DE2364373A1 - Pharmaceutical and/or cosmetic prepns. - contg. methyl-substd. xanthine, oestriol and/or a mucopolysaccharide - Google Patents
Pharmaceutical and/or cosmetic prepns. - contg. methyl-substd. xanthine, oestriol and/or a mucopolysaccharideInfo
- Publication number
- DE2364373A1 DE2364373A1 DE2364373A DE2364373A DE2364373A1 DE 2364373 A1 DE2364373 A1 DE 2364373A1 DE 2364373 A DE2364373 A DE 2364373A DE 2364373 A DE2364373 A DE 2364373A DE 2364373 A1 DE2364373 A1 DE 2364373A1
- Authority
- DE
- Germany
- Prior art keywords
- contg
- mucopolysaccharide
- estriol
- contain
- prepns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Abstract
Description
49 149 ' 49 149 '
Anmelder; Dr. Carl Hahn GmbH, 4 Düsseldorf Applicant; Dr. Carl Hahn GmbH, 4 Düsseldorf
Pharmazeutische und kosmetische Präparate zur äußerlichen AnwendungPharmaceutical and cosmetic preparations for external use
Die vorliegende Erfindung betrifft neue pharmazeutische und/ oder kosmetische Präparate, die als WirkstoffeThe present invention relates to new pharmaceutical and / or cosmetic preparations that act as active ingredients
a) eine Verbindung der allgemeinen Formel Ia) a compound of the general formula I.
509828/0998509828/0998
worin R^ und R2 Wasserstoff oder die Methylgruppe sind und mindestens einer der Substituenten R. und Rp die Methylgruppe ist,where R ^ and R 2 are hydrogen or the methyl group and at least one of the substituents R. and Rp is the methyl group,
b) Östriol undb) estriol and
c) ein Mucopolysaccharidc) a mucopolysaccharide
enthalten, wobei mindestens zwei der drei Verbindungen a), b) und c) anwesend sind. Bevorzugt enthalten die erfindungsgemäßen Kombinationspräparate die Verbindungen der Formel 1 in Mengen von 0,01 bis 1,2 Gew.%, die Verbindung Östriol in Mengen von 0,005 bis 0,1 Gew.%' und das Mucopolysaccharid in Mengen von 0,01 bis 5,0 Gew.96.included, with at least two of the three compounds a), b) and c) being present. The combination preparations according to the invention preferably contain the compounds of formula 1 in amounts from 0.01 to 1.2% by weight , the compound estriol in amounts from 0.005 to 0.1% by weight and the mucopolysaccharide in amounts from 0.01 to 5 % , 0 wt. 96.
Die Wirkstoffe der erfindungsgemäßen Kombinationspräparate zur äußerlichen Anwendung sind zum größten Teil bekannt. Bei den Verbindungen der allgemeinen Formel I handelt es sich um die Xanthine Coffein, Theobromin und Theophyllin. Bei dem Mucopolysaccharid handelt es sich bevorzugt um Heparin und Heparinoide, die Hyaluronsäure und Chondroitinschwefelsäure und -sulphate A und B.The active ingredients of the combination preparations according to the invention for external use are for the most part known. The compounds of general formula I are the xanthines caffeine, theobromine and theophylline. In which Mucopolysaccharide is preferably heparin and heparinoids, hyaluronic acid and chondroitin sulfuric acid and sulphates A and B.
Die neuen Kombinationspräparate gemäß der vorliegenden Erfindung zeichnen sich durch eine synergistisch-verstärkte Wirksamkeit auf die Haut und insbesondere auf die Kopfhaut aus.The new combination preparations according to the present invention are characterized by a synergistic increased effectiveness on the skin and especially on the scalp.
Bevorzugt sind solche erfindungsgemäße pharmazeutische Präpa-Such pharmaceutical preparations according to the invention are preferred
50 982 8/09 98 8ADORiGiNAL50 982 8/09 98 8 ADORiGiNAL
rate, die als Xanthin das 1,3>7-Trimethylxanthin (Coffein) und als Mucopolysaccharid Heparin enthalten.rate, the 1,3> 7-trimethylxanthine (caffeine) and contain heparin as a mucopolysaccharide.
