CN1499926A - 改进的无支链淀粉可食用膜组合物及其制备方法 - Google Patents
改进的无支链淀粉可食用膜组合物及其制备方法 Download PDFInfo
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Abstract
本发明提供改进和便宜的无支链淀粉可食用膜组合物及其制备方法。无支链淀粉可食用膜组合物包括有效量的至少一种成膜剂、至少一种容积填充剂、至少一种增塑剂和任选的至少一种增稠剂。药物和其它添加剂也可以加入至可食用膜中。本发明还提供使用所述的无支链淀粉可食用膜组合物传递药物、治疗口臭、治疗口腔干燥和治疗牙斑或齿龈炎的方法。
Description
发明背景
本发明一般涉及可食用膜。更具体地,本发明涉及无支链淀粉的可食用膜组合物及其制备方法。
保持口腔清洁和呼吸清新有时可能是困难或不便的,取决于所期望的呼吸清新的性质和须进行呼吸清新的场合。使用各种各样的设备和组合物刷拭、使用牙线清除牙垢(flossing)、清洁舌头和漱口是普遍的口腔护理操作,非常适合于家中隐私。但是,这种设备和组合物在用于远离家居的地方是不太方便的,其浴室的设施可能缺乏、不能获得或不卫生。但是,较少引人注目的口用产品已经开发出来,其中包括呼吸清新胶、锭剂、口腔喷雾剂和可食用膜。
许多可食用薄膜由支链淀粉制成,支链淀粉可用于向口腔传递药物或其它药剂如香料和甜味剂。但支链淀粉是用于制备这种可食用膜的昂贵成份,因为它在膜配制工业中可供性有限。其它如改性淀粉和纤维素类可食用原料已经作为支链淀粉的替代品用于可食用膜组合物中。不幸的是,这些材料一般都缺少一个或多个支链淀粉所预期的膜特性。其特性包括如:快速溶解性、柔韧性、非吸湿性、口感清洁、香味纯正和易制备性能。
因此,在膜配制工业中,需要一种改进的无支链淀粉可食用膜组合物及其制备方法,所述组合物含有可供性广、费用低、易制备并且呈现出在基于支链淀粉的可食用膜中发现的所期望的膜特性的膜成份。
发明概述
本发明提供改进的无支链淀粉可食用膜组合物及其制备方法。此外,本发明还提供使用改进的无支链淀粉可食用膜组合物传递药物、治疗口臭、治疗口腔干燥和治疗牙斑或齿龈炎的改进的方法。
为此,本发明提供一种含有有效量的至少一种成膜剂、有效量的至少一种容积填充剂和有效量的至少一种增塑剂的无支链淀粉可食用膜组合物。
在一实施方案中,有效量的成膜剂为组合物干重的约10%-约90%。
在一实施方案中,成膜剂选自:纤维素醚、改性淀粉、天然胶、可食用聚合物、水状胶体粉、海藻提取物、陆地植物提取物、它们的衍生物及其组合。
在一实施方案中,有效量的容积填充剂为组合物干重的约10%-约90%。
在一实施方案中,容积填充剂选自:碳酸镁、碳酸钙、磷酸钙、硫酸钙、硅酸镁、硅酸铝、碎石灰、粘土、滑石、二氧化钛、微晶纤维素、纤维素聚合物、它们的衍生物及其组合。
在一实施方案中,有效量的增塑剂为多达组合物干重的约20%。
在一实施方案中,增塑剂选自:甘油、聚乙二醇、丙二醇、多元醇、氢化淀粉水解液、玉米糖浆、它们的衍生物及其组合。
在一实施方案中,无支链淀粉可食用膜组合物还包括有效量的至少一种增稠剂。
在一实施方案中,增稠剂是至少一种纤维素醚。
在一实施方案中,无支链淀粉可食用膜组合物还包括有效量的至少一种药物。
在一实施方案中,药物选自:pH控制剂、口腔护理剂、呼吸清新剂、药剂、滋补剂(nutraceutial agent)、唾液刺激剂、维生素、矿物、它们的衍生物及其组合。
在一实施方案中,无支链淀粉可食用膜组合物还包括有效量的至少一种添加剂。
在一实施方案中,添加剂选自:表面活性剂、粘合剂、着色剂、甜味剂、食用香料、香精、乳化剂、它们的衍生物及其组合。
本发明也提供一种制备无支链淀粉可食用膜组合物的方法,所述方法包括下列步骤:提供有效量的至少一种成膜剂,以及随成膜剂一起添加有效量的至少一种容积填充剂和有效量的至少一种增塑剂,从而生产出无支链淀粉可食用膜组合物。
在一实施方案中,该方法还包括添加有效量的至少一种增稠剂以形成无支链淀粉可食用膜组合物的步骤。
另外,本发明也提供一种传递药物的方法,其步骤包括:向个体提供一种膜中含有有效量的至少一种药物的无支链淀粉可食用膜组合物,其中膜组合物还包含有效量的至少一种成膜剂、有效量的至少一种容积填充剂、和有效量的至少一种增塑剂;以及通过个体口部消耗膜组合物而将药物释放至口腔以便吸收。
在上述方法的一实施方案中,药物选自:pH控制剂、口腔护理剂、呼吸清新剂、药剂、滋补剂、唾液刺激剂、维生素、矿物、它们的衍生物及其组合。
在上述方法的一实施方案中,方法还包括将有效量的至少一种增稠剂加入到膜组合物中的步骤。
此外,本发明也提供一种治疗口臭的方法,其步骤包括:向个体提供一种含有有效量的至少一种呼吸清新剂的无支链淀粉可食用膜组合物,其中膜组合物还包含有效量的至少一种成膜剂、有效量的至少一种容积填充剂和有效量的至少一种增塑剂;和通过个体口部消耗膜组合物而将呼吸清新剂释放至口腔中以治疗口臭。
在上述方法的一实施方案中,方法还包括将有效量的至少一种增稠剂加入到膜组合物中的步骤。
另外,本发明还提供一种治疗口腔干燥的方法,步骤包括:向个体提供一种含有有效量的至少一种唾液刺激剂的无支链淀粉可食用膜组合物,其中膜组合物还包含有效量的至少一种成膜剂、有效量的至少一种容积填充剂和有效量的至少一种增塑剂;以及通过个体口部消耗膜组合物而将唾液刺激剂释放至口腔中以治疗口腔干燥。
在上述方法的一实施方案中,方法还包括将有效量的至少一种增稠剂加入到膜组合物中的步骤。
在另一实施方案中,本发明提供一种治疗牙斑或齿龈炎的方法,步骤包括:向个体提供一种含有有效量的至少一种口腔护理剂的无支链淀粉可食用膜组合物,其中膜组合物还包含有效量的至少一种成膜剂、有效量的至少一种容积填充剂和有效量的至少一种增塑剂;以及通过个体口部消耗膜组合物而将口腔护理剂释放至口腔中以治疗牙斑或齿龈炎。
在上述方法的一实施方案中,方法还包括将有效量的至少一种增稠剂加入到膜组合物中的步骤。
因此,本发明的优点是提供一种含有可供性广的成份的改进的无支链淀粉可食用膜组合物及其制备方法。
本发明的另一个优点是提供一种便宜的改进的无支链淀粉可食用膜组合物及其制备方法。
本发明的另一个优点是提供一种呈现快速溶解、柔韧性、非吸湿性、口感清洁、香味纯正和易制备性的无支链淀粉可食用膜组合物。
本发明的又一优点是提供一种包含具有可供性广的成份的无支链淀粉可食用膜组合物的口香糖组合物。
另外,本发明的另一优点是提供一种利用具有可供性广的成份的无支链淀粉可食用膜组合物向个体传递药物的方法,所述组合物对于口腔是生理上可接受的,能很适合地附着于口腔表面,并快速溶解以通过敞开的伤口或粘膜向口腔释放药物便于吸收。
此外,本发明的另一优点是提供一种利用具有成膜剂的无支链淀粉可食用膜组合物通过向个体口腔传递有效量的至少一种呼吸清新剂而治疗口臭的改进方法,所述组合物将呼吸清新剂捕获于口腔中以提供持续的呼吸清新功效。
本发明的又一优点是提供一种利用具有成膜剂的无支链淀粉可食用膜组合物通过向个体口腔传递有效量的至少一种唾液刺激剂而治疗口腔干燥的改进方法,所述组合物将唾液刺激剂捕获于口腔中来提供持续的唾液腺刺激。
本发明其他优点是提供一种利用具有成膜剂的无支链淀粉可食用膜组合物通过向个体口腔传递有效量的至少一种口腔护理剂而治疗牙斑或齿龈炎的改进方法,所述组合物将口腔护理剂捕获于口腔中来提供长期的抗牙斑或抗牙龈炎效果。
本发明另外的特性和优点将在本发明优选实施方案的详述中描述和显而易见。
本发明优选实施方案的详述
依照本发明,提供了改进的无支链淀粉可食用膜组合物及其制备方法。另外,也同样提供了使用本发明的可食用膜组合物传递药物、治疗口臭、口腔干燥和牙斑或齿龈炎的改进方法。
为此,在本发明的一实施方案中,提供了一种无支链淀粉的可食用膜组合物。该组合物包括有效量的至少一种成膜剂、有效量的至少一种容积填充剂和有效量的至少一种增塑剂。
成膜剂提供形成本发明的无支链淀粉可食用膜的结构。有效量的成膜剂范围为膜组合物干重的约10%-约90%,更优选为膜组合物干重的25%-约75%。
可用于本发明的无支链淀粉可食用膜组合物中的成膜剂包括,但不限于纤维素醚、改性淀粉、天然胶、可食用聚合物、水状胶体粉、海藻提取物、陆地植物提取物、它们的衍生物及其组合。
纤维素醚的例子包括,但不限于甲基纤维素、乙基纤维素、羟甲基纤维素、羟乙基纤维素、羟丙基甲基纤维素、羧甲基纤维素、它们的衍生物及其组合。改性淀粉的例子包括,但不限于酸或酶水解的玉米或马铃薯淀粉。此外,天然胶的例子包括,但不限于阿拉伯树胶、瓜耳胶、刺槐豆胶、角叉胶、金合欢胶、刺梧桐树胶、茄替胶、黄蓍胶、罗望子胶、黄原胶、它们的衍生物及其组合。
可食用聚合物的例子包括,但不限于微晶纤维素、纤维素醚、黄原胶、它们的衍生物及其组合。此外,水状胶体粉的例子包括,但不限于瓜耳胶、刺槐豆、微晶纤维素、秘鲁树荚、它们的衍生物及其组合。
海藻提取物的例子包括,但不限于海藻盐、角叉胶、它们的衍生物及其组合。陆地植物提取物的例子包括,但不限于魔芋、果胶、阿拉伯半乳聚糖、它们的衍生物及其组合。
本发明优选的成膜剂是角叉胶。
本领域的技术人员应意识到的是,其它呈现出本发明所期望的特性且具有广泛可供性的可食用水溶性成膜剂也可以使用。将本发明的容积填充剂加入到无支链淀粉的可食用膜组合物中以降低组合物的“粘稠”特性。有效量的容积填充剂为膜组合物干重的约10%-约90%,更优选为膜组合物干重的25%-约75%。
本发明适合的容积填充剂包括,但不限于碳酸镁、碳酸钙、磷酸钙、硫酸钙、硅酸镁、硅酸铝、碎石灰、粘土、滑石、二氧化钛、微晶纤维素、纤维素聚合物如木材、它们的衍生物及其组合。本发明优选的容积填充剂是微晶纤维素。
为增加本发明的无支链淀粉可食用膜组合物的柔韧性及降低其脆性,使用了软化剂,也称作增塑剂。本发明有效量的增塑剂为膜组合物干重的约0%-约20%,更优选为膜组合物干重的2%-约8%。
本发明适合的增塑剂包括,但不限于多元醇如山梨醇、甘油、聚乙二醇、丙二醇、氢化淀粉水解液、玉米糖浆、它们的衍生物及其组合。本发明优选的增塑剂是聚乙二醇。
为进一步增强本发明的膜组合物的结构,可使用有效量的至少一种增稠剂。本发明适合的增稠剂包括,但不限于纤维素醚。本发明优选的增稠剂是羟乙基纤维素。
在本发明一优选的实施方案中,无支链淀粉的可食用膜组合物包括有效量的角叉胶作为成膜剂;有效量的微晶纤维素作为容积填充剂;和有效量的聚乙二醇作为增塑剂。另外,为了增强所形成的膜的结构,有效量的羟乙基纤维素可作为增稠剂加入到优选的实施方案中。
本发明的无支链淀粉可食用膜组合物比现有技术领域中可比较的膜具有诸多优点。本发明的可食用膜不要求使用支链淀粉,这极大地降低了它们的制造费用。因为本发明的可食用膜与基于支链淀粉的膜不同,具有广泛的可供性,在没有失去所期望的特性的情况下,本发明使经济上节约。
虽然不想被束缚于任何特殊的理论上,但相信本发明的成膜剂、容积填充剂、增塑剂和任选的增稠剂的独特组合生产出“独立(standalone)”的可食用膜组合物,其呈现出在更昂贵的基于支链淀粉的膜内发现的许多相同的所期望的性能。还发现与现有的基于支链淀粉的膜一样,本发明的无支链淀粉可食用膜组合物还展现出快速溶解、非吸湿性、口感清洁、香味纯正和易制备性能。
此外,本发明的可食用膜组合物克服了其它现有的无支链淀粉膜组合物的缺陷。本发明提供了不需要加入昂贵的结构支撑成份的“独立”的可食用膜。本发明还呈现出比其它现有的无支链淀粉可食用膜组合物更好的可食用膜特性。
本发明的膜组合物也包括有效量的至少一种药物和/或有效量的至少一种添加剂。能加入到本发明的可食用膜中的药物包括,但不限于pH控制剂、口腔护理剂、呼吸清新剂、药剂、滋补剂、唾液刺激剂、维生素、矿物、它们的衍生物及其组合。
pH控制剂的例子包括,但不限于尿素和口部可接受的缓冲剂。口腔护理剂的例子包括,但不限于龋齿控制剂如磷酸盐和氟化物;抗牙斑/抗齿龈炎剂如洗必泰(chlorohexidene)、西波林、三氯生;杀菌剂;和唾液刺激剂如柠檬酸、乳酸、苹果酸、琥珀酸、抗坏血酸、己二酸、延胡索酸、酒石酸、和其它可食用的食品级酸。
呼吸清新剂包括,但不限于葡糖酸锌、柑橘油、水果香精、欧薄荷油、荷兰薄荷油、其它薄荷油、丁香油、鹿蹄草油、茴香油和薄荷醇。
可加入本发明的可食用膜组合物的药剂、滋补剂、维生素和矿物质包括,但不限于那些适合于口腔消费并能放置于膜制型中的药剂。
可加入本发明的可食用膜组合物的添加剂包括,但不限于表面活性剂、粘合剂、着色剂、甜味剂、食用香料、香精、乳化剂、它们的衍生物及其组合。
表面活性剂和粘合剂的例子包括膜制型领域中公知的任何现有的可食用表面活性剂和粘合剂。着色剂的例子包括,但不限于适于食物、药和化妆品应用的食品色素和颜料如FD&C色淀和颜料。甜味剂包括,但不限于天然甜味剂如蔗糖、葡萄糖和麦芽糖;以及人工甜味剂如蔗糖合素(sucralose)、天冬甜素和丁磺胺盐。
各种不同的食用香料也可以用于本发明的可食用膜中。优选地,食用香料约含有可食用膜组合物干重的0.1%-约20%,更优选为10%-约15%。适合的食用香料包括,但不限于从植物和水果中得到的香精油和合成香料或其混合物。人工香料也可以使用。天然和人工香料可以以任何感觉上可接受的方式组合。
香精的例子包括,但不限于任何适用于可食用膜制型的香精如薄荷油。
适用于本发明的乳化剂包括,但不限于任何适用于可食用膜制型的乳化剂如部分氢化的蔬菜油。
本领域的技术人员应当了解的是这里未列出的其它适用于可食用膜制型的药物和添加剂可以加入到本发明的无支链淀粉膜组合物中。
在下面实施例1-12中陈述的无支链淀粉可食用膜组合物通过实施例的方式而不是限制方式,详细描述了本发明的不同的实施方式。本领域的技术人员应当了解的是本发明的膜制型可以以适于它们所要达到的目的和市场的各种不同的方式生产。当然,一旦掌握本发明的基本概念和原理,许多其它的制型是可能的,并能被专业技术人员所了解。
对下面描述的本发明的实施方案的大范围的变化和修正对本领域的技术人员是显而易见的。下面的实施例不被认为是对本发明的强加限制,而仅仅被包含进来以描述各种各样的实施方案。
实施例1-12
(%干重)
成份 实施例1 实施例2 实施例3 实施例4
LustreClear* 75.00 82.00 78.00 71.25
卵磷脂 3.50 1.65 2.50 3.30
山梨醇 - - 2.50 3.75
甘油 4.50 4.00 2.00 3.50
食用香料 13.80 11.25 12.75 14.00
蔗糖合素 2.85 1.00 1.00 -
天冬甜素 - - 1.00 2.25
柠檬酸 - - - 1.00
薄荷醇 0.25 - - 0.75
颜料
0.10
0.10
0.25
0.20
100.00 100.00 100.00 100.00
成份 实施例5 实施例6 实施例7 实施例8
微晶纤维素 20.00 40.25 27.85 -
角叉胶 54.00 34.00 50.00 42.00
聚乙二醇 2.00 8.00 - -
羟乙基纤维素 - 1.50 3.50 -
碳酸钙 - - - 39.00
卵磷脂 3.00 - 2.00 2.00
山梨醇 - 1.50 1.00 -
甘油 10.00 - 2.00 4.00
食用香料 9.00 11.75 13.00 10.50
蔗糖合素 1.85 1.50 - 2.00
天冬甜素 - - 0.50 -
柠檬酸 - 0.75 - -
薄荷醇 - 0.65 - 0.25
颜料
0.15
0.10
0.15
0.25
100.00 100.00 100.00 100.00
成份 实施例9 实施例10 实施例11 实施例12
微晶纤维素 - 19.00 44.00 -
瓜耳胶 - - - 42.50
角叉胶 - 48.35 30.35 -
海藻酸盐 37.50 - - -
聚乙二醇 - 3.50 8.00 -
羟乙基纤维素 - - 3.00 6.50
碳酸钙 39.40 14.00 - 32.00
卵磷脂 - 0.50 1.50 -
氢化淀粉水解物 5.00 - - -
木糖醇 1.50 - - 2.00
甘油 - - 2.00 4.00
食用香料 13.90 11.00 8.00 10.00
蔗糖合素 1.00 2.50 - -
丁磺胺K 1.00 - 3.00 2.00
洗必泰 2.00 - - -
己二酸 1.00 - -
薄荷醇 0.50 - - 1.00
颜料
0.10
0.15
0.15
0.00
100.00 100.00 100.00 100.00
实施例1-4
为制备实施例1-4的膜制型,在搅拌下将LustreClear(FMC公司的商标,意在用作药片的透明包衣)加入到水中。LustreClear含有微晶纤维素、角叉胶、聚乙二醇、羟乙基纤维素和麦芽糖糊精。,
然后,混合物加热至50℃,且在搅拌下加入其它所列成份。其它成份也可以在加热前和LustreClear一同加入。在混合物温热的时候,将混合物倾注到玻璃板上,并用0.08”的片压制成薄膜。然后将膜组合物在50℃下干燥约15分钟。膜放置后接着将增厚。
实施例1-4制备的膜呈现出好的柔韧性、非吸湿性和易制备性是确定的。另外,对下列实施例1-4中的膜构成进行基准水平感官分析。实施例1-4制备的膜展现出好的口感、快速溶解、香味纯正和特性是确定的。
实施例5-12
为制备实施例5-12的膜制型,成膜剂、容积填充剂和增塑剂在搅拌下加入水中。然后,混合物加热至50℃,并将其它成份在搅拌下加入到混合物中。在混合物温热的时候,把混合物倾注到玻璃板上,且用近似尺寸的叶片将混合物压制成薄膜。接着在50℃下将膜干燥15分钟以使其增厚。所制备的实施例5-12的膜呈现出好的柔韧性、非吸湿性和易制备性是确定的。
实施例1-12详细描述本发明的可食用无支链淀粉膜的制型利用了可供性广的成份。此外,以这种独特方法结合的那些成份展现出预期的膜特性,这种膜特性以前仅仅在更昂贵的基于支链淀粉的可食用膜组合物中产生。然而,由于本发明的成份可供性广,现在可以制备出呈现快速溶解、口感清洁、柔韧性和易制备性的较低成本的膜。
在一实施方案中,本发明提供了制备无支链淀粉可食用膜组合物的方法,正如提供有“独立”膜。方法包括下列步骤:提供有效量的至少一种成膜剂;和添加有效量的至少一种容积填充剂和有效量的至少一种增塑剂至成膜剂中以制备出无支链淀粉可食用膜组合物。
本发明的方法还可以包括添加有效量的至少一种增稠剂至可食用膜组合物中以增强膜结构的步骤。与现有的可食用膜不同,本发明的方法制备的是“独立”的无支链淀粉可食用膜组合物。
结果,根据本发明的方法制备的无支链淀粉可食用膜组合物不要求额外使用昂贵的结构形成成份如支链淀粉及类似物。相反,所述膜是用减少了制备这种膜的费用的获得性广的成份而成的。
更进一步地,当本发明的膜成份用这样一种独特的方式结合时,直至本发明可以取得仅有基于支链淀粉的可食用膜才能达到的理想的膜特性。本发明的方法提供了一种降低费用的基于支链淀粉膜的可替代品,而没有丢失预期的膜特性。在本发明更进一步的实施方案中,还提供了传递药物的方法。该方法包括下列步骤:向个体提供一种膜组合物中含有有效量的至少一种药物的无支链淀粉可食用膜组合物,其中膜组合物还包括有效量的至少一种成膜剂、有效量的至少一种容积填充剂和有效量的至少一种增塑剂;和使个体口部消耗膜组合物将药物释放至口腔以便吸收。
适合放置于无支链淀粉可食用膜组合物的药物包括,但不限于pH控制剂、口腔护理剂、呼吸清新剂、药剂、滋补剂、唾液刺激剂、维生素、矿物、它们的衍生物及其组合。
方法还包括添加有效量的至少一种增稠剂至膜组合物中以增强作为传递药物载体的膜结构的步骤。再者,虽然不想被束缚于任何特定的理论上,但与现有的支链淀粉和无支链淀粉可食用膜组合物相比,相信本发明的的可食用膜组合物更适宜附着于口部表面、对口腔更具生理可接受性以及在口部环境中更能快速溶解。
在这种情况下,相信本发明的无支链淀粉可食用膜组合物更均一地向口腔释放药物使之通过敞开的伤口或粘膜以比先前所能得到的方式更多地吸收。此外,也相信本发明的成膜剂将药物捕获至口腔中保持一段持续的时间,延长和增强了药物的效能。另外,通过延长药物在口腔中的接触时间,药物被更大范围地吸收因此增加了它的生物利用度。
在本发明的另一实施方案中,提供了治疗口臭的方法。口臭常常指坏气味呼吸的症状。治疗的方法包括下列步骤:向个体提供一种含有有效量的至少一种呼吸清新剂的无支链淀粉可食用膜组合物,其中膜组合物还包括有效量的至少一种成膜剂、有效量的至少一种容积填充剂和有效量的至少一种增塑剂;和使个体口部消耗膜组合物将呼吸清新剂释放至口腔中以治疗口臭。该方法还可以包括添加有效量的至少一种增稠剂至膜组合物中以增强膜结构的步骤。
在本方法优选的实施方案中,呼吸清新剂是葡萄糖酸锌。相信本发明的口臭治疗方法比当前现有的口臭治疗形式更有效,因为无支链淀粉的可食用膜组合物将呼吸清新剂捕获至口腔中。通过捕获呼吸清新剂,清新剂较长时间留在口腔中以提供持续的呼吸清新效果。
因此,本发明的治疗口臭的方法降低了个体利用传统的口臭辅助设备所要求治疗的数量。因为呼吸清新剂通过本发明的方法存在于口腔内,不需要用呼吸清新剂频繁的再处理。
在本发明的另一实施方案中,提供了治疗口腔干燥的方法。口腔干燥是一种医学症状,其中口腔内出现过分的干燥。各种不同的医学症状和药物治疗均会引起口腔干燥,有必要对口腔干燥进行治疗。
本发明的治疗口腔干燥的方法包括下列步骤:向个体提供一种含有有效量的至少一种唾液刺激剂的无支链淀粉可食用膜组合物,其中膜组合物还包括有效量的至少一种成膜剂、有效量的至少一种容积填充剂和有效量的至少一种增塑剂;和使个体口部消耗膜组合物将唾液刺激剂释放至口腔中以治疗口腔干燥。另外,该方法还包括添加有效量的至少一种增稠剂至膜组合物中以增强膜结构的步骤。
通过本发明的无支链淀粉可食用膜组合物将唾液刺激剂捕获至口腔中,可取得比用现有的口腔干燥辅助治疗所达到的效果有更持久的唾液腺刺激。另外,因为唾液刺激剂在口腔中保持一持续的时间,发生了对唾液腺较长时间的刺激,故降低了需要再治疗的频率。
此外,本发明的治疗口腔干燥的方法也提供额外的优点,允许口腔干燥患者有能力谨慎地处理这种症状。患者仅仅将本发明的可食用膜或口香糖组合物用传统的保存机理如包装纸保存,并在需要唾液安慰时,将膜或口香糖明显地放置在口中即可。
在本发明的更进一步的实施方案中,提供了治疗牙斑或齿龈炎的方法。该方法包括下列步骤:向个体提供一种含有有效量的至少一种口腔护理剂的无支链淀粉可食用膜组合物,其中膜组合物还包括有效量的至少一种成膜剂、有效量的至少一种容积填充剂和有效量的至少一种增塑剂;和使个体口部消耗膜组合物将口腔护理剂释放至口腔中以治疗牙斑或齿龈炎。另外,该方法还可以包括添加有效量的至少一种增稠剂至膜组合物中以增强膜结构的步骤。
适用于该方法的口腔护理剂包括,但不限于pH控制剂如尿素和缓冲液;牙垢或龋齿控制剂如磷酸盐和氟化物;抗牙斑/抗齿龈炎剂如洗必泰、西波林、三氯生;杀菌剂;和杀菌化合物如商标名为Listerine的产品。
所述方法提供了将口腔护理剂捕获至口腔中以延长护理剂的抗牙斑和/或抗齿龈炎效果的方式。这时,本发明的方法通过比现有的可食用膜组合物更长时间地将这些药剂保存在口腔中,增强了它们抗窝洞的效能。结果,本发明的这种方法允许个体实现比先前所能达到的更高的牙齿护理标准。
应当理解这里描述的优选的实施方案的各种不同的变化和修正对于本领域的技术人员是显而易见的。在不背离本发明的实质和范围,不减少它所预期的优点的情况下,可以做这种变化和修正。因此,这些变化和修正意图覆盖在所附的权利要求中。
Claims (24)
1.一种无支链淀粉可食用膜组合物,其包括:
有效量的至少一种成膜剂;
有效量的至少一种容积填充剂;和
有效量的至少一种增塑剂。
2.如权利要求1所述的组合物,其中有效量的成膜剂为组合物干重的约10%-约90%。
3.如权利要求2所述的组合物,其中成膜剂选自纤维素醚、改性淀粉、天然胶、可食用聚合物、水状胶体粉、海藻提取物、陆地植物提取物、它们的衍生物及其组合。
4.如权利要求1所述的组合物,其中有效量的容积填充剂为组合物干重的约10%-约90%。
5.如权利要求4所述的组合物,其中容积填充剂选自碳酸镁、碳酸钙、磷酸钙、硫酸钙、硅酸镁、硅酸铝、碎石灰、粘土、滑石、二氧化钛、微晶纤维素、纤维素聚合物、它们的衍生物及其组合。
6.如权利要求1所述的组合物,其中有效量的增塑剂为组合物干重的0%-约20%。
7.如权利要求6所述的组合物,其中增塑剂选自甘油、聚乙二醇、丙二醇、多元醇、氢化淀粉水解液、玉米糖浆、它们的衍生物及其组合。
8.如权利要求1所述的组合物,其中组合物还包括有效量的至少一种增稠剂。
9.如权利要求8所述的组合物,其中增稠剂是至少一种纤维素醚。
10.如权利要求1所述的组合物,其中组合物还包括有效量的至少一种药物。
11.如权利要求10所述的组合物,其中药物选自pH控制剂、口部护理剂、呼吸清新剂、药剂、滋补剂、唾液刺激剂、维生素、矿物、它们的衍生物及其组合。
12.如权利要求1所述的组合物,其中组合物还包括有效量的至少一种添加剂。
13.如权利要求12所述的组合物,其中添加剂选自表面活性剂、粘合剂、着色剂、甜味剂、食用香料、香精、乳化剂、它们的衍生物及其组合。
14.一种无支链淀粉可食用膜组合物的制备方法,其包括下列步骤:
提供有效量的至少一种成膜剂;和
与成膜剂一起添加有效量的至少一种容积填充剂和有效量的至少一种增塑剂以制备出无支链淀粉可食用膜组合物。
15.如权利要求18所述的制备方法,其中方法还包括添加有效量的至少一种增稠剂以形成无支链淀粉可食用膜组合物的步骤。
16.一种传递药物的方法,其步骤包括下列步骤:
向个体提供一种膜组合物中含有有效量的至少一种药物的无支链淀粉可食用膜组合物,其中膜组合物还包括:
有效量的至少一种成膜剂;
有效量的至少一种容积填充剂;和
有效量的至少一种增塑剂;以及
通过个体口部消耗膜组合物将药物释放至口腔。
17.如权利要求20所述的方法,其中药物选自pH控制剂、口腔护理剂、呼吸清新剂、药剂、滋补剂、唾液刺激剂、维生素、矿物、它们的衍生物及其组合。
18.如权利要求20所述的方法,其中方法还包括将有效量的至少一种增稠剂加入到膜组合物的步骤。
19.一种治疗口臭的方法,其步骤包括:
向个体提供一种含有有效量的至少一种呼吸清新剂的无支链淀粉可食用膜组合物,其中膜组合物还包括:
有效量的至少一种成膜剂;
有效量的至少一种容积填充剂;和
有效量的至少一种增塑剂;以及
通过个体口部消耗膜组合物将呼吸清新剂释放至口腔中以治疗口臭。
20.如权利要求23所述的方法,其中方法还包括将有效量的至少一种增稠剂加入到膜组合物的步骤。
21.一种治疗口腔干燥的方法,其步骤包括:
向个体提供一种含有有效量的至少一种唾液刺激剂的无支链淀粉可食用膜组合物,其中膜组合物还包括:
有效量的至少一种成膜剂;
有效量的至少一种容积填充剂;和
有效量的至少一种增塑剂;以及
通过个体口部消耗膜组合物将唾液刺激剂释放至口腔中以治疗口腔干燥。
22.如权利要求25所述的方法,其中方法还包括将有效量的至少一种增稠剂加入到膜组合物的步骤。
23.一种治疗牙斑或齿龈炎的方法,其步骤包括:
向个体提供一种含有有效量的至少一种口腔护理剂的无支链淀粉可食用膜组合物,其中膜组合物还包括:
有效量的至少一种成膜剂;
有效量的至少一种容积填充剂;和
有效量的至少一种增塑剂;以及
通过个体口部消耗膜组合物将口腔护理剂释放至口腔中以治疗牙斑或齿龈炎。
24.如权利要求27所述的方法,其中方法还包括将有效量的至少一种增稠剂加入到膜组合物的步骤。
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EP (1) | EP1337148A4 (zh) |
CN (1) | CN1499926A (zh) |
AU (2) | AU2002217789B2 (zh) |
CA (1) | CA2428445A1 (zh) |
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US20120037039A1 (en) * | 2010-08-11 | 2012-02-16 | Tic Gums, Inc. | Pullulan replacements for films and coatings |
US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
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-
2001
- 2001-11-08 US US10/036,681 patent/US20020131990A1/en not_active Abandoned
- 2001-11-21 CN CNA018197787A patent/CN1499926A/zh active Pending
- 2001-11-21 RU RU2003118646/15A patent/RU2003118646A/ru not_active Application Discontinuation
- 2001-11-21 AU AU2002217789A patent/AU2002217789B2/en not_active Withdrawn - After Issue
- 2001-11-21 AU AU1778902A patent/AU1778902A/xx active Pending
- 2001-11-21 CA CA002428445A patent/CA2428445A1/en not_active Abandoned
- 2001-11-21 EP EP01998309A patent/EP1337148A4/en not_active Withdrawn
- 2001-11-21 WO PCT/US2001/043397 patent/WO2002043657A2/en not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101678217B (zh) * | 2007-02-22 | 2013-12-25 | 生技化妆品有限公司 | 用于治疗口干燥症或口干的组合物 |
CN109350577A (zh) * | 2018-12-13 | 2019-02-19 | 广州睿森生物科技有限公司 | 一种护肤组合物及其应用 |
CN109350577B (zh) * | 2018-12-13 | 2021-09-21 | 广州睿森生物科技有限公司 | 一种护肤组合物及其应用 |
Also Published As
Publication number | Publication date |
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AU1778902A (en) | 2002-06-11 |
US20020131990A1 (en) | 2002-09-19 |
EP1337148A4 (en) | 2005-03-16 |
WO2002043657A2 (en) | 2002-06-06 |
EP1337148A2 (en) | 2003-08-27 |
RU2003118646A (ru) | 2004-12-10 |
AU2002217789B2 (en) | 2005-02-24 |
CA2428445A1 (en) | 2002-06-06 |
WO2002043657A3 (en) | 2002-08-01 |
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