CN1248451A - Shenmei soft and hard capsule - Google Patents
Shenmei soft and hard capsule Download PDFInfo
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- CN1248451A CN1248451A CN 98114357 CN98114357A CN1248451A CN 1248451 A CN1248451 A CN 1248451A CN 98114357 CN98114357 CN 98114357 CN 98114357 A CN98114357 A CN 98114357A CN 1248451 A CN1248451 A CN 1248451A
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- rose hip
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Abstract
The present invention relates to a Shenmei soft and hard capsule preparation, including hard capsule made up by using 27-32% of acanthopanax root extract powder, 26-32% of Dahurian rose fruit flesh fine powder and adding natural rose essence or citric acid, and soft capsule made up by using Dahurian rose fruit seed oil and adding vitamin E. These capsules can be matched for use, ad possess the functions of improving sleeping, fortifying brain, regulating blood pressure, softening blood vessel, reducing blood fat, and delaying senility. It is a pure natural health-care product, its nutrient is rich, its raw material resource is rich, and it is suitable for all people including diabetic.
Description
The present invention relates to a kind of health-caring capsule, specifically is a kind of health-caring capsule that contains wild plant Radix Et Caulis Acanthopanacis Senticosi and rose hip.
Radix Et Caulis Acanthopanacis Senticosi and rose hip all are wild plants that China abounds with, and at the medium-term and long-term Radix Et Caulis Acanthopanacis Senticosi of using of China's traditional medicine, confirm that it has the effect of " invigorating middle warmer benefit essence, hard muscles and bones, strong will ", also has strengthening the body resistance effect preferably simultaneously; Rose hip is the dry mature fruit (pseudocarp) of rosaceous plant Flos rosae multiflorae." Chinese medicine voluminous dictionary " calls that it acts on that two spleen invigorating are regulated the flow of vital energy, nourishing blood for regulating menstruation etc.It is reversal as fruit in normal employing among the people.Now existing human Radix Et Caulis Acanthopanacis Senticosi and rose hip are cooked beverage and health product, as Chinese patent 92109660.7 disclosed " a kind of preparation method that contains the nutrient health beverage electuary of Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis ", with the Radix Et Caulis Acanthopanacis Senticosi is that main component is made, do not contain rose hip, and contain rose hip powder or extractum in Chinese patent 93119310.9 disclosed " the anti-radiation health care beverage and preparation method thereof " composition, but do not contain Radix Et Caulis Acanthopanacis Senticosi, though above-mentioned two kinds of electuaries all have certain health-care tonic effect, but all exist certain limitation, effect is very not outstanding.Now Radix Et Caulis Acanthopanacis Senticosi and rose hip are lumped together as health product, especially make capsularly, also do not see.In addition, existing health promoting beverage great majority all contain sugar, are not suitable for the diabetes patient and the part old people takes.
The objective of the invention is Radix Et Caulis Acanthopanacis Senticosi extractum powder, rose hip meat essence powder and rose hip seed oil are organically fitted over together, make the organic combination of effective ingredient of " oily insoluble powder; the insoluble oil of powder ", provide remarkably productive to body-care, be suitable for comprising the your of diabetics, remarkably productive to body-care, pure natural, no any poison are paid the health product Shenmei soft and hard capsule of effect.
The present invention is made up of Radix Et Caulis Acanthopanacis Senticosi extractum powder, rose hip meat essence powder, rose hip seed oil, vitamin E, natural rose essence or citric acid, and its percentage by weight is Radix Et Caulis Acanthopanacis Senticosi extractum powder 27-32%, rose hip meat essence powder 26-32%, wild rose seed oil 36-42%, vitamin E 0.98-0.99%, natural rose essence or citric acid 0.01-0.02%.
Manufacture method of the present invention is: by proportioning Radix Et Caulis Acanthopanacis Senticosi extractum powder, rose hip meat essence powder are added natural rose essence citric acid flavoring, stir, dry, adorn capsule, plastic uptake pressing plate, be refined into hard capsule; The VE injection soft capsule that wild rose seed oil is added antioxidation is refined into soft capsule, and the soft or hard capsule is supporting to be taken.
Soft or hard capsule of the present invention, supporting taking can be played and be improved sleep, nourishing the brain and improving intelligence, blood pressure regulation, vessel softening, comfortable, the function in delaying senility of blood fat reducing.
Be some researchs and experimental result below to Radix Et Caulis Acanthopanacis Senticosi, rose hip.
Studies show that one of primary raw material of the present invention Radix Et Caulis Acanthopanacis Senticosi extractum comprises eight seed amino acids, multivitamin, various trace elements, multiple organic acid, the coumarin chemical compound of needed by human, and a-linolenic acid oil, r-linolenic acid wet goods.Confirm through the LD50 of Heilongjiang Province college of traditional Chinese medicine subacute toxicity test, this product safety non-toxic, and carry out the reaction that is negative of Ames experimental result, show this product non-carcinogenesis.
