DE1255235B - Skin care products - Google Patents

Description

FEDERAL REPUBLIC OF GERMANY

GERMAN

PATENT OFFICE

EDITORIAL

Int. Cl .:

A61k

German KX: 30 h - 13/01

Number: 1255 235

File number: C 32201IV a / 30 h

Filing date: February 19, 1964

Open date: November 30, 1967

The invention relates to a skin care product for distributing the sebum secretions of the skin, the is characterized by a content of at least 20% of a water-soluble ether of the formula

R_O- (Alk-O) "- R '

9
where R is a lower alkyl radical, R 'has the same meanings as R or hydrogen, «is an integer from 1 to 4 and Alk is a lower alkylene radical with at most 3 carbon atoms and at least 2 carbon atoms in the chain between the two oxygen atoms . The alkyl radical can preferably be one with 1 to 4 carbon atoms, ζ. B. be methyl, ethyl, propyl or butyl, R 'have the same meaning as R or be hydrogen, Alk be an alkylene (1,2) radical containing at most 3 carbon atoms, especially an ethylene (1,2) - Or propylene (1,2) or - (1,3) radical and η be an integer from 1 to 4. The alkylene radicals can optionally also be different from one another. Water-soluble ethers of the formula mentioned are z. B.

Triethylene glycol monomethyl ether,

Triethylene glycol monoethyl ether,

Triethylene glycol dimethyl ether,

Tetraethylene glycol dimethyl ether,

Isopropylene glycol monomethyl ether,

Dipropylene glycol monomethyl ether,

Tripropylene glycol monomethyl ether,

Ethylene glycol monomethyl ether,

Ethylene glycol monoethyl ether,

Ethylene glycol monobutyl ether,

Ethylene glycol dimethyl ether,

Ethylene glycol diethyl ether,

Diethylene glycol monomethyl ether,

Diethylene glycol monoethyl ether,

Diethylene glycol monobutyl ether,

Diethylene glycol dimethyl ether and

Diethylene glycol diethyl ether.

Those skin care products of the specified type with at least 20% are particularly preferred a water-soluble ether of the formula

R - O - (CH ₂ - CH ₂ - O) _n - H

where R is a lower alkyl radical with 1 to 4 carbon atoms, especially methyl or ethyl, and η = 2, 3 or 4, especially diethylene glycol monoethyl ether or diethylene glycol monomethyl ether. The active ether content of the new agents is advantageously between approximately 20 to 50%.
The skin oil, also called sebum or sebum, is a skin care product

Applicant:

CIBA Aktiengesellschaft, Basel (Switzerland)

Representative:

Dr.ring. Dr. jur. F. Redies, Dr. rer. nat. B. Redies and Dr. rer. nat. D. Türk, patent attorneys,
Düsseldorf-Benrath 3, Erich-Ollenhauer-Str. 7th

Named as inventor:
Burkhart Lange, Basel (Switzerland)

Claimed priority:

Switzerland of February 25, 1963 (2372),

dated November 29, 1963 (14 614)

From the point of view of cosmetics, represents a special substance. The following properties are remarkable:

1. It forms a protection against the leaching of the skin by water.

2. It protects the skin against aqueous noxa.

3. It protects the skin against alkaline noxae.

4. It does not hinder the perspiratio insensibilis or, above all, the general perspiration.

5. It gives the upper layers of the skin a pleasant, soft feel.

6. It is kind to the skin in the strictest sense of the word.

7. Its places of origin are physiologically correct, i. that is, there is most sebum in the places separately where it is most needed by the skin as a natural protection.

The distribution of the sebum can be seen in such a way that a small part is generally in the skin arises while the main amount is supplied by the sebum glands. This localizes emerging The main part should be evenly distributed over the surrounding areas through the spreading effect, with im Ideally, a certain balance between the produced, localized resulting amount and spreading

709 690/464

3 4

speed arises. This balance can cause sebum production to be too great. Because of this, however, one leads to being disturbed in two ways. On the one hand, such a liquefying and dissolving effect also cannot cause the surface quality of the skin to cause undesirable sebum congestion in the skin,
The use of substances of the type described above can increase the production of sebum in the glands for other purposes, e.g. B. as the fact that the sebum formed no longer completely infectious agents for the skin or as a solvent flows off. But while the flowing sebum is a z. B. for essential oils is known. So z. B. has a soft, creamy consistency, the non-British patent 906 870 tends to use flowing sebum to harden. This appearance of ethylene glycol monoethyl ether as a disinfectant then inevitably leads to a congestion at the upper io medium. Furthermore, in the case of a commercial product, the end of the gland, which can then lead to acne-like appearances in particularly serious use as a solvent in cosmetic cases. Certificates indicated, but with a maximum. In all these cases, a means would prove to be a concentration of 3%. 15 cannot be derived from these writings.

The means now on the market are to be applied to the skin is expedient only partially suitable for this purpose. Cleaning agent in the form of an aqueous solution, advantageously with a and also powders remove more or less the water-soluble ether of the above starch Measure the lipids and lipoids and damage given formula between 20 and 50% · Optionally thereby the protective film. Gels based on ao, these solutions can be thickened, e.g. B. of glycerine or higher alcohols as well as carbon with gelling agents, such as carboxyvinyl polymers, hydrates do not dissolve sebum. Propyrene glycol alginic acid esters or ionogenic Cellu-Noch Fatty emulsion ethers should be best suited to facilitate application because its constituents dissolve sebum loosening digits. When using the polyacrylic acid preparations can. They do, however, have a number of negative effects Disadvantages: suitable base, such as diisopropanolamine, is added. That

"". ,. ,. , τ · .j,,. _TT application in the form of an emulsion is technical

1. They bring lipids that are foreign to the body onto the skin. _{possible; however} ^^ _{you have additional bodies here} .

2. You will be un- foreign fats and also significant amounts are distributed to physiologically from the nature of things, because they do not require overall ₃₀ emulsifiers, so that such products targeting the skin condition accordingly not distributed to the particularly preferred embodiments are. forms of the invention belong.

3. Overdosing with other, undesired agents The agents according to the invention can also have auxiliary effects are unavoidable. contain substances such as B. Preservatives,

4. They bring a more or less strong occlusive gelling or thickening agent, odoriferous substances, etc., effect, as the fat film extends over the skin area, but also substances with a special skin area effect, such as local anesthetics, strong disinfectants

5. The additional fat film applied to the skin by means of keratolytic, metabolic, etc.

must be treated with more detergents _t ^Dle fofeenAsn ^ ¹⁸ P ¹⁶ If ₁ ^soll . ^{en eim} ^ application

will wash, which in turn illustrate the danger of the * ° ^ f of ^the invention, but without the

Overdosing of these means, at least limiting the invention.

but additional exogenous substances

brings the skin. B e i s ρ i e 1 1

But just before using detergents, 45 g of diethylene glycol monoethyl ether

especially in high concentration, warn the distilled water 65 g

Dermatologist. Perfume q. s.

It therefore also derives from the idea of the invention

away if you can achieve the desired effect with the help of example 2
water-insoluble fats or oils in their pure form 50

tried to achieve. It is true that such sub-carboxyvinyl polymers have 1.2 g

punch a solvent for the sebum, to their diisopropanolamine 1.8 g

Removal, however, requires additional detergent ethylene glycol dimethyl ether 40.0 g

use. Perfume q. s.

Surprisingly, it has now been found that 55 water 56.0 g

Substances of the formula given above have the “ _r . _,. ,, _ "-

Meet requirements. They have good dissolving properties. B. to 2 g

capacity for the sebum, but can be based on carboxyvinyl polymers and 4.5 g of pusopropanolamine

their water solubility with a minimum of ^ O g or 35 g water-soluble ether and 73.5 resp.

