DE102010053792A1 - Device for germ-free keeping of surfaces, such as door handles, handrails, grip bars, handles of shopping carts and toilet seating surfaces, has flat support material and self-adhesive portion formed on one side of flat support material - Google Patents

Abstract

The device has a flat support material and a self-adhesive portion, which is formed on one side of the flat support material. One or multiple germ-free active preparations containing the self-adhesive portion are provided, which are released to the other side of the flat support material in a controlled manner. An active substance reservoir (2) is provided, in which an active substance-containing preparation is formed in solid, liquid or molecularly dispersed form. The active substance-containing preparation is introduced into superabsorbent polymers.

Description

The invention relates to a planar system for preventing the contamination of hands and other body parts in contact with handles, doorknobs, etc.

Many infections with microorganisms that can be harmful to humans are caused by the touch of hands and other parts of the body with contaminated surfaces. This concerns, for example, the contamination with MRSA germs and ESBL-producing bacteria in hospitals, salmonella and the like in food factories, germs in toilet facilities and swimming pools, sauna companies, sports studios etc.

Above all, the "killer germ" MRSA (for methicillin-resistant Staphylococcus aureus) has long been part of everyday life in German hospitals. Every 70th intensive care patient is infected.

In the United States, approximately 19,000 people died of MRSA infections in 2005 alone. Furthermore, more and more illnesses occur due to so-called ESBL * -Extended Spectrum Beta-Lactamase-forming intestinal bacteria. These germs are an enzyme that can destroy penicillins, cephalosporins and other antibiotics. These germs are transmitted via contact surfaces.

For Germany, estimates of deaths from hospital-acquired infections vary widely, from about 1,500 people died each year to about 40,000. Every day in Germany at least four people unnecessarily die from a hospital infection. (Robert Koch Institute) In 2009, the German Society for Hospital Hygiene also estimated some 40,000 deaths annually from infections in German hospitals.

These infections are transmitted by touch, especially surfaces that are touched by several people and on which germs are deposited and then transmitted by contact with a body part, especially with one hand.

Usually, to prevent the transmission of germs via contact surfaces cleaning agents and disinfectants are used with which the contact surfaces are sprayed or wetted. Some contact surfaces are sterilized or - like laundry and towels - exposed to high temperatures, oxygen or chlorine during washing. Such measures only help for a short time because disinfecting agents are removed by frequent contact surface contact and new germs can be applied. In addition, the substances used are often very aggressive and damage the skin, especially in the relatively high concentration used.

Also known are coatings of door handles with antibacterial substances, some nano particles, as well as door handle coatings with silver. It is also known to provide door handles with a coating of copper.

All the known solutions have a number of disadvantages. When coating door handles, these additional manufacturing steps must be subjected. Existing door handles can not be retrofitted. Door handle covers with silver are very expensive, for example, an antibacterial door handle cover CLEAN HAND silver per piece costs more than four euros. In addition, such a coating by dirt (dander, impurities of the hands, etc.) is applied by the touch, soon unsightly, then he loses its effectiveness, because germs can settle on the dirt. In addition, such expensive door handle covers can be easily removed and thus discreetly stolen

One possible solution would be to apply an active ingredient on an absorbent material system applied to the surface, or to soak it with an active ingredient on an absorbent surface. However, such a system would soon lose its germ-preventing properties through contact or evaporation.

It is therefore an object to provide a contamination protection for surfaces of all kinds including door handles, handrails, handrails (for example, in elevators) handles of shopping carts, toilet seats ("toilet seats") and contact surfaces such as control buttons in elevators, light switches, etc., the a long-term effectiveness, is cheap, easy to install and long-acting ...

The object is achieved according to the invention in that a flat system is used, which adheres to the germ-free object, and on the contact side has a surface which is provided with a germ-free acting active substance-containing preparations in sufficient quantity, the germ-free holds, and which therefore acts long, because active ingredient from the system controlled to the surface penetrates and replaced active ingredient on the surface.

Any known disinfectants can be used. It is not necessary to use large quantities as in a cleaning process to use, since even the presence of very small amounts prevents the colonization of germs and kills applied germs.

In particular, active substances which cleave off chlorine (NaOCl, NaClO, HClO, KClO) and oxygen (MnO ² , KClO ³ , TCCS, H ² O ^2, etc.), as well as others such as 1-propanol and 2-propanol.2 -Propanol, ethanol, benzalkonium chloride, glyoxal, triglycol, benzalkonium saccharinate, quaternary ammonium compounds, meconium acetyl sulfate, polyvidone-iodine, povidone-iodine or phenols.

These relatively aggressive skin-damaging substances can be used in the system according to the invention, because only very small amounts reach the contact surface of a system according to the invention.

In a preferred embodiment, approved disinfectants harmless to human skin are used.

Such disinfectants include:
AHD 2000½ A Lysoform, Active DHH ½ A Fritz Osch. Michalek, Amphisept E ½ A Goldschmidt / Bode Chemistry, Aseptomaniac ½A Desomed, Aseptopur ½A Desomed, C 20 ½ A Orochemistry, Descoderm ½ A Schumacher, Desderman N ½ A Schülke & Mayr, Desmanol ½ A Schülke & Mayr, Ethanol (DAB 10) 80 Vol.% ½ A, Frekaderm colorless ½ A Fresenius Kabi
Frekasept 80 ½ A Frekasteril ½ A Fresenius Kabi, Hospisept ½ A Lysoform, Isopropanol 70% v / v A, Kaniderm ½ A Dental Dental, Kentoman ½ A HLZ Logistics, Kodan tincture forte ½ A Schülke & Mayr, Mucasept A ½ A Merz, Novaderm ½ A Nova Practice Hygiene
Nüscoman ½ A dr. Nüsken Chemie, OP-Sept ½ A Laboratory Dr. med. Deppe Poly-Alcohol Hands Antisepticum ½ A Antiseptica, Poly-Alcohol Skin colorless Antisepticum ½ A Antiseptics, Promanum N ½ A B. Brown, n-Propanol 60 Vol.% ½ A, Sensiva Hand Disinfection ½ A Schülke & Mayr, Septoderm Hands ½ A Dr. Schumacher, Skinman asept ½ A Ecolab, Skinman soft ½ A Ecolab, Skinsept F ½ A Ecolab, Softa Man ½ A B. Brown, Spitacid ½ A Ecolab, Sterillium ½ A Bode chemistry, Sterillium classic pure ½ A Bode chemistry, Sterillium Virugard ½ A Bode Chemistry, Sterillium Virugard 2 B3 Bode Chemistry, Suprades HD ½ A HYPROCLEAN, Tremosan ½ A EW 80 Systems, Halogens, Betaisodona Solution 1 A Mundipharma, Braunol 1 A B. Brown, Chloramine T (DAB 9) 1% 2 A2B3 , 4, chloramine T (DAB 9) 2% 1 A2B3, 4, chloramine T-lysoform 1% 2 A2B3, 4 lysoform, chloramine T-lysoform 2% 1 A2B3, 4 lysoform, trichlorol 1% 2 A2B3, 4 lysoform, trichlorol 2% 1 A2B3, 4 lysoform, other Primasept Med 1 A Schülke & Mayr active ingredients wofasteril 0.5% 1 A, benzalkonium chloride, nitrofurazone, nystatin, acetosulfamine, clotrimazole, etc., antifungal agents: pentamycin, amphotericin B, pyrrolnitrin, clotrimazole ,

Thus, according to the invention, in order to keep the contact surfaces germ-free, so-called presentation medications (all substances or compositions intended as agents with properties for the healing or prevention of human diseases) and particularly alternatively or cumulatively approved or admissible are presented as well as functional medications (all Substances and compositions of matter that are administered in or on the human body to either restore, correct or influence the human physiological functions through pharmacological, immunological or metabolic action, or to make a medical diagnosis) are used without special approval of the invention planar system according to the invention requires, since these drugs are intended not to disinfect the hands, but used to keep germs of the contact surfaces, but nevertheless are safe in terms of Berüh tion with human skin.

These active substances or these active ingredients or active substance-containing preparations - hereinafter uniformly referred to as active substance-containing preparations (active ingredient, if appropriate with one or more non-active constituents, "auxiliaries") - are incorporated into the planar system similar to a transdermal therapeutic system. In this case, the systems according to the invention on one side are removable (easy) pressure-sensitive, either by the nature of the carrier layer or by applying a pressure-sensitive adhesive layer, on the other side with a drug reservoir or more active substance-containing layers that release the drug to the outside and ensure that the Surface are wetted for a long time in a controlled manner with one / more antiseptic agents, so that germs can not form there or be killed when they are applied by touch.

