DE1467836A1 - New dentifrice - Google Patents

New dentifrice

Info

Publication number
DE1467836A1
DE1467836A1 DE19641467836 DE1467836A DE1467836A1 DE 1467836 A1 DE1467836 A1 DE 1467836A1 DE 19641467836 DE19641467836 DE 19641467836 DE 1467836 A DE1467836 A DE 1467836A DE 1467836 A1 DE1467836 A1 DE 1467836A1
Authority
DE
Germany
Prior art keywords
weight
dentifrice
cariostatic
effect
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19641467836
Other languages
German (de)
Inventor
Lange Dr Burkhart
Loustalot Dr Prosper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
BASF Schweiz AG
Original Assignee
Ciba Geigy AG
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Ciba AG filed Critical Ciba Geigy AG
Publication of DE1467836A1 publication Critical patent/DE1467836A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Description

AnmeldungBunterlagenRegistration documents

Unser Zeichen: 20 254 BH/Lu ' *Our reference: 20 254 BH / Lu '*

CIBA AKTIENGESELLSCHAFT, BASEL (SCHWEIZ) CIBA AKTIENGESELLSCHAFT, BASEL (SWITZERLAND)

P 14 67 836.5
CaseP 14 67 836.5
Case

DeutschlandGermany

Neues ZahnpflegemittelNew dentifrice

Gegenstand der Erfindung ist ein neues Zahnpflegemittel, insbesondere eine Zahnpaste, das insbesondere durch eine gute kariostatische Wirkung ausgezeichnet ist. Dieses neue Zahnpflegemittel ist dadurch gekennzeichnet, . dass es in gelöster Form neben einem Alkalifluorid N-(ß-Phenoxy-äthyl)-N,N-dimethyl-dodecylammonium-bromid in einer Mindestkonzentration von ungefähr 0,08 Gewichtsprozent enthält. The invention relates to a new dental care product, in particular a toothpaste, which in particular is distinguished by a good cariostatic effect. This new dentifrice is characterized by. that it is in dissolved form next to an alkali fluoride N- (ß-phenoxy-ethyl) -N, N-dimethyl-dodecylammonium bromide at a minimum concentration of about 0.08 percent by weight.

8 09812/13308 09812/1330

tArt.7STAb8.2Nr.1tArt.7STAb8.2Nr.1

Die Verwendung von Alkalifluoriden, insbesondere des Natriumfluorids in Zahnpflegemitteln ist bereits durch das Schweizer Patent Nr. 2βΟ 995 bekannt. Man weiss jedoch, dass Zahnpflegemittel, die als kariostatischen Wirkstoff Natriumfluorid enthalten, nur eine gewisse, beschränkte Wirkung am Zahn entfalten können. Ausserdem muss man annehmen, dass bei der Entstehung der Karies ver schiedene Faktoren eine Rolle'spielen, so dass es wünschens- wert erscheint, den Zahnpflegemitteln noch andere kario- statische Wirkstoffe zuzusetzen.The use of alkali fluorides, especially sodium fluoride, in dental care products is already known from Swiss patent no. One, however, that dental care products, which can develop on the tooth white included as Cariostatic active ingredient sodium fluoride only a certain, limited effect. , Also must assume that ver in the development of caries different factors one Rolle'spielen so that it seems desirable to add the dentifrice other kario- static agents.

Als kariostatische Wirkstoffe bezeichnet man Substanzen, die z.B. im Tierversuch eindeutig kariostatisch,- wirken. Nach den bis jetzt vorliegenden Ergebnissen kann man nämlich annehmen, dass der Karies beim Tier und beim Mensch ein ähnlicher Entstehungsmechanismus zu Grunde liegt. Cariostatic agents are substances which, for example, have a clear cariostatic effect in animal experiments. According to the results available so far, it can be assumed that caries in animals and humans is based on a similar mechanism of origin .

N- (ß-Phenoxyäthyl)-N,N-dimethyl-dodecylammoniumbromid war bereits Gegenstand von Untersuchungen aif kariostatische Wirkung, die zu dem Ergebnis geführt hatten, dass diese Substanz keine praktisch verwendbare kariostatische Wirkung besitzt. Es wurde nun gefunden, dass N-(/3-Phenoxyäthyl)-N, N-dimethyl-dodecylammoniumionen im Gegensatz zu diesen Befunden eine ausgezeichnete kariostatische Wirkung entfalten,, wenn man sie in einer Mindestkonzentration von ungefähr 0,08 GewichtsprozentN- (ß-phenoxyethyl) -N, N-dimethyl-dodecylammoniumbromid has been the subject of investigations aif cariostatic effect that led to the conclusion that this substance has no practically usable cariostatic effect. It has now been found that N - (/ 3-phenoxyethyl) -N, N-dimethyl-dodecylammonium ions, in contrast to these findings, develop an excellent cariostatic effect when they are used in a minimum concentration of approximately 0.08 percent by weight

809812/ 1330. " .- ^ \809812 / 1330. ".- ^ \

verwendet. Diese Wirkung ist umso überraschender,als üblicherweise verwendete Desinfektionsmittel, wie Hexachlorophen, im Tierexperiment nicht kariostatisch wirken. Das folgende Beispiel soll eine Anwendungsform der Erfindung illustrieren, ohne jedoch die Erfindung zu beschränken.used. This effect is even more surprising than Commonly used disinfectants, such as hexachlorophene, do not have a cariostatic effect in animal experiments. The following example is intended to illustrate one embodiment of the invention, but without the invention to restrict.

