MX158743A
(es)
*
|
1980-02-29 |
1989-03-10 |
University Patents Inc |
Procedimiento para la produccion de oligonucleotidos
|
US6692941B1
(en)
*
|
1980-08-26 |
2004-02-17 |
The Regents Of The University Of California |
Bovine growth hormone
|
US7101981B1
(en)
|
1980-08-26 |
2006-09-05 |
Regents Of The University Of California |
Bovine growth hormone recombinantly produced in E. coli
|
US4973679A
(en)
*
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
JPS58109498A
(ja)
*
|
1981-08-24 |
1983-06-29 |
Agency Of Ind Science & Technol |
オリゴリボヌクレオチド
|
EP0090789A1
(de)
*
|
1982-03-26 |
1983-10-05 |
Monsanto Company |
Chemische DNA-Synthese
|
CA1223831A
(en)
|
1982-06-23 |
1987-07-07 |
Dean Engelhardt |
Modified nucleotides, methods of preparing and utilizing and compositions containing the same
|
EP0148356B1
(de)
*
|
1982-09-30 |
1990-12-05 |
Aktiebolaget Iro |
Garnspeicher- und Zuführvorrichtung
|
DE3239887A1
(de)
*
|
1982-10-28 |
1984-05-03 |
Hubert Prof. Dr. 2000 Hamburg Köster |
Verfahren zur herstellung von oligonucleotiden
|
US5198540A
(en)
*
|
1982-10-28 |
1993-03-30 |
Hubert Koster |
Process for the preparation of oligonucleotides in solution
|
FR2544720B1
(fr)
*
|
1983-04-19 |
1987-11-27 |
California Inst Of Techn |
Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides
|
WO1984004749A1
(en)
*
|
1983-06-01 |
1984-12-06 |
Beckman Instruments Inc |
Novel preparation of nucleoside phosphoramidite intermediates
|
USRE34069E
(en)
*
|
1983-08-18 |
1992-09-15 |
Biosyntech Gmbh |
Process for the preparation of oligonucleotides
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
DE3332068A1
(de)
*
|
1983-09-06 |
1985-03-21 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
|
US5166330A
(en)
*
|
1983-09-06 |
1992-11-24 |
Hoechst Aktiengesellschaft |
Process for the preparation of nucleoside alkyl-aralkyl- and aryl-phosphonites and -phosphonates
|
US5015733A
(en)
*
|
1983-12-20 |
1991-05-14 |
California Institute Of Technology |
Nucleosides possessing blocked aliphatic amino groups
|
US5118800A
(en)
*
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
US5118802A
(en)
*
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
|
JPS60197698A
(ja)
*
|
1983-12-20 |
1985-10-07 |
カリフオルニア・インステイテユ−ト・オブ・テクノロジ− |
アミノ誘導化されたオリゴヌクレオチドの合成
|
US5821058A
(en)
|
1984-01-16 |
1998-10-13 |
California Institute Of Technology |
Automated DNA sequencing technique
|
USRE43096E1
(en)
|
1984-01-16 |
2012-01-10 |
California Institute Of Technology |
Tagged extendable primers and extension products
|
US5367066A
(en)
*
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
JPS61112093A
(ja)
*
|
1984-11-05 |
1986-05-30 |
Wakunaga Seiyaku Kk |
ヌクレオチド誘導体
|
FR2575751B1
(fr)
*
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
DE3507881A1
(de)
*
|
1985-03-06 |
1986-09-11 |
Hoechst Ag, 6230 Frankfurt |
Verfahren und mittel zur phosphorylierung
|
US5252760A
(en)
*
|
1985-03-28 |
1993-10-12 |
Chiron Corporation |
Method of using colored phosphorylating reagents
|
US5332845A
(en)
*
|
1985-03-28 |
1994-07-26 |
Chiron Corporation |
Phosphorylating reagents
|
WO1986006726A1
(en)
*
|
1985-05-15 |
1986-11-20 |
Integrated Genetics, Inc. |
Cytidine analogs
|
US4797355A
(en)
*
|
1985-06-13 |
1989-01-10 |
Amgen Inc. |
Methods for attaching polynucleotides to supports
|
US4751177A
(en)
*
|
1985-06-13 |
1988-06-14 |
Amgen |
Methods and kits for performing nucleic acid hybridization assays
|
US4739044A
(en)
*
|
1985-06-13 |
1988-04-19 |
Amgen |
Method for derivitization of polynucleotides
|
WO1986007362A1
(en)
*
|
1985-06-14 |
1986-12-18 |
University Patents, Inc. |
Method for synthesizing deoxyoligonucleotides
|
US4757141A
(en)
*
|
1985-08-26 |
1988-07-12 |
Applied Biosystems, Incorporated |
Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
|
EP0216357A3
(de)
*
|
1985-09-25 |
1988-08-31 |
Nippon Zeon Co., Ltd. |
Phosphoramidit-Verbindungen und Verfahren zu deren Herstellung
|
US4808708A
(en)
*
|
1985-11-02 |
1989-02-28 |
Toagosei Chemical Industry Co., Ltd. |
Phosphorsulfide derivatives of deoxynucleosides or deoxynucleotides and their uses
|
US4855225A
(en)
*
|
1986-02-07 |
1989-08-08 |
Applied Biosystems, Inc. |
Method of detecting electrophoretically separated oligonucleotides
|
US5242823A
(en)
*
|
1986-03-07 |
1993-09-07 |
International Genetic Engineering, Inc. |
Cloning of the 38kd Mycoplasma hyorhinis regression-associated antigen
|
DE3788914T2
(de)
*
|
1986-09-08 |
1994-08-25 |
Ajinomoto Kk |
Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
|
DE3751468T2
(de)
*
|
1986-10-30 |
1996-02-29 |
Daicel Chem |
Verfahren zur herstellung von oligonukleotiden und verbindungen zur bildung hochmolekularer schutzgruppen.
|
US5071974A
(en)
*
|
1986-10-31 |
1991-12-10 |
Amoco Corporation |
Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
|
US4923901A
(en)
*
|
1987-09-04 |
1990-05-08 |
Millipore Corporation |
Membranes with bound oligonucleotides and peptides
|
US5585481A
(en)
*
|
1987-09-21 |
1996-12-17 |
Gen-Probe Incorporated |
Linking reagents for nucleotide probes
|
US6031091A
(en)
*
|
1987-09-21 |
2000-02-29 |
Gen-Probe Incorporated |
Non-nucleotide linking reagents for nucleotide probes
|
US4965349A
(en)
*
|
1987-12-24 |
1990-10-23 |
Applied Biosystems, Inc. |
Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
|
WO1989009780A1
(en)
*
|
1988-04-15 |
1989-10-19 |
Chemical Industry Institute Of Toxicology |
Site-specific tritium-labeled oligodeoxynucleotides
|
IL90359A0
(en)
*
|
1988-05-26 |
1989-12-15 |
University Patents Inc |
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their production
|
US5218103A
(en)
*
|
1988-05-26 |
1993-06-08 |
University Patents, Inc. |
Nucleoside thiophosphoramidites
|
US5278302A
(en)
*
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
US5602244A
(en)
*
|
1988-05-26 |
1997-02-11 |
Competitive Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
US5750666A
(en)
*
|
1988-05-26 |
1998-05-12 |
Competitve Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
US5216141A
(en)
*
|
1988-06-06 |
1993-06-01 |
Benner Steven A |
Oligonucleotide analogs containing sulfur linkages
|
JPH0291088A
(ja)
*
|
1988-09-29 |
1990-03-30 |
Central Glass Co Ltd |
ホスファイトおよびヌクレオシド‐3’‐ホスファイト誘導体およびこれを用いるオリゴヌクレオチドの合成法
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
JPH04501804A
(ja)
*
|
1989-02-24 |
1992-04-02 |
シティ・オブ・ホープ |
異種ブロックオリゴマー
|
AU5418290A
(en)
*
|
1989-03-31 |
1990-11-05 |
University Patents Inc. |
Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
|
US6254861B1
(en)
|
1989-05-23 |
2001-07-03 |
Chandra Choudhury |
Hematopoietic growth factor derived from T lymphocytes
|
DE3916871A1
(de)
*
|
1989-05-24 |
1990-11-29 |
Boehringer Mannheim Gmbh |
Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
|
GR890100349A
(el)
*
|
1989-05-26 |
1994-03-31 |
University Patents Inc |
Ενώσεις νουκλεοσιδίων & πολυνουκλεοτιδίων, θειοφωσφοραμιδίων & φωσφοροδιθειικών εστέρων & μέθοδοι.
|
WO1990015065A1
(en)
*
|
1989-06-05 |
1990-12-13 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides and methods for preparing the same
|
US5256775A
(en)
*
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
US6300486B1
(en)
|
1989-06-15 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Large scale synthesis of oligonucleotides and their associated analogs
|
US5164491A
(en)
*
|
1989-06-15 |
1992-11-17 |
Gilead Sciences |
Large scale synthesis of oligonucleotides and their associated analogs
|
US5204455A
(en)
*
|
1989-06-15 |
1993-04-20 |
Froehler Brian C |
Monomethoxytrityl protected oligonucleotides bound to a solid support
|
US5545522A
(en)
|
1989-09-22 |
1996-08-13 |
Van Gelder; Russell N. |
Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
|
US7049102B1
(en)
|
1989-09-22 |
2006-05-23 |
Board Of Trustees Of Leland Stanford University |
Multi-gene expression profile
|
US5003097A
(en)
*
|
1989-10-02 |
1991-03-26 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method for the sulfurization of phosphorous groups in compounds
|
AU6603690A
(en)
*
|
1989-10-05 |
1991-04-28 |
University Patents Inc. |
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes
|
US5914396A
(en)
*
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
EP0463712A3
(en)
|
1990-06-27 |
1992-04-08 |
University Patents, Inc. |
Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
|
US5316908A
(en)
*
|
1990-07-13 |
1994-05-31 |
Life Technologies, Inc. |
Size markers for electrophoretic analysis of DNA
|
DE69130331T2
(de)
*
|
1990-10-26 |
1999-03-04 |
Genta Inc |
Verbessertes verfahren zur synthese von oligomeren
|
US6605712B1
(en)
*
|
1990-12-20 |
2003-08-12 |
Arch Development Corporation |
Gene transcription and ionizing radiation: methods and compositions
|
US5594121A
(en)
*
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
US5556961A
(en)
*
|
1991-11-15 |
1996-09-17 |
Foote; Robert S. |
Nucleosides with 5'-O-photolabile protecting groups
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
AU3222793A
(en)
*
|
1991-11-26 |
1993-06-28 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
US6235887B1
(en)
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
TW393513B
(en)
*
|
1991-11-26 |
2000-06-11 |
Isis Pharmaceuticals Inc |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
AU3250093A
(en)
|
1991-12-12 |
1993-07-19 |
Gilead Sciences, Inc. |
Nuclease stable and binding competent oligomers and methods for their use
|
US5644048A
(en)
*
|
1992-01-10 |
1997-07-01 |
Isis Pharmaceuticals, Inc. |
Process for preparing phosphorothioate oligonucleotides
|
DE69333073T2
(de)
*
|
1992-02-12 |
2004-04-15 |
Chromagen, Inc., San Diego |
Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
|
US5652099A
(en)
*
|
1992-02-12 |
1997-07-29 |
Conrad; Michael J. |
Probes comprising fluorescent nucleosides and uses thereof
|
US5616700A
(en)
*
|
1992-04-24 |
1997-04-01 |
Beckman Instruments, Inc. |
Processes for synthesizing nucleotides and modified nucleotides using N.sub.