Die erfindungsgemäßen Kombinationspräparate enthalten neben den genannten Wirkstoffen zur Herstellung äußerlich anzuwendender pharmazeutischer und/oder kosmetischer Präparate übliche Träger-, Yerdünnungs- und/oder Lösungsmittel. Die wichtigsten Formen der erfindungsgemäßen Präparate sind wässrig-alkoholische Lotionen, Wasser/Öl-Emulsionen, Öl/Wasser-Emulsionen, wasserfreie Salben sowie transparente und andere Gele. Für die Behandlung der,Kopfhaut kommen bevorzugt wässrigalkoholische, eine Verbindung der Formel I und Östriol ent- The combination preparations according to the invention contain in addition to the active ingredients mentioned for the production of externally applicable common carriers, thinners and / or solvents for pharmaceutical and / or cosmetic preparations. the are the most important forms of the preparations according to the invention aqueous-alcoholic lotions, water / oil emulsions, oil / water emulsions, anhydrous ointments, as well as transparent and other gels. For the treatment of the scalp, preference is given to aqueous-alcoholic, a compound of the formula I and estriol.
haltende Lotionen, für die Behandlung der Haut bevorzugt die genannten Emulsionen, Salben und Gele in Betracht, die Östriol in Kombination mit Mucopolysaccharid allein oder in VerbindungHolding lotions, preferably the emulsions, ointments and gels mentioned for the treatment of the skin, the estriol in combination with mucopolysaccharide alone or in conjunction
enthalten mit einem Xanthin der Formel I/ Speziell für die Akne-Behandlung werden eine Verbindung der Formel I und östriol enthaltende alkoholhaltige Gele eingesetzt.Contained with a xanthine of the formula I / Especially for acne treatment a compound of formula I and estriol-containing alcohol-containing gels are used.
Die erfindungsgemäßen Kombinationspräparate können weiterhin Duftstoffe und/oder Farbstoffe enthalten. Sie können auch weitere zusätzliche Wirkungskomponenten ergebende Wirkstoffe, insbesondere Cholesterin, Lecithin, Nukleinsäuren, Pyrimidine, Purine und/oder Vitamine enthalten.The combination preparations according to the invention can also Contain fragrances and / or dyes. You can also use other active ingredients that provide additional active components, in particular contain cholesterol, lecithin, nucleic acids, pyrimidines, purines and / or vitamins.
Die erfindungsgemäßen Präparate werden nach üblichen VerfahrenThe preparations according to the invention are made by customary methods
• ORIGINAL INSPECTED . 50 98 28/0998• ORIGINAL INSPECTED. 50 98 28/0998
hergestellt. Sie werden auf den für die Anwendung auf der Haut optimalen pH-Bereich mit für diesen Zweck geeigneten Puff er systemen wie Natriummonohydrogenphosphat/Kaliumdihydrogenphosphat (Phosphatpuffer) und/oder Natriumlactat/Kilchsäune (Lactatpuffer) eingestellt. Für Haarpräparate ist der optimale pH-Bereich 6,0 bis 7,0, für Hautpräparate 5,4 bis 5,8.manufactured. They are adjusted to the optimal pH range for application on the skin with suitable for this purpose Buffer systems such as sodium monohydrogen phosphate / potassium dihydrogen phosphate (Phosphate buffer) and / or sodium lactate / Kilchsäune (Lactate buffer). For hair preparations the optimal pH range is 6.0 to 7.0, for skin preparations 5.4 to 5.8.
Die folgenden Beispiele dienen der weiteren Erläuterung der vorliegenden Erfindung.The following examples serve to further explain the present invention.
Herstellung von alkoholisch-wässrigen, Coffein und östriol enthaltenden Lotionen.Production of alcoholic-aqueous, caffeine and estriol containing lotions.
509828/09 98509828/09 98
Isopropanol Hexadecylalkohol Eiweißhydrolysat Konservans Destilliertes WasserIsopropanol hexadecyl alcohol protein hydrolyzate Conservant distilled water
60
0,5 5,0 0,3 ad 10060
0.5 5.0 0.3 ad 100
Die Bestandteile wurden in Isopropanol und der wesentlichen Menge des destillierten Wassers vollständig gelöst und mit destilliertem Wasser auf 100 Gew.% aufgefüllt.The ingredients were completely dissolved in isopropanol and the substantial amount of distilled water and with distilled water made up to 100% by weight.
Herstellung einer Östriol und o6-Heparin enthaltenden Wasserin-Öl-Emulsion (W/0-Emulsion).Production of a water-in-oil emulsion containing estriol and o6-heparin (W / 0 emulsion).
vorwiegend Mischester aus
Pentaerythrit-Fettsäureester und
Zitronensäurealkohole sterMixture of higher molecular esters,
predominantly mixed esters
Pentaerythritol fatty acid esters and
Citric Acid Alcohols
509828/0998509828/0998
vorwiegend Mischester aus
Pentaerythrit-Fettsäureester und
ZitronensäurealkoholesterMixture of higher molecular esters,
predominantly mixed esters
Pentaerythritol fatty acid esters and
Citric acid alcohol ester
Die Bestandteile wurden innig mit den wasserfreien ölbestandteilen vermischt und sodann das demineralisierte Wasser unter heftigem mechanischen Rühren eingemischt.The ingredients became intimate with the anhydrous oil ingredients mixed and then the demineralized water under vigorous mechanical stirring.
Herstellung einer östriol und oC-Heparin enthaltenden öl-in-Waeeer-Ejaulsion (0/¥-Emulsion).Production of an oil-in-waeeer ejaulsion containing oestriol and oC-heparin (0 / ¥ emulsion).
509828/0998509828/0998
a) Zusammensetzung ' Gewichtsteile Östriol 0,008 c£-Heparin 0,12a) Composition : parts by weight of estriol 0.008 c £ -heparin 0.12
äthoxylierter Cetylsteary!alkoholEthoxylated cetylstearyl alcohol
mit ca. 12 Molekülen Äthylenoxidwith approx. 12 molecules of ethylene oxide
pro Alkoholmolekül ' 2per alcohol molecule '2
Gemisch aus Mono- und DiglyceridenMixture of mono- and diglycerides
der Palmitin- und Stearinsäure 12of palmitic and stearic acid 12
2-Octyldodecanol 102-octyldodecanol 10
Capryl-Caprinsäuretriglycerid 15Caprylic-capric acid triglyceride 15
1,2-Propylenglykol 51,2-propylene glycol 5
Nipastat (Konservans) 0,18Nipastat (canned food) 0.18
Demineralisiertes Wasser ad 100Demineralized water ad 100
b) Zusammensetzung Gewichtsteile östriol 0,012 oC-Heparin 0,17b) Composition parts by weight of estriol 0.012 oC-heparin 0.17
äthoxylierter Cetylstearylalkoholethoxylated cetostearyl alcohol
mit ca. 12 Molekülen Äthylenoxidwith approx. 12 molecules of ethylene oxide
pro Alkoholmolekül ' 3per alcohol molecule '3
Gemisch aus Mono- und Diglyceriden .Mixture of mono- and diglycerides.
der Palmitin- und Stearinsäure 15of palmitic and stearic acid 15
2-0ctyldodecanol 202-octyldodecanol 20
Capryl-Caprinsäuretriglycerid 8Caprylic-capric acid triglyceride 8
1,2-Propylenglykol 0 r 51,2-propylene glycol 0 r 5
Nipastat (Konservans) 0,18Nipastat (canned food) 0.18
Demineralisiertes Wasser ad 100Demineralized water ad 100
Die Bestandteile wurden wie im Beispiel 2 beschrieben vermischt. The ingredients were mixed as described in Example 2.
