DE202004007120U1 - Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes - Google Patents

Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes Download PDF

Info

Publication number
DE202004007120U1
DE202004007120U1 DE200420007120 DE202004007120U DE202004007120U1 DE 202004007120 U1 DE202004007120 U1 DE 202004007120U1 DE 200420007120 DE200420007120 DE 200420007120 DE 202004007120 U DE202004007120 U DE 202004007120U DE 202004007120 U1 DE202004007120 U1 DE 202004007120U1
Authority
DE
Germany
Prior art keywords
biochemical
lightening holes
parts including
lightweight construction
including material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE200420007120
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ZEITZ PATRIC
Zeitz Patric Dr
Original Assignee
ZEITZ PATRIC
Zeitz Patric Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ZEITZ PATRIC, Zeitz Patric Dr filed Critical ZEITZ PATRIC
Priority to DE200420007120 priority Critical patent/DE202004007120U1/en
Publication of DE202004007120U1 publication Critical patent/DE202004007120U1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires

Abstract

A biochemical microarray printer (I) comprises upper part (b), lower part (c) and universal head (a) with distance block for matching different needle types and is made lightweight using material reductions and lightening holes.

Description

Einleitung:Introduction:

Die Herstellung von Microarrays bestehend aus biochemischen Substanzen ist in der Wissenschaft weit verbreitet. Diese werden in der Regel für die Analytik eingesetzt. Microarrays herzustellen ist ein Unterfangen, das eine hohe Präzision und Genauigkeit verlangt. Bei der Verwendung von Nadeldruckverfahren werden in der Regel Standarddruckköpfe verwendet, wie sie z.B. von den Firmen TeleChem bzw. BioRobotics angeboten werden.The Production of microarrays consisting of biochemical substances is widely used in science. These are usually for the Analytics used. Producing microarrays is an endeavor that a high precision and accuracy demands. When using dot matrix printing typically standard printheads are used, as e.g. offered by the companies TeleChem and BioRobotics.

Unserer Erfahrung nach weisen die Druckköpfe bisher deutliche Schwächen auf. Diese beruhen zum einen der zu grossen Masse des Druckkopfes und der – jeweilgen Halterungen. Zum anderen neigen die Nadeln dazu, sich während des Druckprozesses im Druckkopf festzusetzen, das sogenannte „sticky pin" Problem. Dieses beruht auf einer zu grossen Kontaktfläche der Nadeln mit dem Druckkopf. Wird jedoch die Bohrung der Nadelhalterungen erweitert, so erhalten die Nadeln zu viel Spiel, was zu mangelner Präzision bzw. Genauigkeit führt. Um das „Sicky Pin" Problem zu vermidern, sind aufwendige Reinigungsprozesse notwendig. Ein solcher ist z.B. im Patent US6101946 von der Firma TeleChem beschrieben.our Experience has shown the printheads so far significant weaknesses on. These are based on the one hand too much mass of the print head and the - respectively Holders. On the other hand, the needles tend to move during the To set printing process in the printhead, the so-called "sticky pin "problem. This is due to too large contact area of the needles with the print head. Becomes However, the bore of the needle holders extended so get the Needles too much play, which leads to poor precision or accuracy. Around the "Sicky Pin "problem too reduce the complexity of cleaning processes. Such a is e.g. in patent US6101946 by TeleChem.

Zusammenfassung:Summary:

