount 95% ethanol and divides heating and refluxing extraction three times, and each 4 hours, filter, merge alcohol extract, reclaim ethanol, concentrate standby;

2. Ramulus Cinnamomi adds the water distillation altogether of 9 times of amounts of water, and it is standby to reclaim 5 liters of Aromatic water;

3. will be 1., 2. gained medicinal residues and residue medicinal liquid add excess-three flavor Chinese medicine and add water according to a conventional method and boil and boil 2 times, head adds 9 times of amounts of water, 5 times for the second time, boil and boil 2 hours, filter, merging filtrate is concentrated into 100%, add 2.5 times of amounts of 95% ethanol and stir, staticly settled 48 hours, merge with the Radix Ginseng concentrated solution that 1. gets behind filtration, the filtrate recycling ethanol, wave most ethanol, standby;

4. merge 3., 2. gained medicinal liquid and add each sweeting agent, antiseptic, stir evenly and adding distil water to 15 liter, filter, packing, sterilization, the check labeling promptly gets oral liquid.

If need the glue capsule, 3. the gained medicine liquid spray dry dry extract, 2. the gained Aromatic water is refined into volatile oil and adds auxiliary shape agents such as adding starch in the extract powder again to 1.20kg, branch is encapsulated 3000 behind the mixing, packing gets product.

Finished product, the semi-manufactured goods quality that this law is made meets " each related item standard under Chinese pharmacopoeia (90 years versions) oral liquid and the capsule item.

Claims (2)

1. prevent and treat coronary heart disease, anginal Chinese medicine preparation for one kind, it is characterized in that the raw material of Chinese medicine formula range is: (parts by weight)

1-3 parts of 2-5 parts of Ramulus Cinnamomi of 1-3 parts of Poria of 2-6 parts of Hirudos of 1-4 parts of Fructus Trichosanthis of Radix Ginseng

2. a preparation method of preventing and treating coronary heart disease and anginal Chinese medicine preparation as claimed in claim 1 is characterized in that: with the independent effective component extracting of ethanol, be made into aqueous solution or make dry extract standby behind the recovery ethanol Radix Ginseng; Ramulus Cinnamomi earlier after hydrodistillation extracts the volatile oil Aromatic water, with remaining medicinal residues and medicinal liquid and ginseng residue and other three flavors Chinese medicine mixes or separately with decocting in water, concentrated, precipitate with ethanol make with extra care be made into aqueous solution or be refined into dry extract standby; Each aqueous solution mix by formula proportion and add sweeting agent, antiseptic can be made into oral liquid, each dry extract is pulverized the back by the formula proportion mixing and add dextrin starch etc. and can be made into capsule.