CN1220613A - 医疗用弹力分送装置 - Google Patents

医疗用弹力分送装置 Download PDF

Info

Publication number
CN1220613A
CN1220613A CN97195179A CN97195179A CN1220613A CN 1220613 A CN1220613 A CN 1220613A CN 97195179 A CN97195179 A CN 97195179A CN 97195179 A CN97195179 A CN 97195179A CN 1220613 A CN1220613 A CN 1220613A
Authority
CN
China
Prior art keywords
mentioned
locking device
spring
dispensing member
primary importance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97195179A
Other languages
English (en)
Inventor
T·E·维斯顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Weston Medical Ltd
Original Assignee
Weston Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weston Medical Ltd filed Critical Weston Medical Ltd
Publication of CN1220613A publication Critical patent/CN1220613A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Abstract

一种分送装置,譬如无针头注射器,它包括提供能量储存的弹簧,和可移动分送构件,以在弹簧力的作用下有效的输送。一锁定块,具有第一位置,在该位置它限制分送构件的运动,以及第二位置,在该位置它允许这种运动。一个由使用者操作的触发装置,它可将锁定块从第一位置移动到第二位置。一个安全装置是在分送构件内适当形状的槽,它在本装置被安装完毕前有效的阻止锁定块移动到第二位置。

Description

医疗用弹力分送装置
本发明与分送装置有关，它用弹簧推动分送构件输送一剂量的液体，粉未或颗粒之类的药剂。该弹簧，例如，可以是机械弹簧，如金属簧；或是压缩气体弹簧，如压缩空气。
这种分送装置的一个实例是无针头注射器。尤其是，不同类型的无针头注射器在国际专利公布第WO93/03779和WO95/03844号中有描述；它们均以本申请人的名义发表。本发明将参考无针头注射器进行详细描述，但是应理解，它同样适用于其它类型的弹力分送装置。
在上述国际专利公布中描述的那类弹力无针头位射器，在使用之前，其弹簧在分送构件上持续施加一个力，同时，为阻止分送构件在弹簧力作用下的移动，提供一种限制装置。实际上，无针头注射器的注射动作是推动注射器进入一种状态，在该状态下该限制装置不再具有限制效力，从而允许分送构件的移动。
但是，组装这种装置存在一个潜在问题，如果这种装置容易被使用者操作的话，它就容易，或至少可能在制造过程中这种装置会意外地被发射。这不仅是不经济的，同时也对有关人员的安全造成危害。本发明的目的就是提供克服这个问题的装置。
根据本发明，所提供的分送或送物品的装置包括弹簧，它提供能量储存；一个可移动的分送构件，以在弹簧力的作用下有效地输送；锁定装置，它具有第一位置，在该位置，它阻止分送构件的运动，以及第二位置，在该位置上它允许这种运动；可由使用者操作的触发装置，以便将锁定装置从上述第一位置移到上述第二位置；以及一个安全装置，可在装置安装完毕之前有效地防止锁定装置向第二位置的移动。
在本发明的优选实施例中，下文将作更详细描述，安全装置与锁定装置相配合，从而具有一安全位置，在此位置触发装置不能将它移到第二位置；它还具有一个非安全位置，在此位置它可被移动到第二位置。
参考附图，现将进一步描述本发明。其中：
图1是据本发明的无针头注射器的实施例的纵向剖视图，所显示的注射器处在使用前，其锁定块位于安全位置；
图1a显示用在图1中的放大的锁定块；以及
图2a、2b和2c示意地显示图1和图1a实施例的部分，依次处于3个阶段，即锁定块在安全位置；锁定块在发射前的非安全位置；以及锁定块在发射期间所处的位置。
在图1的实施例中，注射力由压缩气体弹簧提供。这是以气筒130形式，其上端是封闭的并含有气体，典型地是空气，气体处于范围从5.5MPa(800Psi)到20.7MPa(3000Psi)的压力之下。气筒容纳推杆111。，推杆111的端部具有截头锥体部分131和凸台132，位于它们之间的是0形密封圈133。在使用前，推杆111由在推杆凹槽内接合的锁定块108固定在图示位置，凹槽的上表面形成推杆的靠模表面109。锁定块108按放大比例显示于图1a中。在图1所显示的位置上，锁定块不能向左移动，因为它紧靠在套筒102的内壁上。
气筒130的下端有一向外伸出的凸缘130a，通过将凸缘130a卷曲在连接套140上端的向外的凸台140a下面，可将气筒固定。套筒102由气筒位于其内的上套筒部分102a和下套筒部分102b形成。套管部分102b通过分别形成在套管部分102b和连接套140的内，外壁上的螺纹141连接到连接套上。
注射器包括药剂管103，它有活塞104，活塞104可滑动并密封地位于其内且与药剂105接触。如果从图1的上端观察，该活塞可包含一圆柱形部分，一较大直径的圆柱形密封部分，和一个截头圆锥部分，例如，下文涉及的专利号PCT/GB96/00551的图1中所示。药剂管103有一喷孔106。喷孔106由弹性密封件134密封，该密封件由密封托135固定。密封托135通过易断个连接部136与下套筒部分102b相连。
为防止意外的发射，撕裂带137设置为下套筒部分102b的下部。撕裂带137的下边缘紧靠在环142上，而该环被连接到连接套140的外表面上，或(未显示)与其形成整体。该环的作用是，只要撕裂带137存在，即阻止套管部分102a相对于连接套140向下移动。相应地，环142不需完全环绕着连接套的周边延伸，并可由一个或多个元件代替。
环状空间138形成在套筒102内壁中，在套管与气筒130相邻的地方。该空间用缓冲油脂填满(图示中顺序的黑条)从而，油脂与套筒102和气筒130直接接触。应注意，尽管被确定的环状空间从为油脂提供特定位置上看是方便的，然而它可被省忽略，油脂可仅涂敷在整个或部分气筒130外侧上和/或套筒102内侧上。
当图1的实施例要被使用时，使用者在易断连接部136上折断密封托135，随之取下密封件134，露出喷孔106。然后使用者除去撕裂带137，并抓住套筒102的上部，将喷孔紧靠待注射的物体(例如使用者自己的皮肤)，相对下套筒部分102b向下推动上套筒部分102a。这使得在上套筒部分102a壁上的开口139与锁紧块108对正，气筒130内的气体的力通过形成在推杆111的靠模表面109作用于锁定块上，使之侧向地移入开口内，从而导致注射器的发射。作为一种预防措施，如果锁定块在靠模表面109的作用下没有移动，还有一个辅助的靠模表面143形成在套管部分102a的内侧，由缓冲油脂缓冲形成的反弹。
仅作为举例的方式，下面是图1实施例典型尺寸：
气体气筒外径和滑动套筒内径之间的直径径间隙    0.05mm
横断面积(即油脂的横截面)大约                  375mm2
油脂粘度                                      2.2千泊
                                              (Kilopoise)
推杆冲击时的动量                              0.06kg.m/s
套筒部分102a的质量                            1.3g
推杆的质量                                    2.5g
推杆和活塞之间的冲击间隙                      4mm
气压                                          6.2MPa
气体气筒孔径                                  5.0mm
在油脂已被认为是一种优选的缓冲介质，而使用空气或油质缓冲装置，通常是缸体和活塞的组合，即称之为“缓冲器”，在其中，流体物质经节流流动，由此阻尼运动，也可获得相似的结果。其它粘滞阻尼方法是使用一个叶片，或多个叶片，在缓冲介质例如空气中旋转，如果适用的话，可以在特殊应用场合中使用这些方法。缓冲油脂的效果和目的在我们待审的国际申请号PCT/GB96/00551中有更详细的讨论。
应当理解，对于无针头注射器或者甚至是任何在其中储存有能量的注射器来说，不应过早的发射是重要的。一旦上述装置已组装到了撕裂带137已存在的地步，那么直至它被卸除前，该装置不能发射。但是，在纽装该装置时有一个潜在的问题，其中，待组装的倒数第二个构件是上套筒部分102a，它携带撕裂带137(最后被组装的构件是药剂管1(B)，除非套筒部分102a安装到位，意外的发射是可能的。
装配过程中的意外发射是确实可能的。首先，在上套筒部分102a安装以前紧接着有一个阶段，在该阶段，被部分安装好的装置有一段隔离期以检查气体的泄漏。其次，在上套筒部分102a安装期间，该装置将受到各种力和来自于安装设备的振动。甚至在上套筒部分102a安装后，安装药剂管所产生的装配应力足以引起意外的发射，尽管撕裂带137存在。
为解决这一问题，本装置具有一个安全装置。在图示的实施例中，这是由形成在推杆内的槽所提供的，它不仅带有靠模表面109，也带有锁定表面109a，它沿垂直于推杆轴向的方向伸展，并位于靠模表面109径向向内的位置。为能使靠模表面109和锁定表面109a的结合以按照预期的方式使用，上套筒部分102a的成形有一开口144，该开口延伸过一区域，该开口在装置被发射前与锁定块108的距推杆槽较远的一端对正。
安全装置的操作方式可从图2a、2b和2c中看出。当锁定块和推杆开始相互配合时，锁定块所占据的位置如图2a所示，这就是安全位置。在这里，接合推杆的锁紧部108a受锁紧部109a的作用。摩擦力保证锁定块与锁紧表面的保持接触；一般，推杆施加的力至少200N，因此锁定块被固定在钳形夹中。
一旦装置已经安装，特别是安装完毕后，且至少达到上套筒部分102a就位的程度，通过开口144插入一个工具，沿图中箭头P的方向推动锁定块进入图2b(和图1)所示位置。在这个位置上，接合推杆的锁紧部位108a与靠模表面109的径向内端保持接触。因此，当装置按上述方式操纵时，它能发射，且锁定块移到如图2c所示的位置。

Claims (10)

1．分送材料或物品的装置，它包括提供能量储存的弹簧，一可移动的分送构件，以在弹簧力的作用下有效的输送；锁定装置，它具有第一位置，在该位置上它限制分送构件的运动；和第二位置，在该位置上它允许这种运动；使用者操作的触发装置，以将锁定装置从上述第一位置移动到上述第二位置；以及一安全装置，以便在整个装置安装完毕之前有效地阻止锁定装置移动到上述第二位置。
2．根据权利要求1的装置，其中，由具有一安全位置锁定装置提供安全装置，在该安全位置触发装置不能将其移动到第二位置。
3．根据权利要求2的装置，其中，分送构件有一对形成在其内的锁紧连接表面，锁定装置处在它的安全位置时，它与其中之一的该表面接合，当处在它的上述第一位置时，它与另一该表面接合。
4．根据权利要求3的装置，其中，分送构件有一槽，从其外表面延伸入其中，该槽部分地由上述一对表面确定。
5．根据权利要求3或4的装置，其中，上述一个表面大体垂直于分送构件预定的运动方向，而上述另一个表面倾斜于上述的运动方向，以便分送构件沿上述方向的运动对锁定装置施加力并在锁定装置处在上述第一位置时，把它朝上述第二位置推动。
6．根据权利要求2至5的任一权利要求的装置，它具有一外壳，围绕该分送构件和该锁定装置，该外壳具有在该锁定装置的区域内的开口，，开口形成通道以允许工具插入外壳的内部并使锁定装置从它的安全位置移动到它的上述第一位置。
7．根据上述任一权利要求的装置，它为无针头注射器的形式。
8．根据权利要求7的装置，它包括含有待注射液体的腔，，在其一端形成一个输出喷孔，以及在腔内的一可移动的活塞，以通过输出喷孔排出上述液体，当锁定装置在上述第一位置时，分送构件与活塞间隔；当锁定装置移到上述第二位置时，该构件冲击活塞使其有效的移动。
9．根据上述任一权利要求的装置，其中，该弹簧是气体弹簧。
10．根据权利要求1至8的任一权利要求的装置，其中，该弹簧是机械弹簧。
CN97195179A 1996-04-11 1997-03-21 医疗用弹力分送装置 Pending CN1220613A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9607549.4 1996-04-11
GBGB9607549.4A GB9607549D0 (en) 1996-04-11 1996-04-11 Spring-powered dispensing device

