DE3486179T2 - Verfahren zur herstellung vielkettige polypeptide oder proteine. - Google Patents

Verfahren zur herstellung vielkettige polypeptide oder proteine.

Info

Publication number
DE3486179T2
DE3486179T2 DE84301996T DE3486179T DE3486179T2 DE 3486179 T2 DE3486179 T2 DE 3486179T2 DE 84301996 T DE84301996 T DE 84301996T DE 3486179 T DE3486179 T DE 3486179T DE 3486179 T2 DE3486179 T2 DE 3486179T2
Authority
DE
Germany
Prior art keywords
host cell
proteins
transformed
processes
chain polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE84301996T
Other languages
English (en)
Other versions
DE3486179D1 (de
DE3486179T3 (de
Inventor
Michael Alan Boss
John Henry Kenten
John Spencer Emtage
Clive Ross Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10540204&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3486179(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of DE3486179D1 publication Critical patent/DE3486179D1/de
Publication of DE3486179T2 publication Critical patent/DE3486179T2/de
Application granted granted Critical
Publication of DE3486179T3 publication Critical patent/DE3486179T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/461Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804Affinity chromatography
    • B01D15/3809Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
DE3486179T 1983-03-25 1984-03-23 Verfahren zur Herstellung von Immunglobulinen Expired - Lifetime DE3486179T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838308235A GB8308235D0 (en) 1983-03-25 1983-03-25 Polypeptides
GB8308235 1983-03-25

Publications (3)

Publication Number Publication Date
DE3486179D1 DE3486179D1 (de) 1993-08-26
DE3486179T2 true DE3486179T2 (de) 1993-11-04
DE3486179T3 DE3486179T3 (de) 2004-03-04

Family

ID=10540204

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3486179T Expired - Lifetime DE3486179T3 (de) 1983-03-25 1984-03-23 Verfahren zur Herstellung von Immunglobulinen

Country Status (7)

Country Link
US (1) US4816397A (de)
EP (2) EP0526953A1 (de)
JP (4) JP2594900B2 (de)
AT (1) ATE91716T1 (de)
DE (1) DE3486179T3 (de)
GB (2) GB8308235D0 (de)
WO (1) WO1984003712A2 (de)

Families Citing this family (1913)

* Cited by examiner, † Cited by third party
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GB2137631A (en) 1984-10-10
JP3186463B2 (ja) 2001-07-11
JPH07173200A (ja) 1995-07-11
JP2001286291A (ja) 2001-10-16
GB8308235D0 (en) 1983-05-05
WO1984003712A2 (en) 1984-09-27
DE3486179D1 (de) 1993-08-26
EP0120694B2 (de) 2002-04-24
EP0526953A1 (de) 1993-02-10
JP2594900B2 (ja) 1997-03-26
EP0120694A2 (de) 1984-10-03
JPS60500892A (ja) 1985-06-20
EP0120694B1 (de) 1993-07-21
EP0120694A3 (en) 1985-07-03
GB2137631B (en) 1986-11-12
US4816397A (en) 1989-03-28
ATE91716T1 (de) 1993-08-15
JPH1080296A (ja) 1998-03-31
DE3486179T3 (de) 2004-03-04
GB8407571D0 (en) 1984-05-02
WO1984003712A3 (en) 1984-11-22

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