|
US5428148A
(en)
*
|
1992-04-24 |
1995-06-27 |
Beckman Instruments, Inc. |
N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
|
US5348868A
(en)
*
|
1992-04-24 |
1994-09-20 |
Beckman Instruments, Inc. |
Methods and reagents for cleaving and deprotecting oligonucleotides
|
US5583211A
(en)
*
|
1992-10-29 |
1996-12-10 |
Beckman Instruments, Inc. |
Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
|
US5955591A
(en)
*
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
US5428149A
(en)
*
|
1993-06-14 |
1995-06-27 |
Washington State University Research Foundation |
Method for palladium catalyzed carbon-carbon coulping and products
|
WO1995000638A2
(en)
*
|
1993-06-23 |
1995-01-05 |
Genesys Pharma Inc. |
Antisense oligonucleotides and therapeutic use thereof in human immunodeficiency virus infection
|
US5623068A
(en)
*
|
1994-03-07 |
1997-04-22 |
Beckman Instruments, Inc. |
Synthesis of DNA using substituted phenylacetyl-protected nucleotides
|
US6639061B1
(en)
|
1999-07-07 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate oligomers and related compounds
|
US5510476A
(en)
*
|
1994-07-07 |
1996-04-23 |
Isis Pharmaceuticals, Inc. |
Carbocation scavenging during oligonucleotide synthesis
|
US5552471A
(en)
*
|
1994-08-17 |
1996-09-03 |
The Perkin-Elmer Corporation |
Solid support reagents for the synthesis of 3'-Nitrogen containing polynucleotides
|
US5703223A
(en)
*
|
1994-09-02 |
1997-12-30 |
Thomas Jefferson University |
Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
|
US6558633B1
(en)
|
1994-09-21 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Chemical reaction apparatus and methods
|
US5604097A
(en)
|
1994-10-13 |
1997-02-18 |
Spectragen, Inc. |
Methods for sorting polynucleotides using oligonucleotide tags
|
USRE43097E1
(en)
|
1994-10-13 |
2012-01-10 |
Illumina, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
US5717085A
(en)
*
|
1994-11-23 |
1998-02-10 |
Terrapin Technologies, Inc. |
Process for preparing codon amidites
|
US5908926A
(en)
*
|
1995-03-16 |
1999-06-01 |
Duke University |
5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group
|
US5750341A
(en)
|
1995-04-17 |
1998-05-12 |
Lynx Therapeutics, Inc. |
DNA sequencing by parallel oligonucleotide extensions
|
US6531589B1
(en)
*
|
1995-06-01 |
2003-03-11 |
Hybridon, Inc. |
Base protecting groups and synthons for oligonucleotide synthesis
|
US5614622A
(en)
*
|
1995-06-01 |
1997-03-25 |
Hybridon, Inc. |
5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
|
US5856464A
(en)
*
|
1995-06-07 |
1999-01-05 |
Lajolla Pharmaceutical Company |
Selective capping solution phase oligonucleotide synthesis
|
US6111095A
(en)
*
|
1995-06-07 |
2000-08-29 |
Merck & Co., Inc. |
Capped synthetic RNA, analogs, and aptamers
|
EP1967592B1
(de)
|
1995-06-07 |
2010-04-28 |
Solexa, Inc. |
Verfahren zur Verbesserung der Effizienz der Polynukleotidsequenzierung
|
US5889136A
(en)
*
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
AU712779C
(en)
*
|
1995-10-19 |
2002-02-07 |
Proligo Llc |
Method for solution phase synthesis of oligonucleotides
|
US6476216B1
(en)
*
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
US5734041A
(en)
*
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
US6160109A
(en)
*
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
US5705621A
(en)
*
|
1995-11-17 |
1998-01-06 |
Isis Pharmaceuticals, Inc. |
Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
|
US20030119724A1
(en)
*
|
1995-11-22 |
2003-06-26 |
Ts`O Paul O.P. |
Ligands to enhance cellular uptake of biomolecules
|
US5808035A
(en)
*
|
1995-12-08 |
1998-09-15 |
Usher; David A. |
Protected nucleoside and method for its synthesis
|
US5736626A
(en)
|
1996-01-29 |
1998-04-07 |
The Perkin-Elmer Corporation |
Solid support reagents for the direct synthesis of 3'-labeled polynucleotides
|
WO1997036005A1
(en)
*
|
1996-03-26 |
1997-10-02 |
Lynx Therapeutics, Inc. |
Oligonucleotide treatments and compositions for human melanoma
|
US5959100A
(en)
*
|
1996-03-27 |
1999-09-28 |
Nexstar Pharmaceuticals, Inc. |
Pyrimidine nucleosides as therapeutic and diagnostic agents
|
US6020481A
(en)
|
1996-04-01 |
2000-02-01 |
The Perkin-Elmer Corporation |
Asymmetric benzoxanthene dyes
|
US5852168A
(en)
*
|
1996-04-30 |
1998-12-22 |
Regents Of The University Of Minesota |
Sulfurization of phosphorus-containing compounds
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US6060240A
(en)
*
|
1996-12-13 |
2000-05-09 |
Arcaris, Inc. |
Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
|
US6103891A
(en)
*
|
1996-12-27 |
2000-08-15 |
Isis Pharmaceuticals, Inc. |
Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
|
US6172217B1
(en)
|
1996-12-27 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Method of synthesizing phosphorothioate oligonucleotides
|
US5955600A
(en)
*
|
1996-12-27 |
1999-09-21 |
Isis Pharmaceuticals, Inc. |
Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
|
US5760209A
(en)
*
|
1997-03-03 |
1998-06-02 |
Isis Pharmaceuticals, Inc. |
Protecting group for synthesizing oligonucleotide analogs
|
US5902881A
(en)
|
1997-03-03 |
1999-05-11 |
Isis Pharmaceuticals, Inc. |
Reagent useful for synthesizing sulfurized oligonucleotide analogs
|
JP3435416B2
(ja)
|
1997-03-12 |
2003-08-11 |
ピーイー コーポレイション(エヌワイ) |
改善された標識ヌクレオチド取込み特性を有するdnaポリメラーゼ
|
WO1998044156A1
(en)
|
1997-03-27 |
1998-10-08 |
Life Technologies, Inc. |
Nucleic acid ladders
|
AU8403298A
(en)
|
1997-07-15 |
1999-02-10 |
Life Technologies, Inc. |
Nucleic acid ladders
|
US6008379A
(en)
|
1997-10-01 |
1999-12-28 |
The Perkin-Elmer Corporation |
Aromatic-substituted xanthene dyes
|
US6583168B1
(en)
|
1997-11-25 |
2003-06-24 |
Applera Corporation |
Sulfonated diarylrhodamine dyes
|
US5936087A
(en)
|
1997-11-25 |
1999-08-10 |
The Perkin-Elmer Corporation |
Dibenzorhodamine dyes
|
US6441150B1
(en)
|
1997-12-16 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Compounds for the Synthesis of Nucleotide or oligonucleotide phosphoramidites
|
US7427678B2
(en)
*
|
1998-01-08 |
2008-09-23 |
Sigma-Aldrich Co. |
Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
|
ATE477850T1
(de)
*
|
1998-01-12 |
2010-09-15 |
Massachusetts Inst Technology |
Vorrichtung zur mikrotestdurchführung
|
US6893877B2
(en)
|
1998-01-12 |
2005-05-17 |
Massachusetts Institute Of Technology |
Methods for screening substances in a microwell array
|
US20020164585A1
(en)
*
|
1998-01-16 |
2002-11-07 |
Sean Chapman |
Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
|
US6426185B1
(en)
|
1998-01-16 |
2002-07-30 |
Large Scale Biology Corporation |
Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
|
US20030027173A1
(en)
*
|
1998-01-16 |
2003-02-06 |
Della-Cioppa Guy |
Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
|
US6303848B1
(en)
|
1998-01-16 |
2001-10-16 |
Large Scale Biology Corporation |
Method for conferring herbicide, pest, or disease resistance in plant hosts
|
US6080868A
(en)
|
1998-01-23 |
2000-06-27 |
The Perkin-Elmer Corporation |
Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
US6020475A
(en)
*
|
1998-02-10 |
2000-02-01 |
Isis Pharmeuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
US7273933B1
(en)
|
1998-02-26 |
2007-09-25 |
Isis Pharmaceuticals, Inc. |
Methods for synthesis of oligonucleotides
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
US6531590B1
(en)
*
|
1998-04-24 |
2003-03-11 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligonucleotide compounds
|
US6590092B1
(en)
*
|
1998-05-19 |
2003-07-08 |
Nam Q. Ngo |
Process for preparing a “universal support” and the reagents used for generating such support
|
US6274725B1
(en)
|
1998-06-02 |
2001-08-14 |
Isis Pharmaceuticals, Inc. |
Activators for oligonucleotide synthesis
|
US6335439B1
(en)
|
1998-06-11 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Method of preparing phosphoramidites
|
US6919437B1
(en)
|
1998-06-11 |
2005-07-19 |
Isis Pharmaceuticals, Inc. |
Synthetic methods and intermediates for triester oligonucleotides
|
US6270730B1
(en)
|
1998-06-16 |
2001-08-07 |
Northwest Engineering Inc. |
Multi-well rotary synthesizer
|
US7087148B1
(en)
|
1998-06-23 |
2006-08-08 |
Clinical Micro Sensors, Inc. |
Binding acceleration techniques for the detection of analytes
|
US6326478B1
(en)
|
1998-07-08 |
2001-12-04 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
US6124484A
(en)
|
1998-07-17 |
2000-09-26 |
Isis Pharmaceuticals, Inc. |
Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
|
US6271042B1
(en)
*
|
1998-08-26 |
2001-08-07 |
Alpha Innotech Corporation |
Biochip detection system
|
US6335437B1
(en)
|
1998-09-07 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Methods for the preparation of conjugated oligomers
|
US6069243A
(en)
*
|
1998-10-06 |
2000-05-30 |
Isis Pharmaceuticals, Inc. |
Process for oligonucleotide synthesis
|
US6667176B1
(en)
|
2000-01-11 |
2003-12-23 |
Geron Corporation |
cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
|
US6153411A
(en)
|
1998-10-30 |
2000-11-28 |
American Water Works Company, Inc. |
Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
|
US6169177B1
(en)
|
1998-11-06 |
2001-01-02 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomeric compounds
|
WO2000036152A1
(en)
|
1998-12-14 |
2000-06-22 |
Li-Cor, Inc. |
A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
|
US6380378B1
(en)
|
1998-12-24 |
2002-04-30 |
Toagosei Company, Ltd. |
Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
|
US6432642B1
(en)
*
|
1999-01-15 |
2002-08-13 |
Pe Corporation (Ny) |
Binary probe and clamp composition and methods for a target hybridization detection
|
US6465628B1
(en)
*
|
1999-02-04 |
2002-10-15 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
US6207819B1
(en)
|
1999-02-12 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
|
US6121437A
(en)
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
US20040082774A1
(en)
*
|
1999-03-16 |
2004-04-29 |
Guzaev Andrei P. |
Novel phosphate and thiophosphate protecting groups
|
US6399765B1
(en)
|
1999-03-17 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Methods for removing dimethoxytrityl groups from oligonucleotides
|
CN1348396A
(zh)
|
1999-03-19 |
2002-05-08 |
金克克国际有限公司 |
用于高效筛选的多通孔测试板
|
US6965041B1
(en)
|
1999-03-24 |
2005-11-15 |
The United States Of America As Represented By The Department Of Health And Human Services |
N-acylphosphoramidites and their use in oligonucleotide synthesis
|
US20020177135A1
(en)
*
|
1999-07-27 |
2002-11-28 |
Doung Hau H. |
Devices and methods for biochip multiplexing
|