Publications (1)

Publication Number Publication Date
CN1220613A true CN1220613A (zh) 1999-06-23

Family

ID=10791916

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97195179A Pending CN1220613A (zh) 1996-04-11 1997-03-21 医疗用弹力分送装置

Country Status (27)

Country Link
US (1) US6135979A (zh)
EP (1) EP0892648B1 (zh)
JP (1) JP3450012B2 (zh)
KR (1) KR20000005273A (zh)
CN (1) CN1220613A (zh)
AT (1) ATE231402T1 (zh)
AU (1) AU716237B2 (zh)
BG (1) BG102807A (zh)
BR (1) BR9708767A (zh)
CA (1) CA2251256A1 (zh)
CZ (1) CZ326698A3 (zh)
DE (1) DE69718631T2 (zh)
ES (1) ES2191822T3 (zh)
GB (1) GB9607549D0 (zh)
HU (1) HUP9902139A3 (zh)
ID (1) ID16590A (zh)
IL (1) IL126356A0 (zh)
IS (1) IS4859A (zh)
NO (1) NO984720D0 (zh)
NZ (1) NZ332232A (zh)
PL (1) PL329187A1 (zh)
RU (1) RU2171119C2 (zh)
SK (1) SK139398A3 (zh)
TR (1) TR199802021T2 (zh)
WO (1) WO1997037705A1 (zh)
YU (1) YU43598A (zh)
ZA (1) ZA973011B (zh)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101715371B (zh) * 2007-05-14 2012-09-05 Shl集团有限责任公司 输送装置
CN101466614B (zh) * 2006-06-13 2013-05-01 诺信公司 液体分配注射器
CN104736992A (zh) * 2012-08-30 2015-06-24 Lts勒曼治疗系统股份公司 用于将物质配送到介质中的测试装置
CN104968384A (zh) * 2012-12-17 2015-10-07 赛诺菲-安万特德国有限公司 药物输送装置
CN106975127A (zh) * 2011-02-04 2017-07-25 株式会社大赛璐 无针注射器