5098 2 8/09985098 2 8/0998
Herstellung einer Östriol und oC-Heparin enthaltenden, wasserfreien Salbe.Production of an anhydrous containing estriol and oC-heparin Ointment.
a) Zusammensetzung Gewichtsteile a) Composition parts by weight
mit ca. 20 Molekülen Äthylenoxid
pro Alkoholmolekülethoxylated cetostearyl alcohol
with approx. 20 molecules of ethylene oxide
per alcohol molecule
cC-Heparin 0,17cC-heparin 0.17
östriol 0,015estriol 0.015
Glycerinmonostearat 16,0Glycerol monostearate 16.0
äthoxylierter Cetylstearylalkoholethoxylated cetostearyl alcohol
mit ca. 20 Molekülen Äthylenoxidwith approx. 20 molecules of ethylene oxide
pro Alkoholmolekül 3,5per alcohol molecule 3.5
Cholesterin 1,0Cholesterol 1.0
Lecithin - 1,0Lecithin - 1.0
oC-Tocopherol (Antioxidans) 0,18oC-tocopherol (antioxidant) 0.18
ölsäuredecylester ad 100oleic acid decyl ester ad 100
509828/0998509828/0998
Die Bestandteile wurden in einer Salbenmühle (Dreiwalzwerk mit Hartporzellanwalzen) innig vermischt, bis eine homogene Salbe erreicht war.The ingredients were intimately mixed in an ointment mill (three-roll mill with hard porcelain rolls) until homogeneous Ointment was reached.
Herstellung eines Coffein, Östriol und oC-Heparin enthaltenden, transparenten Gels.Production of a caffeine, estriol and oC-heparin containing, transparent gels.
a) Zusammensetzung GewichtsteiIe a) Composition by weight
mit ca. 30 Molekülen Äthylenoxid
pro Alkoholmolekül 11,0ethoxylated cetostearyl alcohol
with about 30 molecules of ethylene oxide
per alcohol molecule 11.0
äthoxylierter Cetylstearylalkohol mit ca. 30 Molekülen Äthylenoxid . pro Alkoholmolekül . 13»0Ethoxylated cetostearyl alcohol with approx. 30 molecules of ethylene oxide . per alcohol molecule. 13 »0
509828/0998509828/0998
Polyolfettsäureester 20,0Polyol fatty acid ester 20.0
Palmitinsäureisopropylester 4,0 . Lecithin 1,1Isopropyl palmitate 4.0. Lecithin 1.1
Nipastat (Konservans) 0,2Nipastat (canned food) 0.2
Destilliertes Wasser ad 100Distilled water ad 100
Der bei ca. 900C geschmolzenen Fettphase wird ca. 2/3 der Wasserphase gleicher Temperatur zugegeben. Das entstandene Gel wird unter Rühren auf ca. 500C -abgekühlt, die Wirkstoffe in der restlichen Wassermenge gelöst oder aufgeschwemmt, •zugegeben und der Rührprozeß kurz nach der Verteilung beendet, um die Einarbeitung von Luft zu vermeiden.The molten at about 90 0 C fat phase is about 2/3 of the same temperature of the water phase was added. The resulting gel is -abgekühlt with stirring to about 50 0 C, releasing the active ingredients in the remaining amount of water or suspended, • added and the stirring process ends soon after the distribution to the incorporation to avoid air.
Herstellung eines Coffein und Östriol enthaltenden Gels für die Aknebehandlung.Manufacture of a gel containing caffeine and estriol for the acne treatment.
a) Zusammensetzung Gewichtsteile a) Composition parts by weight
mit ca. 30 Molekülen Äthylenoxid
pro Alkoholmolekülethoxylated cetostearyl alcohol
with about 30 molecules of ethylene oxide
per alcohol molecule
509828/0998509828/0998
10,04.0
10.0
mit ca. 30 Molekülen Äthylenoxid.
pro Alkoholmolekül 13»0ethoxylated cetostearyl alcohol
with about 30 molecules of ethylene oxide.
per alcohol molecule 13 »0
Äthanol 70 % Isopropyl palmitate
Ethanol 70 %
Die Herstellung des Gels geschieht entsprechend Beispiel 5.The gel is produced according to Example 5.
Bei den in den vorstehenden Beispielen aufgeführten Konser-In the case of the consoles listed in the above examples
R RR R
vierungsmitteln Nipastrat und Phenonip handelt es sich um Produkte der englischen Firma Nipa Laboratories, London/ England. Bei dem Konservierungsmittel Bronopol handelt es sich um 2-Brom-2-nitropropan-1,3-diol.It is a matter of nipastrat and phenonip as the additives to products from the English company Nipa Laboratories, London / England. The preservative bronopol is are 2-bromo-2-nitropropane-1,3-diol.
509828/0998509828/0998
Claims (6)
0,01 bis 1,2 Gew.% enthalten.4. Preparations according to claim 1 to 3 »characterized in that they contain the compound of formula I in an amount of
0.01 to 1.2 wt.% Contain.
bis 0,1 Gevr.% enthalten.5. Preparations according to claim 1 .to 4, characterized in that they contain the compound estriol in an amount of 0.005
up to 0.1 Gevr.% included.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2364373A DE2364373A1 (en) | 1973-12-22 | 1973-12-22 | Pharmaceutical and/or cosmetic prepns. - contg. methyl-substd. xanthine, oestriol and/or a mucopolysaccharide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2364373A DE2364373A1 (en) | 1973-12-22 | 1973-12-22 | Pharmaceutical and/or cosmetic prepns. - contg. methyl-substd. xanthine, oestriol and/or a mucopolysaccharide |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2364373A1 true DE2364373A1 (en) | 1975-07-10 |
Family
ID=5901843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2364373A Withdrawn DE2364373A1 (en) | 1973-12-22 | 1973-12-22 | Pharmaceutical and/or cosmetic prepns. - contg. methyl-substd. xanthine, oestriol and/or a mucopolysaccharide |
Country Status (1)
Country | Link |
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DE (1) | DE2364373A1 (en) |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2369840A1 (en) * | 1976-11-08 | 1978-06-02 | Oreal | NEW COSMETIC COMPOSITION WITH SLIMMING AND ANTI-CELLULITIC ACTION |
FR2437207A1 (en) * | 1978-09-29 | 1980-04-25 | Henkel Kgaa | Anti dandruff hair prepn. - contg. substd. theophylline cpds. as active ingredient |
EP0011821A2 (en) * | 1978-11-27 | 1980-06-11 | Henkel Kommanditgesellschaft auf Aktien | Antiseborrhoeic hair treatment composition |
JPS61236732A (en) * | 1985-04-05 | 1986-10-22 | フイデイ−ア・ソシエタ・ペル・アチオニ | Novel local medicine |
EP0305743A2 (en) * | 1987-08-01 | 1989-03-08 | Hoechst Aktiengesellschaft | Pharmaceutical mixture preparation, its manufacture and use |
FR2627388A1 (en) * | 1988-02-18 | 1989-08-25 | Roussel Uclaf | NOVEL COSMETIC COMPOSITIONS FOR COMBATTING CELLULITE |
WO1994028905A1 (en) * | 1993-06-08 | 1994-12-22 | Herbert Kuhl | Oestriol-containing hormonal agent for the prophylaxis and treatment of arterial conditions in humans, method of preparing it and its use |
US5442053A (en) * | 1982-09-28 | 1995-08-15 | Fidia, S.P.A. | Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions |
US5614506A (en) * | 1991-07-03 | 1997-03-25 | Hyal Pharmaceutical Corporation | Use of hyaluronic acid and forms to prevent arterial restenosis |
US5639738A (en) * | 1992-02-20 | 1997-06-17 | Hyal Pharmaceutical Corporation | Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs |
US5767106A (en) * | 1992-02-21 | 1998-06-16 | Hyal Pharmaceutical Corporation | Treatment of disease and conditions associated with macrophage infiltration |
