DE19727740C1 - Injection equipment introducing contrast medium into vessel, to display its internal structure by sonography - comprises needle or catheter with porous sintered tip, dispersing carbon dioxide bubbles into bloodstream - Google Patents
Injection equipment introducing contrast medium into vessel, to display its internal structure by sonography - comprises needle or catheter with porous sintered tip, dispersing carbon dioxide bubbles into bloodstreamInfo
- Publication number
- DE19727740C1 DE19727740C1 DE1997127740 DE19727740A DE19727740C1 DE 19727740 C1 DE19727740 C1 DE 19727740C1 DE 1997127740 DE1997127740 DE 1997127740 DE 19727740 A DE19727740 A DE 19727740A DE 19727740 C1 DE19727740 C1 DE 19727740C1
- Authority
- DE
- Germany
- Prior art keywords
- catheter
- vessel
- carbon dioxide
- sonography
- display
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 title claims abstract 10
- 229910002092 carbon dioxide Inorganic materials 0.000 title claims abstract 5
- 239000001569 carbon dioxide Substances 0.000 title claims abstract 5
- 239000002872 contrast media Substances 0.000 title claims description 10
- 238000002347 injection Methods 0.000 title 1
- 239000007924 injection Substances 0.000 title 1
- 239000011159 matrix material Substances 0.000 claims abstract description 11
- 239000012528 membrane Substances 0.000 claims abstract description 4
- 239000004809 Teflon Substances 0.000 claims description 2
- 229920006362 Teflon® Polymers 0.000 claims description 2
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 claims description 2
- 229910045601 alloy Inorganic materials 0.000 claims description 2
- 239000000956 alloy Substances 0.000 claims description 2
- 239000000919 ceramic Substances 0.000 claims description 2
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 230000003068 static effect Effects 0.000 claims 1
- 239000007789 gas Substances 0.000 description 7
- 238000002604 ultrasonography Methods 0.000 description 5
- 229940039231 contrast media Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 229910052688 Gadolinium Inorganic materials 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000010968 computed tomography angiography Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000002961 echo contrast media Substances 0.000 description 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/005—Devices for introducing or retaining media, e.g. remedies, in cavities of the body for contrast media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
Abstract
Description
Gemäß der Patentschrift US 3,640,271 sowie der Offenlegungsschrift DE 29 46 662 A1 werden Gasbläschen zur Laufzeitbestimmung und damit zur Blutstromcharakterisierung genutzt. Die Bläschen treten einzeln nacheinander aus den Öffnungen aus und ihre Geschwindigkeit im Blutstrom wird mittels Ultraschall gemessen. Aus dem Ergebnis wird die Flußgeschwindigkeit bestimmt. In der Patentschrift US 5,249,579 wird CO2 für die Röntgen- bzw. CT-Angiographie im digitalen Subtraktionsverfahren genutzt. Dabei wird je ein Bild mit CO2-Blutverdrängung und eins ohne, also mit normalem Strom, aufgenommen und beide Bilder digital voneinander abgezogen. In der amerikanischen Patentschrift US 3,640,271 wird ein Verfahren oder eine Apparatur vorgestellt, mit Gasbläschen die Geschwindigkeit des Blutes zu bestimmen, nicht jedoch wird hier das Gefäß als solches in seinen Maßen bestimmt. Die amerikanische Patentschrift US 5,163,421 offenbart eine antennenartige Ultraschallstruktur, die sich im Ultraschallbild darstellt, jedoch nicht die Maße des Gefäßes darzustellen vermag. In der deutschen Offenlegungsschrift DE 29 46 662 A1 wird ebenfalls aus der Geschwindigkeit der Gasbläschen in einer Ultraschalltechnik die Blutflußgeschwindigkeit bestimmt. Angiologische Untersuchungen sind hierbei auch nicht möglich.According to US Pat. No. 3,640,271 and published patent application DE 29 46 662 A1, gas bubbles are used for determining the transit time and thus for characterizing the blood flow. The bubbles emerge one after the other from the openings and their speed in the blood stream is measured using ultrasound. The flow rate is determined from the result. In US Pat. No. 5,249,579, CO 2 is used for X-ray or CT angiography in the digital subtraction process. One image with CO 2 blood displacement and one without, i.e. with normal current, is taken and both images are digitally subtracted from each other. In the US Pat. No. 3,640,271, a method or an apparatus is presented for determining the speed of the blood with gas bubbles, but the dimensions of the vessel as such are not determined here. The American patent US 5,163,421 discloses an antenna-like ultrasound structure, which is shown in the ultrasound image, but is unable to display the dimensions of the vessel. In the German patent application DE 29 46 662 A1, the blood flow rate is also determined from the speed of the gas bubbles in an ultrasound technique. Angiological examinations are also not possible here.
Das hier erfundene Verfahren erlaubt es, CO2-Bläschen als Ultraschallkontrastmittel zu nutzen.The method invented here allows CO 2 bubbles to be used as ultrasound contrast agents.