Families Citing this family (328)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6264629B1 (en) 1998-11-18 2001-07-24 Bioject, Inc. Single-use needle-less hypodermic jet injection apparatus and method
US6132395A (en) * 1998-12-08 2000-10-17 Bioject, Inc. Needleless syringe with prefilled cartridge
US6383168B1 (en) 1998-12-08 2002-05-07 Bioject Medical Technologies Inc. Needleless syringe with prefilled cartridge
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7074210B2 (en) * 1999-10-11 2006-07-11 Felton International, Inc. Universal protector cap with auto-disable features for needle-free injectors
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6776776B2 (en) 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US6770054B1 (en) 1999-11-23 2004-08-03 Felton International, Inc. Injector assembly with driving means and locking means
US7887506B1 (en) 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
US7029457B2 (en) * 1999-11-23 2006-04-18 Felton International, Inc. Jet injector with hand piece
US6558348B2 (en) 2000-04-07 2003-05-06 Equidyne Systems, Inc. Low cost disposable needleless injector system for variable and fixed dose applications
WO2001087385A1 (en) 2000-05-16 2001-11-22 Weston Medical Limited Liquid transfer device for drug reconstitution or liquid drug transfer
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
EP2269639B1 (en) 2001-02-23 2018-11-28 GlaxoSmithKline Biologicals s.a. Influenza vaccine formulations for intradermal delivery
JP2002263106A (ja) * 2001-03-12 2002-09-17 Olympus Optical Co Ltd 光プローブ装置
CA2440983A1 (en) 2001-03-14 2002-09-26 Penjet Corporation System and method for removing dissolved gas from a solution
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
WO2002087663A2 (en) 2001-04-27 2002-11-07 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
TWI228420B (en) 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
GB0125506D0 (en) * 2001-10-24 2001-12-12 Weston Medical Ltd Needle free injection method and apparatus
GB0206560D0 (en) 2002-03-20 2002-05-01 Glaxo Group Ltd Novel device
TWI314464B (en) 2002-06-24 2009-09-11 Alza Corp Reusable, spring driven autoinjector
WO2004018023A1 (en) 2002-08-26 2004-03-04 Penjet Corporation Apparatus for needle-less injection with a degassed fluid
AU2004272972A1 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
WO2005034949A1 (en) 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
DE10342058B4 (de) * 2003-09-11 2007-10-25 Tecpharma Licensing Ag Verabreichungsvorrichtung für ein injizierbares Produkt mit einer Auslösesicherung
ES2586387T3 (es) 2003-11-05 2016-10-14 Dana-Farber Cancer Institute, Inc. Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular
US7776007B2 (en) 2003-12-05 2010-08-17 Zogenix, Inc. Device for readying a needle free injector for delivery
US7717874B2 (en) 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
EP1781180A2 (en) * 2004-07-08 2007-05-09 CliniWave, Inc. Rolling tube apparatus and method for treating a wound
ES2540770T3 (es) 2004-09-22 2015-07-13 Glaxosmithkline Biologicals Sa Composición inmunógena para uso en vacunación contra estafilococos
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
EP2532378B1 (en) 2004-12-01 2016-04-27 AcuShot, Inc. Needle-free injector
AU2006226543B2 (en) 2005-03-23 2011-10-06 Glaxosmithkline Biologicals S.A. Use of an influenza virus an oil-in-water emulsion adjuvant to induce CD4 T-cell and/or improved B-memory cell response
ES2614086T3 (es) 2005-04-04 2017-05-29 University Of Florida Research Foundation, Inc. Análogos de poliéter de desferritiocina
EP1919504B1 (en) 2005-08-03 2013-10-16 iBio, Inc. Antibody to bacillus anthracis protective antigen
US20070055199A1 (en) 2005-08-10 2007-03-08 Gilbert Scott J Drug delivery device for buccal and aural applications and other areas of the body difficult to access
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
CN101378778B (zh) 2005-12-22 2013-02-06 葛兰素史密丝克莱恩生物有限公司 肺炎球菌多糖缀合物疫苗
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
EP1984405A4 (en) 2006-02-13 2010-06-30 Fraunhofer Usa Inc INFLUENZA ANTIGENS, VACCINE COMPOSITIONS AND ASSOCIATED METHODS
WO2007111806A2 (en) 2006-03-23 2007-10-04 Massachusetts Eye And Ear Infirmary Cyclopentane heptanoic acid compounds for reducing body fat
EA015833B1 (ru) 2006-03-30 2011-12-30 Глаксосмитклайн Байолоджикалс С.А. Иммуногенная композиция
CA2648099C (en) 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
WO2007133807A2 (en) 2006-05-15 2007-11-22 Massachusetts Institute Of Technology Polymers for functional particles
EP2492684B1 (en) 2006-06-02 2016-12-28 President and Fellows of Harvard College Protein surface remodeling
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
DK2043682T3 (da) 2006-07-17 2014-06-02 Glaxosmithkline Biolog Sa Influenzavaccine
US9115358B2 (en) 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
SI2086582T1 (sl) 2006-10-12 2013-02-28 Glaxosmithkline Biologicals S.A. Cepivo, ki obsega emulzijo olja v vodi kot adjuvans
BRPI0717219B8 (pt) 2006-10-12 2021-05-25 Glaxosmithkline Biologicals Sa composição imunogênica, e, uso de uma composição imunogênica
BRPI0719756A2 (pt) 2006-12-01 2014-01-21 Anterios Inc Nanopartículas de entidades anfifílicas
DK2474525T3 (da) 2006-12-26 2020-07-13 Lantheus Medical Imaging Inc Ligander til billeddannelse af hjerte-innervation
ES2558928T3 (es) 2007-01-31 2016-02-09 Dana-Farber Cancer Institute, Inc. Péptidos p53 estabilizados y usos de los mismos
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
WO2008103997A2 (en) 2007-02-23 2008-08-28 Bioject Inc. Needle-free injection devices and drug delivery systems therefor
JP5439193B2 (ja) 2007-03-15 2014-03-12 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． デスフェリチオシンポリエーテル類似体
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
WO2008124632A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
US8778348B2 (en) 2007-04-28 2014-07-15 Ibio Inc. Trypanosoma antigens, vaccine compositions, and related methods
US8524444B2 (en) 2007-06-15 2013-09-03 President And Fellows Of Harvard College Methods and compositions for detections and modulating O-glycosylation
JP2010531330A (ja) 2007-06-26 2010-09-24 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 肺炎連鎖球菌莢膜多糖コンジュゲートを含むワクチン
EP2178558B1 (en) 2007-07-11 2014-04-30 iBio, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
EP2205074A4 (en) 2007-10-04 2013-07-31 Harvard College ANALOGUES OF THE MOENOMYCIN, METHODS OF SYNTHESIS AND USES THEREOF
EP3424525A1 (en) 2007-10-12 2019-01-09 Massachusetts Institute Of Technology Vaccine nanotechnology
CN101951927A (zh) 2008-01-03 2011-01-19 麻省理工学院 诱饵流感疗法
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
MX2010011412A (es) 2008-04-16 2010-11-12 Glaxosmithkline Biolog Sa Vacuna.
ES2563061T3 (es) 2008-04-28 2016-03-10 Zogenix, Inc. Nuevas formulaciones para el tratamiento de la migraña
US20110212157A1 (en) 2008-06-26 2011-09-01 Anterios, Inc. Dermal delivery
US8680020B2 (en) 2008-07-15 2014-03-25 Academia Sinica Glycan arrays on PTFE-like aluminum coated glass slides and related methods
EP2356139A4 (en) 2008-07-23 2013-01-09 Harvard College LIGATURE OF STAPLED POLYPEPTIDES
JP2012503025A (ja) 2008-09-22 2012-02-02 エルロン・セラピューティクス・インコーポレイテッド 精製されたポリペプチド組成物を調製するための方法
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
CA2743904A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
WO2010077806A1 (en) 2008-12-15 2010-07-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
DE102008063517A1 (de) * 2008-12-18 2010-07-01 Lts Lohmann Therapie-Systeme Ag Einmalinjektor mit einem biegeelastischen Gehäuse II
DE102008063519A1 (de) * 2008-12-18 2010-07-01 Lts Lohmann Therapie-Systeme Ag Einmalinjektor mit einem biegeelastischen Metallgehäuse
BRPI1006139A2 (pt) 2009-01-14 2017-05-30 Aileron Therapeutics Inc macrociclos peptidomiméticos
WO2010129023A2 (en) 2009-04-28 2010-11-11 President And Fellows Of Harvard College Supercharged proteins for cell penetration
JP2012528858A (ja) 2009-06-01 2012-11-15 プレジデント アンド フェロウズ オブ ハーバード カレッジ Ｏ−ＧｌｃＮＡｃ転移酵素阻害剤およびその使用
US9163330B2 (en) 2009-07-13 2015-10-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2011041391A1 (en) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
GB2477487A (en) * 2009-10-12 2011-08-10 Owen Mumford Ltd Injection device
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
GB0921295D0 (en) 2009-12-04 2010-01-20 Owen Mumford Ltd Injection appaeratus
AU2011210840B2 (en) 2010-01-27 2014-12-11 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
WO2011112635A1 (en) 2010-03-08 2011-09-15 Sloan-Kettering Institute For Cancer Research Cdc7 kinase inhibitors and uses thereof
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
US9102697B2 (en) 2010-03-22 2015-08-11 President And Fellows Of Harvard College Trioxacarcins and uses thereof
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
WO2011140296A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Triazoles as inhibitors of fatty acid synthase
EP2566853B1 (en) 2010-05-05 2017-01-25 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
EP2566953B1 (en) 2010-05-07 2019-01-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
BR122020018186B1 (pt) 2010-05-11 2021-07-27 Lantheus Medical Imaging, Inc Uso de agentes de imagiologia para preparação de uma composição para detecção do transportador de norepinefrina (net) e método para a detecção de net
WO2011143657A1 (en) 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc. Male contraceptive compositions and methods of use
ES2664872T3 (es) 2010-06-18 2018-04-23 Taiho Pharmaceutical Co., Ltd Moduladores PRPK-TPRKB y sus usos
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
DK2603600T3 (da) 2010-08-13 2019-03-04 Aileron Therapeutics Inc Peptidomimetiske makrocyklusser
EP2611922A1 (en) 2010-08-31 2013-07-10 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
WO2012037268A2 (en) 2010-09-15 2012-03-22 Zogenix, Inc. Needle-free injectors and design parameters thereof that optimize injection performance
US8802110B2 (en) 2010-09-21 2014-08-12 Massachusetts Institute Of Technology Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
EP4108671A1 (en) 2010-10-01 2022-12-28 ModernaTX, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
BR112013007946B1 (pt) 2010-10-04 2022-07-12 Massachusetts Institute Of Technology Composições farmacêuticas e imunogênicas compreendendo polipeptídeos de hemaglutinina
EP2438945A1 (en) * 2010-10-08 2012-04-11 Sanofi-Aventis Deutschland GmbH Reusable engine for an auto-injector
WO2012064973A2 (en) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
UA115767C2 (uk) 2011-01-10 2017-12-26 Інфініті Фармасьютікалз, Інк. Способи отримання ізохінолінонів і тверді форми ізохінолінонів
CN103370092B (zh) * 2011-01-10 2016-09-28 周吉尼克斯股份有限公司 无针注射器
US9089579B2 (en) 2011-01-19 2015-07-28 Topokine Therapeutics, Inc. Methods and compositions for treating metabolic syndrome
WO2012103037A1 (en) 2011-01-24 2012-08-02 Anterios, Inc. Oil compositions
DK2667854T3 (en) 2011-01-24 2019-04-23 Anterios Inc NANO PARTICLE FORMATIONS
KR20140005998A (ko) 2011-01-24 2014-01-15 안테리오스, 인코퍼레이티드 나노입자 조성물, 이의 제형, 및 그의 용도
US8703818B2 (en) 2011-03-03 2014-04-22 Tersus Pharmaceuticals, LLC Compositions and methods comprising C16:1n7-palmitoleate
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
US9193767B2 (en) 2011-03-30 2015-11-24 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
CN103533953A (zh) 2011-05-17 2014-01-22 葛兰素史密丝克莱恩生物有限公司 针对肺炎链球菌的疫苗
WO2012177997A1 (en) 2011-06-22 2012-12-27 The General Hospital Corporation Treatment of proteinopathies
AU2012284091B2 (en) 2011-07-19 2015-11-12 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
US8969363B2 (en) 2011-07-19 2015-03-03 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PT2734510T (pt) 2011-07-22 2019-02-13 Massachusetts Inst Technology Ativadores de histona desacetilases de classe i (hdacs) e seus usos
WO2013032591A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CN104159890B (zh) 2011-09-09 2018-04-10 蓝瑟斯医学影像公司 用于合成和使用显像剂的组合物、方法和系统
CA2846893A1 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
EP2755693A4 (en) 2011-09-12 2015-05-20 Moderna Therapeutics Inc MODIFIED NUCLEIC ACIDS AND METHODS OF USE
US9630979B2 (en) 2011-09-29 2017-04-25 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
CN103974724B (zh) 2011-10-03 2019-08-30 现代泰克斯公司 修饰的核苷、核苷酸和核酸及其用途
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6106685B2 (ja) 2011-11-17 2017-04-05 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）の阻害剤
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
CA2859387A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
WO2013123267A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
AU2013221432B2 (en) 2012-02-15 2018-01-18 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2850090B1 (en) 2012-04-06 2018-10-03 President and Fellows of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs
WO2013152277A2 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
EP2850091A1 (en) 2012-04-06 2015-03-25 President and Fellows of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
WO2013163088A1 (en) 2012-04-23 2013-10-31 Zogenix, Inc. Piston closures for drug delivery capsules
EP2841098A4 (en) 2012-04-23 2016-03-02 Allertein Therapeutics Llc NANOPARTICLES FOR THE TREATMENT OF ALLERGIES
KR102122618B1 (ko) 2012-05-10 2020-06-29 메사츄세츠 인스티튜트 어브 테크놀로지 인플루엔자 중화를 위한 작용제
WO2014024026A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Method for eliciting in infants an immune response against rsv and b. pertussis
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
JP6302909B2 (ja) 2012-08-18 2018-03-28 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ シアリダーゼの同定および画像化のための細胞透過性プローブ
CA3113959A1 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
RS58700B1 (sr) 2012-10-12 2019-06-28 Broad Inst Inc Gsk3 inhibitori i postupci njihove primene
WO2014063068A1 (en) 2012-10-18 2014-04-24 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2014063061A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
MX2015005244A (es) 2012-11-01 2015-07-14 Aileron Therapeutics Inc Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos.
CN105102000B (zh) 2012-11-01 2021-10-22 无限药品公司 使用pi3激酶亚型调节剂的癌症疗法
WO2014071247A1 (en) 2012-11-02 2014-05-08 Dana-Farber Cancer Institute, Inc. Pyrrol-1 -yl benzoic acid derivates useful as myc inhibitors
EP2922542A4 (en) 2012-11-21 2016-10-05 Topokine Therapeutics Inc METHODS AND COMPOSITIONS FOR LOCALLY INCREASING BODY FAT
