CN203060612U - Ultrasonic focusing device for treating Parkinson's disease - Google Patents
Ultrasonic focusing device for treating Parkinson's disease Download PDFInfo
- Publication number
- CN203060612U CN203060612U CN 201220741837 CN201220741837U CN203060612U CN 203060612 U CN203060612 U CN 203060612U CN 201220741837 CN201220741837 CN 201220741837 CN 201220741837 U CN201220741837 U CN 201220741837U CN 203060612 U CN203060612 U CN 203060612U
- Authority
- CN
- China
- Prior art keywords
- magnetic resonance
- ultrasonic
- treatment
- information setting
- equipment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The utility model discloses an ultrasonic focusing device for treating a Parkinson's disease. The ultrasonic focusing device is formed by a magnetic resonance scanning device, an ultrasonic transmitting device, an ultrasonic information setting device, an ultrasonic development device, a magnetic resonance information converting device and an magnetic resonance image display system, wherein the magnetic resonance scanning device is connected with the magnetic resonance information converting device, the magnetic resonance image display system and the ultrasonic information setting device, and the ultrasonic information setting device is connected with the ultrasonic transmitting device and the ultrasonic development device. The ultrasonic focusing device utilizes functional magnetic resonance to position brain structures and is accurate in positioning.
Description
Technical field
This utility model belongs to the armarium technical field, relates to a kind of burnt equipment of ultrasonic copolymerization for the treatment of parkinsonism.
Background technology
Parkinson disease (PD) are a kind of gradual nervous system degenerative diseases, it is characterized in that bradykinesia, and are stiff, tremble trunk forerunner tendency and astasia during rest.
Clinical employing surgery brain be implanted into deep brain stimulation (deep brain stimulation, DBS is commonly called as: brain pacemaker) Zeng Qiang ?the matter irritability, improve the DA activity.At present since magnetic Resonance Imaging MRI and (electronic computer x-ray tomography technology) can accurately locate each nerve nucleus (Bao Kuo of brain ?matter and striatum.In recent years because the development of molecular imaging can be carried out the function phenomenon to partial nerve cell in the nuclear group.Except the brain pacemaker of deep, the radio frequency heat of rising is gradually in recent years coagulated and is damaged the treatment critical treatment method that treatment is the brain stereotactic operation, is used for the treatment of PD.In addition, treatment such as electrical transcranial stimulation has been used for the PD treatment, but uncertain therapeutic efficacy is cut.
The brain pacemaker has the following disadvantages: implant microelectrode in brain kernel group and improve symptom, cerebral hemorrhage and cerebral edema may take place in postoperative, symptomatic recurrence in part patient's postoperative a period of time; There is the patient of serious cardiopulmonary kidney disease, unmanageable hypertension and spiritedness symptom to use; Expense costliness in addition, present one-sided treatment need more than 10 ten thousand yuan approximately, and bilateral treatment needs more than 20 ten thousand yuan approximately, need the periodic replacement battery, and required expense is higher, and general patient often is difficult to bear; Be prone to equipment fault simultaneously.
High intensity focused ultrasound as a kind of new oncotherapy means make some lose surgical engine can get old and weak lose put, chemotherapeutic machine can tumour patient provide treatment may, and obtained widely approval.Focus ultrasonic utilizes ultrasound wave as the energy exactly.A lot of bundle ultrasound wave go from external being transmitted in the health, in the middle of the transmission process, focus on, focusing on a point is on the tumor, transform by sound wave and heat energy, in 0.5～1 second, form 70 ℃～100 ℃ hyperthermia treatment points, it is that a scalpel is cutting tumor that this high temperature dot cans be compared to, and none escapes by luck the tumor of focal area.Focus ultrasonic knife makes tumor tissues produce coagulation necrosis, loses propagation, infiltration and transfer ability.This machine principle is similar to the poly-sunlight of solar cooker and produces huge energy in the focus place.Therefore, use the MRI molecular image and learn a skill, use high intensity focused ultrasound and destroy an amount of Ach neuronal cell, make its active reduction, make ?matter-striatal DA and Ach reach new balance, clinical cure PD is the clinical approach that can select.