US6610842B1
(en)
*
|
1999-05-06 |
2003-08-26 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomers using phosphoramidite compositions
|
US6221635B1
(en)
|
1999-05-06 |
2001-04-24 |
The Wistar Institute |
Methods for solid-phase amplification of DNA template (SPADT) using multiarrays
|
JP2003522119A
(ja)
|
1999-05-24 |
2003-07-22 |
インビトロジェン コーポレイション |
標識されたオリゴヌクレオチドの脱ブロック化方法
|
US20070059752A1
(en)
*
|
1999-06-09 |
2007-03-15 |
Biosearch Technologies, Inc. |
Fluorescence energy transfer probes with stabilized conformations
|
US7183405B2
(en)
|
1999-06-25 |
2007-02-27 |
Syn Gen, Inc. |
Compositions and methods for labeling oligonucleotides
|
US6750357B1
(en)
|
1999-06-25 |
2004-06-15 |
Syngen, Inc. |
Rhodamine-based fluorophores useful as labeling reagents
|
US6593466B1
(en)
|
1999-07-07 |
2003-07-15 |
Isis Pharmaceuticals, Inc. |
Guanidinium functionalized nucleotides and precursors thereof
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
US6346423B1
(en)
|
1999-07-16 |
2002-02-12 |
Agilent Technologies, Inc. |
Methods and compositions for producing biopolymeric arrays
|
US6306599B1
(en)
|
1999-07-16 |
2001-10-23 |
Agilent Technologies Inc. |
Biopolymer arrays and their fabrication
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
US6114518A
(en)
*
|
1999-09-30 |
2000-09-05 |
Becton, Dickinson And Company |
Synthesis and use of labelled phosphoramidite compositions
|
JP2003511045A
(ja)
|
1999-10-04 |
2003-03-25 |
ユニバーシティー オブ メディシン アンド デンティストリー オブ ニュー ジャージー |
Rna結合化合物の同定方法
|
US6451998B1
(en)
|
1999-10-18 |
2002-09-17 |
Agilent Technologies, Inc. |
Capping and de-capping during oligonucleotide synthesis
|
AU2622101A
(en)
*
|
1999-11-02 |
2001-05-14 |
Celine Hu |
Molecular microarrays and methods for production and use thereof
|
US6875619B2
(en)
|
1999-11-12 |
2005-04-05 |
Motorola, Inc. |
Microfluidic devices comprising biochannels
|
US6361958B1
(en)
|
1999-11-12 |
2002-03-26 |
Motorola, Inc. |
Biochannel assay for hybridization with biomaterial
|
EP1233976A4
(de)
*
|
1999-11-17 |
2003-06-11 |
Jiuping Ji |
Simultaner nachweis von hbv, hcv und hiv in plasmaproben mit hilfe eines multiplexen fixierungstests
|
US6716994B1
(en)
*
|
2000-01-04 |
2004-04-06 |
Applera Corporation |
Mobility-Modifying Cyanine Dyes
|
US20010055765A1
(en)
|
2000-02-18 |
2001-12-27 |
O'keefe Matthew |
Apparatus and methods for parallel processing of micro-volume liquid reactions
|
US20020151040A1
(en)
|
2000-02-18 |
2002-10-17 |
Matthew O' Keefe |
Apparatus and methods for parallel processing of microvolume liquid reactions
|
US7019129B1
(en)
|
2000-05-09 |
2006-03-28 |
Biosearch Technologies, Inc. |
Dark quenchers for donor-acceptor energy transfer
|
EP1313880A2
(de)
*
|
2000-05-30 |
2003-05-28 |
PE Corporation (NY) |
Methoden zur detektion gewünschter nukleinsäuren mittels kombinierter ligation und amplifizierung
|
US6887664B2
(en)
|
2000-06-06 |
2005-05-03 |
Applera Corporation |
Asynchronous primed PCR
|
EP1287154A4
(de)
|
2000-06-07 |
2010-12-15 |
Pacific Biosciences California |
Ladungswechsel-nukleotide
|
US6936702B2
(en)
|
2000-06-07 |
2005-08-30 |
Li-Cor, Inc. |
Charge-switch nucleotides
|
US6869764B2
(en)
|
2000-06-07 |
2005-03-22 |
L--Cor, Inc. |
Nucleic acid sequencing using charge-switch nucleotides
|
US7135565B2
(en)
*
|
2000-07-28 |
2006-11-14 |
Agilent Technologies, Inc. |
Synthesis of polynucleotides using combined oxidation/deprotection chemistry
|
DE60138916D1
(de)
|
2000-09-26 |
2009-07-16 |
Boston Probes Inc |
Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
|
US6811979B2
(en)
*
|
2000-10-11 |
2004-11-02 |
Applera Corporation |
Fluorescent nucleobase conjugates having anionic linkers
|
US6693187B1
(en)
|
2000-10-17 |
2004-02-17 |
Lievre Cornu Llc |
Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
|
AU2002225605A1
(en)
*
|
2000-11-09 |
2002-05-21 |
Invitrogen Corporation |
Method for removing a universal linker from an oligonucleotide
|
AU2002217980A1
(en)
|
2000-12-01 |
2002-06-11 |
Cell Works Inc. |
Conjugates of glycosylated/galactosylated peptide
|
US6794141B2
(en)
|
2000-12-22 |
2004-09-21 |
Arcturus Bioscience, Inc. |
Nucleic acid amplification
|
US6825338B2
(en)
|
2001-03-30 |
2004-11-30 |
Isis Pharmaceuticals, Inc. |
Labeled oligonucleotides, methods for making same, and compounds useful therefor
|
US8034791B2
(en)
|
2001-04-06 |
2011-10-11 |
The University Of Chicago |
Activation of Egr-1 promoter by DNA damaging chemotherapeutics
|
US20040242523A1
(en)
*
|
2003-03-06 |
2004-12-02 |
Ana-Farber Cancer Institue And The Univiersity Of Chicago |
Chemo-inducible cancer gene therapy
|
WO2002080849A2
(en)
*
|
2001-04-06 |
2002-10-17 |
University Of Chicago |
Chemotherapeutic induction of egr-1 promoter activity
|
EP1377683A4
(de)
*
|
2001-04-11 |
2004-09-08 |
Us Gov Health & Human Serv |
Modifizierte zufallsprimer zur sondenmarkierung
|
US20030170675A1
(en)
*
|
2001-04-11 |
2003-09-11 |
The Gov't Of The U.S Of America As Represented By The Secretary Of The Dept. Of Health & Human Serv. |
Methods of manipulating nucleic acids
|
CA2381367A1
(en)
|
2001-04-12 |
2002-10-12 |
Hironori Komatsu |
Method for purifying 5'-protected 2'-deoxypurine nucleosides
|
US6867050B2
(en)
*
|
2001-05-16 |
2005-03-15 |
Academia Sinica |
Apparatus and methods for chemical synthesis
|
US20050009101A1
(en)
*
|
2001-05-17 |
2005-01-13 |
Motorola, Inc. |
Microfluidic devices comprising biochannels
|
WO2002095356A2
(en)
*
|
2001-05-21 |
2002-11-28 |
Aclara Biosciences, Inc. |
Methods and compositions for analyzing proteins
|
EP2070939B1
(de)
|
2001-05-25 |
2014-04-02 |
Duke University |
Modulatoren von pharmakologischen Wirkstoffen
|
EP2842964A1
(de)
|
2001-06-05 |
2015-03-04 |
Curevac GmbH |
Virtuelles Verfahren zur Ermittlung einer modifzierten mRNA-Sequenz
|
US7118907B2
(en)
*
|
2001-06-06 |
2006-10-10 |
Li-Cor, Inc. |
Single molecule detection systems and methods
|
AU2002322351A1
(en)
*
|
2001-06-28 |
2003-03-03 |
Ia, Inc. |
Fiber-optic sensor array
|
US7153954B2
(en)
|
2001-07-12 |
2006-12-26 |
Santaris Pharma A/S |
Method for preparation of LNA phosphoramidites
|
ATE421091T1
(de)
|
2001-07-16 |
2009-01-15 |
Caprotec Bioanalytics Gmbh |
Fangverbindungen, ihre entnahme und verfahren zur analysierung des proteoms und von komplexen zusammensetzungen
|
US6822088B2
(en)
|
2001-07-17 |
2004-11-23 |
Isis Pharmaceuticals, Inc. |
Synthesis of oligonucleotides on solid support
|
US20050042629A1
(en)
|
2002-09-13 |
2005-02-24 |
Applera Corporation |
Thermus scotoductus nucleic acid polymerases
|
US7052877B2
(en)
|
2001-11-30 |
2006-05-30 |
Applera Corporation |
Thermus brockianus nucleic acid polymerases
|
AU2002353001A1
(en)
*
|
2001-12-03 |
2003-06-17 |
The Government Of The United States Of America, Represented By The Secretary Of The Department Of He |
Thermolabile hydroxyl protecting groups and methods of use
|
DE10162480A1
(de)
|
2001-12-19 |
2003-08-07 |
Ingmar Hoerr |
Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
|
US7255874B1
(en)
|
2001-12-21 |
2007-08-14 |
Closure Medical Corporation |
Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
|
GB0200526D0
(en)
*
|
2002-01-11 |
2002-02-27 |
Science And Technology The |
Methods
|
US7098326B2
(en)
*
|
2002-01-23 |
2006-08-29 |
Sigma-Aldrich Co. |
Methods for the integrated synthesis and purification of oligonucleotides
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
CA2474910A1
(en)
|
2002-02-01 |
2003-08-07 |
Sequitur, Inc. |
Oligonucleotide compositions with enhanced efficiency
|
US20030166282A1
(en)
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
ATE421088T1
(de)
*
|
2002-03-11 |
2009-01-15 |
Caprotec Bioanalytics Gmbh |
Verbindungen und verfahren für die analyse des proteoms
|
AU2003220249A1
(en)
*
|
2002-03-15 |
2003-09-29 |
Arcturus Bioscience, Inc. |
Improved nucleic acid amplification
|
US7169916B2
(en)
*
|
2002-04-01 |
2007-01-30 |
Isis Pharmaceuticals, Inc. |
Chloral-free DCA in oligonucleotide synthesis
|
WO2003096015A1
(fr)
|
2002-05-08 |
2003-11-20 |
Matsushita Electric Industrial Co., Ltd. |
Substrat biomoleculaire, masse moleculaire d'essai ou de diagnostic utilisant ce substrat, et appareil s'y rapportant
|
US7291460B2
(en)
*
|
2002-05-31 |
2007-11-06 |
Verenium Corporation |
Multiplexed systems for nucleic acid sequencing
|
CN100424091C
(zh)
|
2002-06-05 |
2008-10-08 |
三井化学株式会社 |
保护化2’-脱氧胞苷类的精制法
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
DE10229872A1
(de)
|
2002-07-03 |
2004-01-29 |
Curevac Gmbh |
Immunstimulation durch chemisch modifizierte RNA
|
US7504215B2
(en)
|
2002-07-12 |
2009-03-17 |
Affymetrix, Inc. |
Nucleic acid labeling methods
|
EP1386925A1
(de)
*
|
2002-07-31 |
2004-02-04 |
Girindus AG |
Verfahren zur Herstellung von Oligonukleotiden
|
US8277753B2
(en)
|
2002-08-23 |
2012-10-02 |
Life Technologies Corporation |
Microfluidic transfer pin
|
ATE449103T1
(de)
*
|
2002-09-08 |
2009-12-15 |
Applera Corp |
Festphasengebundene pna-dimere und deren synthese
|
US20040235005A1
(en)
*
|
2002-10-23 |
2004-11-25 |
Ernest Friedlander |
Methods and composition for detecting targets
|
US7030230B2
(en)
|
2002-10-25 |
2006-04-18 |
Isis Pharmaceuticals, Inc. |
Process of purifying phosphoramidites
|
WO2004044136A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2’-modified nucleosides for use in gene modulation
|
US9150606B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
US20060069248A1
(en)
*
|
2002-12-09 |
2006-03-30 |
Mitsui Chemicals, Inc. |
Process for producing phosphoroamidite
|
GB0229423D0
(en)
*
|
2002-12-18 |
2003-01-22 |
Avecia Ltd |
Process
|
AU2003302264A1
(en)
|
2002-12-20 |
2004-09-09 |
Biotrove, Inc. |
Assay apparatus and method using microfluidic arrays
|
EP1585755B1
(de)
*
|
2002-12-31 |
2015-08-05 |
Sigma-Aldrich Co. LLC |
Verfahren und zusammenstellungen für die tandem-synthese von zwei oder mehr oligonukleotiden auf einen festen träger
|
US20060051879A9
(en)
*
|
2003-01-16 |
2006-03-09 |
Hubert Koster |
Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
JP3936300B2
(ja)
*
|
2003-02-28 |
2007-06-27 |
独立行政法人科学技術振興機構 |
新規なグアノシン誘導体及びその用途
|
JP2006521116A
(ja)
|
2003-03-27 |
2006-09-21 |
ピーティーシー セラピューティクス,インコーポレーテッド |
抗真菌性および/または抗増殖性分子を同定するためのtRNAスプライシング経路の酵素の標的化
|
EP1613158A4
(de)
|
2003-03-27 |
2007-08-22 |
Ptc Therapeutics Inc |
Verfahren zur identifikation von verbindungen mit einer trna-splicenden endonuklease als angriffsort, sowie verwendungen für diese verbindungen als proliferationshemmende mittel
|
WO2004092331A2
(en)
*
|
2003-04-08 |
2004-10-28 |
Li-Cor, Inc. |