Der Druckkopf besteht aus einem gewichtsminimierten Ober und Unterteil (siehe 1+2). Diese können je nach verwendetem Nadeltyp mit (siehe 1) oder ohne einen Distanzblock (siehe 2) (Beispiele ohne Distanzblock: TeleChem Micro Spotting Pins oder mit Distanzblock: BioRobotics Microspot Pins) in eine Universelle Halterung montiert werden, die z.B. mit einem Bajonettadapter für Biorobotics Microgrid Drucker versehen ist (z.B. siehe Abb. 1+2). Adapter sind natürlich für alle denkbaren Druckertypen herstellbar. Durch die Verwendung zweier dünner, gewichts- und versteifungsoptimierter Platten wird das Gesamtgewicht des Druckkopfes minimiert. Zudem werden die Berührungsflächen der Nadeln mit dem Druckkopf minimiert, so dass praktisch kein „Sticky pin" Problem mehr auftritt.The print head consists of a weight minimized upper and lower part (see 1 + 2 ). These can vary depending on the type of needle used (see 1 ) or without a spacer block (see 2 ) (Examples without spacer block: TeleChem Micro Spotting Pins or with spacer block: BioRobotics Microspot Pins) are mounted in a universal holder, which is eg equipped with a bayonet adapter for Biorobotics Microgrid printer (eg see fig. 1 + 2 ). Of course, adapters can be produced for all conceivable printer types. Using two thin, weight and stiffening optimized plates minimizes the total weight of the printhead. In addition, the contact surfaces of the needles are minimized with the print head, so that virtually no "sticky pin" problem occurs.

Genaue Beschreibung:Precise description:

Der Printkopf nimmt maximal 64 Nadeln auf. Es sind 16 Bohrungen in x Achse und 4 verläuft bis x=3,575-45,425 mm y=17,75 mm und ist lediglich durch die Bohrungen unterbrochen. Es gibt insgesamt 7 Verdickungsleisten mit einem Abstand Mitte zu Mitte von x=4,5 mm, einer Breite von 1,85 mm .Of the Print head takes a maximum of 64 needles. There are 16 holes in x Axis and 4 runs to x = 3.575-45.425 mm y = 17.75 mm and is only through the holes interrupted. There are a total of 7 thickening strips at a distance Center to center of x = 4.5 mm, a width of 1.85 mm.

Der Universaldruckkopf enthält einen Standard Bajonettadapter für Biorobotics Printer und das passende Design für Lage der Pins. Die Distanz der zu befestigenden Printplatten beträgt 5 mm für Telechem Microspotting Pins. Bei Microspot Pins von Biorobotics wird zusätzlich der Distanzblock verwendet.Of the Universal printhead contains a standard bayonet adapter for Biorobotics Printer and the matching design for location of the pins. The distance the PCB to be attached is 5 mm for Telechem Microspotting pins. Microspot pins from Biorobotics also use the spacer block.

Der Distanzblock hat eine Höhe von 17,5 mm, eine Breite von 72 mm und eine Tiefe von 5 mm. Auf der Ober und Unterseite sind längs Leisten von 1 mm Höhe und 1 mm Tiefe, so dass ein Kanal von 5 mm Tiefe die ganze Breite überspannt. An der Position von 4,5 mm Breite befindet sich mittig (2,5 mm) eine 3 mm durchmessende Bohrung. In Abständen von 4,5 mm (Center zu Center) befinden sich 15 weitere 3 mm durchmessende Bohrungen. Die erste und die 16te Bohrung sind 6 mm tief (je von der Ober- bzw. Unterseite gemessen). Die mittleren 14 Bohrungen sind durchgängig.Of the Distance block has a height of 17.5 mm, a width of 72 mm and a depth of 5 mm. On the top and bottom are longitudinal Bars of 1 mm height and 1 mm depth, so that a channel of 5 mm depth spans the entire width. At the position of 4.5 mm width is in the middle (2.5 mm) one 3 mm diameter bore. At intervals of 4.5 mm (center to Center) there are 15 further 3 mm diameter holes. The first and the 16th hole are 6 mm deep (depending on the upper or Underside measured). The middle 14 holes are continuous.

Die Freimasstoleranz beträgt +/-0,1.The Tolerance tolerance is +/- 0.1.

Abb1: Druckkopf ohne Distanzblock:

1.1
Frontansicht
1.2
Seitenansicht
1.3
Aufsicht
1.4
räumliche Ansicht
a
Universelle Halterung mit Bajonettadapter
b
Oberteil
c
Unterteil
Fig1: Printhead without spacer block:
1.1
front view
1.2
sideview
1.3
At sight
1.4
spatial view
a
Universal mount with bayonet adapter
b
top
c
lower part

Abb2: Druckkopf mit Distanzblock

2.1
Frontansicht
2.2
Seitenansicht
2.3
Aufsicht
3.4
räumliche Ansicht
a
Universelle Halterung mit Bajonettadapter
b
Oberteil
c
Unterteil
d
Distanzblock
Abb2: Printhead with spacer block
2.1
front view
2.2
sideview
2.3
At sight
3.4
spatial view
a
Universal mount with bayonet adapter
b
top
c
lower part
d
spacer block

Claims (6)

Eine Vorrichtung zum Drucken von Microarrays die ein Oberteil, ein Unterteil und einen Universalkopf enthält.A device for printing microarrays which contains a top, a bottom and a universal head. Eine Vorrichtung nach Anspruch 1 die zusätzlich noch einen Distanzblock zur Anpassung an unterschiedliche Nadeltypen enthält.An apparatus according to claim 1 additionally a spacer block to adapt to different types of needles contains. Eine Vorrichtung nach den Ansprüchen 1 und 2 die bis zu 64 verschiedener Nadeln enthalten kann.A device according to claims 1 and 2, up to 64 may contain different needles. Eine Vorrichtung nach den Ansprüchen 1–3 die zur Gewichtsersparniss spezifisch materialtreduziert ist.A device according to claims 1-3 which specifically reduces material for weight savings is. Eine Vorrichtung nach den Ansprüchen 4 die zur Gewichtsersparniss spezifische Bohrungen enthält.A device according to claims 4 for weight saving contains specific holes. Eine Vorrichtung nach den Ansprüchen 1–4 die spezifische Verdickungen zur Stabilisierung enthält.A device according to claims 1-4 the specific thickening for stabilization.
DE200420007120 2004-05-03 2004-05-03 Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes Expired - Lifetime DE202004007120U1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE200420007120 DE202004007120U1 (en) 2004-05-03 2004-05-03 Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE200420007120 DE202004007120U1 (en) 2004-05-03 2004-05-03 Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes

Publications (1)

Publication Number Publication Date
DE202004007120U1 true DE202004007120U1 (en) 2005-09-29

Family

ID=35070725

Family Applications (1)

Application Number Title Priority Date Filing Date
DE200420007120 Expired - Lifetime DE202004007120U1 (en) 2004-05-03 2004-05-03 Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes

Country Status (1)

Country Link
DE (1) DE202004007120U1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2572786A1 (en) * 2011-09-20 2013-03-27 CyBio AG Pipetting device with pipette head with a number of pipette channels arranged in a pattern

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882930A (en) * 1997-11-10 1999-03-16 Hyseq, Inc. Reagent transfer device
WO2000008474A1 (en) * 1998-08-07 2000-02-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Dosing head for parallel treatment of a plurality of fluid probes
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
US6146594A (en) * 1999-02-10 2000-11-14 Robbins Scientific Corporation Syringe array with adjustable needle spacing
US20020173048A1 (en) * 2001-04-26 2002-11-21 Touji Nakazawa Microarraying head and microarryer
EP1273347A2 (en) * 2001-06-28 2003-01-08 Genetix Limited Microarraying apparatus, pin head therefor and spotting method
US20030027345A1 (en) * 2001-07-31 2003-02-06 Friswell David R. Liquid handling system with automatically interchangeable cannula array
US6558623B1 (en) * 2000-07-06 2003-05-06 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
US20030108868A1 (en) * 2001-09-07 2003-06-12 Affymetrix, Inc. Apparatus and method for aligning microarray printing head
US6692701B2 (en) * 2001-02-01 2004-02-17 V & P Scientific, Inc. Microarrayer
WO2004014555A1 (en) * 2002-08-07 2004-02-19 Perkinelmer Las, Inc. Dispensing apparatus