Die Aufgabe der hier dargelegten Erfindung betrifft die Darstellung eines neuen Kontrastmittels, welches billig und nebenwirkungsfrei ist sowie eine Vorrichtung zur Dosierung dieses Kontrastmittels.The object of the invention presented here relates to the representation of a new contrast medium, which is cheap and has no side effects and a device for metering this contrast medium.
Die Erfindung betrifft eine Vorrichtung nach dem Oberbegriff des Anspruchs 1.The invention relates to a device according to the preamble of claim 1.
In der Darstellung von Blutgefäßen, Körperhöhlen und Kavernen werden heutzutage verschiedene Kontrastmittel genutzt. Diese reichen von jodhaltigen Kontrastmitteln über CO2-Gas bis gadoliniumhaltigen Kontrastmitteln für die Kernspintomographie. Neuerer Zeit werden auch Kontrastmittel für die Ultraschallbildgebung genutzt. Hier bestehen diese Kontrastmittel aus Gelen mit kleinsten Bläschen. Solche Kontrastmittel sind teuer und nicht nebenwirkungsfrei. Die vorgelegte Erfindung löst dieses Problem durch die Erzeugung von Mikrobläschen aus einem physiologischen oder inertem Gas, wie z. B. CO2.Various contrast media are used in the display of blood vessels, body cavities and caverns today. These range from contrast media containing iodine and CO 2 gas to contrast media containing gadolinium for magnetic resonance imaging. Contrast agents have also recently been used for ultrasound imaging. Here these contrast media consist of gels with tiny bubbles. Such contrast agents are expensive and not free of side effects. The present invention solves this problem by generating microbubbles from a physiological or inert gas, such as. B. CO 2 .
Die Erfindung ist in den folgenden Figuren dargestellt:The invention is illustrated in the following figures:
Fig. 1 Querschnitt durch einen mit einer porösen Matrix versehenen Katheter durch ein Gefäß Fig. 1 cross section through a catheter provided with a porous matrix through a vessel
Fig. 2 Poröse Matrix an der Spitze eine Nadel Fig. 2 Porous matrix at the tip of a needle
Fig. 3 Verschiedene Oberflächenformen des Katheters oder der Nadel Fig. 3 Different surface shapes of the catheter or the needle
Prinzipiell löst die Erfindung das Problem dadurch, daß ein stetiger CO2-Gasstrom in eine Vielzahl von kleinen Mikrobläschen oder Feinstbläschen geteilt wird, an deren Oberflächen die Ultraschallwellen reflektieren und vom Sender über die Bläschen zum Detektor zurückgeworfen werden.In principle, the invention solves the problem in that a steady stream of CO 2 gas is divided into a large number of small microbubbles or very fine bubbles, the surfaces of which reflect the ultrasound waves and are reflected back by the transmitter via the bubbles to the detector.
Fig. 1 zeigt hierfür einen Katheter 2 in einem Gefäß 3 mit einer Gefäßwand 4. Der Katheter trägt an seiner Spitze eine poröse Matrix 1 mit einer planaren Frontoberfläche 14. Das im Katheter 2 befindliche Gas CO2 wird mit einem konstanten Druck durch die poröse Matrix 1 gedrückt und tritt an der Frontoberfläche 14 in Form von Mikrobläschen aus. Die poröse Matrix kann aus verschiedenen Materialien aufgebaut sein, wie z. B. Keramik, gesinterten Metall- oder Kunststofflegierungen wie z. B. Nickeltitan, Edelstahl oder Teflon. Fig. 1 shows this catheter 2 in a vessel 3 having a vessel wall 4. The tip of the catheter has a porous matrix 1 with a planar front surface 14 . The CO 2 gas contained in the catheter 2 is pressed with a constant pressure through the porous matrix 1 and emerges in the form of microbubbles at the front surface fourteenth The porous matrix can be constructed from various materials, such as. B. ceramic, sintered metal or plastic alloys such as. B. nickel titanium, stainless steel or Teflon.
Fig. 2 zeigt, daß eine solche poröse Matrix auch an einer Nadelspitze 6 einer Nadel 5 eingefügt sein kann. Dabei ist die poröse Matrix 1 entsprechend der Nadel angeschliffen. Fig. 2 shows that such a porous matrix can also be inserted at a needle tip 6 of a needle 5 . The porous matrix 1 is ground according to the needle.
Fig. 3 zeigt verschiedene Oberflächen an der Spitze des Katheters 2 oder der Nadel 5. So kann das poröse Medium mit der Zuführung 2 kreisrund konvex abschließen 11 sowie nicht kreisrund konvex 12 oder konkav 13. Ebenso kann eine Membran wie in Fig. 3d gezeigt an der Stirnseite des Katheters 2 angebracht sein, die mit Mikrolöchern versehen ist, so daß beim Durchtreten des Gases ebenfalls Bläschen entstehen. Fig. 3e zeigt dies noch einmal in einer Ansichtsdarstellung. Fig. 3 shows various surfaces at the tip of the catheter 2 or the needle 5. Thus, the porous medium may with the supply 2 to complete circular convex 11 and not circular convex 12 or concave. 13 Likewise, a membrane, as shown in FIG. 3d, can be attached to the end face of the catheter 2 , which is provided with microholes, so that bubbles also form when the gas passes through. Fig. 3e shows this again in a view representation.