Composition and method for nucleic acid sequencing
|
US20070179100A1
(en)
*
|
2003-04-09 |
2007-08-02 |
Muthiah Manoharan |
Protected monomers
|
WO2004101582A2
(en)
*
|
2003-05-09 |
2004-11-25 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Thermolabile hydroxyl protecting groups and methods of use
|
EP1660512A4
(de)
|
2003-06-02 |
2009-12-23 |
Isis Pharmaceuticals Inc |
Oligonucleotid-synthese mit alternativen lösungsmitteln
|
WO2005001129A2
(en)
*
|
2003-06-06 |
2005-01-06 |
Applera Corporation |
Mobility cassettes
|
DE10335833A1
(de)
|
2003-08-05 |
2005-03-03 |
Curevac Gmbh |
Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie
|
EP1662863A4
(de)
*
|
2003-09-18 |
2009-01-28 |
Mayo Foundation |
Transgene nichthumane tieg-tiere
|
JP5379347B2
(ja)
|
2003-09-18 |
2013-12-25 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
4’−チオヌクレオシドおよびオリゴマー化合物
|
WO2005049621A1
(en)
|
2003-11-13 |
2005-06-02 |
Isis Pharmaceuticals, Inc. |
5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis
|
DE602004030041D1
(de)
|
2003-12-22 |
2010-12-23 |
Univ Pennsylvania |
Verfahren und zusammensetzungen zur identifikation von rna-bindenden proteinen
|
EP1706149A2
(de)
*
|
2004-01-15 |
2006-10-04 |
Alza Corporation |
Liposom-zusammensetzung zur abgabe von therapeutischen mitteln
|
US7691316B2
(en)
*
|
2004-02-12 |
2010-04-06 |
Chemistry & Technology For Genes, Inc. |
Devices and methods for the synthesis of nucleic acids
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
EP1735097B1
(de)
|
2004-03-12 |
2016-11-30 |
Life Technologies Corporation |
Ladung eines nanoliter-arrays
|
CN1980947B
(zh)
|
2004-04-22 |
2013-01-30 |
雷加多生物科学公司 |
改良的凝血因子调节物
|
JP4592060B2
(ja)
*
|
2004-04-26 |
2010-12-01 |
キヤノン株式会社 |
Pcr増幅反応装置、ならびに、該装置を利用するpcr増幅反応方法
|
IL162276A0
(en)
*
|
2004-06-01 |
2005-11-20 |
Hadasit Med Res Service |
Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
US20060105453A1
(en)
|
2004-09-09 |
2006-05-18 |
Brenan Colin J |
Coating process for microfluidic sample arrays
|
US7427675B2
(en)
|
2004-08-23 |
2008-09-23 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
DE102004042546A1
(de)
*
|
2004-09-02 |
2006-03-09 |
Curevac Gmbh |
Kombinationstherapie zur Immunstimulation
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
US7256292B2
(en)
|
2004-09-16 |
2007-08-14 |
Applera Corporation |
Fluorescent dye compounds, conjugates and uses thereof
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
JP4948413B2
(ja)
|
2004-09-23 |
2012-06-06 |
ジェネンテック, インコーポレイテッド |
システイン操作抗体および結合体
|
WO2006065751A2
(en)
*
|
2004-12-13 |
2006-06-22 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
JP2008527979A
(ja)
*
|
2005-01-12 |
2008-07-31 |
アプレラ コーポレイション |
核酸の選択的増幅のための組成物、方法およびキット
|
US7608433B2
(en)
|
2005-02-09 |
2009-10-27 |
Idexx Laboratories |
Method of detection of classical swine fever
|
EP2505591A1
(de)
|
2005-02-11 |
2012-10-03 |
Memorial Sloan-Kettering Cancer Center |
Verfahren und Zusammensetzungen zur Detektion eines arzneimittelresistenten EGFR-Mutanten
|
DE102005023170A1
(de)
|
2005-05-19 |
2006-11-23 |
Curevac Gmbh |
Optimierte Formulierung für mRNA
|
CA2609622C
(en)
|
2005-05-26 |
2013-01-15 |
Eragen Biosciences, Inc. |
Reagents for the improved synthesis of isoguanosine-containing oligonucleotides
|
JP2009501024A
(ja)
*
|
2005-07-12 |
2009-01-15 |
テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション |
癌の診断及び治療における遺伝的及びエピジェネティックな変化
|
US7892795B2
(en)
|
2005-08-02 |
2011-02-22 |
Focus Diagnostics, Inc. |
Methods and compositions for detecting BK virus
|
US20070202515A1
(en)
*
|
2005-10-12 |
2007-08-30 |
Pathologica, Llc. |
Promac signature application
|
EP1949152A4
(de)
*
|
2005-11-14 |
2014-02-05 |
Bayer Ip Gmbh |
Planare wellenleiter-erkennungschips und kammer zur ausführung von multiplex-pcr-tests
|
US7579459B2
(en)
*
|
2005-12-12 |
2009-08-25 |
Ngo Nam Q |
Activator bound solid supports for nucleic acid synthesis via the phosphoramidite approach
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
CA2640171C
(en)
|
2006-01-27 |
2014-10-28 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
WO2007095155A2
(en)
|
2006-02-13 |
2007-08-23 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Primers and probes for detection and discrimination of types and subtypes of influenza viruses
|
EP2012810A2
(de)
*
|
2006-03-24 |
2009-01-14 |
Archemix Corp. |
Festsubstratreagenzien für synthese
|
AU2007258117B2
(en)
|
2006-05-05 |
2013-05-30 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating gene expression
|
ES2389737T3
(es)
|
2006-05-11 |
2012-10-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos modificados en 5'
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
CA2655018A1
(en)
*
|
2006-06-16 |
2007-12-21 |
Pacific Biosciences Of California, Inc. |
Controlled initiation of primer extension
|
EP2442108B1
(de)
|
2006-07-14 |
2016-11-16 |
The Regents of The University of California |
Krebsbiomarker und Anwendungsverfahren dafür
|
DE102006035618A1
(de)
|
2006-07-31 |
2008-02-07 |
Curevac Gmbh |
Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz
|
JP2010507361A
(ja)
|
2006-07-31 |
2010-03-11 |
キュアバック ゲーエムベーハー |
具体的には免疫刺激剤/アジュバントとしての、一般式(I):GlXmGn、または一般式(II):ClXmCnで表される核酸
|
US8138330B2
(en)
*
|
2006-09-11 |
2012-03-20 |
Sigma-Aldrich Co. Llc |
Process for the synthesis of oligonucleotides
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
US7947447B2
(en)
|
2007-01-16 |
2011-05-24 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
WO2008141248A2
(en)
*
|
2007-05-10 |
2008-11-20 |
Agilent Technologies, Inc. |
Thiocarbon-protecting groups for rna synthesis
|
EP2152890A1
(de)
*
|
2007-05-23 |
2010-02-17 |
MannKind Corporation |
Multicistronische vektoren und verfahren zu deren konstruktion
|
WO2008150729A2
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
EP2173760B2
(de)
|
2007-06-08 |
2015-11-04 |
Isis Pharmaceuticals, Inc. |
Carbozyklische bizyklische nukleinsäureanaloga
|
EP2171088B1
(de)
|
2007-06-19 |
2015-10-14 |
Stratos Genomics Inc. |
Nukleinsäuresequenzierung mit hohem durchsatz mittels expansion
|
US8278283B2
(en)
|
2007-07-05 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
6-disubstituted or unsaturated bicyclic nucleic acid analogs
|
US8404830B2
(en)
*
|
2007-07-17 |
2013-03-26 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
KR101654007B1
(ko)
|
2007-08-15 |
2016-09-05 |
아이오니스 파마수티컬즈, 인코포레이티드 |
테트라하이드로피란 핵산 유사체
|
WO2009030254A1
(en)
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
WO2009039173A2
(en)
|
2007-09-19 |
2009-03-26 |
Applied Biosystems Inc. |
SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF
|
WO2009046738A1
(en)
|
2007-10-09 |
2009-04-16 |
Curevac Gmbh |
Composition for treating lung cancer, particularly of non-small lung cancers (nsclc)
|
EP3222290A1
(de)
|
2007-10-09 |
2017-09-27 |
CureVac AG |
Zusammensetzung zur behandlung von prostatakrebs
|
US7829735B2
(en)
*
|
2007-10-26 |
2010-11-09 |
Northwestern University |
Universal phosphoramidite for preparation of modified biomolecules and surfaces
|
AU2008323923A1
(en)
*
|
2007-11-06 |
2009-05-14 |
Pharmaessentia Corporation |
Novel synthesis of beta-nucleosides
|
PT2176408E
(pt)
|
2008-01-31 |
2015-04-23 |
Curevac Gmbh |
Ácidos nucleicos compreendendo a fórmula (nuglxmgnnv)a e os seus derivados como agentes/adjuvantes imunoestimuladores
|
EP2265627A2
(de)
|
2008-02-07 |
2010-12-29 |
Isis Pharmaceuticals, Inc. |
Bicyclische cyclohexitolnukleinsäureanaloga
|
WO2009102427A2
(en)
|
2008-02-11 |
2009-08-20 |
Rxi Pharmaceuticals Corp. |
Modified rnai polynucleotides and uses thereof
|
WO2009117589A1
(en)
|
2008-03-21 |
2009-09-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
US9290534B2
(en)
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
NZ610482A
(en)
|
2008-05-14 |
2014-08-29 |
Genomic Health Inc |
Predictors of patient response to treatment with egf receptor inhibitors
|
WO2010005693A1
(en)
*
|
2008-06-23 |
2010-01-14 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Cyclized ngr peptide compounds, compositions, and methods of their use
|
JP5438922B2
(ja)
*
|
2008-06-25 |
2014-03-12 |
日東電工株式会社 |
核酸の製造方法
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
US10138485B2
(en)
|
2008-09-22 |
2018-11-27 |
Rxi Pharmaceuticals Corporation |
Neutral nanotransporters
|
EP2346883B1
(de)
|
2008-09-23 |
2016-03-23 |
Scott G. Petersen |
Selbstfreisetzende biolabile phosphatgeschützte pro-oligos für therapeutika auf oligonukleotidbasis und vermittlung von rna-interferenz
|
US8604192B2
(en)
|
2008-09-24 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acids analogs
|
EP2356129B1
(de)
|
2008-09-24 |
2013-04-03 |
Isis Pharmaceuticals, Inc. |
Substituierte alpha-l-bicyclische nukleoside
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
KR101979134B1
(ko)
|
2008-10-15 |
2019-05-15 |
아이오니스 파마수티컬즈, 인코포레이티드 |
인자 11 발현의 조정
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
US8883752B2
(en)
|
2008-10-24 |
2014-11-11 |
Isis Pharmaceuticals, Inc. |
5′ and 2′ BIS-substituted nucleosides and oligomeric compounds prepared therefrom
|
US9074211B2
(en)
|
2008-11-19 |
2015-07-07 |
Rxi Pharmaceuticals Corporation |
Inhibition of MAP4K4 through RNAI
|
ES2616051T3
(es)
|
2008-12-02 |
2017-06-09 |
Wave Life Sciences Japan, Inc. |
Método para la síntesis de ácidos nucleicos modificados en el átomo de fósforo
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
EP2389452A2
(de)
|
2009-01-21 |
2011-11-30 |
Vertex Pharmaceuticals Incorporated |
Verfahren zur amplifikation von hepatitis-c-virus-nukleinsäuren
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
WO2010090969A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
US8835117B2
(en)
|
2009-05-29 |
2014-09-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Nucleic acids for detection and discrimination of genotypes of Chlamydophila psittaci
|
AU2010270714B2
(en)
|
2009-07-06 |
2015-08-13 |
Wave Life Sciences Ltd. |
Novel nucleic acid prodrugs and methods use thereof
|
EP2278334A1
(de)
|
2009-07-22 |
2011-01-26 |
Etablissement Francais du Sang |
Membranbasierte Mikroarray-Vorrichtung zur Erkennung eines hohen Multianalyt-Durchlaufs
|
EP2462153B1
(de)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclische cyclohexosenukleinsäureanaloga
|
US20110053829A1
(en)
|
2009-09-03 |
2011-03-03 |
Curevac Gmbh |
Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
|
MX2012006406A
(es)
|
2009-12-04 |
2012-07-25 |
Genentech Inc |
Anticuerpos multiespecificos, analogos de anticuerpo, composiciones y metodos.
