CN1284379A - Production process of salt algae powder and preparation of salt algae powder capsule - Google Patents
Production process of salt algae powder and preparation of salt algae powder capsule Download PDFInfo
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- CN1284379A CN1284379A CN 00119359 CN00119359A CN1284379A CN 1284379 A CN1284379 A CN 1284379A CN 00119359 CN00119359 CN 00119359 CN 00119359 A CN00119359 A CN 00119359A CN 1284379 A CN1284379 A CN 1284379A
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- salt
- salt alga
- alga powder
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Abstract
The present invention belongs to the technology of culturing and separating microbial algae and producing health food. Salt alage is cultured in enclosed culture pond, salt algae paste is spray dried into algae powder; and algae powder is further produced through extrusion process into soft salt algae powder capsule containing salt algae powder, corn oil and vitamin E. As one green instant health food, the salt algae powder capsule has the functions of regulating immunity, inhibiting tumor and resisting radiation.
Description
The invention belongs to both culturing microalgae, separation and health food processing technology.
Salt alga (Dunaliella salina) belongs to the unicellular alga of Chlorophyta, salt genus, frond contains rich in protein, there are 18 seed amino acids and multivitamin and a large amount of beta-carotene can reach the 5-10% of dry weight, also contain the necessary various trace elements of human body simultaneously.Beta-carotene has the free radical of catching, in conjunction with effects such as active oxygen, antioxidation, antitumor, enhancing immunity and slow down aging.
Chinese patent CN1044200A, CN1044277A disclose " salt alga outdoor breeding method and breed pond " and " extracting method of carotene in the salt alga ".Above-mentioned patented technology is mainly invented outdoor open breed pond and salt alga cultural method.Its collecting method is to adopt the flocculating agent gentle float glass process of flocculating.Culturing Dunaliella salina (being commonly called as salt alga) mainly is in order to extract carotene.The salt alga of gathering with this method can only also have many active substances to the human body beneficial to fail to obtain to utilize as extracting carotene easily degraded again in the algae-residue after the extraction, its constituent is unclear.Secondly, outdoor open breed pond is subjected to meteorological condition effect bigger, and the breeding production phase is short.
The preparation method that the purpose of this invention is to provide a kind of salt alga powder, it is to adopt the closed culture chamber, reduced the culture fluid pollution, solved because of the rainfall loss that breed causes to salt alga, improve the utilization rate of salt alga, simplified production technology, solved the separation problem of salt alga, prolong the salt alga breeding production phase, improved the output and the quality of outdoor cultivating large area salt alga.
Another object of the present invention provides a kind of salt alga powder preparation of soft capsule method.For people provide a kind of new environmental protective hygienic food, instant has immunomodulating, suppresses tumor, radiation-resistant function.
The prescription (every) of salt alga powder soft capsule is among the present invention: salt alga powder (natural carrot cellulose content＞3%) 140～150mg, vitamin E 1～2mg, Semen Maydis oil 350mg.
The present invention is that (weight ratio is 2～4: 5～9 with exsiccant salt alga powder and Semen Maydis oil, be preferably 3: 7), vitamin E (for salt alga powder and 2 of Semen Maydis oil gross weight～4 ‰) mixes, make uniform pasty mass, adopt the extrusion legal system to be equipped with into the salt alga powder capsule again.
The concrete steps of the invention process invention: utilize have agitating device outdoor closed culture pond under field conditions (factors), adopt through disinfectant sea water, lake water and cultivate salt alga (index of culture fluid: NaCL15%～20%, PH7～9).The culture fluid inoculum density is 10～150,000/ml.In incubation, add N, P, C, Fe element (0.2～0.5mM carbamide, 0.3mMKH
2PO
4, 0.3mMFeCl
3, 8mMNaHCO
3) etc., culture after 7～10 days, treat that the culture fluid Biomass reaches 40～600,000/ml and can adopt physical method (centrifugal, micro-filtration) to separate, the stillness of night is returned culture pond and continues to use.Algae after the separation is stuck with paste and carries out spray drying.
The present invention adopts the method and the facility of large tracts of land closed culture salt alga, cultures the pond to be: cell body has armored concrete to be paved into, and there is the isolation strip centre, and agitating device is arranged in the pond, and culture fluid is circulated; The pond is provided with by steel etc. and makes the awning that skeleton, fiberglass and glass are done wall, top, around the canopy by the ventilation window.This breed pond need not be keeped in repair all the year round, can reduce culture fluid and pollute, and improves algae opaque amount, prolongs the breeding production phase, and annual production can improve more than 20%.
The present invention adopts the high-speed dish piece centrifuge to separate salt alga, and any chemical substance is not added in separation process, and the stillness of night after the separation can directly be returned and culture the pond use.
The invention solves food grade salt alga collecting method.The present invention adopts the high-speed dish piece centrifugation apparatus, has solved food grade salt alga powder separation problem, and the stillness of night after the separation can directly be returned and culture the pond use, does not need any processing.
The present invention has prolonged the salt alga breeding production phase, has improved the output and the output of culturing salt alga greatly; Produce food grade algae powder, develop the afterproduct of high added value.
The present invention is an environmental protective hygienic food, and instant has immunomodulating, suppresses tumor, radiation-resistant function.
Salt alga powder soft capsule product shows that to the large and small Mus oral administration acute toxicity test of two kinds of sexes LD50 is all greater than 15g/kg by diseases prevention center, Tianjin.According to the acute toxicity classification, this product belongs to nontoxic level.Three genetic toxicity test results are all negative.The immunomodulating result of the test is positive: the dosage group is compared difference in delayed allergy ear swelling method with matched group significance (P＜0.05).Toes thicken in the method, and basic, normal, high three dosage groups are compared obvious enhancing with matched group, and each dosage group difference all has significance (P＜0.05).Low, middle dosage group is compared antibody-producting cell in the antibody-producting cell test with matched group obviously increases (P＜0.05).The result shows that this product has immunoregulation effect.It is positive to suppress the tumor result: heavy the comparing with matched group of each dosage group tumor-bearing mice tumor all has notable difference (P＜0.05).So this product has function of tumor inhibition.The radioprotective test of being radiated the salt alga carotene that is carried out by the Chinese Academy of Medical Sciences shows that carotene has the effect of radioprotective and leukocyte increasing.In sum, this product belongs to nontoxic marine organisms goods, has immunomodulating, radioprotective and radioprotective, rises the contour painting energy.
Outstanding substantial characteristics of the present invention and good effect can be embodied from following embodiment, but they are not that the present invention is imposed any restrictions.
Embodiment 1
Salt after the sterilization is pumped into the breed pond as culture fluid, inoculate to culturing the pond from algae kind pond, inoculum density is 10～150,000/ml, disposable then adding 0.2mM carbamide, 0.3mMKH
2PO
4, 0.3mMFeCl
3, 8mMNaHCO
3As nutritive salt.Stirred 0.5 hour every 2～3 hours daytime, cultures and can gather after 7 days.With pump algae liquid is sent into disk plate centrifuge and separate, the algae liquid after the separation enters hold-up tank, returns after 1 hour and cultures the pond.Isolated algae paste enters spray dryer and is drying to obtain.The inlet temperature of spray dryer is 180 ℃, and outlet temperature is 85 ℃.Exsiccant salt alga powder is mixed with Semen Maydis oil, vitamin E, make uniform pasty mass, make capsule with the extrusion method, then through milling treatment of colloid, every capsules contains salt alga powder 140mg, Semen Maydis oil 350mg, vitamin E 1.5mg.
Claims (7)
1, a kind of salt alga powder soft capsule is characterized in that it comprises salt alga powder, vitamin E and Semen Maydis oil composition; The weight ratio of said salt alga powder and Semen Maydis oil is 2～4: 5～9, and vitamin E is 2～4 ‰ of salt alga powder and a Semen Maydis oil gross weight.
2, according to the said salt alga powder soft capsule of claim 1, it is characterized in that natural carrot cellulose content＞3% in the said salt alga powder.
3, according to the said salt alga powder soft capsule of claim 1-2, the weight ratio that it is characterized in that said salt alga powder and Semen Maydis oil is 3: 7.
4, the preparation method of the said salt alga powder of claim 1 is characterized in that it is through following step:
(1) under field conditions (factors), disinfectant sea water, lake water are put into the outdoor closed culture pond that has agitating device, NaCL15%～20% wherein, PH is 7～9;
(2) add the salt algae culturing liquid, inoculum density is 10～150,000/ml, adds nutrient, and stirred 0.5 hour every 2～3 hours daytime, cultured 7～10 days;
(3) treat that the culture fluid Biomass reaches 40～600,000/ml and can adopt centrifugalize or micro-filtration to separate, the stillness of night is returned culture pond and continues to use;
(4) algae after separating is stuck with paste spray drying in spray dryer, and inlet temperature is 180 ℃, and outlet temperature is 85 ℃, get final product salt alga powder.
5,, it is characterized in that said nutrient is N, P, C, Fe element, disposable adding 0.2～0.5mM carbamide, 0.3mM KH according to the preparation method of the said salt alga powder of claim 4
2PO
4, 0.3mM FeCl
3With 8mM NaHCO
3
6,, it is characterized in that said centrifugalize is to adopt the high-speed dish piece centrifuge to separate according to the preparation method of the said salt alga powder of claim 4.
7, according to the preparation method of the said salt alga powder of claim 4, it is characterized in that constituting of said closed culture pond: cell body is paved into by armored concrete, and there is the isolation strip centre, and agitating device is arranged in the pond, and culture fluid is circulated; The pond is provided with by steel and makes skeleton, and fiberglass and glass are made the awning on wall, top, and the ventilation window is arranged around the canopy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00119359A CN1110317C (en) | 2000-06-29 | 2000-06-29 | Production process of salt algae powder and preparation of salt algae powder capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00119359A CN1110317C (en) | 2000-06-29 | 2000-06-29 | Production process of salt algae powder and preparation of salt algae powder capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1284379A true CN1284379A (en) | 2001-02-21 |
| CN1110317C CN1110317C (en) | 2003-06-04 |
Family
ID=4587616
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00119359A Expired - Fee Related CN1110317C (en) | 2000-06-29 | 2000-06-29 | Production process of salt algae powder and preparation of salt algae powder capsule |
Country Status (1)
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|---|---|
| CN (1) | CN1110317C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8075910B2 (en) | 2004-05-20 | 2011-12-13 | Pbm Pharmaceuticals, Inc. | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions |
| CN104367572A (en) * | 2014-10-22 | 2015-02-25 | 中盐工程技术研究院有限公司 | Natural dunaliella salina beta-carotene vitamin E soft capsule |
| CN106072652A (en) * | 2016-06-13 | 2016-11-09 | 合肥赛为智慧医疗有限公司 | A kind of salt algae powder/DHA goods |
| CN106072670A (en) * | 2016-06-13 | 2016-11-09 | 合肥赛为智慧医疗有限公司 | A kind of salt alga is combined Bovine Lactoferrin powder and preparation method thereof |
| CN106261059A (en) * | 2015-06-12 | 2017-01-04 | 胡培芹 | A kind of preparation method of salt alga powder |
| CN107982513A (en) * | 2017-11-29 | 2018-05-04 | 北京艾沃森科技有限公司 | A kind of salt algae earthworm protein compound recipe health products and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1020285C (en) * | 1990-01-25 | 1993-04-14 | 轻工业部制盐工业科学研究所 | Method for outdoor cultivating Dunaliella and its culture pool |
| CN1085752A (en) * | 1993-07-25 | 1994-04-27 | 赵承侠 | Compounded beverage containing salt alga |
-
2000
- 2000-06-29 CN CN00119359A patent/CN1110317C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8075910B2 (en) | 2004-05-20 | 2011-12-13 | Pbm Pharmaceuticals, Inc. | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions |
| US8173160B2 (en) | 2004-05-20 | 2012-05-08 | Pbm Pharmaceuticals, Inc. | Compositions comprising edible oils and vitamins and/or minerals and methods for making the compositions |
| CN104367572A (en) * | 2014-10-22 | 2015-02-25 | 中盐工程技术研究院有限公司 | Natural dunaliella salina beta-carotene vitamin E soft capsule |
| CN106261059A (en) * | 2015-06-12 | 2017-01-04 | 胡培芹 | A kind of preparation method of salt alga powder |
| CN106072652A (en) * | 2016-06-13 | 2016-11-09 | 合肥赛为智慧医疗有限公司 | A kind of salt algae powder/DHA goods |
| CN106072670A (en) * | 2016-06-13 | 2016-11-09 | 合肥赛为智慧医疗有限公司 | A kind of salt alga is combined Bovine Lactoferrin powder and preparation method thereof |
| CN107982513A (en) * | 2017-11-29 | 2018-05-04 | 北京艾沃森科技有限公司 | A kind of salt algae earthworm protein compound recipe health products and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1110317C (en) | 2003-06-04 |
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