11
poröse Matrix
porous matrix
22nd
Katheter
catheter
33rd
Gefäß
vessel
44th
Gefäßwand
Vessel wall
55
Nadel
needle
66
Nadelspitze
Needle point
77
Nadel
needle
88th
-
-
99
-
-
1010th
-
-
1111
kreisrunde konvexe Oberfläche von circular convex surface of
11
1212th
nicht kreisrunde konvexe Oberfläche von not circular convex surface of
11
1313
konkave Oberfläche von concave surface of
11
1414
planare Oberfläche von planar surface of
11
1515
gelöcherte Membran
perforated membrane
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1997127740 DE19727740C1 (en) | 1997-06-30 | 1997-06-30 | Injection equipment introducing contrast medium into vessel, to display its internal structure by sonography - comprises needle or catheter with porous sintered tip, dispersing carbon dioxide bubbles into bloodstream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1997127740 DE19727740C1 (en) | 1997-06-30 | 1997-06-30 | Injection equipment introducing contrast medium into vessel, to display its internal structure by sonography - comprises needle or catheter with porous sintered tip, dispersing carbon dioxide bubbles into bloodstream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19727740C1 true DE19727740C1 (en) | 1999-09-09 |
Family
ID=7834079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1997127740 Expired - Fee Related DE19727740C1 (en) | 1997-06-30 | 1997-06-30 | Injection equipment introducing contrast medium into vessel, to display its internal structure by sonography - comprises needle or catheter with porous sintered tip, dispersing carbon dioxide bubbles into bloodstream |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE19727740C1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9636082B2 (en) | 2001-08-24 | 2017-05-02 | The Cooper Companies Global Holdings Lp | Medical-surgical devices |
| US10045756B2 (en) | 2003-03-29 | 2018-08-14 | The Cooper Companies Global Holdings Lp | Medical devices |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3640271A (en) * | 1969-06-30 | 1972-02-08 | Ibm | Blood flow pressure measurement technique employing injected bubbled and ultrasonic frequency scanning |
| DE2946662A1 (en) * | 1979-11-19 | 1981-05-27 | Siemens AG, 1000 Berlin und 8000 München | Blood pressure measuring appts. - uses ultrasonic waves with volume variation of injected gas bubbles indicated from size of reflected waves |
| US5163421A (en) * | 1988-01-22 | 1992-11-17 | Angiosonics, Inc. | In vivo ultrasonic system with angioplasty and ultrasonic contrast imaging |
| US5249579A (en) * | 1990-03-09 | 1993-10-05 | E-Z-Em, Inc. | Contrast media injector |
-
1997
- 1997-06-30 DE DE1997127740 patent/DE19727740C1/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3640271A (en) * | 1969-06-30 | 1972-02-08 | Ibm | Blood flow pressure measurement technique employing injected bubbled and ultrasonic frequency scanning |
| DE2946662A1 (en) * | 1979-11-19 | 1981-05-27 | Siemens AG, 1000 Berlin und 8000 München | Blood pressure measuring appts. - uses ultrasonic waves with volume variation of injected gas bubbles indicated from size of reflected waves |
| US5163421A (en) * | 1988-01-22 | 1992-11-17 | Angiosonics, Inc. | In vivo ultrasonic system with angioplasty and ultrasonic contrast imaging |
| US5249579A (en) * | 1990-03-09 | 1993-10-05 | E-Z-Em, Inc. | Contrast media injector |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9636082B2 (en) | 2001-08-24 | 2017-05-02 | The Cooper Companies Global Holdings Lp | Medical-surgical devices |
| US9642591B2 (en) | 2001-08-24 | 2017-05-09 | The Cooper Companies Global Holdings Lp | Medical-surgical devices |
| US9743904B2 (en) | 2001-08-24 | 2017-08-29 | The Cooper Companies Global Holdings Lp | Medico-surgical devices |
| US10478150B2 (en) | 2001-08-24 | 2019-11-19 | The Cooper Companies Global Holdings Lp | Medico—surgical devices |
| US10045756B2 (en) | 2003-03-29 | 2018-08-14 | The Cooper Companies Global Holdings Lp | Medical devices |
| US10639002B2 (en) | 2003-03-29 | 2020-05-05 | The Cooper Companies Global Holdings Lp | Medical devices |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8100 | Publication of the examined application without publication of unexamined application | ||
| D1 | Grant (no unexamined application published) patent law 81 | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MRI DEVICES DAUM GMBH, 19061 SCHWERIN, DE |