|
WO2011069528A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Lyophilization of nucleic acids in lactate-containing solutions
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
US10113206B2
(en)
|
2010-02-24 |
2018-10-30 |
Grifols Therapeutics Inc. |
Methods, compositions, and kits for determining human immunodeficiency virus (HIV)
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
EP2550002B1
(de)
|
2010-03-24 |
2019-05-08 |
Phio Pharmaceuticals Corp. |
Rna-interferenz bei dermalen und fibrotischen erkrankungen
|
US9095504B2
(en)
|
2010-03-24 |
2015-08-04 |
Rxi Pharmaceuticals Corporation |
RNA interference in ocular indications
|
EP2550000A4
(de)
|
2010-03-24 |
2014-03-26 |
Advirna Inc |
Selbstfreisetzende rnai-verbindungen von reduzierter grösse
|
MY160608A
(en)
|
2010-04-12 |
2017-03-15 |
Somalogic Inc |
APTAMERS TO ß-NGF AND THEIR USE IN TREATING ß-NGF MEDIATED DISEASES AND DISORDERS
|
EP3508854A1
(de)
|
2010-04-27 |
2019-07-10 |
The Regents of The University of California |
Krebsbiomarker und verfahren zur verwendung davon
|
WO2011139702A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
EP2625186B1
(de)
|
2010-04-28 |
2016-07-27 |
Ionis Pharmaceuticals, Inc. |
5'-modifizierte nukleoside und daraus hergestellte oligomere verbindungen
|
WO2011139695A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011156202A1
(en)
|
2010-06-08 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
RU2626537C2
(ru)
|
2010-06-08 |
2017-07-28 |
Дженентек, Инк. |
Полученные с помощью генной инженерии антитела с цистеиновыми заменами и их конъюгаты
|
DK2449113T3
(en)
|
2010-07-30 |
2016-01-11 |
Curevac Ag |
Complex formation of nucleic acids with the disulfide cross-linked cationic components for transfection and immunostimulation
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
US10428019B2
(en)
|
2010-09-24 |
2019-10-01 |
Wave Life Sciences Ltd. |
Chiral auxiliaries
|
DK3590949T3
(da)
|
2010-10-01 |
2022-07-11 |
Modernatx Inc |
Ribonukleinsyrer indeholdende n1-methyl-pseudouracil og anvendelse heraf
|
CA2817960C
(en)
|
2010-11-17 |
2020-06-09 |
Isis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
CA2822825C
(en)
|
2010-12-27 |
2016-02-09 |
Eli Lilly And Company |
Bovine viral diarrhea virus type 1b vaccine compositions and methods
|
AR084358A1
(es)
|
2010-12-27 |
2013-05-08 |
Lilly Co Eli |
Composiciones y metodos para identificar y diferenciar componentes virales de vacunas multivalentes de la “fiebre de embarque” (complejo de enfermedad respiratoria bovina (brdc))
|
KR20130130804A
(ko)
|
2010-12-30 |
2013-12-02 |
다우 아그로사이언시즈 엘엘씨 |
공포 atpase c 서브유닛을 표적화하고 딱정벌레목 해충에 대한 저항성을 부여하는 핵산 분자
|
CA2822958A1
(en)
|
2010-12-30 |
2012-07-05 |
Dow Agrosciences Llc |
Nucleic acid molecules that confer resistance to coleopteran pests
|
BRPI1107329A2
(pt)
|
2010-12-30 |
2019-11-19 |
Dow Agrosciences Llc |
moléculas de ácido nucléico que direcionadas à subunidade h de atpase vacuolar que conferem resistência a pragas de coleópteros, vetor de transformação de planta, célula transformada, bem como métodos para controlar uma população de praga de coleóptero, controlar uma infestação pela dita praga, melhorar o rendimento de uma safra e para produzir uma célula transgênica
|
UY33852A
(es)
|
2010-12-30 |
2012-07-31 |
Dow Agrosciences Llc |
?moléculas de ácido nucleico que se dirigen a la proteína de unión a gtp pequeña de rho1 y que confieren resistencia a las plagas de coleópteros?.
|
CA2831613A1
(en)
|
2011-03-31 |
2012-10-04 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
DK2714939T3
(en)
|
2011-05-24 |
2015-06-29 |
Elitech Holding Bv |
DETECTION OF METHICILLIN-RESISTENT STAPHYLOCOCCUS AUREUS
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US9273366B2
(en)
|
2011-06-15 |
2016-03-01 |
Grifols Therapeutics Inc. |
Methods, compositions, and kits for determining human immunodeficiency virus (HIV)
|
EP2734208B1
(de)
|
2011-07-19 |
2017-03-01 |
Wave Life Sciences Ltd. |
Verfahren zur synthese von funktionalisierten nukleinsäuren
|
EP2736916B1
(de)
|
2011-07-26 |
2019-05-22 |
ELITechGroup, Inc. |
Mgb-phosphoramidite und verwendungsverfahren
|
US20140193803A1
(en)
|
2011-09-07 |
2014-07-10 |
Grifols Therapeutics Inc. |
Methods, compositions, and kits for determining hepatitus a virus
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
SG10201602654SA
(en)
|
2011-10-03 |
2016-05-30 |
Moderna Therapeutics Inc |
Modified nucleosides,nucleotides,and nucleic acids,and uses thereof
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
WO2013090648A1
(en)
|
2011-12-16 |
2013-06-20 |
modeRNA Therapeutics |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
WO2013113326A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
|
WO2013148147A1
(en)
|
2012-03-26 |
2013-10-03 |
The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services |
Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
|
US9303079B2
(en)
|
2012-04-02 |
2016-04-05 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
JP2015516143A
(ja)
|
2012-04-02 |
2015-06-08 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
US9221864B2
(en)
|
2012-04-09 |
2015-12-29 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
US10584377B2
(en)
|
2012-05-02 |
2020-03-10 |
Ibis Biosciences, Inc. |
DNA sequencing
|
WO2013166303A1
(en)
|
2012-05-02 |
2013-11-07 |
Ibis Biosciences, Inc. |
Dna sequencing
|
WO2013173844A1
(en)
|
2012-05-18 |
2013-11-21 |
Pacific Biosciences Of California, Inc. |
Heteroarylcyanine dyes
|
EP3884949A1
(de)
|
2012-06-08 |
2021-09-29 |
Translate Bio, Inc. |
Pulmonale verabreichung von mrns an nicht pulmonale zielzellen
|
CN107011400B
(zh)
|
2012-07-13 |
2021-05-25 |
波涛生命科学有限公司 |
不对称辅助基团
|
MX2015000577A
(es)
|
2012-07-13 |
2015-08-14 |
Wave Life Sciences Pte Ltd |
Control quiral.
|
JP6246121B2
(ja)
|
2012-07-13 |
2017-12-13 |
株式会社新日本科学 |
キラル核酸アジュバント
|
EP2885312A4
(de)
|
2012-08-15 |
2016-01-20 |
Isis Pharmaceuticals Inc |
Verfahren zur herstellung oligomerer verbindungen unter verwendung von modifizierten kappungsprotokollen
|
US9950001B2
(en)
|
2012-08-20 |
2018-04-24 |
The Regents Of The University Of California |
Polynucleotides having bioreversible groups
|
WO2014030066A2
(en)
|
2012-08-22 |
2014-02-27 |
Bernitz Mats Nilsson |
Methods for identifying nucleic acid sequences
|
JP6533896B2
(ja)
*
|
2012-09-04 |
2019-06-26 |
株式会社ダナフォーム |
化合物、核酸、標識物質および検出方法
|
WO2014055746A1
(en)
|
2012-10-04 |
2014-04-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and reagents for detection, quantitation, and serotyping of dengue viruses
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
EP2909339B1
(de)
|
2012-10-18 |
2018-05-30 |
IDEXX Laboratories, Inc. |
Kits mit kontrollen für nukleinsäureamplifikation
|
US20160046997A1
(en)
|
2012-10-18 |
2016-02-18 |
Oslo Universitetssykehus Hf |
Biomarkers for cervical cancer
|
LT2922554T
(lt)
|
2012-11-26 |
2022-06-27 |
Modernatx, Inc. |
Terminaliai modifikuota rnr
|
KR102190852B1
(ko)
|
2013-01-31 |
2020-12-14 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 커플링 프로토콜을 이용하는 올리고머 화합물의 제조 방법
|
KR20150128687A
(ko)
|
2013-03-14 |
2015-11-18 |
샤이어 휴먼 지네틱 테라피즈 인크. |
메신저 rna의 정제 방법
|
LT2970456T
(lt)
|
2013-03-14 |
2021-08-10 |
Translate Bio, Inc. |
Būdai ir kompozicijos, skirti mrnr koduojamų antikūnų pristatymui
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
NZ631512A
(en)
|
2013-05-01 |
2016-10-28 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulating apolipoprotein (a) expression
|
WO2014197714A1
(en)
|
2013-06-05 |
2014-12-11 |
Am Chemicals Llc |
Phosphoramidite building blocks for sugar-conjugated oligonucleotides
|
US9069358B2
(en)
|
2013-06-24 |
2015-06-30 |
Biolytic Lab Performance, Inc. |
System for controlling and optimizing reactions in solid phase synthesis of small molecules
|
KR102291045B1
(ko)
|
2013-08-05 |
2021-08-19 |
트위스트 바이오사이언스 코포레이션 |
드 노보 합성된 유전자 라이브러리
|
PL3035955T3
(pl)
|
2013-08-21 |
2020-03-31 |
Curevac Ag |
Kompozycja i szczepionka do leczenia raka płuca
|
WO2015024668A2
(en)
|
2013-08-21 |
2015-02-26 |
Curevac Gmbh |
Respiratory syncytial virus (rsv) vaccine
|
AU2014329452B2
(en)
|
2013-10-03 |
2019-06-20 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
WO2015061246A1
(en)
|
2013-10-21 |
2015-04-30 |
Isis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
JP6893785B2
(ja)
|
2013-10-22 |
2021-06-23 |
トランスレイト バイオ, インコーポレイテッド |
mRNAのCNS送達及びその使用方法
|
MX2016005237A
(es)
|
2013-10-22 |
2016-08-12 |
Shire Human Genetic Therapies |
Terapia de acido ribonucleico mensajero para la deficiencia de argininosuccinato sintetasa.
|
EA201690576A1
(ru)
|
2013-10-22 |
2016-10-31 |
Шир Хьюман Дженетик Терапис, Инк. |
Липидные композиции для доставки матричной рнк
|
EA201992208A1
(ru)
|
2013-10-22 |
2020-07-31 |
Транслейт Био, Инк. |
ЛЕЧЕНИЕ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
|
WO2015062738A1
(en)
|
2013-11-01 |
2015-05-07 |
Curevac Gmbh |
Modified rna with decreased immunostimulatory properties
|
EP3068783B1
(de)
|
2013-11-15 |
2020-09-23 |
The Board of Trustees of the Leland Stanford Junior University |
Agonisten des hypokretin-rezeptors 2 zur verwendung zur behandlung von herzversagen
|
RU2732402C2
(ru)
|
2013-11-21 |
2020-09-16 |
Сомалоджик, Инк. |
Цитидин-5-карбоксамид модифицированные нуклеотидные композиции и способы, относящиеся к ним
|
CN106061488B
(zh)
|
2013-12-02 |
2021-04-09 |
菲奥医药公司 |
癌症的免疫治疗
|
BR102014031844A2
(pt)
|
2013-12-20 |
2015-10-06 |
Dow Agrosciences Llc |
ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros
|
RU2016129435A
(ru)
|
2013-12-20 |
2018-01-25 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Молекулы нуклеиновой кислоты phkп ii-140, которые придают устойчивость к жестококрылым насекомым-вредителям
|
RU2717986C2
(ru)
|
2013-12-30 |
2020-03-27 |
Куревак Аг |
Искусственные молекулы нуклеиновой кислоты
|
EP3495486B1
(de)
|
2013-12-30 |
2020-12-16 |
CureVac AG |
Künstliche nukleinsäuremoleküle
|
JP6584414B2
(ja)
|
2013-12-30 |
2019-10-02 |
キュアバック アーゲー |
人工核酸分子
|
US10322173B2
(en)
|
2014-01-15 |
2019-06-18 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
|
US10149905B2
(en)
|
2014-01-15 |
2018-12-11 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
US10144933B2
(en)
|
2014-01-15 |
2018-12-04 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
KR102423317B1
(ko)
|
2014-01-16 |
2022-07-22 |
웨이브 라이프 사이언시스 리미티드 |
키랄 디자인
|
US10036019B2
(en)
|
2014-03-17 |
2018-07-31 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
CN116970607A
(zh)
|
2014-03-19 |
2023-10-31 |
Ionis制药公司 |
用于调节共济失调蛋白2表达的组合物
|
ME03314B
(de)
|
2014-03-24 |
2019-10-20 |
Translate Bio Inc |
Mrna-therapie zur behandlung von augenerkrankungen
|
EP3129050A2
(de)
|
2014-04-01 |
2017-02-15 |
CureVac AG |
Polymerträger-cargo-komplex zur verwendung als immunstimulierendes mittel oder als ein adjuvans
|
EP3757214B1
(de)
|
2014-04-01 |
2022-06-15 |
Biogen MA Inc. |
Zusammensetzungen zur modulierung der sod-1-expression
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
WO2015164773A1
(en)
|
2014-04-25 |
2015-10-29 |
Shire Human Genetic Therapies, Inc. |
Methods for purification of messenger rna
|
US11279934B2
(en)
|
2014-04-28 |
2022-03-22 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
|
EP3137476B1
(de)
|
2014-04-28 |
2019-10-09 |
Ionis Pharmaceuticals, Inc. |
Verbindungsmodifizierte oligomerverbindungen
|
EP3137478B1
(de)
|
2014-04-30 |
2021-09-22 |
Agilent Technologies, Inc. |
Phosphorschutzgruppen und verfahren zu deren herstellung und verwendung
|
EP3608406B1
(de)
|
2014-05-01 |
2023-02-15 |
Ionis Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur modulation der expression vom komplementfaktor b
|
EP3137115B1
(de)
|
2014-05-01 |
2020-10-14 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur synthese von reaktiven konjugatclustern
|
KR20170002504A
(ko)
|
2014-05-07 |
2017-01-06 |
다우 아그로사이언시즈 엘엘씨 |
딱정벌레류 해충에 대한 저항성을 부여하는 dre4 핵산 분자
|
EP3143022B1
(de)
|
2014-05-16 |
2021-12-22 |
Life Technologies Corporation |
Als diagnostische hilfsmittel geeignete carbopyrononverbindungen
|
CA2949106C
(en)
|
2014-05-30 |
2023-10-24 |
Shire Human Genetic Therapies, Inc. |
Biodegradable lipids for delivery of nucleic acids
|
US9802975B2
(en)
|
2014-06-10 |
2017-10-31 |
Agilent Technologies, Inc. |
Protecting groups for “Z nucleotide” and methods thereof
|
CN106795142B
(zh)
|
2014-06-24 |
2022-11-04 |
川斯勒佰尔公司 |
用于递送核酸的立体化学富集组合物
|
JP6782171B2
(ja)
|
2014-07-02 |
2020-11-11 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
メッセンジャーrnaのカプセル化
|
US10093967B2
(en)
|
2014-08-12 |
2018-10-09 |
The Regents Of The University Of Michigan |
Detection of nucleic acids
|
KR20230037676A
(ko)
|
2014-09-05 |
2023-03-16 |
피오 파마슈티칼스 코프. |
Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법
|
KR20170052600A
(ko)
|
2014-09-12 |
2017-05-12 |
제넨테크, 인크. |
시스테인 가공된 항체 및 콘주게이트
|
BR112017007923B1
(pt)
|
2014-10-17 |
2023-12-12 |
The Penn State Research Foundation |
Método para produzir manipulação genética mediada por reações multiplex com rna em uma célula receptora, construção de ácido nucleico,cassete de expressão, vetor, célula receptora e célula geneticamente modificada
|
WO2016090323A1
(en)
|
2014-12-05 |
2016-06-09 |
Prelude, Inc. |
Dcis recurrence and invasive breast cancer
|
US9943595B2
(en)
|
2014-12-05 |
2018-04-17 |
Translate Bio, Inc. |
Messenger RNA therapy for treatment of articular disease
|
EP3230468B1
(de)
|
2014-12-12 |
2020-09-16 |
ELITechGroup, Inc. |
Verfahren und kits zum nachweis von antibiotikaresistenten bakterien
|
EP4023755B1
(de)
|
2014-12-12 |
2023-04-26 |
CureVac SE |
Künstliche nukleinsäuremoleküle zur verbesserten proteinexpression
|
EP3230467A1
(de)
|
2014-12-12 |
2017-10-18 |
ELITechGroup B.V. |
Verfahren und zusammensetzungen zum nachweis von antibiotikaresistenten bakterien
|
ES2811279T3
(es)
|
2014-12-22 |
2021-03-11 |
Fraunhofer Ges Forschung |
Moléculas de ácido nucleico de Nucampholin para controlar plagas de insectos coleópteros
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
MX2017008670A
(es)
|
2014-12-30 |
2017-10-11 |
Curevac Ag |
Moleculas artificiales de acido nucleico novedosas.