8 0 9 3 ί 2 / 1 3 3 Q8 0 9 3 ί 2/1 3 3 Q

Beispiel :Example :

Hydroxyäthylcellulose GlyzerinHydroxyethyl cellulose glycerine

Natriummetaphosphat Natriumfluorid NetzmittelSodium Metaphosphate Sodium Fluoride Wetting Agent

2,0 Gewichtsteile 15,0 Gewichtsteile 40,0 Gewichtsteile 0,27 Gewichtsteile 1,7 Gewichtsteile2.0 parts by weight 15.0 parts by weight 40.0 parts by weight 0.27 parts by weight 1.7 parts by weight

N-(ß-Phenoxyäthyl)-N,N-dimethyl- 0,1 Gewichtöteile dodecylammonium-brqmidN- (ß-Phenoxyethyl) -N, N-dimethyl- 0.1 parts by weight of dodecylammonium brqmid

Aroma
Süsstoff
dest. WasserAroma
Sweetener
least. water

q.s,
q.s,
.ad 100qs,
qs,
.ad 100

Bei der Auswahl der Rohstoffe kann man sich selbstverständlich auch anderer für die Zahnpaste geeigneter Rohstoffe bedienen, wenn man darauf achtet, dass diese nicht mit den Pluorid- urid/oder N-(ß-Phenoxyäthyl)-N,N-dimethyldodecylammonium-ionen zu einem wasserunlöslichen Niederschlag reagieren. ■When choosing the raw materials, you can of course also choose others that are more suitable for the toothpaste Use raw materials if you make sure that they do not interfere with the fluoride uride / or N- (ß-phenoxyethyl) -N, N-dimethyldodecylammonium ions react to form a water-insoluble precipitate. ■

809812/ 1330809812/1330

Claims (2)

Patentansprüche:Patent claims: ■ 1. Zahnpflegemittel, dadurch gekennzeichnet, dass es in gelöster Form neben einem Alkalifluorid noch N-(ß-Phenoxyäthyl)-N,N-dimethyl-dodecylammonium-bromid in einer Mindestkonzentration von ungefähr 0,08 Gewichtsprozent enthält. ■ 1. dentifrice, characterized in that it contains in dissolved form, in addition to an alkali fluoride, N- (ß-phenoxyethyl) -N, N-dimethyl-dodecylammonium bromide in a minimum concentration of approximately 0.08 percent by weight. 2. Zahnpflegemittel gemäss Anspruch 1, in Form einer Zahnpaste.2. Dentifrice according to claim 1, in the form of a Toothpaste. 809812/1330809812/1330 Unterlagen (Art. 7 § I Abs. 2 Nr. l S-i?z 3 des A-iderungsges. v. 4. 9.1967) Documents (Art. 7, Paragraph I, Paragraph 2, No. 1 Si? Z 3 of the A-iderungsges. V. 04.09.1967)
DE19641467836 1963-12-30 1964-12-28 New dentifrice Pending DE1467836A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1601563A CH448388A (en) 1963-12-30 1963-12-30 New dentifrice

Publications (1)

Publication Number Publication Date
DE1467836A1 true DE1467836A1 (en) 1968-12-12

Family

ID=4413806

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19641467836 Pending DE1467836A1 (en) 1963-12-30 1964-12-28 New dentifrice

Country Status (11)

Country Link
AT (1) AT260422B (en)
BE (1) BE657697A (en)
CH (1) CH448388A (en)
DE (1) DE1467836A1 (en)
DK (1) DK106635C (en)
ES (1) ES307623A1 (en)
FI (1) FI42990C (en)
FR (1) FR1468676A (en)
GB (1) GB1068750A (en)
NL (1) NL6415187A (en)
SE (1) SE322314B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006218A (en) * 1974-07-08 1977-02-01 Johnson & Johnson Potentiated medicaments

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE64854T1 (en) * 1986-05-22 1991-07-15 Atlantic Pharma Prod COMPOSITION WITH AN INHIBITING EFFECT ON AT LEAST ONE UNITONE AND/OR VIRUS, PREPARATION PROCESS AND USES OF THIS COMPOSITION.
FR2598916B1 (en) * 1986-05-22 1988-09-09 Atlantic Pharma Prod FLUORINATED CHEMICAL COMPOUND USED IN A LOCAL CONTRACEPTION METHOD AND FLUORINATED LOCAL CONTRACEPTIVE COMPOSITION, ESPECIALLY SPERMICIDE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006218A (en) * 1974-07-08 1977-02-01 Johnson & Johnson Potentiated medicaments

Also Published As

Publication number Publication date
BE657697A (en) 1965-06-29
ES307623A1 (en) 1965-06-01
GB1068750A (en) 1967-05-10
CH448388A (en) 1967-12-15
FI42990C (en) 1970-12-10
AT260422B (en) 1968-03-11
FI42990B (en) 1970-09-02
DK106635C (en) 1967-02-27
NL6415187A (en) 1965-07-01
SE322314B (en) 1970-04-06
FR1468676A (en) 1967-02-10

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