Radio frequency heat is coagulated and is damaged treatment: by the altofrequency electromagnetic wave, destroy striatal cholinergic neuron treatment PD.Cerebral hemorrhage and cerebral edema may take place in the postoperative that this scheme has overcome the brain pacemaker; There is the patient of serious cardiopulmonary kidney disease, unmanageable hypertension and spiritedness symptom to use; In addition, expense is expensive and the defective of equipment fault.Radio frequency heat is coagulated and damaged the treatment shortcoming: the damage envelope difficulty is confined to very among a small circle (about 100 microns), may damage the peripheral nerve structure, causes critical function unusual.
The utility model content
In order to solve the problems of the technologies described above, this utility model provides that a kind of therapeutic effect is remarkable, side effect is little, the focus ultrasonic equipment of the treatment parkinsonism that cost is low, and its technical scheme is as follows:
A kind of focus ultrasonic equipment for the treatment of parkinsonism is made of magnetic resonance imaging device 1, ultrasonic transmitter 2, ultrasound information setting device 3, ultrasonoscopy device 4, magnetic resonance information transformation device 5 and magnetic resonance image (MRI) display system 6.Magnetic resonance imaging device 1 is connected with magnetic resonance information transformation device 5, and magnetic resonance imaging device 1 is connected with ultrasound information setting device 3 with magnetic resonance image (MRI) display system 6, and ultrasound information setting device 3 is connected with ultrasonoscopy device 4 with ultrasonic transmitter 2.
Further preferred, the quantity of described ultrasonic transmitter 2 is 3.
The principle of equipment described in the utility model is: the parkinson pathogenesis be since the aging Dao Zhi of nervous system ?matter striatum dopamine neuron secretion dopamine mediator reduce, cholinergic neuron is active to be strengthened relatively.The main means of clinical treatment parkinson are to replenish dopamine, activation dopamine neuron activity, antagonism acetylcholine active treatment at present.This equipment principle: locate cholinergic neuron with functional MRI, can accurately locate and destroy 100 microns left and right sides architectural characteristics with ultrasonic copolymerization Jiao, destroy cholinergic neuron, thereby subtract the cholinergic transmitter in few ?matter striatum zone, thus treatment PD.
Compared with prior art, the beneficial effects of the utility model: this device first utilizes ultrasonic copolymerization Jiao can destroy the more Magnocellular characteristic of single volume, Po Huai ?matter striatum cholinergic neuron, the treatment parkinson disease.First from Po Hua ?matter striatum cholinergic neuron set about, the treatment parkinson disease.Utilize ultrasonic copolymerization Jiao first, the accurate characteristics of focusing range are destroyed single neuron.This equipment filled up domestic and international useless destruction Nao ?the blank of the cholinergic neuron special for treating PD of matter striatum system, compare the various complication that can reduce operation of opening cranium with operative treatment PD, aftereffect assessment is in time repeatedly treated simultaneously, reaches the effect of therapeutic purposes.Compare can avoid taking medicine for a long time and bring constant with Drug therapy, and side effects of pharmaceutical drugs (acting on the effect of other cholinergic neurons in the body).Therefore this equipment with existing treatment means compare have safe, convenient, feasible, side effect is little, simultaneously than operative treatment with Drug therapy is more economical for a long time.The following aspect of main performance:
(1) utilize functional MRI to brain structure location, accurate positioning;
(2) accurately Po Huai ?the cholinergic neuron in matter striatum zone, thereby reduce the secretion of acetylcholine;
(3) more do not need operation of opening cranium with deep brain electromagnetic technique treatment PD;
(3) controllability is good, and the assessment for the treatment of back, but repeated multiple times treatment are up to reaching therapeutic purposes.
Description of drawings
Fig. 1 is the structure chart of the burnt equipment of ultrasonic copolymerization of this utility model treatment parkinsonism.
The specific embodiment
Below in conjunction with the drawings and specific embodiments the technical solution of the utility model is done explanation in further detail.