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
WO2016115490A1
(en)
|
2015-01-16 |
2016-07-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of dux4
|
CA2975855A1
(en)
|
2015-02-04 |
2016-08-11 |
Twist Bioscience Corporation |
Compositions and methods for synthetic gene assembly
|
CA2975852A1
(en)
|
2015-02-04 |
2016-08-11 |
Twist Bioscience Corporation |
Methods and devices for de novo oligonucleic acid assembly
|
WO2016137923A1
(en)
|
2015-02-23 |
2016-09-01 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
EP3067424A1
(de)
|
2015-03-13 |
2016-09-14 |
Dow AgroSciences LLC |
Rna-polymerase-i1-nukleinsäuremoleküle zur kontrolle von insektenschädlingen
|
AU2016233135B2
(en)
|
2015-03-19 |
2021-07-08 |
Translate Bio, Inc. |
mRNA therapy for pompe disease
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
WO2016172377A1
(en)
|
2015-04-21 |
2016-10-27 |
Twist Bioscience Corporation |
Devices and methods for oligonucleic acid library synthesis
|
BR102016012010A2
(pt)
|
2015-05-29 |
2020-03-24 |
Dow Agrosciences Llc |
Molécula de ácido nucleico, de ácido ribonucleico (rna) e de ácido ribonucleico de filamento duplo (dsrna), usos de célula, planta e semente, produto primário, bem como métodos para controlar uma população de pragas coleópteras e/ou hemípteras, para melhorar o rendimento de uma cultura, e para produzir uma célula vegetal transgênica e uma planta transgênica
|
GB201511470D0
(en)
|
2015-06-30 |
2015-08-12 |
Cellcall Kft |
HPV detection method
|
KR20180026739A
(ko)
|
2015-07-06 |
2018-03-13 |
알엑스아이 파마슈티칼스 코포레이션 |
슈퍼옥시드 디스뮤타제 1 (sod1)을 표적화하는 핵산 분자
|
US10808247B2
(en)
|
2015-07-06 |
2020-10-20 |
Phio Pharmaceuticals Corp. |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
US11458205B2
(en)
|
2015-08-04 |
2022-10-04 |
Duke University |
Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
|
WO2017036580A1
(en)
|
2015-08-28 |
2017-03-09 |
Curevac Ag |
Artificial nucleic acid molecules
|
KR20180050411A
(ko)
|
2015-09-18 |
2018-05-14 |
트위스트 바이오사이언스 코포레이션 |
올리고핵산 변이체 라이브러리 및 그의 합성
|
CN113604546A
(zh)
|
2015-09-22 |
2021-11-05 |
特韦斯特生物科学公司 |
用于核酸合成的柔性基底
|
PT3353303T
(pt)
|
2015-09-25 |
2023-10-10 |
Academisch Ziekenhuis Leiden |
Composições e métodos para modulação da expressão de ataxina 3
|
CN109563509B
(zh)
|
2015-10-19 |
2022-08-09 |
菲奥医药公司 |
靶向长非编码rna的减小尺寸的自递送核酸化合物
|
WO2017095958A1
(en)
|
2015-12-01 |
2017-06-08 |
Twist Bioscience Corporation |
Functionalized surfaces and preparation thereof
|
WO2017096395A1
(en)
|
2015-12-04 |
2017-06-08 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
US11752213B2
(en)
|
2015-12-21 |
2023-09-12 |
Duke University |
Surfaces having reduced non-specific binding and antigenicity
|
CA3006599A1
(en)
|
2016-01-05 |
2017-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing lrrk2 expression
|
AU2017234678A1
(en)
|
2016-03-16 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
WO2017177169A1
(en)
|
2016-04-08 |
2017-10-12 |
Rana Therapeutics, Inc. |
Multimeric coding nucleic acid and uses thereof
|
EP3443123B1
(de)
|
2016-04-11 |
2021-08-11 |
Board of Regents, The University of Texas System |
Verfahren und zusammensetzungen zum nachweis der affinität einzelner t-zellrezeptoren und sequenz
|
US11467156B2
(en)
|
2016-06-01 |
2022-10-11 |
Duke University |
Nonfouling biosensors
|
JP2019522047A
(ja)
|
2016-06-13 |
2019-08-08 |
トランスレイト バイオ, インコーポレイテッド |
オルニチントランスカルバミラーゼ欠損症治療のためのメッセンジャーrna療法
|
WO2017219017A1
(en)
|
2016-06-17 |
2017-12-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
WO2018013999A1
(en)
|
2016-07-15 |
2018-01-18 |
Am Chemicals Llc |
Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis
|
JP2019530434A
(ja)
|
2016-08-05 |
2019-10-24 |
ジェネンテック, インコーポレイテッド |
アゴニスト活性を有する多価及び多重エピトープ抗体ならびに使用方法
|
US10907156B2
(en)
|
2016-08-19 |
2021-02-02 |
Fundación Para La Investigación Biomédica Del Hospital Univ. Ramón Y Cajal |
MiR-127 agents for use in the treatment of renal fibrosis
|
WO2018038772A1
(en)
|
2016-08-22 |
2018-03-01 |
Twist Bioscience Corporation |
De novo synthesized nucleic acid libraries
|
KR102217487B1
(ko)
|
2016-09-21 |
2021-02-23 |
트위스트 바이오사이언스 코포레이션 |
핵산 기반 데이터 저장
|
US11400161B2
(en)
|
2016-10-06 |
2022-08-02 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
MA46756A
(fr)
|
2016-11-10 |
2019-09-18 |
Translate Bio Inc |
Formulation de nanoparticules lipidiques à base de glace améliorée pour l'administration de l'arnm
|
US11400109B2
(en)
|
2016-11-10 |
2022-08-02 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger RNA
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
AU2017357758B2
(en)
|
2016-11-10 |
2023-11-16 |
Translate Bio, Inc. |
Improved process of preparing mRNA-loaded lipid nanoparticles
|
US11033570B2
(en)
|
2016-12-02 |
2021-06-15 |
Cold Spring Harbor Laboratory |
Modulation of Lnc05 expression
|
EA201991262A1
(ru)
|
2016-12-16 |
2020-04-07 |
Твист Байосайенс Корпорейшн |
Библиотеки вариантов иммунологического синапса и их синтез
|
EP3342780A1
(de)
|
2016-12-30 |
2018-07-04 |
Dow AgroSciences LLC |
Nukleinsäuremoleküle mit prä-mrna-verarbeitungsfaktor 8 (prp8) zur kontrolle von insektenschädlingen
|
WO2018132732A1
(en)
|
2017-01-12 |
2018-07-19 |
Duke University |
Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
|
CA3054303A1
(en)
|
2017-02-22 |
2018-08-30 |
Twist Bioscience Corporation |
Nucleic acid based data storage
|
CA3054323A1
(en)
|
2017-02-27 |
2018-08-30 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
EP3585891B1
(de)
|
2017-02-27 |
2021-10-27 |
Translate Bio, Inc. |
Verfahren zur reinigung von messenger-rna
|
WO2018165257A1
(en)
|
2017-03-07 |
2018-09-13 |
Translate Bio, Inc. |
Polyanionic delivery of nucleic acids
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
CA3056388A1
(en)
|
2017-03-15 |
2018-09-20 |
Twist Bioscience Corporation |
Variant libraries of the immunological synapse and synthesis thereof
|
WO2018213320A1
(en)
|
2017-05-15 |
2018-11-22 |
Duke University |
Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
|
WO2018213476A1
(en)
|
2017-05-16 |
2018-11-22 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
|
EP3638716B1
(de)
|
2017-06-12 |
2022-01-05 |
Translate Bio, Inc. |
Poly(phosphoester) zur verabreichung von nukleinsäuren
|
KR20240013290A
(ko)
|
2017-06-12 |
2024-01-30 |
트위스트 바이오사이언스 코포레이션 |
심리스 핵산 어셈블리를 위한 방법
|
WO2018231864A1
(en)
|
2017-06-12 |
2018-12-20 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
US10780183B2
(en)
|
2017-06-19 |
2020-09-22 |
Translate Bio, Inc. |
Messenger RNA therapy for the treatment of Friedreich's ataxia
|
US11680083B2
(en)
|
2017-06-30 |
2023-06-20 |
Duke University |
Order and disorder as a design principle for stimuli-responsive biopolymer networks
|
EP3645546A4
(de)
|
2017-06-30 |
2021-12-01 |
Solstice Biologics, Ltd. |
Chirale phosphoramidithilfsmittel und verfahren zu ihrer verwendung
|
CA3071033A1
(en)
|
2017-08-18 |
2019-02-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
GB2581620A
(en)
|
2017-09-11 |
2020-08-26 |
Twist Bioscience Corp |
GPCR binding proteins and synthesis thereof
|
CN111565834B
(zh)
|
2017-10-20 |
2022-08-26 |
特韦斯特生物科学公司 |
用于多核苷酸合成的加热的纳米孔
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
US11167043B2
(en)
|
2017-12-20 |
2021-11-09 |
Translate Bio, Inc. |
Composition and methods for treatment of ornithine transcarbamylase deficiency
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
EP3735459A4
(de)
|
2018-01-04 |
2021-10-06 |
Twist Bioscience Corporation |
Digitale informationsspeicherung auf dna-basis
|
CN111902537A
(zh)
|
2018-01-15 |
2020-11-06 |
Ionis制药公司 |
Dnm2表达的调节剂
|
WO2019152802A1
(en)
|
2018-02-02 |
2019-08-08 |
Translate Bio, Inc. |
Cationic polymers
|
WO2019169243A1
(en)
|
2018-03-02 |
2019-09-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of amyloid-beta precursor protein
|
TW202000199A
(zh)
|
2018-03-02 |
2020-01-01 |
美商Ionis製藥公司 |
Irf4 表現之調節劑
|
US11661601B2
(en)
|
2018-03-22 |
2023-05-30 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating FMR1 expression
|
US11365416B2
(en)
|
2018-04-11 |
2022-06-21 |
Ionis Pharmaceuticals, Inc. |
Modulators of EZH2 expression
|
US11613554B2
(en)
|
2018-04-13 |
2023-03-28 |
Bristol-Myers Squibb Company |
Phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds
|
WO2019217572A1
(en)
|
2018-05-08 |
2019-11-14 |
Sanford Burnham Prebys Medical Discovery Institute |
Role of pvt1 in the diagnosis and treatment of myc-driven cancer
|
BR112020021253A2
(pt)
|
2018-05-09 |
2021-02-02 |
Ionis Pharmaceuticals, Inc. |
compostos e métodos para redução da expressão de atxn3
|
EP3799604A4
(de)
|
2018-05-09 |
2022-09-07 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur verminderung der fxi-expression
|
CA3097912A1
(en)
|
2018-05-15 |
2019-11-21 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger rna
|
WO2019222424A1
(en)
|
2018-05-16 |
2019-11-21 |
Translate Bio, Inc. |
Ribose cationic lipids
|
CA3100739A1
(en)
|
2018-05-18 |
2019-11-21 |
Twist Bioscience Corporation |
Polynucleotides, reagents, and methods for nucleic acid hybridization
|
US20220008338A1
(en)
|
2018-05-24 |
2022-01-13 |
Translate Bio, Inc. |
Thioester Cationic Lipids
|
CN112672761A
(zh)
|
2018-05-30 |
2021-04-16 |
川斯勒佰尔公司 |
磷酸酯阳离子脂质
|
US20210206739A1
(en)
|
2018-05-30 |
2021-07-08 |
Translate Bio, Inc. |
Vitamin Cationic Lipids
|
EP3801467A1
(de)
|
2018-05-30 |
2021-04-14 |
Translate Bio, Inc. |
Messenger rna-impfstoffe und verwendungen davon
|
JP7463006B2
(ja)
|
2018-05-30 |
2024-04-08 |
トランスレイト バイオ, インコーポレイテッド |
ステロイド性部分を含むカチオン性脂質
|
US11384376B2
(en)
|
2018-05-31 |
2022-07-12 |
Roche Molecular Systems, Inc. |
Reagents and methods for post-synthetic modification of nucleic acids
|
EP3807411A4
(de)
|
2018-06-14 |
2022-08-03 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur verminderung der atxn3-expression
|
SG11202011864XA
(en)
|
2018-06-27 |
2020-12-30 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing lrrk2 expression
|
US20220073915A1
(en)
|
2018-06-29 |
2022-03-10 |
Eberhard-Karls-Universität-Tübingen |
Artificial nucleic acids for rna editing
|
CN112638362A
(zh)
|
2018-07-23 |
2021-04-09 |
川斯勒佰尔公司 |
信使rna的干粉制剂
|
SG11202100077PA
(en)
|
2018-07-25 |
2021-02-25 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing atxn2 expression
|
EP3829622A4
(de)
|
2018-08-02 |
2022-05-11 |
Duke University |
Doppel-agonisten-fusionsproteine
|
CN112930396A
(zh)
|
2018-08-24 |
2021-06-08 |
川斯勒佰尔公司 |
用于纯化信使rna的方法
|
KR20210091120A
(ko)
|
2018-08-29 |
2021-07-21 |
트랜슬레이트 바이오 인코포레이티드 |
Mrna-로딩된 지질 나노입자를 제조하는 개선된 공정
|
CA3112792A1
(en)
|
2018-09-14 |
2020-03-19 |
Prelude Corporation |
Method of selection for treatment of subjects at risk of invasive breast cancer
|
WO2020056294A1
(en)
|
2018-09-14 |
2020-03-19 |
Translate Bio, Inc. |
Composition and methods for treatment of methylmalonic acidemia
|
CA3112837A1
(en)
|
2018-10-19 |
2020-04-23 |
Translate Bio, Inc. |
Pumpless encapsulation of messenger rna
|
EP3877538A1
(de)
|
2018-11-08 |
2021-09-15 |
Translate Bio, Inc. |
Verfahren und zusammensetzungen zur aufreinigung von messenger-rna
|
MX2021005482A
(es)
|
2018-11-09 |
2021-09-08 |
Translate Bio Inc |
Lípidos de 2,5-dioxopiperazina con porciones éster, tioéster, disulfuro y anhidrido intercaladas.