US9775915B2 (en) 2012-11-26 2017-10-03 President And Fellows Of Harvard College Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof
JP6144355B2 (ja) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． 化学修飾ｍＲＮＡ
US9908887B2 (en) 2012-12-21 2018-03-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
JP2016505002A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するｐｒｍｔ５阻害剤およびその使用
EP2935222B1 (en) 2012-12-21 2018-09-05 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US9365555B2 (en) 2012-12-21 2016-06-14 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2014113089A2 (en) 2013-01-17 2014-07-24 Moderna Therapeutics, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
US20140335504A1 (en) 2013-02-07 2014-11-13 Massachusetts Institute Of Technology Human adaptation of h5 influenza
EP2953638B1 (en) 2013-02-07 2023-07-05 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
EA033537B1 (ru) 2013-03-11 2019-10-31 Durect Corp Инъекционная композиция с контролируемым высвобождением, содержащая жидкий носитель с высокой вязкостью
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
EP2991665A4 (en) 2013-03-13 2016-11-09 Harvard College AGRAFES AND SUTURE POLYPEPTIDES AND USES THEREOF
WO2014151386A1 (en) 2013-03-15 2014-09-25 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
EP3760223A1 (en) 2013-04-03 2021-01-06 N-Fold Llc Nanoparticle composition for desensitizing a subject to peanut allergens
US9982005B2 (en) 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
ES2774330T3 (es) 2013-04-09 2020-07-20 Massachusetts Inst Technology Polímero de suministro de fármaco y usos del mismo
US10301359B2 (en) 2013-04-30 2019-05-28 Massachusetts Institute Of Technology Human adaptation of H3 influenza
WO2014179562A1 (en) 2013-05-01 2014-11-06 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (zh) 2013-05-10 2018-06-16
RU2705204C2 (ru) 2013-05-30 2019-11-06 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ piз-киназы
US10526375B2 (en) 2013-06-05 2020-01-07 Massachusetts Institute Of Technology Human Adaptation of H7 HA
JP6469661B2 (ja) 2013-06-11 2019-02-13 カラ ファーマシューティカルズ インコーポレイテッド 尿素誘導体及びその使用
KR20160019547A (ko) 2013-06-14 2016-02-19 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 안정화된 폴리펩티드 인슐린 수용체 조절제
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
BR112016001457A2 (pt) 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc Inibidores de fatores de transcrição e usos dos mesmos
CN105555304A (zh) 2013-08-05 2016-05-04 葛兰素史密丝克莱恩生物有限公司 联合免疫原性组合物
WO2015021058A2 (en) 2013-08-05 2015-02-12 Greenlight Biosciences, Inc. Engineered proteins with a protease cleavage site
CN105682666B (zh) 2013-09-06 2021-06-01 中央研究院 使用醣脂激活人类iNKT细胞
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TWI657085B (zh) 2013-10-04 2019-04-21 英菲尼提製藥股份有限公司 雜環化合物及其用途
US9982009B2 (en) 2013-10-15 2018-05-29 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
US9902986B2 (en) 2013-10-16 2018-02-27 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
WO2015058140A1 (en) 2013-10-18 2015-04-23 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2015061204A1 (en) 2013-10-21 2015-04-30 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9458169B2 (en) 2013-11-01 2016-10-04 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA2929652A1 (en) 2013-11-08 2015-05-14 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors
AU2014369834B2 (en) 2013-12-24 2018-12-20 President And Fellows Of Harvard College Cortistatin analogues and syntheses and uses thereof
EP3094352B1 (en) 2014-01-16 2020-09-23 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
US10925881B2 (en) 2014-02-28 2021-02-23 Tensha Therapeutics, Inc. Treatment of conditions associated with hyperinsulinaemia
EP3119415A4 (en) 2014-03-07 2017-11-29 The Arizona Board of Regents on behalf of the University of Arizona Non-narcotic crmp2 peptides targeting sodium channels for chronic pain
JP6701088B2 (ja) 2014-03-19 2020-05-27 インフィニティー ファーマシューティカルズ， インコーポレイテッド Ｐｉ３ｋ−ガンマ媒介障害の治療で使用するための複素環式化合物
EP3129767B1 (en) 2014-03-27 2021-09-01 Academia Sinica Reactive labelling compounds and uses thereof
US10293035B2 (en) 2014-03-28 2019-05-21 University Of Washington Through Its Center For Commercialization Breast and ovarian cancer vaccines
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
WO2015168380A1 (en) 2014-04-30 2015-11-05 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
WO2015172686A1 (zh) * 2014-05-14 2015-11-19 苏州大学张家港工业技术研究院 气动蓄能式无针注射器
JP6759109B2 (ja) 2014-05-21 2020-09-23 プレジデント アンド フェローズ オブ ハーバード カレッジ Ｒａｓ抑制性ペプチドおよびその使用
TWI679020B (zh) 2014-05-27 2019-12-11 中央研究院 抗ｈｅｒ２醣抗體及其用途
TWI717319B (zh) 2014-05-27 2021-02-01 中央研究院 得自類桿菌屬之岩藻糖苷酶及其用途
KR20170003720A (ko) 2014-05-27 2017-01-09 아카데미아 시니카 항-ｃｄ20 글리코항체 및 이의 용도
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
KR102494193B1 (ko) 2014-05-28 2023-01-31 아카데미아 시니카 항-ｔｎｆ-알파 글리코항체 및 이의 용도
CA2951430A1 (en) 2014-06-13 2015-12-17 Glaxosmithkline Biologicals Sa Immunogenic combinations
CR20170011A (es) 2014-06-19 2017-04-04 Ariad Pharma Inc Compuestos de heteroarilo para la inhibición de cinasa
WO2015200425A1 (en) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Topical dosage regimen
WO2016004202A1 (en) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
WO2016011386A1 (en) 2014-07-18 2016-01-21 University Of Washington Cancer vaccine compositions and methods of use thereof
US10736966B2 (en) 2014-08-12 2020-08-11 Massachusetts Institute Of Technology Brush-poly (glycoamidoamine)-lipids and uses thereof
CN107001404B (zh) 2014-09-08 2021-06-29 中央研究院 使用醣脂激活人类iNKT细胞
MX2017003819A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y formulaciones de los mismos.
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
EA035145B1 (ru) 2014-10-21 2020-05-06 Ариад Фармасьютикалз, Инк. Кристаллические формы 5-хлор-n4-[2-(диметилфосфорил)фенил]-n2-{2-метокси-4-[4-(4-метилпиперазин-1-ил)пиперидин-1-ил]фенил}пиримидин-2,4-диамина
EP3212654B1 (en) 2014-10-27 2020-04-08 Tensha Therapeutics, Inc. Bromodomain inhibitors
US20180015101A1 (en) 2014-10-28 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for antigen-specific tolerance
EP3461904A1 (en) 2014-11-10 2019-04-03 ModernaTX, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof
WO2016086026A1 (en) 2014-11-26 2016-06-02 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
EP3230272B1 (en) 2014-12-10 2020-08-19 Kala Pharmaceuticals, Inc. 1-amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof
AU2015369707B2 (en) 2014-12-23 2020-07-23 Sloan-Kettering Institute For Cancer Research Polymorph of granaticin B
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
JP6779887B2 (ja) 2015-01-24 2020-11-04 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 新規なグリカンコンジュゲートおよびその使用方法
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2016160617A2 (en) 2015-03-27 2016-10-06 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
JP6843065B2 (ja) 2015-03-30 2021-03-17 グリーンライト バイオサイエンシーズ インコーポレーテッドＧｒｅｅｎｌｉｇｈｔ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． リボ核酸の無細胞生産
AU2016255770A1 (en) 2015-04-27 2017-11-16 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
CA2990172A1 (en) 2015-06-19 2016-12-22 Massachusetts Institute Of Technology Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN108368161A (zh) 2015-09-10 2018-08-03 艾瑞朗医疗公司 作为mcl-1调节剂的拟肽大环化合物