With reference to Fig. 1, a kind of focus ultrasonic equipment for the treatment of parkinsonism, constituted by magnetic resonance imaging device 1, ultrasonic transmitter 2, ultrasound information setting device 3, ultrasonoscopy device 4, magnetic resonance information transformation device 5 and magnetic resonance image (MRI) display system 6, magnetic resonance imaging device 1 is connected with magnetic resonance information transformation device 5, magnetic resonance imaging device 1 is connected with ultrasound information setting device 3 with magnetic resonance image (MRI) display system 6, and ultrasound information setting device 3 is connected with ultrasonoscopy device 4 with ultrasonic transmitter 2.Magnetic resonance imaging device 1 is connected with magnetic resonance information transformation device 5, and magnetic resonance imaging device 1 is connected with ultrasound information setting device 3 with magnetic resonance image (MRI) display system 6, and ultrasound information setting device 3 is connected with ultrasonoscopy device 4 with ultrasonic transmitter 2.The quantity of described ultrasonic transmitter 2 is 3.
Equipment described in the utility model in use, 1 scanning of magnetic resonance imaging device, the information of scanning is sent to magnetic resonance information transformation device 5, magnetic resonance information transforms 5 information that will sweep 1 scanning of magnetic resonance imaging device and changes, pass to ultrasound information setting device 3 during the information of same of scanning, ultrasound information setting device 3 passes to demonstration with this information and passes to ultrasonoscopy device 4, ultrasound information setting device 3 is integrated the information that comes from magnetic resonance information transformation device 5, and the burnt position of ultrasonic copolymerization is set, and with this position display on ultrasonoscopy device 4, device 3 arranges the burnt position of copolymerization according to the information from 5, and be sent to device 2,2 and send ultrasonic damage and show neuron.Cooperate functional MRI show Da Nao ?matter striatum cholinergic neuron, by magnetic resonance information transformation device 5 process informations, target image is presented on the magnetic resonance image (MRI) display system 6.
This equipment mainly can destroy people's in-vivo tissue structure with the burnt high temperature that forms of ultrasonic copolymerization.The tumor of the burnt treatment of ultrasonic copolymerization at present technology maturation, wide clinical application.But the burnt treatment of ultrasonic copolymerization tumor, general focusing range is big, and the volume that destroys tumor tissues is bigger.The ultrasound destruction cell is neuronal cell in this device, and about neurocyte diameter 100 μ m, therefore, the precision to copolymerization Jiao in this device fixes on 100 μ m.At present to parkinson disease treatments adopt replenish dopamine, Ji Huo ?matter striatum dopamine neuron, the treatment of cholinergic agonist drug.This device is at present unique accurately broken bad ?matter striatum cholinergic neuron therapeutic equipment, and this device uses present functional MRI can cerebral nerve meta function phenomenon accurately be shown and show ?matter striatal neuron.?matter striatum cholinergic neuron diameter at 100 μ m, in the true scope of ultrasonic copolymerization pyrogene, theoretical feasible.
This equipment is the task equipment of a treatment PD, this equipment comprises functional MRI function and the burnt function of ultrasonic copolymerization, utilize functional MRI Zhun determine Wei ?matter striatum cholinergic neuron, accurately locate with the burnt equipment division of ultrasonic copolymerization, focus among a small circle and form high-order disorganize structure.This equipment treatment same cholinergic antagonist of PD (trihexyphenidyl, benzhexol etc.) has common target spot and same mechanism; But this equipment treatment more remarkable treatment effect is avoided the inconvenience of taking medicine for a long time and to the side effect of other histoorgans.
The above; it only is this utility model preferred forms; anyly be familiar with those skilled in the art in the technical scope that this utility model discloses, the simple change of the technical scheme that can obtain apparently or equivalence are replaced and are all fallen in the protection domain of the present utility model.