Below be the experimental result that rose hip is studied: give the inspection of examination method with the plant chemical ingredient system, find to contain in the rose hip chemical constituent of organic acid, flavonoid, Coumarins, sterol, triterpenes, polyene hydrocarbons, Saponin, aminoacid, protein, saccharide, fatty oil, volatile oil, vitamin E, multiple complexity.And then the kind of trace element in the rose hip is identified with tannin plasma spectroscopies such as atomic absorption spectrography (AAS) and inductance couplings, and measured its content, found that 28 kinds of elements such as containing K, Na, Ca, Mg, Fe, Al, Zn, Cu, P, Ba, Sr, Ni, B, Cr, Cd, Pd, Co, Ag, Sn, As, Si, Ba, Se, Sb, Au, Bi, Ca in the rose hip, wherein except that the K that belongs to constant, Na, Ca, Mg etc., still contain other clearer and more definite trace element of abundant biological activity;
Use Hitachi's 8350 type high-speed amino acid analyzers that free amino acid in the rose hip and hydrolysis amino acid have been carried out evaluation and assay, found that and contain 17 seed amino acids in the rose hip, wherein threonine, valine, isoleucine, leucine, methionine, phenylalanine and lysine etc. be all human body can not self synthetic essential amino acids.Aminoacid relative amount by weight, in free amino acid, with arginine, phenylalanine, lysine, proline and serine for the highest; In hydrolysis amino acid, then with glutamic acid, aspartic acid, arginine, leucine, valine and lysine for the highest.
Contain a large amount of fatty oils in the rose hip, to its fatty oil with evaluations such as gas chromatogram-mass spectrum and gas chromatographys and carried out fatty acid compositional analysis.Found that, contain Palmic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, eicosadienoic acid and eicosatrienoic acid in its fatty oil.The percentage composition of fatty acid is Palmic acid 15.8%, stearic acid 6.7%, oleic acid 35.3%, linoleic acid 18.8%, linolenic acid 12.3%, other acid 9.2% in its fat wax oil.In addition,---mass spectrography also identifies and contains glycosyl acetas, n-hexyl furan, 2 in this fatty oil---furyl valeral and sitosterol with gas chromatogram.
With high performance liquid chromatography (HPLC), thin layer chromatography scanning method and fluorescence method etc. vitamin kind in the rose hip and content are also measured, found in the rose hip except that the vitamin C known to containing before, beta-carotene, vitamin E, still to contain vitamin B
1And B
2
With silica gel column chromatography the rose hip methanolic extract is separated, the result isolates two kinds of crystallizations.Measure and spectrum analysis through these two kinds of crystallizations being carried out physicochemical constant, identify that at last brilliant I is a betulic acid, brilliant II is an oleanolic acid.
The bioactivity research of rose hip
1) LD
50Study with sub-acute toxicity test: measure with Sun Shi improvement Guan Shi method, throw the LD that gives rose hip extractum liquid in the intraperitoneal mouse
50Be 6.08 ± 0.2g/kg, can be considered rose hip does not thus have toxicity.
With rose hip extract to irritate stomach mode and rat, every day secondary, dosage is respectively 1.03g/kg, 2.57g/kg, throw and 35 continuously, discovery does not all have obvious influence to rats'liver, renal function and peripheral hemogram, pathological section shows that the organizational structure of the rat heart, liver, kidney is not all had obvious influence, shows that the toxicity of rose hip is very low.
2) Ames experimentation: with rose hip extractum serves as to detect the inspection product, selects Salmonella typhimurium histidine defect type bacterial strain TA for use
98And TA
100Two kinds of bacterial strains carry out Salmonella reversion test with scraps of paper bayonet point and the plate method of mixing.The result proves, the reaction that is negative of rose hip extractum scraps of paper point examination method Salmonella reversion test.Mix in the method at plate, no matter be+sq or-test of sq in, in each of each concentration time test, its clump count is compared from beaming back parameter with corresponding, its MR value does not all reach 2, more surpasses more than 2, and the reaction that also is negative of Salmonella reversion test that rose hip extractum plate mixes method is described thus.
3) resisting fatigue and resisting oxygen lack: loading swimming test and white mice hypoxia endurance test result that white mice is carried out prove that rose hip has significantly (P＜0.05) resisting fatigue and resisting oxygen lack.
4) class sex hormone function: the chickling test shows, throws with the weightening finish of rose hip group chickling cockscomb and is significantly higher than matched group (P＜0.05), shows that rose hip has the class gonadotropic Effect.
5) promote DNA, RNA and protein synthesis: the rose hip extract powder is thrown and white mice to irritate the stomach mode, thrown continuously, put to death with after seven days.Getting femur bone marrow and measure, find at [3H]---Tdr mixes in the DNA synthetic test, and throwing is 0.87 ± 0.07 with the incorporation of rose hip extract powder group, and matched group is 0.24 ± 0.04, two group differences significantly (P＜0.01); At [3H]---Ur mixes in the RNA synthetic test, and the administration group is 0.94 ± 0.09, and matched group is that there were significant differences between 0.49 ± 0.07, two groups (P＜0.01); At (3H)---Leu mixes in the protein synthesis test, and the administration group is 0.14 ± 0.04, and matched group is also to have significant difference (P＜0.01) between 0.09 ± 0.05, two groups.Above-mentioned experimental result shows: rose hip has the effect that promotes DNA, RNA and protein synthesis.
6) monoamine oxidase, MAO inhibitory action: the rose hip extract powder is thrown and mice, measure the content of MAO in its brain, the content that found that MAO in the administration group mouse brain is 0.195 ± 0.05, matched group is 0.259 ± 0.109, as seen the content of MAO is starkly lower than matched group (P＜0.05) in the administration group mouse brain, thereby shows that rose hip has the ammoxidation single enzyme inhibitory action.
7) anti-aging effects: rose hip extract powder, the total Saponin of rose hip and rose hip solubility glycoside are added respectively in the fruit bat culture medium, observe the life-span of fruit bat.The result shows that the average life of rose hip extract powder group fruit bat prolongs 10.84% and 15.93% than positive controls, and the total Saponin group of rose hip prolongs 16.6% and 15.56%; Rose hip solubility glycoside group prolongs 13.12% and 18.71%.More than three groups compare with the Ganoderma positive controls, it is close that life span of drosophila melanogaster prolongs amplitude.
Rose hip is also investigated the influence of fruit bat behavior and reproductive performance, and experimental technique is this random packet of fruit bat works that will just sprout wings, cultivates after 40 days, tests the person's of remaining ability of circling in the air one by one.The result shows: the volant individual percentage number average of each experimental group of rose hip and positive controls is higher than matched group, and, the 41-48 days average layings of each female fly, each rose hip group is high than matched group all.
Rose hip is studied the influence of mouse life, and the result also proves that the average life of rose hip extract powder administration group mice prolongs 94 days than matched group, has prolonged 16.38%.Two groups of food consumptions are close, illustrate that there is not the interference of Mccay effect in The above results.
Above result shows that rose hip truly has the effect of anti-ageing life-prolonging.
8) effect of raise immunity: mice is divided into the normal control group, and cyclophosphamide (CYT) administration group and CYT+ rose hip extract powder group experimentize.As seen the result CYT group mice administration withered, movable slow, hunchbacked, coolness of extremities of hair color after 18 days, becomes thin.CYT+ rose hip extract powder group mice is then movable normal, and hair color is flourish as normality, does not see and becomes thin.The immunology digital examination is the result show, CYT group mouse humoral immune, cellular immune function obviously reduce, and the above index of CYT+ rose hip extract powder group all obtains good setting upright, notable difference (P＜0.05) is arranged between two groups, and obviously the immunologic function of CYT+ rose hip extract powder group group fails to return to normal level.This result shows that rose hip resists abominable factor good effect is arranged.
9) rose hip extract is to cardiovascular pharmacological action and the existing report of toxicity.
Be the clinical research result below:
The rose hip extract powder is used for clinical, observes patient's 150 examples in 45-90 year, matched group 50 examples.Rose hip is thrown with the patient and is taken every day 2 times, and continuous use three months is respectively once experienced before and after medication comprehensively, and measured every aging index, and SOD, T in the inspection group
3, T
4Content.The result proves, after taking rose hip, compare with matched group, patient's diet desires 39% raising, statistical procedures has significant difference (0.05＞P＞0.01), rate of increase 76% is measured in memory, has compared highly significant meaning (P＜0.01) with matched group, and visual acuity is measured rate of increase 76%, compare other visible stool of highly significant meaning (0.01＜P＜0.05) with matched group and taken a turn for the better 8%, muscle power increment rate 18%, heart rate is basicly stable, and does not have anyone by existing adverse side effect.Especially to the hyperpietic, its blood pressure of back of taking medicine can drop to normal range, and very stable.Be also shown in patients with coronary heart disease angina pectoris attacks number of times is reduced, cerebrovascular disease patient's muscle power, the mental enhancing, alopecia person's renewable hair, verruca senilis disappears, comes off etc.
Superization thing dismutase (SOD) is extensively to be present in intravital resistance to exceed the loss limit and hinder the main enzyme of body with the defence free radical, in the body normal physiological activity, play defying age, anti-inflammatory, antitumor, radioprotective, the effect of anti-immune disease, after taking rose hip extract powder preparation, check its influence to SOD, find that the content of pill taker's (37 example) SOD is not 177.90 ± 39.88u/ml, taking medicine just, the content of (77 example) SOD is 203.32 ± 42.87u/ml, with the preceding comparison of taking medicine, the content of SOD obviously increases after taking medicine, and statistical procedures result shows that its difference has significance meaning (P＜0.05).
After taking rose hip, T among the patients serum
3, T
4All have significantly before (being serum trilute and thyroxine level) takes medicine and increase, its statistical result is respectively difference highly significant (P＜0.01) and remarkable (P＜0.05).
Use " examining of human body degree monitoring system ", the pharmacological action to human body integral and each main system of rose hip is monitored.Adopt the method for stepwise regression analysis showed, set up mathematical model, and carry out the overall merit of human senility degree and each organ function situation by electronic computer.In this way the middle-aged and elderly people of taking the rose hip extract powder is carried out clinical observation, the result proves, the rose hip extract powder has stimulating appetite, hypnotic, improve muscle power and energy and adaptive faculty, improve brain function, make sensory function, motor function, equilibrium function, the from outside function of cone, thinking memory function etc. all is significantly improved, for causing cerebral ischemia owing to cerebral arteriosclerosis and changing the old brain syndrome that causes with increasing the aging brain parenchymal cell degeneration that produces of order, after with the rose hip extract powder, can improve cerebral blood flow, increasing blood flow speed changes disturbance of cerebral circulation, recovers brain function, and blood viscosity lowering, can avoid taking place cerebrovascular disease.Simultaneously, cardio-pulmonary function also there is in various degree improvement.Clinical observation also proves, takes the generation that has no side effect in this product process.
Embodiment:
Radix Et Caulis Acanthopanacis Senticosi extractum powder 29%, rose hip meat essence powder 30%, wild rose seed oil 40%, vitamin E 0.99%, citric acid 0.01% by weight percentage, get above-mentioned various main ingredient, with Radix Et Caulis Acanthopanacis Senticosi extractum powder, rose hip meat essence powder, adding citric acid flavoring, stir oven dry, the dress capsule, aluminium foil plastic uptake pressing plate is made hard capsule, with gelatin foil wild rose seed oil is added antioxidant VE, make soft capsule with encapsulating machine, the soft or hard capsule is supporting to be taken.
Claims (1)
1, a kind of Shenmei soft and hard capsule, it is made up of Radix Et Caulis Acanthopanacis Senticosi extractum powder, rose hip meat essence powder, rose hip seed oil and vitamin E, natural rose essence or citric acid, and the percentage by weight that it is characterized in that them is Radix Et Caulis Acanthopanacis Senticosi extractum powder 27-32%, rose hip meat essence powder 26-32%, wild rose seed oil 36-42%, vitamin E 0.98-0.99%, natural rose essence 0.01-0.02%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98114357A CN1067269C (en) | 1998-09-24 | 1998-09-24 | Shenmei soft and hard capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98114357A CN1067269C (en) | 1998-09-24 | 1998-09-24 | Shenmei soft and hard capsule |
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| Publication Number | Publication Date |
|---|---|
| CN1248451A true CN1248451A (en) | 2000-03-29 |
| CN1067269C CN1067269C (en) | 2001-06-20 |
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ID=5224027
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98114357A Expired - Fee Related CN1067269C (en) | 1998-09-24 | 1998-09-24 | Shenmei soft and hard capsule |
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| Country | Link |
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| CN (1) | CN1067269C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8075910B2 (en) | 2004-05-20 | 2011-12-13 | Pbm Pharmaceuticals, Inc. | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions |
| CN104522666A (en) * | 2015-01-04 | 2015-04-22 | 吉林省农业科学院 | Dahurian rose fruit seed oil and purple perilla seed oil composite microcapsule capable of assisting in reducing blood fat and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066600A (en) * | 1992-07-03 | 1992-12-02 | 刘长海 | The preparation method of dual ginsengs tonic health medicine for taken with mixed in water instautly |
| CN1129536A (en) * | 1992-10-30 | 1996-08-28 | 黑龙江省科学院汇通新技术公司 | Anti-radiation health-care beverages and process therefor |
-
1998
- 1998-09-24 CN CN98114357A patent/CN1067269C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8075910B2 (en) | 2004-05-20 | 2011-12-13 | Pbm Pharmaceuticals, Inc. | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions |
| US8173160B2 (en) | 2004-05-20 | 2012-05-08 | Pbm Pharmaceuticals, Inc. | Compositions comprising edible oils and vitamins and/or minerals and methods for making the compositions |
| CN104522666A (en) * | 2015-01-04 | 2015-04-22 | 吉林省农业科学院 | Dahurian rose fruit seed oil and purple perilla seed oil composite microcapsule capable of assisting in reducing blood fat and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1067269C (en) | 2001-06-20 |
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