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882930A (en) * 1997-11-10 1999-03-16 Hyseq, Inc. Reagent transfer device
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
WO2000008474A1 (en) * 1998-08-07 2000-02-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Dosing head for parallel treatment of a plurality of fluid probes
US6146594A (en) * 1999-02-10 2000-11-14 Robbins Scientific Corporation Syringe array with adjustable needle spacing
US6558623B1 (en) * 2000-07-06 2003-05-06 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
US6692701B2 (en) * 2001-02-01 2004-02-17 V & P Scientific, Inc. Microarrayer
US20020173048A1 (en) * 2001-04-26 2002-11-21 Touji Nakazawa Microarraying head and microarryer
EP1273347A2 (en) * 2001-06-28 2003-01-08 Genetix Limited Microarraying apparatus, pin head therefor and spotting method
US20030027345A1 (en) * 2001-07-31 2003-02-06 Friswell David R. Liquid handling system with automatically interchangeable cannula array
US20030108868A1 (en) * 2001-09-07 2003-06-12 Affymetrix, Inc. Apparatus and method for aligning microarray printing head
WO2004014555A1 (en) * 2002-08-07 2004-02-19 Perkinelmer Las, Inc. Dispensing apparatus

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2572786A1 (en) * 2011-09-20 2013-03-27 CyBio AG Pipetting device with pipette head with a number of pipette channels arranged in a pattern
CN103008039A (en) * 2011-09-20 2013-04-03 西比欧公司 Pipetting device with pipette head with a number of pipette channels arranged in a pattern
US9084993B2 (en) 2011-09-20 2015-07-21 Analytik Jena Ag Pipetting apparatus with a pipetting head comprising a multiplicity of pipetting channels disposed in an arrangement pattern

Similar Documents

Publication Publication Date Title
EP1163116B1 (en) Handstamp
DE60316562T2 (en) TISSUE ARRAY CONSTRUCTION INSTRUMENT
DE2205430C3 (en) Inking device for a gravure form in a printing machine
DE102016200465B4 (en) Method for operating a printer for three-dimensional objects with the generation of test patterns for measuring a distance between print head and substrate and printer for three-dimensional objects
DE19754000A1 (en) Device and method for the electrically triggered microdrop delivery with a dispensing head
DE2508356C2 (en) Device for printing capsule parts
DE60310304T2 (en) Device for loading and delivering solid ink
DE202004007120U1 (en) Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes
CN107233853A (en) The predefined droplet array maker of reagent and preparation method and drop formation method
EP0908313A3 (en) Machine for lettering of eggs
DE102011120209A1 (en) Device, useful to generate pourable markings on core or mold for casting of molded part, includes position-variable mechanical units, an elastically deformable element, and a system to produce and transmit restoring force to position units
DE2624930C3 (en) Grids for rotogravure printing
EP3890949B1 (en) Method and device for producing a three-dimensional object
DE730819C (en) Device for changing the electrolytically effective surface of the anodes in galvanic baths
DE202011108698U1 (en) Device for producing a pourable marking on a core or on a casting mold for the casting of a cast part
DE102019121862A1 (en) Form-flexible insert, shaping tool, use of a form-flexible insert, method for producing a shaping tool, method for producing a molded part containing plastic, molded part containing plastic
DE69910340T2 (en) Monolithic inkjet printing chassis
DE804295C (en) pen
EP2374594B1 (en) Injection moulding machine
EP3766961B1 (en) Method for producing biological tissue
DE102008001178B4 (en) Method for operating a printing machine
DE10032811B4 (en) Device for the production of oligomer arrays
DE845640C (en) Printing device with one or more adjustable, endless belts
DE33325C (en) Forming process for the manufacture of cast nails
DE202005006443U1 (en) Machine molding confectionery, especially pralines, has plate carrying molding plungers which is flexibly-mounted

Legal Events

Date Code Title Description
R086 Non-binding declaration of licensing interest
R163 Identified publications notified
R207 Utility model specification

Effective date: 20051103

R150 Term of protection extended to 6 years

Effective date: 20071206

R151 Term of protection extended to 8 years

Effective date: 20101203

R158 Lapse of ip right after 8 years

Effective date: 20121201