Claims (2)
1. focus ultrasonic equipment for the treatment of parkinsonism, it is characterized in that, constituted by magnetic resonance imaging device, ultrasonic transmitter, ultrasound information setting device, ultrasonoscopy device, magnetic resonance information transformation device and magnetic resonance image (MRI) display system, the magnetic resonance imaging device is connected with the magnetic resonance information transformation device, the magnetic resonance imaging device is connected with the ultrasound information setting device with the magnetic resonance image (MRI) display system, and the ultrasound information setting device is connected with the ultrasonoscopy device with ultrasonic transmitter.
2. the focus ultrasonic equipment for the treatment of parkinsonism according to claim 1 is characterized in that, the quantity of described ultrasonic transmitter 2 is 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220741837 CN203060612U (en) | 2012-12-28 | 2012-12-28 | Ultrasonic focusing device for treating Parkinson's disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220741837 CN203060612U (en) | 2012-12-28 | 2012-12-28 | Ultrasonic focusing device for treating Parkinson's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203060612U true CN203060612U (en) | 2013-07-17 |
Family
ID=48759443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220741837 Expired - Fee Related CN203060612U (en) | 2012-12-28 | 2012-12-28 | Ultrasonic focusing device for treating Parkinson's disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203060612U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102989089A (en) * | 2012-12-28 | 2013-03-27 | 成都信息工程学院 | Ultrasonic focusing device for treating Parkinson's disease |
-
2012
- 2012-12-28 CN CN 201220741837 patent/CN203060612U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102989089A (en) * | 2012-12-28 | 2013-03-27 | 成都信息工程学院 | Ultrasonic focusing device for treating Parkinson's disease |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210186600A1 (en) | Electroporation with cooling to treat tissue | |
| Martin et al. | High‐intensity focused ultrasound for noninvasive functional neurosurgery | |
| Rohani et al. | Focused ultrasound for essential tremor: review of the evidence and discussion of current hurdles | |
| AU2014203524B2 (en) | Systems, methods and devices for a skull/brain interface | |
| CN103002950B (en) | Be used for the treatment of equipment and the implementation method thereof of brain disorder | |
| US20150201996A1 (en) | Electroporation controlled with real time imaging | |
| Lindstrom | Prefrontal ultrasonic irradiation—a substitute for lobotomy | |
| Mahmood et al. | Optimizing clinical performance and geometrical robustness of a new electrode device for intracranial tumor electroporation | |
| US20140094682A1 (en) | Image guided high intensity focused ultrasound treatment of nerves | |
| US20050240126A1 (en) | Ultrasound guided high intensity focused ultrasound treatment of nerves | |
| CN105963002A (en) | Three-dimensional printed minimally invasive guide template and making method thereof | |
| Ballantine Jr et al. | Focal destruction of nervous tissue by focused ultrasound: biophysical factors influencing its application | |
| AU2012367867A1 (en) | Apparatus and method for irradiating biological tissue | |
| Ilham et al. | In vitro single-unit recordings reveal increased peripheral nerve conduction velocity by focused pulsed ultrasound | |
| US20070135877A1 (en) | Use of microwave energy for thermotherapy | |
| Metman et al. | Advances in functional neurosurgery for Parkinson's disease | |
| CN107281635A (en) | Electrode physical therapy device and electrode position method | |
| Lin | Studies on microwaves in medicine and biology: From snails to humans | |
| CN102989089A (en) | Ultrasonic focusing device for treating Parkinson's disease | |
| CN101485920B (en) | Laser therapy device | |
| CN203060612U (en) | Ultrasonic focusing device for treating Parkinson's disease | |
| Wei et al. | Higher dosage of HIFU treatment may lead to higher and longer efficacy for moderate to severe perennial allergic rhinitis | |
| CN108245314A (en) | For carrying out the generating means for the ultrasonic wave that the sense of hearing resumes treatment | |
| Lee et al. | An efficient noninvasive neuromodulation modality for overactive bladder using time interfering current method | |
| CN112774048A (en) | Closed-loop ultrasonic nerve regulation and control system and method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130717 Termination date: 20141228 |
|
| EXPY | Termination of patent right or utility model |