|
US20220016265A1
(en)
|
2018-11-09 |
2022-01-20 |
Translate Bio, Inc. |
Messenger rna therapy for treatment of ocular diseases
|
AU2019374871A1
(en)
|
2018-11-09 |
2021-05-27 |
Translate Bio, Inc. |
PEG lipidoid compounds
|
WO2020097376A1
(en)
|
2018-11-09 |
2020-05-14 |
Translate Bio, Inc. |
Multi-peg lipid compounds
|
AU2019378763A1
(en)
|
2018-11-12 |
2021-06-03 |
Translate Bio, Inc. |
Methods for inducing immune tolerance
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
JOP20210108A1
(ar)
|
2018-11-15 |
2023-01-30 |
Ionis Pharmaceuticals Inc |
معدِّلات تعبير irf5
|
AU2019383413A1
(en)
|
2018-11-21 |
2021-05-27 |
Translate Bio, Inc. |
Cationic lipid compounds and compositions thereof for use in the delivery of messenger RNA
|
MX2021005969A
(es)
|
2018-11-21 |
2021-09-14 |
Translate Bio Inc |
Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr nebulizado.
|
JP2022516356A
(ja)
|
2019-01-07 |
2022-02-25 |
トランスレイト バイオ, インコーポレイテッド |
原発性線毛機能不全症の治療のための組成物および方法
|
CA3128093A1
(en)
|
2019-01-31 |
2020-08-06 |
Ionis Pharmaceuticals, Inc. |
Modulators of yap1 expression
|
KR20210144698A
(ko)
|
2019-02-26 |
2021-11-30 |
트위스트 바이오사이언스 코포레이션 |
항체 최적화를 위한 변이 핵산 라이브러리
|
EP3930753A4
(de)
|
2019-02-26 |
2023-03-29 |
Twist Bioscience Corporation |
Variante nukleinsäurebibliotheken für glp1-rezeptor
|
TW202045724A
(zh)
|
2019-02-27 |
2020-12-16 |
美商Ionis製藥公司 |
Malat1表現之調節劑
|
CN117431244A
(zh)
|
2019-03-29 |
2024-01-23 |
Ionis制药公司 |
用于调节ube3a-ats的化合物和方法
|
EP3956303A1
(de)
|
2019-04-18 |
2022-02-23 |
Translate Bio, Inc. |
Kationische cystin-enthaltende lipide
|
EP3959195B1
(de)
|
2019-04-22 |
2023-11-08 |
Translate Bio, Inc. |
Kationische thioester-lipide
|
US20220257724A1
(en)
|
2019-05-03 |
2022-08-18 |
Translate Bio, Inc. |
Di-thioester cationic lipids
|
WO2020232276A1
(en)
|
2019-05-14 |
2020-11-19 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
SG11202112350XA
(en)
|
2019-05-15 |
2021-12-30 |
Translate Bio Inc |
Methods for purification of messenger rna
|
EP3976593A1
(de)
|
2019-05-31 |
2022-04-06 |
Translate Bio, Inc. |
Makrocyclische lipide
|
WO2020257611A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Cationic lipids comprising an hydroxy moiety
|
WO2020257716A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Tricine and citric acid lipids
|
CN114729342A
(zh)
|
2019-06-21 |
2022-07-08 |
特韦斯特生物科学公司 |
基于条形码的核酸序列装配
|
US20230181483A1
(en)
|
2019-07-08 |
2023-06-15 |
Translate Bio, Inc. |
Improved mrna-loaded lipid nanoparticles and processes of making the same
|
US11512314B2
(en)
|
2019-07-12 |
2022-11-29 |
Duke University |
Amphiphilic polynucleotides
|
CN114401748A
(zh)
|
2019-07-23 |
2022-04-26 |
川斯勒佰尔公司 |
负载mRNA的脂质纳米颗粒的稳定组合物及制备方法
|
US11786546B2
(en)
|
2019-07-26 |
2023-10-17 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating GFAP
|
WO2021021988A1
(en)
|
2019-07-30 |
2021-02-04 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr
|
CN114555621A
(zh)
|
2019-08-15 |
2022-05-27 |
Ionis制药公司 |
键修饰的寡聚化合物及其用途
|
AU2020405214A1
(en)
|
2019-12-20 |
2022-08-11 |
Translate Bio, Inc. |
Improved process of preparing mRNA-loaded lipid nanoparticles
|
CN115515559A
(zh)
|
2019-12-20 |
2022-12-23 |
翻译生物公司 |
信使rna的直肠递送
|
WO2021142245A1
(en)
|
2020-01-10 |
2021-07-15 |
Translate Bio, Inc. |
Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues
|
CN115443338A
(zh)
|
2020-02-10 |
2022-12-06 |
翻译生物公司 |
用于信使rna纯化的方法和组合物
|
CN115427021A
(zh)
|
2020-02-25 |
2022-12-02 |
翻译生物公司 |
制备负载mrna的脂质纳米颗粒的改进方法
|
US20220064638A1
(en)
|
2020-02-28 |
2022-03-03 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating smn2
|
WO2021202694A1
(en)
|
2020-04-01 |
2021-10-07 |
Translate Bio, Inc. |
Phenolic acid lipid based cationic lipids
|
JP2023521042A
(ja)
|
2020-04-02 |
2023-05-23 |
ミレキュール インコーポレイテッド |
操作されたオリゴヌクレオチドを使用する標的化された阻害
|
CA3181546A1
(en)
|
2020-05-01 |
2021-11-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating atxn1
|
EP4146680A1
(de)
|
2020-05-07 |
2023-03-15 |
Translate Bio, Inc. |
Zusammensetzung und verfahren zur behandlung von primärer ziliardyskinesie
|
US20230226219A1
(en)
|
2020-05-14 |
2023-07-20 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
EP4149425A1
(de)
|
2020-05-15 |
2023-03-22 |
Translate Bio, Inc. |
Lipidnanopartikelformulierungen zur mrna-abgabe
|
JP2023532518A
(ja)
|
2020-06-29 |
2023-07-28 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Plp1を調節するための化合物及び方法
|
WO2022006527A1
(en)
|
2020-07-02 |
2022-01-06 |
Maritime Therapeutics, Inc. |
Compositions and methods for reverse gene therapy
|
WO2022066678A1
(en)
|
2020-09-23 |
2022-03-31 |
Translate Bio, Inc. |
Tes-based cationic lipids
|
WO2022066916A1
(en)
|
2020-09-23 |
2022-03-31 |
Translate Bio, Inc. |
Piperazine-based cationic lipids
|
CN117255711A
(zh)
|
2020-10-01 |
2023-12-19 |
翻译生物公司 |
用于纯化信使rna的方法
|
JP2023544197A
(ja)
|
2020-10-06 |
2023-10-20 |
トランスレイト バイオ, インコーポレイテッド |
脂質ナノ粒子の改善された方法および製剤
|
WO2022078569A1
(en)
|
2020-10-12 |
2022-04-21 |
Eberhard Karls Universität Tübingen |
Artificial nucleic acids for rna editing
|
US20220133631A1
(en)
|
2020-10-12 |
2022-05-05 |
Translate Bio, Inc. |
Process of preparing ice-based lipid nanoparticles
|
AU2021361986A1
(en)
|
2020-10-12 |
2023-06-15 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
TW202233232A
(zh)
|
2020-11-06 |
2022-09-01 |
法商賽諾菲公司 |
遞送mRNA疫苗的脂質奈米顆粒
|
EP4136092A4
(de)
|
2020-11-18 |
2023-10-11 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur modulation der angiotensinogenexpression
|
WO2022178438A1
(en)
|
2021-02-22 |
2022-08-25 |
Duke University |
Non-immunogenic poegma-aptamer conjugates
|
TW202309002A
(zh)
|
2021-04-15 |
2023-03-01 |
美商轉譯生技公司 |
基於「古德」緩衝液的陽離子脂質
|
WO2022240960A1
(en)
|
2021-05-14 |
2022-11-17 |
Crispr Therapeutics Ag |
Mrna large scale synthesis and purification
|
WO2022261075A1
(en)
|
2021-06-07 |
2022-12-15 |
The Board Of Trustees Of The University Of Illinois |
Photoactivatable gasdermin proteins
|
CA3223192A1
(en)
|
2021-06-18 |
2022-12-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ifnar1 expression
|
IL309408A
(en)
|
2021-06-18 |
2024-02-01 |
Sanofi Sa |
Multivalent flu vaccines
|
WO2023288289A2
(en)
|
2021-07-14 |
2023-01-19 |
Mirecule, Inc. |
Oligonucleotides and compositions thereof for neuromuscular disorders
|
WO2023031856A1
(en)
|
2021-09-02 |
2023-03-09 |
Sanofi |
Compositions and methods for rna affinity purification
|
WO2023035003A1
(en)
|
2021-09-03 |
2023-03-09 |
Elegen Corp. |
Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources
|
CA3234107A1
(en)
|
2021-10-05 |
2023-04-13 |
Florent PERAL |
Methods for freezing and freeze-drying lipid nanoparticles (lnps) and lnps obtained with the same
|
WO2023059412A1
(en)
|
2021-10-05 |
2023-04-13 |
Microsoft Technology Licensing, Llc |
Regulation of dna synthesis by nucleotides linked to protecting groups
|
WO2023077107A1
(en)
|
2021-10-29 |
2023-05-04 |
Sana Biotechnology, Inc. |
Methods and reagents for amplifying viral vector nucleic acid products
|
US20230302112A1
(en)
|
2021-11-05 |
2023-09-28 |
Sanofi |
Respiratory synctial virus rna vaccine
|
WO2023086893A1
(en)
|
2021-11-10 |
2023-05-19 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
WO2023102373A1
(en)
|
2021-11-30 |
2023-06-08 |
Sanofi Pasteur Inc. |
Human metapneumovirus vaccines
|
WO2023111262A1
(en)
|
2021-12-17 |
2023-06-22 |
Sanofi |
Lyme disease rna vaccine
|
WO2023135305A1
(en)
|
2022-01-17 |
2023-07-20 |
Sanofi |
Lipidic compounds, and uses thereof
|
TW202345835A
(zh)
|
2022-03-16 |
2023-12-01 |
美商轉譯生技公司 |
非對稱的基於哌嗪之陽離子脂質
|
WO2023186842A1
(en)
|
2022-03-28 |
2023-10-05 |
F. Hoffmann-La Roche Ag |
Synthesis of isomerically pure polyol-based phosphoramidites
|
WO2023198857A1
(en)
|
2022-04-13 |
2023-10-19 |
Sanofi |
"good" buffer-based cationic lipids
|
WO2023214082A2
(en)
|
2022-05-06 |
2023-11-09 |
Sanofi |
Signal sequences for nucleic acid vaccines
|
WO2023242425A1
(en)
|
2022-06-17 |
2023-12-21 |
Sanofi |
Compositions and methods for circular rna affinity purification
|
WO2024002924A2
(en)
|
2022-06-28 |
2024-01-04 |
F. Hoffmann-La Roche Ag |
Fluorescent dyes with large stokes shift
|
US20240043826A1
(en)
|
2022-07-29 |
2024-02-08 |
Sanofi |
Methods for ethanol-free mrna purification
|
WO2024044108A1
(en)
|
2022-08-22 |
2024-02-29 |
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. |
Vaccines against coronaviruses
|