DE3481844D1 - Blutersatz. - Google Patents

Blutersatz.

Info

Publication number
DE3481844D1
DE3481844D1 DE8484307070T DE3481844T DE3481844D1 DE 3481844 D1 DE3481844 D1 DE 3481844D1 DE 8484307070 T DE8484307070 T DE 8484307070T DE 3481844 T DE3481844 T DE 3481844T DE 3481844 D1 DE3481844 D1 DE 3481844D1
Authority
DE
Germany
Prior art keywords
haemoglobin
molecular weight
linked
oxygen
oxygen affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8484307070T
Other languages
English (en)
Inventor
Jeffrey Tze-Fei Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Application granted granted Critical
Publication of DE3481844D1 publication Critical patent/DE3481844D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
DE8484307070T 1983-10-28 1984-10-16 Blutersatz. Expired - Fee Related DE3481844D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838328917A GB8328917D0 (en) 1983-10-28 1983-10-28 Blood substitute

Publications (1)

Publication Number Publication Date
DE3481844D1 true DE3481844D1 (de) 1990-05-10

Family

ID=10550912

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484307070T Expired - Fee Related DE3481844D1 (de) 1983-10-28 1984-10-16 Blutersatz.

Country Status (12)

Country Link
US (2) US4650786A (de)
EP (1) EP0140640B1 (de)
JP (2) JPH0643444B2 (de)
AT (1) ATE51629T1 (de)
AU (1) AU567593B2 (de)
CA (1) CA1236014A (de)
DE (1) DE3481844D1 (de)
DK (1) DK162395C (de)
FI (1) FI74979C (de)
GB (1) GB8328917D0 (de)
IL (1) IL73334A (de)
NO (1) NO165709C (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4831012A (en) * 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
FR2600894B1 (fr) * 1986-07-02 1989-01-13 Centre Nat Rech Scient Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
DE3636590A1 (de) * 1986-10-28 1988-05-26 Braun Melsungen Ag Blutersatzmittel
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
GB8712240D0 (en) * 1987-05-23 1987-07-01 Fisons Plc Pharmaceutical formulation
DK110188D0 (da) * 1988-03-02 1988-03-02 Claus Selch Larsen High molecular weight prodrug derivatives of antiinflammatory drugs
FR2630329B1 (fr) * 1988-04-20 1991-07-05 Merieux Inst Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
US4900780A (en) * 1988-05-25 1990-02-13 Masonic Medical Research Laboratory Acellular resuscitative fluid
JP3021041B2 (ja) * 1990-03-14 2000-03-15 ザ ユニバーシティ オブ トロント イノベーションズ ファンデーション アシルリン酸エステルおよびそれによる蛋白質の改質
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5334705A (en) * 1991-08-15 1994-08-02 Duke University Benzenetricarboxylate derivative-crosslinked low oxygen affinity hemoglobin
JP3426599B2 (ja) * 1991-11-08 2003-07-14 ヘモゾル インコーポレイテッド 薬物担体としてのヘモグロビン
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5900477A (en) * 1992-01-30 1999-05-04 Baxter International, Inc. Use of hemoglobin in the treatment of hemorrhagic shock
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5578564A (en) * 1993-07-23 1996-11-26 Somatogen, Inc. Nickel-free hemoglobin and methods for producing such hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US6458762B1 (en) 1994-03-28 2002-10-01 Baxter International, Inc. Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
AU693354B2 (en) * 1995-04-10 1998-06-25 Baxter International Inc. The use of cross-linked hemoglobin in treating subarachnoid hemorrhage
US5733869A (en) * 1995-10-06 1998-03-31 Baxter International, Inc. Therapeutic administration of hemoglobin in cardiac arrest
WO1998017289A1 (en) * 1996-10-21 1998-04-30 Baxter International Inc. Therapeutic use of hemoglobin to treat head injury
AU735799C (en) * 1997-02-28 2005-04-28 Regents Of The University Of California, The Methods and compositions for optimisation of oxygen transport by cell-free systems
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6894150B1 (en) 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
CA2319966A1 (en) * 2000-09-19 2002-03-19 Dextro-Sang Corporation Improved dextran-hemoglobin conjugate as potential blood substitute
FR2828206B1 (fr) * 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
EP1503768B1 (de) * 2002-04-29 2015-10-28 NormOxys, Inc. Inositolpyrophosphate und deren Anwendung
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
BRPI0407106A (pt) * 2003-01-29 2006-01-24 Northfield Lab Soluções de hemoglobina polimerizadas com quantidade reduzida de tetrâmero e método para preparação
US20060106000A1 (en) * 2004-07-06 2006-05-18 Claude Nicolau Use of inositol-tripyrophosphate in treating tumors and diseases
US20060258626A1 (en) * 2004-07-06 2006-11-16 Claude Nicolau Use of inositol-tripyrophosphate in treating tumors and diseases
US20070135389A1 (en) * 2004-07-06 2007-06-14 Claude Nicolau Tumor eradication by inositol-tripyrophosphate
US7745423B2 (en) * 2004-07-06 2010-06-29 NormOxys, Inc Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin
EP1978802A2 (de) * 2006-01-24 2008-10-15 Northfield Laboratories, Inc. Polymerisiertes hämoglobinmedium und verwendung davon bei der isolierung und transplantation von inselzellen
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US7494974B2 (en) * 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) * 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
EP2152085A4 (de) * 2007-05-01 2012-05-23 Normoxys Inc Erythropetinkomplementierung oder -ersatz
US20140227677A1 (en) * 2013-02-07 2014-08-14 OPK Biotech, LLC Perfusion of prospective donor hearts with polymerized hemoglobin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2449885C3 (de) * 1974-10-21 1980-04-30 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
CA1055932A (en) * 1975-10-22 1979-06-05 Hematech Inc. Blood substitute based on hemoglobin
DE2616086C2 (de) * 1976-04-13 1986-04-03 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg Substanz zur Verwendung in einem kolloidalen Blutvolumenersatzmittel aus Hydroxyethylstärke und Hämoglobin
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release
DE2740053A1 (de) * 1977-09-06 1979-05-03 Klaus Prof Dr Med Gersonde Verwendung von allosterischen effektoren mit hilfe von lipidvesikeln ueber eine irreversible inkorporierung zwecks verbesserter o tief 2 -entladung des haemoglobins in erythrozyten
JPS5716815A (en) * 1980-07-02 1982-01-28 Ajinomoto Co Inc Oxygen transporting agent for artificial blood
US4343715A (en) * 1980-10-10 1982-08-10 Duke University Immobilized hemoglobin, and processes for extracting oxygen from fluids using the same
US4401652A (en) * 1980-12-31 1983-08-30 Allied Corporation Process for the preparation of stroma-free hemoglobin solutions
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
IN158551B (de) * 1981-08-12 1986-12-06 Gen Electric Co Plc
US4473496A (en) * 1981-09-14 1984-09-25 The United States Of America As Represented By The Secretary Of The Army Intramolecularly crosslinked hemoglobin
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
FR2551660B1 (fr) * 1983-09-13 1986-11-14 Centre Nat Rech Scient Hemoglobine modifiee chimiquement, sa preparation, solutions aqueuses en contenant et leur utilisation
US4600531A (en) * 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield

Also Published As

Publication number Publication date
ATE51629T1 (de) 1990-04-15
EP0140640A2 (de) 1985-05-08
FI74979C (fi) 1988-04-11
NO165709B (no) 1990-12-17
EP0140640A3 (en) 1986-05-28
US4710488A (en) 1987-12-01
JPH0714961B2 (ja) 1995-02-22
GB8328917D0 (en) 1983-11-30
JPS60123503A (ja) 1985-07-02
AU567593B2 (en) 1987-11-26
NO165709C (no) 1991-04-03
JPH06298802A (ja) 1994-10-25
IL73334A (en) 1989-03-31
US4650786A (en) 1987-03-17
AU3475384A (en) 1985-05-09
JPH0643444B2 (ja) 1994-06-08
IL73334A0 (en) 1985-01-31
DK509884A (da) 1985-04-29
FI844204L (fi) 1985-04-29
DK509884D0 (da) 1984-10-25
CA1236014A (en) 1988-05-03
NO844282L (no) 1985-04-29
FI844204A0 (fi) 1984-10-26
EP0140640B1 (de) 1990-04-04
DK162395B (da) 1991-10-21
FI74979B (fi) 1987-12-31
DK162395C (da) 1992-03-09

Similar Documents

Publication Publication Date Title
DE3481844D1 (de) Blutersatz.
AU3085184A (en) Silicon hydride compounds and polymers modified therewith
ES8307806A1 (es) "procedimiento para la preparacion de 1,2-a piridinas y pirazinas".
AU554125B2 (en) 4(aryl-alkyl)imidazole derivatives
LU88306I2 (fr) Felodipine (Plendil)
IL77396A (en) Pharmaceutical compositions containing bicyclic heteroarylpiperazine derivatives,certain such novel compounds and their preparation
WO1979000853A1 (en) Medicine for circulatory organ
ES8703472A1 (es) Procedimiento para preparar nuevos derivados imidazo
NL940026I1 (nl) Peritoneale dialyse en samenstellingen ten gebruike daarbij.
ATE70283T1 (de) Verfahren zum herstellen von homopolymerisaten des ethens sowie copolymerisaten des ethens mit hoeheren alpha-monoolefinen mittels eines ziegler- katalysatorsystems.
HUP9802518A2 (hu) Szulfonamidcsoporttal szubsztituált benzopiránszármazékok, eljárás előállításukra, gyógyszerként történő alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
EA199900897A2 (ru) Катализаторы на основе ванадия, их получение и применение при (со)полимеризации альфа-олефинов
ES2000614A6 (es) Procedimiento de obtencion de nuevos complejos de platino (ii) derivados del 2,3-dimercapto-2-butene-dinitrilato (2-)-s,s'"
ES511836A0 (es) "procedimiento para la preparacion de nuevos a1-pirrolin-tiolactimeteres".
PT74787A (de) Verfahren zur herstellung von neuen dioxaheterozyklischen verbindungen
FR2426054A1 (fr) Acide 6-(a-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0.)hept-2-ene (et heptane)-2-carboxylique et ses derives utile comme medicament
EP0396078A3 (de) 1-Hydroxi-azolverbindungen und diese enthaltende Fungizide
JPS55141484A (en) Pyridazine derivative

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee