DE3169939D1 - 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation - Google Patents

2-penem compounds, pharmaceutical compositions containing them and methods for their preparation

Info

Publication number
DE3169939D1
DE3169939D1 DE8181101210T DE3169939T DE3169939D1 DE 3169939 D1 DE3169939 D1 DE 3169939D1 DE 8181101210 T DE8181101210 T DE 8181101210T DE 3169939 T DE3169939 T DE 3169939T DE 3169939 D1 DE3169939 D1 DE 3169939D1
Authority
DE
Germany
Prior art keywords
hydrogen
lower alkyl
aralkyl
aryl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181101210T
Other languages
English (en)
Inventor
Adriano Afonso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE3169939D1 publication Critical patent/DE3169939D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
DE8181101210T 1980-02-28 1981-02-20 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation Expired DE3169939D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12581180A 1980-02-28 1980-02-28

Publications (1)

Publication Number Publication Date
DE3169939D1 true DE3169939D1 (en) 1985-05-23

Family

ID=22421531

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181101210T Expired DE3169939D1 (en) 1980-02-28 1981-02-20 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation

Country Status (9)

Country Link
US (1) US4448782A (de)
EP (1) EP0035188B1 (de)
JP (1) JPS56142284A (de)
AT (1) ATE12773T1 (de)
AU (1) AU539769B2 (de)
DE (1) DE3169939D1 (de)
IL (1) IL62221A (de)
NZ (1) NZ196360A (de)
ZA (1) ZA811305B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
US4411906A (en) * 1981-11-25 1983-10-25 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
US4540579A (en) * 1982-11-16 1985-09-10 Schering Corporation 2-[(R) Amino acid alkyl]penems
DE3572490D1 (en) * 1984-02-02 1989-09-28 Schering Corp Hydrazone substituted penems
US4559333A (en) * 1984-03-01 1985-12-17 Schering Corporation Hydrazone substituted penems
DE4032163C2 (de) * 1990-10-10 1995-03-30 Gradinger F Hermes Pharma S-Retinoyl-L-aminomercapto-Verbindungen und Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung
HRP931047B1 (en) * 1993-07-09 2000-02-29 Pliva Pharm & Chem Works 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, processes for the preparation thereof and their use
US20030099945A1 (en) * 1994-09-20 2003-05-29 Invenux, Inc. Parallel selex
WO2003051314A2 (en) * 2001-12-18 2003-06-26 Medallion Biomedical, Llc Antibiotic compounds
CN110590599B (zh) * 2019-09-30 2022-07-26 大连民族大学 一种群体感应信号分子结构类似物及其制备方法
CN111943963B (zh) * 2020-08-19 2022-01-04 杭州瑞思新材料有限公司 一种6-溴青霉烷酸的生产装置及方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
US4290948A (en) * 1978-11-22 1981-09-22 Beecham Group Limited Process for their preparation of β-lactam antibacterial agents
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
EP0023887B1 (de) * 1979-08-01 1984-11-07 Ciba-Geigy Ag 3-Substituierte bicyclische Azetidinonderivate, Verfahren zu ihrer Herstellung und Zwischenprodukte, sowie deren Herstellung

Also Published As

Publication number Publication date
AU6768281A (en) 1981-09-03
EP0035188A1 (de) 1981-09-09
EP0035188B1 (de) 1985-04-17
IL62221A0 (en) 1981-03-31
US4448782A (en) 1984-05-15
IL62221A (en) 1985-09-29
JPS56142284A (en) 1981-11-06
AU539769B2 (en) 1984-10-18
ATE12773T1 (de) 1985-05-15
ZA811305B (en) 1982-03-31
NZ196360A (en) 1984-07-06

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee