DE2438648A1 - Dispersal and removal of thromboses within blood vessels - using ultrasonic sound conducting cannulae bundle with central suction opening and transmission facility for infusion liquids - Google Patents

Dispersal and removal of thromboses within blood vessels - using ultrasonic sound conducting cannulae bundle with central suction opening and transmission facility for infusion liquids

Info

Publication number
DE2438648A1
DE2438648A1 DE2438648A DE2438648A DE2438648A1 DE 2438648 A1 DE2438648 A1 DE 2438648A1 DE 2438648 A DE2438648 A DE 2438648A DE 2438648 A DE2438648 A DE 2438648A DE 2438648 A1 DE2438648 A1 DE 2438648A1
Authority
DE
Germany
Prior art keywords
cannula
sound conducting
bundle
thromboses
cannulae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE2438648A
Other languages
German (de)
Inventor
Reimar Prof Dr Phil Pohlman
Ulrich Dipl Phys Stumpff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE2438648A priority Critical patent/DE2438648A1/en
Publication of DE2438648A1 publication Critical patent/DE2438648A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2217/00—General characteristics of surgical instruments
    • A61B2217/002—Auxiliary appliance
    • A61B2217/005—Auxiliary appliance with suction drainage system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2217/00—General characteristics of surgical instruments
    • A61B2217/002—Auxiliary appliance
    • A61B2217/007—Auxiliary appliance with irrigation system

Abstract

A device for the removal or dispersal of thromboses counts of one or more sound conducting devices inserted into the artery or vein. The sound conducting devices are connected to an ultrasonic generator at their external end. The sound conducting devices are surrounded by a protective pipe and have a suction device mounted within their circumference. The sound conducting devices are thin cannulae which form a hollow cylinder having rounded ends and with the smaller diameter suction device mounted within the cannula bundle. Infusion fluid may be introduced through this device since the cannula bundle is only loosely bound and permits transmission of liquid.

Description

Vorrichtung zum Entfernen von Thromben Die Erfindung betrifft eine Vorrichtung, welche gestattet, Thromben im Innern von Adern durch intensive Ultraschallschwingungen aufzulösen und abzusaugen.Device for removing thrombi. The invention relates to a Device, which allows thrombi inside veins by means of intense ultrasonic vibrations dissolve and suck off.

Bisher sind in der Medizin nur wenige Mittel bekannt, Thromben oder thromböse Substanzen wirkungsvoll und gefahrlos zu entfernen: 1. Operativ (Embolektomie) 2. Fibrinolyse (Sh-Behandlung) 3. Transluminale Katheterdilatation Jede dieser Methoden weist entscheidende Nachteile auf, z.B.So far only a few remedies are known in medicine, thrombi or To remove thrombotic substances effectively and safely: 1. Surgical (embolectomy) 2. Fibrinolysis (Sh treatment) 3. Transluminal catheter dilation Any of these methods has significant disadvantages, e.g.

keine Auflösung älterer Thromben (Embolektomie), Nichtanwendbarkeit bei Hypertonie, Magenulcus, Apoplexie usw. Außerdem muß die Behandlung so kurzfristig wie möglich nach der Thrombenbildung einsetzen.no resolution of older thrombi (embolectomy), inapplicability in hypertension, gastric ulcer, apoplexy, etc. In addition, the treatment must be so short-term as possible after thrombus formation.

Alle diese Nachteile lassen sich mit Hilfe der erfindungsgemäßen Vorrichtung zum Entfernen von Thromben, welche einen oder mehrere in die Ader einführbare Schalleiter, die an ihrem hinteren Ende mit einem Ultraschallerzeuger verbunden, von einem Schutzschlauch umgeben und mit einer Saugvorrichtung versehen sind, besitzt, weitgehend vermeiden.All these disadvantages can be overcome with the aid of the device according to the invention for the removal of thrombi, which one or more sound conductors that can be inserted into the vein, which are connected at their rear end to an ultrasonic generator by a protective hose are surrounded and provided with a suction device, largely avoid.