Therapeutic systems for the transdermal delivery of drugs continuously deliver one or more active agents to the skin at a predetermined rate for a predetermined period of time at a predetermined application site.

Systems according to the invention, like all systems based on sheet-like substrates, eg. As adhesive tapes and films and paving - in a manner known to those skilled in the art by coating - solvent and hotmelt coating and lamination and subsequent assembly can be prepared. They are therefore - especially if not the high quality requirements for drugs or high-quality technical systems (screen-printed adhesive films with Function designations z. B. for electronic devices) are to be met - easy and very inexpensive to manufacture.

Typically, transdermal systems have at least one drug reservoir in which the drug substance is in solid, liquid, or molecularly disperse form, and an adhesion layer that tightly bonds the system to the skin and through which drug delivery occurs, and a control membrane and protective layers / cover layers which are substantially impermeable to the active agent.

In a preferred embodiment, as in the case of corresponding TTS, pure active substance is introduced into a pressure-sensitive adhesive polymer in finely crystalline form so that the finely divided, finely divided active substance will dissolve over time as depot crystals in the adhesive matrix layer ( DE-OS 35 00 508 ), if the humidity - which is high in most applications such as swimming pools, saunas, hospitals, etc. - is added, or if the system deposits perspiration, and so on.

In another embodiment, drug depots in the form of microcapsules enclosed by a control microporous membrane are embedded in a pressure-sensitive adhesive layer of such a system (see U.S. Patent 3,598,123 and U.S. Patent 3,731,683 ).

Microporous membranes are z. B. from cellulose esters or polyolefins by phase separation (cellulose ester) or by extrusion near the melting point (isotactic polypropylene, CelgardÒ, Hoechst) won. The films then have pore diameters of 20-200 nm.

In another embodiment will be similar DE-PS 3 424 837 a cover sheet is used, which has a liquid active ingredient in a bulged portion of the cover sheet and an active substance covering, for the drug-permeable control membrane, so. s. 1 and 3

In this case, in a preferred embodiment between the cover sheet and the control membrane is an active ingredient distribution device, namely a nonwoven, and / or another absorbent sheet material such as foam, filter paper, felt, etc., which distributes the drug liquid uniformly on the control membrane and over a larger area can be effective. In this case, cover sheet and control membrane are welded together at their outer areas, respectively, in order to prevent leakage of the liquid active ingredient.

In a preferred embodiment, the cover sheet and the control membrane are connected in discrete sections to form pads and / or channels which prevent the formation of drug deposits at the lower end of a non-horizontally applied applied sheet system.

In another embodiment will be similar GB-A-1 361 289 spatially defined to each other discrete drug depots used. Here, a reservoir with a polymeric base material that can be self-crosslinked or externally solidified in the patch is needed, using an active-ingredient-containing polymer produced in a precursor.

In another embodiment similar EP 117,027 a planar system is used with an ointment-like or highly viscous depot, wherein the depot components are produced outside the planar system by mixing the ointment base and the active ingredient and then introduced into the planar system.

In a preferred embodiment, the sheet system may be prepared in a manner known to those skilled in the art by solvent or hotmelt coating such as a sheet transdermal system using a plastic film backing such as polyolefins such as polyethylene (PE) or polypropylene (PP). But also suitable are polyvinyl chloride (PVC), polystyrene (PS), various polyesters and polycarbonate (PC), cellulose cellophane.

In a preferred embodiment, bio-based plastics such as polylactide (PLA), cellulose acetate and starch blends are used to ensure biodegradability.

In the system according to the invention, one or more antiseptic agents may be incorporated as in a matrix patch, wherein the active ingredient-containing preparation contained in one of one or more layers (multilayer system), the release of the active ingredient-containing preparation to the surface controlling matrix is, s. 2 ,

The active ingredient can also be contained in microporous plastic reservoirs, particles, nanoparticles, or in absorbent surface substrates such as nonwovens, absorbent paper (blotting paper, filter paper, "edible paper") and plastic sponges.

The object can also be achieved in a preferred embodiment by a planar system with hollow bodies. Hollow fibers are used as emergency lubricants in cutting or grinding tools or by release of liquid adhesives to eliminate hairline cracks in Used plastics. It is now technically possible to adapt the physical properties of elongated hollow bodies to the specific application. The spectrum z. B. from glassy brittle to flexible rubber flexible, from gas-tight to highly permeable. The outer diameter of elongated hollow body can be from below 10 nm (nanotube) to several 100 μm (hollow fibers). For example, a layer of hollow fibers is used which have radially attached pores. In this case, the active ingredients can either be embedded in the hollow fibers themselves, or else the hollow fibers are empty and the active substance passes through diffusion a layer of hollow fibers in order to reach the surface. In this application, hollow fibers are used in the function of a control membrane, or cause a slow, controlled release of the active ingredient.

In a preferred embodiment, the filling medium comprises at least one active substance; the release of the active substance or of the active substances takes place by breaking, dissolving or perforating the hollow bodies.

In a preferred embodiment, similar JP 2004-168734 a planar system for use, wherein hollow fibers with open pores, filled with a mixture of active ingredient and a low molecular weight substance are used. The release of active ingredient from the planar system is thereby delayed. By supplying energy, a change in the structure of the hollow body is generated, through which the filling medium or the filling media are released from the hollow bodies. The energy can be supplied as mechanical, thermal, electrical, magnetic, electro-magnetic or chemical energy. This depends on the respective properties of the hollow body.

Preferably, the energy is supplied in the form of pressure or train, heat, radiation, electricity or sound.

In a preferred embodiment of the planar system, brittle hollow bodies are subjected to mechanical stress by bending, stretching, stretching, twisting or buckling, by which they are irreversibly deformed. By breaking or bursting of the structure of the hollow body in the planar system, the filling medium or more filling media from the elongated hollow bodies is released and can - depending on the intended embodiment - react in various ways. The degree of mechanical stress leading to the onset of breakage or rupture of the hollow bodies depends on the particular application and on the material of the hollow bodies. For example, it is possible to actively buckle a planar system prior to application or to pull it over a bend edge from a donor roll in order to activate it. Thus, the functionality of the system is achieved only by the activation.

In another embodiment, when the sheet system is removed from a dispenser in which a roll with the system (similar to a roll of household foil, possibly combined with a cover sheet as in office writing correction ribbons) automatically moves when over an edge reached such a strong bend that break the hollow body used according to this application and release the drug.

In a preferred embodiment, the carrier material together with the active agent matrix can be made transparent, so that the system hardly attracts any attention visually, and so that underlying control surfaces such as light switches and elevator buttons, can be seen. Such transparent systems have long been known in other fields, in the similar transdermal therapeutic systems, e.g. B. EP 1140039 as well as the cited therein US 3,598,123 ; US 3731,683 ; US 3797,494 ; US 4,031,894 ; US 4,155,317 etc.

In a preferred embodiment, the carrier material used can also be a textile, such as nonwoven fabric, woven fabric or knitwear, in which one thread loop is looped into another.

In a preferred embodiment, the active ingredient-containing preparation can be incorporated into the planar system in a known manner in superabsorbent (superabsorbent polymer, SAP). The superabsorber is a copolymer of acrylic acid (propenoic acid, C ₃ H ₄ O ₂ ) and sodium acrylate (sodium salt of acrylic acid, NaC ₃ H ₃ O ₂ ), it being possible for the ratio of the two monomers to vary from one another. In addition, a so-called core crosslinker (core-crosslinker, CXL) is added to the monomer solution, which connects the long-chain polymer molecules formed in places with each other by chemical bridges (they "crosslinked"). Also suitable is surface post-crosslinking (SXL). In doing so, another chemical is applied to the surface of each particle, and a reaction taking place under heat forms a second network only on the outer layer of the grain.

In a preferred embodiment, composite granules are used which consist of a highly porous mineral matrix and hydrogel polymers deposited thereon. In a preferred embodiment, superabsorbents of starch are used as a renewable raw material.

In a preferred embodiment, the active compounds can be applied in the form of nanoparticles.

In another preferred embodiment, the active ingredients can be incorporated into porous particles.

In another preferred embodiment, the sheet systems may also contain copper or silver which are known to be bactericidal.

In another preferred embodiment, the planar system is wound into a donor roll and perforated for tearing or provided with a predetermined breaking point or tearing edge.

In a preferred embodiment, the adhesive layer may be partially interrupted by grasping aids in the form of non-adhesive strips of paper, plastic foil, etc.

In a preferred embodiment, the flat system as a textile such as nonwoven fabric, fabric, or knitted fabric without adhesive layer - z. As bedding, sheets, etc. - and how a conventional reference, etc. are applied

In a preferred embodiment, the sheet-like system can be used non-adhesive fabric as a wipe, cleaning cloth, towel, secretion-receiving cloth (eg handkerchief) or cloth for (drying) dry.

In a preferred embodiment, the sheet system may consist of a support layer surface and a membrane-like surface with relatively large holes of 0.01 to 0.1 mm diameter, with at least 1 hole and maximum 100 holes on one mm ² , and which are firmly connected at the edges and provided with an active ingredient-containing preparation in the reservoir between the surfaces. These systems are on the one hand - in an alternative to simplify handling not full surface - adhesive equipped.

If this system is attached, z. B. on a doorknob, is pressed by the contact pressure, the active ingredient-containing preparation, which is controlled by the holes on the surface and wets them, so that the germicidal effect is produced. In a preferred embodiment, the two-dimensional system with an indicator of the effectiveness based on the fact that the surface moisture of the system and thus drug concentration has decreased. This is z. As silica gel incorporated into the planar system, which is mixed with a water indicator such as blue cobalt (II) chloride (CoCl ₂ ).

When the silica gel has bound water, the complex hexa-quatobalt (II) chloride ([Co (H ₂ O) ₆ ] Cl ₂ ) is formed, and the indicator is pale pink to whitish; When the system dries, the indicator turns from pale pink to whitish to blue.

In practical application, the detachably adhesive flat system according to the invention in appropriate size around door handles, handles (for example in elevators), stair handrails, taps, handles of shopping trolley etc. wrapped or on switches, control knobs in elevators, light switches, toilet seats ("Klobrillen") or other contact surfaces on which it adheres thanks to its peelable adhesive property, and thus are germ-free or germ-free and reduce or prevent contamination by touching.

The attachment can be done by cleaning personnel during the routine cleaning anyway.

At the next cleaning cycle, the removable adhesive flat system can be removed and replaced with a new one. Thus, the purpose of keeping the contact surface germ-free or even germ-free, achieved in a simple and cost-effective manner.

LIST OF REFERENCE NUMBERS

1

backing

2

reservoir

3

membrane

4

matrix

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• DE 3500508 A [0023]
• US 3598123 [0024, 0041]
• US 3731683 [0024, 0041]
• DE 3424837 [0026]
• GB 1361289 A [0029]
• EP 117027 [0030]
• JP 2004-168734 [0037]
• EP 1140039 [0041]
• US 3797494 [0041]
• US 4031894 [0041]
• US 4155317 [0041]

Claims (10)

Device for sterilization of surfaces, consisting of A flat carrier material, • that is pressure-sensitive on one side, • containing one or more active-substance-containing preparations which are released in a controlled manner to the other side, Device according to Claim 1, characterized in that the active substance-containing preparation is a medicinal product (presentation medicine or functional medicine) approved for use on human skin, Device according to claims 1 and / or 2, characterized in that at least one active substance reservoir, in which the active substance-containing preparation is in solid, liquid or molecular disperse form exists Device according to claims 1 and / or 2 to 3, characterized in that there is at least one control membrane, Device according to claims 1 and / or 2 to 4, characterized in that a matrix system with one or more thin layers, in which the active substance-containing preparation is embedded, is used Device according to claims 1 and / or 2 to 5, characterized in that hollow fibers with open pores filled with a mixture of active ingredient and a low molecular weight substance are used. Device according to claims 1 and / or 2 to 6, characterized in that a textile is used as the carrier material, Device according to claims 1 and / or 2 to 7, characterized in that the active ingredient-containing preparation is also contained in microporous plastic reservoirs such as particles and nanoparticles. Device according to claims 1 and / or 2 to 8, characterized in that the active substance-containing preparation is incorporated in superabsorbent (superabsorbent polymers, SAP) Device according to claims 1 and / or 2 to 9, characterized in that the system is transparent.

Images