Remove detergents again. In addition, 60 ⁵⁸ > ⁵ f ^water > ^{where the ethers ώβ} are:

divide the sebum via the corresponding upper ethylene glycol monomethyl ether,

area. In addition, they also work in ethylene glycol dimethyl ether,

Meaning a depth distribution, what two special diethylene glycol dimethyl ethers,

Has advantages. On the one hand, the increased one-diethylene glycol monoethyl ether,

give skin sebum the resistance capacity of 65 diethylene glycol diethyl ether,

the upper layer of the skin is strengthened, and on the other hand tripropylene glycol monomethyl ether,

this means even in such cases still a good triethylene glycol monoethyl ether and

Cosmetic effects unfold where in and of itself tetraethylene glycol dimethyl ether.

Example 3

1. Diethylene glycol monoethyl ether 30 g

2. Cetyl alcohol 10 g

3. Water 59 g

4. Sodium Lauryl Sulphate Ig

"Ed

An emulsion having the above substances obtained by melting the components 1 and 2 at 70 ⁰ C, heating the solution of 4 at 3 to 70 ° C, adding the aqueous solution to melt and cold stirring.

Example 4

Diethylene glycol monoethyl ether 20 g

Propylene glycol alginic acid ester 2 g

Water 78 g

Example 5

Diethylene glycol monoethyl ether 35 g

Propylene glycol alginic acid ester 2 g

, Water 63 g

Example 6

Ionic cellulose ether 2 g

Water 79 g

Ethylene glycol monomethyl ether 19 g

Other gels of this type contain 19 g of triethylene glycol monoethyl ether instead of 19 g of ethylene glycol monomethyl ether, Tripropylene glycol monomethyl ether, ethylene glycol dimethyl ether, diethylene glycol diethyl ether or tetraethylene glycol dimethyl ether.

35

Example 7

Ionic cellulose ether 2 g

Water 63 g

Ethylene glycol monomethyl ether 35 g

Other gels of this type contain 35 g of triethylene glycol monoethyl ether instead of 35 g of ethylene glycol monomethyl ether, Tripropylene glycol monomethyl ether, ethylene glycol dimethyl ether, diethylene glycol diethyl ether or tetraethylene glycol dimethyl ether.

Claims (6)

Patent claims: 1. Skin care products for distributing the sebum secretions of the skin, marked by containing at least 20% of one water-soluble ether of the formula R - O - (Alk - O) _n - R ' where R is a lower alkyl radical and R 'has the same meanings as R or hydrogen, η is an integer from 1 to 4 and Alk is a lower alkylene radical having at most 3 carbon atoms and at least 2 carbon atoms in the chain between the two oxygen atoms. 2. Skin care product according to claim 1, characterized in that in the ether R is an alkyl radical with 1 to 4 carbon atoms, R 'has the same meaning as R or is hydrogen, Alk is an alkylene containing at most 3 carbon atoms (1, 2) - rest and η is an integer from 1 to 4. 3. skin care agent according to claim 1, characterized in that the water-soluble ether formula R - O - (CH ₂ - CH ₂ - O) _n - H where R is an alkyl radical having 1 to 4 carbon atoms and η - 2, 3 or 4. 4. skin care product according to claims 1 to 3, characterized by a content of approximately 20 to 50% of the active compound. 5. Skin care products according to Claims 1 to 4 in the form of an aqueous solution. 6. skin care agent according to claim 5, characterized by an additional content of a Thickener. Considered publications:
R ο thema η η, Karl, The large recipe book for skin and body care products, 1962, p. 177 under "Glykole"; Winter, Perfumery Handbook and Kosmetik, 1949, pp. 147/148; Gnam.m - Summer, The Solvents and Softeners, 1958, pp. 30 to 39, especially pp. 30/31 and Table 10 (p. 37). 709 690/464 11.67 © Bundesdruckerei Berlin