Versuche haben ergeben, daß verhältnismäßig junge Thromben am stirnseitigen Ende einer zu Ultraschallschwingungen erregten Kanüle derart in ihrer Viskosität herabgesetzt werden können, daß ein Absaugen auch durch verhältnismäßig dünne Kanülen hindurch möglich ist. Bei älteren und entsprechend konsistenteren Thromben hingegen gelingt dieser Vorgang nicht mehr, da sich die zur Auflösung erforderliche Kavitation am Kanülenende nicht mehr erzielen läßt. In solchen Fällen wird die Auflösung dadurch ermöglicht, daß an den Ort der Ultraschalleinwirkung Infusionslösung gebracht wird, welche mittels eines, die Kanüle umgebenden Schutzschlauches dem stirnseitigen Ende bzw. der Angriffsfläche des Thrombus zugeführt wird.Experiments have shown that relatively young thrombi on the frontal The viscosity of the end of a cannula excited to ultrasonic vibrations can be reduced that a suction through relatively thin cannulas through is possible. In the case of older and correspondingly more consistent thrombi, however this process is no longer successful, since the cavitation required for dissolution occurs can no longer be achieved at the end of the cannula. In such cases the resolution is thereby enables infusion solution to be brought to the location of the ultrasound exposure, which by means of a protective tube surrounding the cannula to the front end or the attack surface of the thrombus is supplied.

Die Vorrichtung wird zweckmäßigerweise so gehandhabt, daß zunächst der Schutzschlauch alleine, ohne Kanüle, in die Ader bis zum Thrombus hin vorgeschoben und erst nachträglich die dünne Kanüle im Schutzschlauch entlang nachgeschoben wird. Hierdurch wird nicht nur ein leichtes Gleiten der Kanüle bis zum Thrombus hin gewährleistet sondern außerdem jegliche Verletzung der Gefäßwände mit Sicherheit vermieden. Hierauf wird mit leichtem überdruck die Infusionsflüssigkeit in den Schutzschlauch gegeben, die Kanüle zu Ultraschallschwingungen erregt und ein Unterdruck zum Absaugen der aufgelösten thrombösen Substanz in der Kanüle erzeugt.The device is expediently handled so that initially the protective tube alone, without a cannula, pushed into the vein up to the thrombus and only afterwards is the thin cannula pushed along the protective tube. This not only ensures easy sliding of the cannula up to the thrombus but also any damage to the vessel walls is avoided with certainty. On that the infusion liquid is given into the protective tube with a slight excess pressure, the cannula excited to ultrasonic vibrations and a negative pressure to suck out the dissolved thrombus is generated in the cannula.

Fig. 1 zeigt ein Ausführungsbeispiel der genannten Vorrichtung.Fig. 1 shows an embodiment of the device mentioned.

Mit 1 ist die Ader bezeichnet, mit 2 der in ihr befindliche und aufzulösende Thrombus. 3 stellt den Schutzschlauch dar, beispielsweise aus PTFE, in der sich die Kanüle 4 befindet.1 with the wire is referred to, with 2 that located in it and to be dissolved Thrombus. 3 shows the protective tube, for example made of PTFE, in which the cannula 4 is located.

An ihrem stirnseitigen Ende 5 ist die Kanüle abgerundet, etwas zugezogen und mit einem Loch 6 versehen, dessen Durchmesser kleiner als derjenige der Kanüle 4 sein soll. Diese Anordnung bringt den großen Vorteil, daß sich die Kanüle 4 mit Sicherheit nicht verstopft und eine zügige Absaugung in Richtung des unten in der Figur angegebenen Pfeiles erfolgen kann. Um eine größere Kontaktfläche zu erzielen, kann das stirnseitige Ende entsprechend planer oder auch wulstig ausgeführt sein. Der Doppelpfeil oben in der Kanüle soll zum Ausdruck bringen, daß die Kanüle in ihrer Gesamtheit zu longitudinalen Ultraschallschwingungen erregt wird. Sie ist, wie bereits beschrieben, außerhalb der Ader in bekannter Weise mit einem durchbohrten Ultraschallschwingungserzeuger verbunden. Ebenfalls befindet sich außerhalb der Ader im Schutzschlauch eine seitliche Zuführung 7, welche die Möglichkeit bietet, eine Infusionsflüssigkeit zwischen dem Schutzschlauch 3 und der Kanüle 4 an den Ort der Ultraschalleinwirkung, also an die Berührungsstelle zwischen stirnseitigem Sondenende und dem Thrombus 2 heranzubringen.At its frontal end 5, the cannula is rounded, somewhat closed and provided with a hole 6, the diameter of which is smaller than that of the cannula 4 should be. This arrangement has the great advantage that the cannula 4 is with it Safety not clogged and a swift suction towards the bottom in the Figure indicated arrow can be done. To achieve a larger contact area, the front end can be designed to be planar or beaded accordingly. The double arrow at the top of the cannula is intended to indicate that the cannula is in their entirety is excited to longitudinal ultrasonic vibrations. She is, as already described, outside the vein in a known manner with a pierced Ultrasonic vibrator connected. Also located outside the Wire in the protective tube a side feed 7, which offers the possibility of an infusion fluid between the protective tube 3 and the cannula 4 to the Location of the action of ultrasound, i.e. at the point of contact between the end face Bring the end of the probe and the thrombus 2.

Die Fign. 2a und 2b zeigen ein weiteres Ausführungsbeispiel der Vorrichtung.The FIGS. 2a and 2b show a further embodiment of the device.

Mit 1' ist wiederum die Ader bezeichnet, mit 2' der Thrombus.The vein is again designated with 1 ', the thrombus with 2'.

3' stellt wiederum den Schutzschlauch dar. Im Innern der Anordnung befindet sich ein Absaugschlauch 8', der an seinem frontseitigen Ende durch eine leichte Einstülpung 5' etwas abgerundet ist und eine Öffnung 6' besitzt, deren Durchmesser wiederum kleiner als der lichte Durchmesser des Schlauches 8' ist. Als Ultraschallübertrager dienen in diesem Falle achsenparallel um den Absaugschlauch 8' herum eingelagerte Drähte 4', zwischen denen über einen seitlichen Zufluß 7' die Infusionsflüssigkeit an den Ort der Ultraschalleinwirkung gelangt. Die Absaugung erfolgt hier nicht mehr über einen zentral angeordneten Ultraschalleiter sondern über einen biegsamen Schlauch. Es leuchtet ein, daß diese Anordnung wesentlich flexibler ist als diejenige von Fig. 1, was in vielen Fällen sehr wertvoll sein kann.3 'again represents the protective tube. Inside the arrangement there is a suction hose 8 ', which at its front end through a slight indentation 5 'is slightly rounded and has an opening 6', the diameter of which is again smaller than the inside diameter of the tube 8 '. As an ultrasonic transmitter serve in this case, axially parallel to the suction hose 8 ' Wires 4 ', between which the infusion liquid via a lateral inlet 7' arrives at the location of the ultrasound exposure. The suction no longer takes place here via a centrally arranged ultrasonic conductor but via a flexible hose. It will be understood that this arrangement is much more flexible than that of Fig. 1, which can be very valuable in many cases.

Claims (6)

PATENTANSPRÜCH#PATENT CLAIM # 1. Vorrichtung zum Entfernen von Thromben gekennzeichnet durch einen oder mehrere in die Ader einführbare Schallleiter, die an ihrem hinteren Ende mit einem Ultraschallerzeuger verbunden, von einem Schutzschlauch umgeben und mit einer Saugvorrichtung versehen sind.1. Device for removing thrombi characterized by a or several sound conductors which can be introduced into the vein and which have at their rear end connected to an ultrasonic generator, surrounded by a protective hose and with a Suction device are provided. 2. Vorrichtung nach Anspruch 1 dadurch gekennzeichnet, daß der Schalleiter aus einer dünnen Kanüle besteht.2. Apparatus according to claim 1, characterized in that the sound conductor consists of a thin cannula. 3. Vorrichtung nach Anspruch 2 dadurch gekennzeichnet, daß die Kanüle frontseitig abgerundet ist, in der Abrundung eine Bohrung besitzt, deren Durchmesser kleiner als der lichte Durchmesser der Kanüle ist und an eine Saugvorrichtung angeschlossen ist.3. Apparatus according to claim 2, characterized in that the cannula is rounded at the front, in the rounding has a hole, the diameter of which is smaller than the clear diameter of the cannula and is connected to a suction device is. 4. Vorrichtung nach Ansprüchen 1 - 3 dadurch gekennzeichnet, daß die Kanüle so locker im Schutzschlauch geführt ist, daß zwischen Kanüle und Schutzschlauch eine Infusionsflüssigkeit bis an den Thrombus herangebracht werden kann.4. Device according to claims 1-3, characterized in that the The cannula is guided so loosely in the protective tube that between the cannula and the protective tube an infusion fluid can be brought up to the thrombus. 5. Vorrichtung nach Anspruch 1 dadurch gekennzeichnet, daß die Schalleiter aus gut schalleltenden in Längsrichtung zwischen zwei Schläuchen angeordneten Drähten bestehen.5. Apparatus according to claim 1, characterized in that the sound conductor made of well-sounding wires arranged lengthways between two hoses exist. 6. Vorrichtung nach Ansprüchen 1 und 5 dadurch gekennzeichnet, daß die Querschnitte der Schläuche so bemessen sind, daß zwischen dem äußeren und inneren Schlauch Infusionsflüssigkeit zugeführt und im inneren Schlauch die aufgelöste Thrombensubstanz abgesaugt werden kann.6. Device according to claims 1 and 5, characterized in that the cross-sections of the hoses are dimensioned so that between the outer and inner Infusion fluid is supplied to the tube and the dissolved thrombus substance is in the inner tube can be sucked off.
DE2438648A 1974-08-12 1974-08-12 Dispersal and removal of thromboses within blood vessels - using ultrasonic sound conducting cannulae bundle with central suction opening and transmission facility for infusion liquids Withdrawn DE2438648A1 (en)

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Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2383649A1 (en) * 1977-03-15 1978-10-13 Fibra Sonics ULTRASONIC MEDICO-SURGICAL DEVICE AND SYSTEM
FR2524798A1 (en) * 1982-04-13 1983-10-14 Go G Medits ULTRASONIC DEVICE FOR DESTRUCTION AND ASPIRATION OF OCULAR GLOBE TISSUES
DE3408809A1 (en) * 1984-03-10 1985-09-12 Werner Dr.med. 4330 Mülheim Schubert Devices on a catheter to improve removal of conducting pathway stenoses
DE8714529U1 (en) * 1987-10-31 1988-12-08 Schnepp-Pesch, Wolfram, 7505 Ettlingen, De
DE4126886A1 (en) * 1991-08-14 1993-02-18 Hp Medica Gmbh RINSING CATHETER
US5269291A (en) * 1990-12-10 1993-12-14 Coraje, Inc. Miniature ultrasonic transducer for plaque ablation
US5304115A (en) * 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5324255A (en) * 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5342292A (en) * 1991-11-04 1994-08-30 Baxter International Inc. Ultrasonic ablation device adapted for guidewire passage
US5368558A (en) * 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having endoscopic component and method of using same
US5380274A (en) * 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
US5382228A (en) * 1992-07-09 1995-01-17 Baxter International Inc. Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
US5390678A (en) * 1993-10-12 1995-02-21 Baxter International Inc. Method and device for measuring ultrasonic activity in an ultrasound delivery system
US5405318A (en) * 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5417672A (en) * 1993-10-04 1995-05-23 Baxter International Inc. Connector for coupling an ultrasound transducer to an ultrasound catheter
US5427118A (en) * 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
EP0820728A2 (en) 1992-05-05 1998-01-28 Baxter International Inc. Ultrasonic angioplasty catheter device
US6689086B1 (en) 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
WO2004018019A2 (en) 2002-08-26 2004-03-04 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
WO2004093736A2 (en) 2003-04-08 2004-11-04 Flowcardia, Inc. Improved ultrasound catheter devices and methods
WO2005053769A2 (en) 2003-11-24 2005-06-16 Flowcardia, Inc. Steerable ultrasound catheter
US6929632B2 (en) 1991-01-11 2005-08-16 Advanced Cardiovascular Systems, Inc. Ultrasonic devices and methods for ablating and removing obstructive matter from anatomical passageways and blood vessels
US6942677B2 (en) 2003-02-26 2005-09-13 Flowcardia, Inc. Ultrasound catheter apparatus
US7540852B2 (en) 2004-08-26 2009-06-02 Flowcardia, Inc. Ultrasound catheter devices and methods
US7604608B2 (en) 2003-01-14 2009-10-20 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
US7708712B2 (en) 2001-09-04 2010-05-04 Broncus Technologies, Inc. Methods and devices for maintaining patency of surgically created channels in a body organ
US8133236B2 (en) 2006-11-07 2012-03-13 Flowcardia, Inc. Ultrasound catheter having protective feature against breakage
US8221343B2 (en) 2005-01-20 2012-07-17 Flowcardia, Inc. Vibrational catheter devices and methods for making same
US8226566B2 (en) 2009-06-12 2012-07-24 Flowcardia, Inc. Device and method for vascular re-entry
US8246643B2 (en) 2006-11-07 2012-08-21 Flowcardia, Inc. Ultrasound catheter having improved distal end
US8506519B2 (en) 1999-02-16 2013-08-13 Flowcardia, Inc. Pre-shaped therapeutic catheter
US8641630B2 (en) 2003-09-19 2014-02-04 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US8647293B2 (en) 2002-08-02 2014-02-11 Flowcardia, Inc. Therapeutic ultrasound system
US9282984B2 (en) 2006-04-05 2016-03-15 Flowcardia, Inc. Therapeutic ultrasound system
US9913969B2 (en) 2006-10-05 2018-03-13 Broncus Medical Inc. Devices for delivering substances through an extra-anatomic opening created in an airway
CN109890448A (en) * 2016-10-26 2019-06-14 莱斯桑柏特医疗解决方案股份有限公司 For transmitting the conduit device of mechanical wave
US10357263B2 (en) 2012-01-18 2019-07-23 C. R. Bard, Inc. Vascular re-entry device
US10582983B2 (en) 2017-02-06 2020-03-10 C. R. Bard, Inc. Ultrasonic endovascular catheter with a controllable sheath
US10758256B2 (en) 2016-12-22 2020-09-01 C. R. Bard, Inc. Ultrasonic endovascular catheter
US10835267B2 (en) 2002-08-02 2020-11-17 Flowcardia, Inc. Ultrasound catheter having protective feature against breakage
US11344750B2 (en) 2012-08-02 2022-05-31 Flowcardia, Inc. Ultrasound catheter system
US11596726B2 (en) 2016-12-17 2023-03-07 C.R. Bard, Inc. Ultrasound devices for removing clots from catheters and related methods
US11633206B2 (en) 2016-11-23 2023-04-25 C.R. Bard, Inc. Catheter with retractable sheath and methods thereof

Cited By (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2383649A1 (en) * 1977-03-15 1978-10-13 Fibra Sonics ULTRASONIC MEDICO-SURGICAL DEVICE AND SYSTEM
FR2524798A1 (en) * 1982-04-13 1983-10-14 Go G Medits ULTRASONIC DEVICE FOR DESTRUCTION AND ASPIRATION OF OCULAR GLOBE TISSUES
DE3408809A1 (en) * 1984-03-10 1985-09-12 Werner Dr.med. 4330 Mülheim Schubert Devices on a catheter to improve removal of conducting pathway stenoses
DE8714529U1 (en) * 1987-10-31 1988-12-08 Schnepp-Pesch, Wolfram, 7505 Ettlingen, De
US5269291A (en) * 1990-12-10 1993-12-14 Coraje, Inc. Miniature ultrasonic transducer for plaque ablation
US5397301A (en) * 1991-01-11 1995-03-14 Baxter International Inc. Ultrasonic angioplasty device incorporating an ultrasound transmission member made at least partially from a superelastic metal alloy
US6929632B2 (en) 1991-01-11 2005-08-16 Advanced Cardiovascular Systems, Inc. Ultrasonic devices and methods for ablating and removing obstructive matter from anatomical passageways and blood vessels
US5304115A (en) * 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5324255A (en) * 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5474530A (en) * 1991-01-11 1995-12-12 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasospasm
US5368558A (en) * 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having endoscopic component and method of using same
US5380274A (en) * 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
US5318518A (en) * 1991-08-14 1994-06-07 Hp Medica Gesellschaft Mbh Fur Medizintechnische Systeme Irrigating catheter
DE4126886A1 (en) * 1991-08-14 1993-02-18 Hp Medica Gmbh RINSING CATHETER
US5342292A (en) * 1991-11-04 1994-08-30 Baxter International Inc. Ultrasonic ablation device adapted for guidewire passage
EP0820728A2 (en) 1992-05-05 1998-01-28 Baxter International Inc. Ultrasonic angioplasty catheter device
US5405318A (en) * 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
EP0820727A2 (en) 1992-05-05 1998-01-28 Baxter International Inc. Ultrasonic angioplasty catheter device
US5382228A (en) * 1992-07-09 1995-01-17 Baxter International Inc. Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
US5427118A (en) * 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
US5417672A (en) * 1993-10-04 1995-05-23 Baxter International Inc. Connector for coupling an ultrasound transducer to an ultrasound catheter
US5390678A (en) * 1993-10-12 1995-02-21 Baxter International Inc. Method and device for measuring ultrasonic activity in an ultrasound delivery system
US6689086B1 (en) 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
US8506519B2 (en) 1999-02-16 2013-08-13 Flowcardia, Inc. Pre-shaped therapeutic catheter
US7708712B2 (en) 2001-09-04 2010-05-04 Broncus Technologies, Inc. Methods and devices for maintaining patency of surgically created channels in a body organ
US8647293B2 (en) 2002-08-02 2014-02-11 Flowcardia, Inc. Therapeutic ultrasound system
US10111680B2 (en) 2002-08-02 2018-10-30 Flowcardia, Inc. Therapeutic ultrasound system
US9265520B2 (en) 2002-08-02 2016-02-23 Flowcardia, Inc. Therapeutic ultrasound system
US10722262B2 (en) 2002-08-02 2020-07-28 Flowcardia, Inc. Therapeutic ultrasound system
US10835267B2 (en) 2002-08-02 2020-11-17 Flowcardia, Inc. Ultrasound catheter having protective feature against breakage
US10285727B2 (en) 2002-08-26 2019-05-14 Flowcardia, Inc. Steerable ultrasound catheter
US10376272B2 (en) 2002-08-26 2019-08-13 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US9421024B2 (en) 2002-08-26 2016-08-23 Flowcardia, Inc. Steerable ultrasound catheter
US8690819B2 (en) 2002-08-26 2014-04-08 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US7955293B2 (en) 2002-08-26 2011-06-07 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
WO2004018019A2 (en) 2002-08-26 2004-03-04 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US8308677B2 (en) 2002-08-26 2012-11-13 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US8956375B2 (en) 2002-08-26 2015-02-17 Flowcardia, Inc. Ultrasound catheter devices and methods
US7621902B2 (en) 2002-08-26 2009-11-24 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US9381027B2 (en) 2002-08-26 2016-07-05 Flowcardia, Inc. Steerable ultrasound catheter
US8043251B2 (en) 2003-01-14 2011-10-25 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
US8152753B2 (en) 2003-01-14 2012-04-10 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
US7604608B2 (en) 2003-01-14 2009-10-20 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
EP2471474A1 (en) 2003-02-26 2012-07-04 Flowcardia Inc. Ultrasound catheter apparatus
US11103261B2 (en) 2003-02-26 2021-08-31 C.R. Bard, Inc. Ultrasound catheter apparatus
US8961423B2 (en) 2003-02-26 2015-02-24 Flowcardia, Inc. Ultrasound catheter apparatus
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