DE3065818D1 - Preparations for parenteral administration of fat-soluble drugs - Google Patents

Preparations for parenteral administration of fat-soluble drugs

Info

Publication number
DE3065818D1
DE3065818D1 DE8080103395T DE3065818T DE3065818D1 DE 3065818 D1 DE3065818 D1 DE 3065818D1 DE 8080103395 T DE8080103395 T DE 8080103395T DE 3065818 T DE3065818 T DE 3065818T DE 3065818 D1 DE3065818 D1 DE 3065818D1
Authority
DE
Germany
Prior art keywords
preparations
fat
parenteral administration
soluble drugs
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080103395T
Other languages
English (en)
Inventor
Jurg Dr Schrank
Hans Dr Steffen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE3065818D1 publication Critical patent/DE3065818D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
DE8080103395T 1979-06-22 1980-06-18 Preparations for parenteral administration of fat-soluble drugs Expired DE3065818D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH586379 1979-06-22

Publications (1)

Publication Number Publication Date
DE3065818D1 true DE3065818D1 (en) 1984-01-12

Family

ID=4300559

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080103395T Expired DE3065818D1 (en) 1979-06-22 1980-06-18 Preparations for parenteral administration of fat-soluble drugs

Country Status (21)

Country Link
US (1) US4411894A (de)
EP (1) EP0021337B1 (de)
JP (1) JPS567714A (de)
KR (1) KR850001301B1 (de)
AR (1) AR230178A1 (de)
AT (1) ATE5508T1 (de)
AU (1) AU534959B2 (de)
CA (1) CA1173360A (de)
DE (1) DE3065818D1 (de)
DK (1) DK155172C (de)
ES (1) ES492676A0 (de)
FI (1) FI72875C (de)
HU (1) HU186296B (de)
IE (1) IE49615B1 (de)
IL (1) IL60326A (de)
MC (1) MC1336A1 (de)
NO (1) NO155226C (de)
NZ (1) NZ194047A (de)
PH (1) PH16795A (de)
PT (1) PT71436B (de)
ZA (1) ZA803567B (de)

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US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5736155A (en) * 1984-08-08 1998-04-07 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
CA1270198C (en) * 1984-08-08 1990-06-12 Marcel B Bally ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES
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US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
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US5622713A (en) * 1985-09-17 1997-04-22 The Regents Of The University Of California Method of detoxifying animal suffering from overdose
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US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
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SE8505047L (sv) * 1985-10-25 1987-04-26 Nutritional Int Res Inst Fettemulsion
US4806343A (en) * 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
JP2792702B2 (ja) * 1988-10-05 1998-09-03 ネクスター・フアーマシユーテイカルズ・インコーポレイテツド 乾燥時に改善された安定性を示すリポソームの調製方法
US5091187A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
WO1992002244A1 (en) * 1990-07-31 1992-02-20 The Liposome Company, Inc. Accumulation of amino acids and peptides into liposomes
US5462740A (en) * 1993-09-17 1995-10-31 Athena Neurosciences, Inc. Rectally-administered, epileptic-seizure-inhibiting composition
US5840328A (en) * 1994-01-11 1998-11-24 The Liposome Company, Inc. Treatment using arachidonic acid metabolite and particulate formulations
WO1996009037A1 (en) * 1994-09-23 1996-03-28 The Liposome Company, Inc. Method of producing a lyophilized liposome product
US6689370B1 (en) 1995-04-20 2004-02-10 Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence
US6117432A (en) * 1995-04-20 2000-09-12 Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence
FR2733151B1 (fr) * 1995-04-20 1997-05-23 Seppic Sa Composition therapeutique comprenant un antigene ou un generateur in vivo d'un compose comprenant une sequence d'acides amines
US20040208922A1 (en) * 1995-06-07 2004-10-21 The Regents Of The University Of California Method for loading lipid like vesicles with drugs or other chemicals
EP0855906B1 (de) 1995-10-17 2008-02-20 Jagotec AG Verabreichung unlöslicher arzneistoffe
GB9609779D0 (en) 1996-05-10 1996-07-17 Univ Bruxelles Freeze dried liposome encapsulated amphiphilic drug compositions and a process for the preparation thereof
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US5827532A (en) * 1997-01-31 1998-10-27 The Reagents Of The University Of California Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations
IT1289938B1 (it) * 1997-02-20 1998-10-19 Angelini Ricerche Spa Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e
US6004925A (en) 1997-09-29 1999-12-21 J. L. Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6046166A (en) * 1997-09-29 2000-04-04 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6518412B1 (en) 1997-09-29 2003-02-11 Jean-Louis Dasseux Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6037323A (en) * 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6287590B1 (en) * 1997-10-02 2001-09-11 Esperion Therapeutics, Inc. Peptide/lipid complex formation by co-lyophilization
IL137734A0 (en) * 1998-02-11 2001-10-31 Res Triangle Pharm Ltd Method and composition for treatment of inflammatory conditions
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
EP1079808B1 (de) 1998-05-29 2004-02-11 Skyepharma Canada Inc. Gegen hitzeeinwirkung geschützte mikropartikel und verfahren zur terminalen dampfsterilisation derselben
ATE252889T1 (de) 1998-08-19 2003-11-15 Skyepharma Canada Inc Injizierbare wässerige propofoldispersionen
CZ20011739A3 (cs) 1998-11-20 2001-10-17 Rtp Pharma Inc. Dispergovatelné fosfolipidem stabilizované mikročástice
AU2001257115B2 (en) 2000-04-20 2005-01-27 Rtp Pharma Inc. Improved water-insoluble drug particle process
US6653062B1 (en) * 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
CA2420597C (en) 2000-08-31 2011-05-17 Rtp Pharma Inc. Milled particles
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
EA006741B1 (ru) * 2000-11-09 2006-04-28 Неофарм, Инк. Липидная композиция, содержащая производное камптотецина (варианты), способ её получения и применение
ES2284646T3 (es) * 2001-02-22 2007-11-16 Jagotec Ag Combinaciones de estatina-fibrato con efectos secundarios en ayunas-alimentado reducidos.
WO2003030864A1 (en) 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
WO2004035032A2 (en) * 2002-08-20 2004-04-29 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
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DE2656333C2 (de) * 1976-12-13 1985-08-08 Karl Prof. Dr.med. 7302 Ostfildern Theurer Verfahren zur Herstellung von Liposomen, welche Arzneistoffe enthalten
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute

Also Published As

Publication number Publication date
US4411894A (en) 1983-10-25
EP0021337B1 (de) 1983-12-07
KR850001301B1 (ko) 1985-09-12
IE801281L (en) 1980-12-22
IL60326A (en) 1983-09-30
CA1173360A (en) 1984-08-28
DK155172C (da) 1989-09-18
HU186296B (en) 1985-07-29
ES8104720A1 (es) 1981-05-16
AU5928980A (en) 1981-01-08
EP0021337A2 (de) 1981-01-07
ZA803567B (en) 1981-06-24
FI72875C (fi) 1987-08-10
PT71436A (en) 1980-07-01
PH16795A (en) 1984-02-28
PT71436B (en) 1981-10-23
NO155226B (no) 1986-11-24
ES492676A0 (es) 1981-05-16
IE49615B1 (en) 1985-10-30
FI72875B (fi) 1987-04-30
JPS567714A (en) 1981-01-27
DK155172B (da) 1989-02-27
DK266680A (da) 1980-12-23
IL60326A0 (en) 1980-09-16
ATE5508T1 (de) 1983-12-15
KR830002327A (ko) 1983-05-28
NO155226C (no) 1987-03-04
AU534959B2 (en) 1984-02-23
FI801876A (fi) 1980-12-23
EP0021337A3 (en) 1981-04-22
NZ194047A (en) 1982-09-14
MC1336A1 (fr) 1981-04-21
AR230178A1 (es) 1984-03-01
NO801863L (no) 1980-12-22

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: LEDERER, F., DIPL.-CHEM. DR., 8000 MUENCHEN RIEDERER FRHR. VON PAAR ZU SCHOENAU, A., DIPL.-ING., PAT.-ANWAELTE, 8300 LANDSHUT