US5792753A (en) | 1991-07-03 | 1998-08-11 | Hyal Pharmaceutical Corporation | Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs |
US5811410A (en) * | 1989-09-21 | 1998-09-22 | Hyal Pharmaceutical Corporation | Method of administering of a hyaluronic acid and an NSAID to decrease side effects of the NSAID |
US5817644A (en) * | 1991-07-03 | 1998-10-06 | Hyal Pharmaceutical Corporation | Targeting of dosages of medicine and therapeutic agents |
US5824658A (en) * | 1990-09-18 | 1998-10-20 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
US5910489A (en) * | 1990-09-18 | 1999-06-08 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
US5942498A (en) * | 1992-02-20 | 1999-08-24 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
US5977088A (en) * | 1991-07-03 | 1999-11-02 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
US5990096A (en) * | 1990-09-18 | 1999-11-23 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
US5990095A (en) * | 1991-07-03 | 1999-11-23 | Hyal Pharmaceutical Corporation | Use of hyaluronic acid and forms to prevent arterial restenosis |
US6140312A (en) * | 1992-02-20 | 2000-10-31 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
US6218373B1 (en) | 1992-02-20 | 2001-04-17 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
WO2003022239A2 (en) * | 2001-09-07 | 2003-03-20 | Western Holdings Llc | Stable water in oil aminophylline emulsions |
US8758819B2 (en) | 2006-09-13 | 2014-06-24 | Enhance Skin Products, Inc. | Cosmetic compositions for the treatment of skin and methods thereof |
-
1973
- 1973-12-22 DE DE2364373A patent/DE2364373A1/en not_active Withdrawn
Cited By (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2369840A1 (en) * | 1976-11-08 | 1978-06-02 | Oreal | NEW COSMETIC COMPOSITION WITH SLIMMING AND ANTI-CELLULITIC ACTION |
FR2437207A1 (en) * | 1978-09-29 | 1980-04-25 | Henkel Kgaa | Anti dandruff hair prepn. - contg. substd. theophylline cpds. as active ingredient |
EP0011821A2 (en) * | 1978-11-27 | 1980-06-11 | Henkel Kommanditgesellschaft auf Aktien | Antiseborrhoeic hair treatment composition |
EP0011821A3 (en) * | 1978-11-27 | 1981-01-14 | Henkel Kommanditgesellschaft auf Aktien | Antiseborrhoeic hair treatment composition |
US5442053A (en) * | 1982-09-28 | 1995-08-15 | Fidia, S.P.A. | Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions |
US5631241A (en) * | 1983-10-10 | 1997-05-20 | Fidia S.P.A. | Pharmaceutical compositions containing hyaluronic acid fractions |
JPS61236732A (en) * | 1985-04-05 | 1986-10-22 | フイデイ−ア・ソシエタ・ペル・アチオニ | Novel local medicine |
EP0305743A2 (en) * | 1987-08-01 | 1989-03-08 | Hoechst Aktiengesellschaft | Pharmaceutical mixture preparation, its manufacture and use |
EP0305743A3 (en) * | 1987-08-01 | 1990-04-04 | Hoechst Aktiengesellschaft | Pharmaceutical mixture preparation, its manufacture and use |
US5055457A (en) * | 1987-08-01 | 1991-10-08 | Hoechst Aktiengesellschaft | Pharmaceutical combinations product and the preparation and use thereof |
FR2627388A1 (en) * | 1988-02-18 | 1989-08-25 | Roussel Uclaf | NOVEL COSMETIC COMPOSITIONS FOR COMBATTING CELLULITE |
BE1005177A4 (en) * | 1988-02-18 | 1993-05-18 | Roussel Uclaf | New cosmetic intended to combat cellulite. |
US5985850A (en) * | 1989-09-21 | 1999-11-16 | Hyal Pharmaceuticals Corporation | Compositions comprising hyaluronic acid and drugs |
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