DK3350333T3 (da) 2015-09-17 2022-01-31 Modernatx Inc Polynukleotider, der indeholder en stabiliserende haleregion
LT3350157T (lt) 2015-09-17 2022-02-25 Modernatx, Inc. Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu
WO2017059389A1 (en) 2015-10-01 2017-04-06 Kythera Biopharmaceuticals, Inc. Compositions comprising a statin for use in methods of adipolysis
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
JP7114465B2 (ja) 2015-12-22 2022-08-08 モデルナティエックス インコーポレイテッド 薬剤の細胞内送達のための化合物および組成物
CA3016170A1 (en) 2016-03-08 2017-09-14 Academia Sinica Methods for modular synthesis of n-glycans and arrays thereof
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
CR20180525A (es) 2016-04-06 2019-02-14 Greenlight Biosciences Inc Producción de ácido ribonucleico libre de células
US11116832B2 (en) 2016-06-03 2021-09-14 Sanofi Pasteur Inc. Modification of engineered influenza hemagglutinin polypeptides
WO2017214337A1 (en) 2016-06-07 2017-12-14 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10549044B2 (en) 2016-06-09 2020-02-04 Becton, Dickinson And Company Spacer assembly for drug delivery system
US10792432B2 (en) 2016-06-09 2020-10-06 Becton, Dickinson And Company Drive assembly and spacer for drug delivery system
US10603445B2 (en) 2016-06-09 2020-03-31 Becton, Dickinson And Company Needle actuator assembly for drug delivery system
US10751476B2 (en) 2016-06-09 2020-08-25 Becton, Dickinson And Company Actuator assembly for drug delivery system
AU2017286606A1 (en) 2016-06-14 2018-12-13 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
MX2019001341A (es) 2016-08-05 2019-07-04 Sanofi Pasteur Inc Composicion de conjugado de polisacarido neumococico multivalente-proteina.
JP7001687B2 (ja) 2016-08-05 2022-02-04 サノフィ パスツール インコーポレイティッド 多価肺炎球菌多糖体－タンパク質コンジュゲート組成物
JP7213549B2 (ja) 2016-08-22 2023-01-27 シーエイチオー ファーマ インコーポレイテッド 抗体、結合性断片、および使用の方法
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
RS63953B1 (sr) 2017-03-15 2023-02-28 Modernatx Inc Jedinjenje i kompozicije za intracelularnu isporuku terapeutskih sredstava
WO2018170336A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
WO2018175324A1 (en) 2017-03-20 2018-09-27 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
WO2018232120A1 (en) 2017-06-14 2018-12-20 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
BR112019027387A8 (pt) 2017-06-23 2022-12-06 Univ Maryland Composições imunogênicas
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS AND USES THEREOF
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS
CA3073211A1 (en) 2017-08-31 2019-03-07 Modernatx, Inc. Methods of making lipid nanoparticles
WO2019075167A1 (en) 2017-10-11 2019-04-18 Greenlight Biosciences, Inc. METHODS AND COMPOSITIONS FOR THE PRODUCTION OF NUCLEOSIDE TRIPHOSPHATE AND RIBONUCLEIC ACID
CN115804885A (zh) 2017-10-16 2023-03-17 贝克顿·迪金森公司 用于药物递送系统的驱动组件
WO2019109079A1 (en) 2017-12-01 2019-06-06 North Carolina State University Fibrin particles and methods of making the same
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
US20220409536A1 (en) 2018-09-19 2022-12-29 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
EP3852728A1 (en) 2018-09-20 2021-07-28 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
WO2020150372A1 (en) 2019-01-16 2020-07-23 Curza Global, Llc Antimicrobial compounds and methods
AU2020209170A1 (en) 2019-01-16 2021-08-12 Curza Global, Llc Antimicrobial compounds and methods
CA3128215A1 (en) 2019-01-31 2020-08-06 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
US20220280639A1 (en) 2019-07-31 2022-09-08 Modernatx, Inc. Compositions and methods for delivery of rna interference agents to immune cells
CN114728050A (zh) 2019-07-31 2022-07-08 圣诺菲·帕斯图尔公司 多价肺炎球菌多糖-蛋白质缀合物组合物及其使用方法
WO2021097061A1 (en) 2019-11-13 2021-05-20 Curza Global, Llc Antimicrobial compounds and methods
US20230285297A1 (en) 2020-01-31 2023-09-14 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2021173965A1 (en) 2020-02-28 2021-09-02 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
US20230390296A1 (en) 2020-10-30 2023-12-07 Keio University Novel treatment and prevention of sarcopenia-related diseases
CN116710116A (zh) 2020-10-30 2023-09-05 Ｘｅｎｏ－Ｉｎｔｅｒｆａｃｅ株式会社 β折叠股桥肽
TW202237068A (zh) 2020-12-09 2022-10-01 美商建南德克公司 製備脂質奈米顆粒的高通量方法及其用途
WO2022146931A1 (en) * 2021-01-03 2022-07-07 Fpin Llc Damped autoinjectors
WO2022192176A1 (en) 2021-03-09 2022-09-15 Massachusetts Institute Of Technology Branched poly(-amino esters) for the delivery of nucleic acids
TW202313065A (zh) 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023018817A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Truncated influenza neuraminidase and methods of using the same
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
WO2023059857A1 (en) 2021-10-08 2023-04-13 Sanofi Pasteur Inc. Multivalent influenza vaccines
WO2023081798A1 (en) 2021-11-05 2023-05-11 Sanofi Pasteur Inc. Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same
WO2023079113A1 (en) 2021-11-05 2023-05-11 Sanofi Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same
TW202333654A (zh) 2021-12-16 2023-09-01 美商現代公司 用於製備脂質奈米顆粒之方法
WO2023129963A1 (en) 2021-12-30 2023-07-06 Curza Global, Llc Antimicrobial compounds and methods
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023177579A1 (en) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Machine-learning techniques in protein design for vaccine generation
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
WO2024026482A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR824357A (fr) * 1936-10-21 1938-02-07 Procédé et dispositifs pour l'introduction de gaz et notamment d'air comprimé dans des ampoules hypodermiques et autres et la fermeture de ces ampoules
US2680439A (en) * 1948-09-08 1954-06-08 Arnold K Sutermeister High-pressure injection device
US2653602A (en) * 1950-06-17 1953-09-29 Becton Dickinson Co Injection device
US3217712A (en) * 1963-01-22 1965-11-16 Otto Konigslow Mfg Company Ampoule applicator
DE6944378U (de) * 1969-11-14 1970-04-16 Georg A Henke Gmbh Fa Selbsttaetiges injektionsgeraet
US3945383A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Unit dose ampul for jet injector
US4351692A (en) * 1981-01-07 1982-09-28 Ouellette Machinery Systems Apparatus and method for automatically filling and heat weld sealing lengths of plastic tubing
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US5026349A (en) * 1988-10-05 1991-06-25 Autoject Systems Inc. Liquid medicament injector system
US4902279A (en) * 1988-10-05 1990-02-20 Autoject Systems Inc. Liquid medicament safety injector
GB9118204D0 (en) * 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
US5681291A (en) * 1992-11-19 1997-10-28 Tebro S.A. Disposable auto-injector for prefilled syringes
KR100223616B1 (ko) * 1993-07-31 1999-10-15 웨스톤 테렌스 에드워드 바늘 없는 주사기
GB9504878D0 (en) * 1995-03-10 1995-04-26 Weston Medical Ltd Viscously coupled actuator
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101466614B (zh) * 2006-06-13 2013-05-01 诺信公司 液体分配注射器
CN101715371B (zh) * 2007-05-14 2012-09-05 Shl集团有限责任公司 输送装置
CN106975127A (zh) * 2011-02-04 2017-07-25 株式会社大赛璐 无针注射器
CN104736992A (zh) * 2012-08-30 2015-06-24 Lts勒曼治疗系统股份公司 用于将物质配送到介质中的测试装置
CN104968384A (zh) * 2012-12-17 2015-10-07 赛诺菲-安万特德国有限公司 药物输送装置

Also Published As

Publication number Publication date
HUP9902139A3 (en) 2000-01-28
AU716237B2 (en) 2000-02-24
CA2251256A1 (en) 1997-10-16
CZ326698A3 (cs) 1999-04-14
ID16590A (id) 1997-10-16
WO1997037705A1 (en) 1997-10-16
AU2038797A (en) 1997-10-29
JP2000508189A (ja) 2000-07-04
IL126356A0 (en) 1999-05-09
JP3450012B2 (ja) 2003-09-22
KR20000005273A (ko) 2000-01-25
NO984720L (no) 1998-10-09
ZA973011B (en) 1998-05-25
ATE231402T1 (de) 2003-02-15
YU43598A (sh) 1999-09-27
US6135979A (en) 2000-10-24
DE69718631D1 (de) 2003-02-27
IS4859A (is) 1998-10-06
RU2171119C2 (ru) 2001-07-27
SK139398A3 (en) 1999-03-12
PL329187A1 (en) 1999-03-15
BR9708767A (pt) 1999-08-03
ES2191822T3 (es) 2003-09-16
NO984720D0 (no) 1998-10-09
NZ332232A (en) 1999-08-30
BG102807A (en) 1999-04-30
EP0892648B1 (en) 2003-01-22
EP0892648A1 (en) 1999-01-27
DE69718631T2 (de) 2003-12-18
HUP9902139A2 (hu) 1999-11-29
TR199802021T2 (xx) 1999-01-18
GB9607549D0 (en) 1996-06-12

Similar Documents

Publication Publication Date Title
CN1220613A (zh) 医疗用弹力分送装置
US8343130B2 (en) Needleless injector
CN1217709C (zh) 具有两级注射速度的无针注射器
RU2218942C1 (ru) Безыгольный шприц для инъекции жидкости, содержащейся в предварительно наполненной ампуле
CN1177305A (zh) 弹簧驱动的撒播装置
JP4125517B2 (ja) 一時的に保持される押し込み手段を有する無針注射器
KR20060108683A (ko) 습식/건식 자동 주사기 조립체
KR20150003179A (ko) 분리력 특징을 가진 사전충전형 주사기
CN1188182C (zh) 由冲击管效应操作的、活性要素侧向预装的无针头注射器
EP1231961B1 (en) Injector assembly with driving means and locking means
HU226500B1 (en) Needleless syringe provided with modular reservoir
KR20040027899A (ko) 연료분사밸브
JP3759726B2 (ja) 薬液収容貯蔵器の圧迫によって働く針無注射器
KR100703258B1 (ko) 기둥
CN1276798C (zh) 流体制品分配设备
CN110769876A (zh) 注射器
JP3076820B1 (ja) 流動物圧入装置
JP2019505323A (ja) スライドする膜を有する無針注射装置
KR102334754B1 (ko) 압전 액추에이터를 이용한 플런저 구동 방식의 무침 주사 장치
KR100489735B1 (ko) 고압 가스 주입 배출용 공압 이탈 밸브

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication