CN1856270A - 构造生物传感器的方法 - Google Patents
构造生物传感器的方法 Download PDFInfo
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- CN1856270A CN1856270A CNA2004800276336A CN200480027633A CN1856270A CN 1856270 A CN1856270 A CN 1856270A CN A2004800276336 A CNA2004800276336 A CN A2004800276336A CN 200480027633 A CN200480027633 A CN 200480027633A CN 1856270 A CN1856270 A CN 1856270A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
Abstract
构造分析物传感器(10)的方法。该方法开始于提供电化学活性表面(24)的步骤。然后,构造由介电材料制成并从电化学活性表面(24)横向向外伸出的至少一个凸起(22)。向电化学活性表面和凸起(22)涂敷可固化的液体,随后使其固化。在此过程中,可能是几个凸起(22)之一的凸起(22)用于在固化之前和固化期间托住所述液体。
Description
技术领域
本发明总体上涉及皮肤分析物传感器的领域。
背景技术
在留置葡萄糖传感器的设计和制造中,在将随后固化的粘性液体层材料涂敷于电化学活性(铂)表面上的处理中遇到了问题。希望具有在大约平方毫米数量级的活性表面区域。不幸地,当将粘性液体浸涂到此相对大的区域上时,很难构造厚度足以对葡萄糖的存在产生足够响应的涂布。
发明内容
在第一独立方面中,本发明是一种具有活性传感区的留置分析物传感器。该传感区包括电化学活性表面和附着于该电化学活性表面的膜系统。此外,介电材料的至少一个凸起(nub)从电化学活性表面向外伸出并用作膜系统的支托结构。
在第二独立方面中,本发明是一种构造分析物传感器的方法。该方法开始于提供电化学活性表面的步骤。随后,构造由介电材料制成并从电化学活性表面横向向外伸出的至少一个凸起。向电化学活性表面涂敷可固化的液体,随后使其固化。在此过程中,所述凸起(可能是几个凸起中的一个)用于在固化之前和固化期间托住液体。
结合附图,考虑到下面对优选实施例的详细说明,将会更容易地理解本发明的前述和其他目的、特征和优点。
附图说明
图1是使用本发明的方法被形成为生物传感器的结构的一部分的工件的侧视图。
图2是由图1的工件构造的传感器的侧视图。
具体实施方式
在分析物(典型地为葡萄糖)传感器10的优选实施例中(图2),用25微米厚的聚酰亚胺层14涂布178微米厚的铂丝12。将银丝16包绕层14的一部分。此外,不锈钢回缩引线(retractor lead)18形成传感器10的一部分。
通过激光削除聚酰亚胺层14来形成各自长2mm的三个凹部20,以形成工件8(图1)。凹部20之间的聚酰亚胺形成依托于聚酰亚胺14在丝12上的附着的一组环形片22。在此激光加工操作之后,可以用使得工件可以检测葡萄糖的材料24对该工件进行浸涂。典型地,材料24由一组通过一系列浸涂操作间以固化操作而构成的层组成。这些层典型地包括如美国专利5,165,407(通过引用将其并入于此,就像在此对其进行充分阐述一样)中所述的干扰物隔绝层、葡萄糖氧化酶层和选择性渗透层。各粘性液体的表面在片22之间趋向于形成有些像悬链线的形状。由此,与不存在片22的附着相比,附着了粘性液体的更大部分。该更大的厚度,特别是针对葡萄糖氧化酶层的更大厚度,对于产生对存在葡萄糖和氧气的健壮响应是很重要的。
工业应用性
本发明通常在生产和提供皮肤分析物传感器方面具有工业应用性。
以上说明书中采用的术语和表达用作描述性而非限制性的术语。使用这些术语和表达并无意将所图示和所描述的特征或者其部分的等同物排除在外,应该认识到本发明的范围仅由所附权利要求定义和限制。
Claims (19)
1、一种留置分析物传感器,具有:
(a)活性传感区,包括:
(i)电化学活性表面;以及
(ii)附着于所述电化学活性表面的膜系统;
(b)介电材料的至少一个凸起,其从所述电化学活性表面向外伸出并用作对所述膜系统的支托结构。
2、根据权利要求1所述的传感器,其中,所述至少一个凸起为片的形式。
3、根据权利要求1所述的传感器,其中,所述电化学活性表面被限定为纵长体的一部分。
4、根据权利要求3所述的传感器,其中,所述纵长体的横截面为圆形。
5、根据权利要求4所述的传感器,其中,所述电化学活性表面是所述圆形纵长体的周面。
6、根据权利要求5所述的传感器,其中,所述凸起更具体地包括环形片。
7、根据权利要求2所述的传感器,其中,所述凸起从所述电化学活性表面纵向地移位。
8、根据权利要求2所述的传感器,其中,所述膜系统包括多个膜。
9、根据权利要求2所述的传感器,其中,所述膜系统包括酶层。
10、一种构造分析物传感器的方法,包括以下步骤:
(a)提供电化学活性表面;
(b)构造由介电材料制成并从所述电化学活性表面横向向外伸出的至少一个凸起;
(c)向所述电化学活性表面和所述至少一个凸起涂敷液体;
(d)使所述液体固化;以及
(e)由此,所述至少一个凸起用于在所述固化步骤之前和所述固化步骤期间托住所述液体。
11、根据权利要求10所述的方法,其中,所述至少一个凸起为片的形式。
12、根据权利要求10所述的方法,其中,所述电化学活性表面被限定为纵长体的一部分。
13、根据权利要求10所述的方法,其中,所述纵长体的横截面为圆形。
14、根据权利要求13所述的方法,其中,所述电化学活性表面是所述圆形纵长体的周面。
15、根据权利要求14所述的方法,其中,所述凸起更具体地包括环形片。
16、根据权利要求10所述的方法,其中,所述凸起从所述电化学活性表面纵向地移位。
17、根据权利要求10所述的方法,其中,所述膜系统包括多个膜。
18、根据权利要求10所述的传感器,其中,所述膜系统包括酶层。
19、根据权利要求10所述的传感器,其中,通过首先提供涂布有介电材料的丝、然后去除形成为所述凸起的所述介电材料的一部分,从而构造所述至少一个凸起。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/640,980 US7529574B2 (en) | 2003-08-14 | 2003-08-14 | Method of constructing a biosensor |
US10/640,980 | 2003-08-14 |
Publications (2)
Publication Number | Publication Date |
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CN1856270A true CN1856270A (zh) | 2006-11-01 |
CN100479739C CN100479739C (zh) | 2009-04-22 |
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Application Number | Title | Priority Date | Filing Date |
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CNB2004800276336A Expired - Fee Related CN100479739C (zh) | 2003-08-14 | 2004-08-11 | 构造生物传感器的方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US7529574B2 (zh) |
EP (2) | EP1659933A4 (zh) |
JP (1) | JP4790612B2 (zh) |
CN (1) | CN100479739C (zh) |
CA (1) | CA2535394C (zh) |
WO (1) | WO2005018420A2 (zh) |
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2003
- 2003-08-14 US US10/640,980 patent/US7529574B2/en not_active Expired - Lifetime
-
2004
- 2004-08-11 EP EP04780742A patent/EP1659933A4/en not_active Withdrawn
- 2004-08-11 JP JP2006523316A patent/JP4790612B2/ja not_active Expired - Fee Related
- 2004-08-11 CA CA2535394A patent/CA2535394C/en not_active Expired - Fee Related
- 2004-08-11 CN CNB2004800276336A patent/CN100479739C/zh not_active Expired - Fee Related
- 2004-08-11 WO PCT/US2004/025957 patent/WO2005018420A2/en active Application Filing
- 2004-08-11 EP EP12194288A patent/EP2564768A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
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WO2005018420A3 (en) | 2005-08-04 |
CA2535394C (en) | 2014-03-25 |
WO2005018420A2 (en) | 2005-03-03 |
EP1659933A2 (en) | 2006-05-31 |
JP4790612B2 (ja) | 2011-10-12 |
CN100479739C (zh) | 2009-04-22 |
EP1659933A4 (en) | 2009-03-11 |
EP2564768A1 (en) | 2013-03-06 |
US7529574B2 (en) | 2009-05-05 |
CA2535394A1 (en) | 2005-03-03 |
JP2007502162A (ja) | 2007-02-08 |
US20050038330A1 (en) | 2005-02-17 |
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