DE3650760T2 - Polynukleotide und Proben mit Verwendung in Nukleinsäure-Sandwichassay in Lösungsphase - Google Patents

Polynukleotide und Proben mit Verwendung in Nukleinsäure-Sandwichassay in Lösungsphase

Info

Publication number
DE3650760T2
DE3650760T2 DE3650760T DE3650760T DE3650760T2 DE 3650760 T2 DE3650760 T2 DE 3650760T2 DE 3650760 T DE3650760 T DE 3650760T DE 3650760 T DE3650760 T DE 3650760T DE 3650760 T2 DE3650760 T2 DE 3650760T2
Authority
DE
Germany
Prior art keywords
group
polynucleotides
nucleic acid
hydrogen
solution phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3650760T
Other languages
English (en)
Other versions
DE3650760D1 (de
Inventor
Michael Steven Urdea
Brian Warner
Thomas Horn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25196815&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3650760(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of DE3650760D1 publication Critical patent/DE3650760D1/de
Application granted granted Critical
Publication of DE3650760T2 publication Critical patent/DE3650760T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/706Specific hybridization probes for hepatitis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
DE3650760T 1985-12-11 1986-12-10 Polynukleotide und Proben mit Verwendung in Nukleinsäure-Sandwichassay in Lösungsphase Expired - Lifetime DE3650760T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/807,624 US4868105A (en) 1985-12-11 1985-12-11 Solution phase nucleic acid sandwich assay

Publications (2)

Publication Number Publication Date
DE3650760D1 DE3650760D1 (de) 2001-09-20
DE3650760T2 true DE3650760T2 (de) 2002-04-18

Family

ID=25196815

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3650760T Expired - Lifetime DE3650760T2 (de) 1985-12-11 1986-12-10 Polynukleotide und Proben mit Verwendung in Nukleinsäure-Sandwichassay in Lösungsphase
DE3650103T Expired - Lifetime DE3650103T2 (de) 1985-12-11 1986-12-10 Nukleinsäure-Sandwichassay in Lösungsphase und dafür geeignete Polynukleotidprobe.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3650103T Expired - Lifetime DE3650103T2 (de) 1985-12-11 1986-12-10 Nukleinsäure-Sandwichassay in Lösungsphase und dafür geeignete Polynukleotidprobe.

Country Status (7)

Country Link
US (1) US4868105A (de)
EP (2) EP0423839B1 (de)
JP (2) JP2655569B2 (de)
AT (2) ATE204288T1 (de)
CA (2) CA1303033C (de)
DE (2) DE3650760T2 (de)
ES (2) ES2160569T3 (de)

Families Citing this family (307)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605800A (en) * 1978-04-13 1997-02-25 Institut Pasteur Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US7220854B1 (en) 1982-06-23 2007-05-22 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US5430136A (en) * 1984-10-16 1995-07-04 Chiron Corporation Oligonucleotides having selectably cleavable and/or abasic sites
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US5192683A (en) * 1987-02-19 1993-03-09 The Royal Institution For The Advancement Of Learning (Mcgill University) Monoclonal antibodies to cruciform DNA structure
US5359100A (en) * 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
CA1339351C (en) * 1987-10-15 1997-08-26 Michael S. Urdea Nucleic acid multimers and amplified nucleic acid hybridization assays using same
JP2565552B2 (ja) * 1987-10-15 1996-12-18 カイロン コーポレイション 核酸マルチマーおよびそれを用いた増幅核酸ハイブリダイゼーション分析法
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5656731A (en) * 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
JP2854058B2 (ja) * 1987-12-01 1999-02-03 ベーリンガー マンヘイム コーポレイション アッセイを実施するための方法及び装置
DE3856224T2 (de) 1988-09-29 1998-12-03 Chiron Corp Nachweis eines Polynukleotids durch Ersätzung einer Kette an einer Fangsonde
FR2642074B1 (fr) * 1989-01-20 1994-04-29 Oris Ind Derives de molecules polyhydroxylees permettant l'introduction d'au moins une ramification dans un oligonucleotide
JP2615200B2 (ja) * 1989-05-31 1997-05-28 株式会社リコー 可逆性感熱記録材料
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
EP0405913B1 (de) * 1989-06-30 1998-12-23 Chiron Corporation Hydrophobe Nukleinsäure-Sonde
JP3156200B2 (ja) 1989-09-15 2001-04-16 国立予防衛生研究所長 新規のhcv分離株
JPH03123500A (ja) * 1989-10-06 1991-05-27 Canon Inc 核酸の分別方法
GB8924989D0 (en) * 1989-11-06 1989-12-28 Scotgen Ltd Method and device for the detection of antibiotic resistance
WO1991008307A1 (en) * 1989-12-04 1991-06-13 Microprobe Corporation Enhanced capture of target nucleic acid by the use of oligonucleotides covalently attached to polymers
JPH05503422A (ja) 1990-01-10 1993-06-10 バイエル コーポレイション 核酸ハイブリダイゼーションアッセイでの信号増幅用レポーター分子としてのdna依存性rnaポリメラーゼ転写産物
US5629153A (en) * 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
US6114513A (en) * 1990-01-11 2000-09-05 Isis Pharmaceuticals, Inc. Thiol-derivatized oligonucleotides
US5578718A (en) * 1990-01-11 1996-11-26 Isis Pharmaceuticals, Inc. Thiol-derivatized nucleosides
US5200314A (en) * 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
AU659798B2 (en) * 1990-05-04 1995-06-01 Chiron Corporation Protein-nucleic acid probes and immunoassays using same
PT98489B (pt) * 1990-07-27 1998-04-30 Chiron Corp Processo para a producao de um grande polinucleotido ramificado do tipo pente
US5556751A (en) * 1991-04-25 1996-09-17 Amoco Corporation Selective amplification system using Q-β replicase
US6190864B1 (en) 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
DE4123540A1 (de) * 1991-07-16 1993-01-21 Boehringer Mannheim Gmbh Immobilisierung von nukleinsaeuren
WO1993003184A1 (en) * 1991-08-09 1993-02-18 Mccann Associates, Inc. Method for detecting lyme disease and composition
US5574141A (en) * 1991-08-28 1996-11-12 Boehringer Mannheim Gmbh Functionalized carrier materials for the simultaneous synthesis and direct labeling of oligonucleotides as primers for template-dependent enzymatic nucleic acid syntheses
US5556961A (en) * 1991-11-15 1996-09-17 Foote; Robert S. Nucleosides with 5'-O-photolabile protecting groups
EP0916396B1 (de) 1991-11-22 2005-04-13 Affymetrix, Inc. (a Delaware Corporation) Kombinatorische Strategien für die Polymersynthese
EP0726963A4 (de) * 1991-12-23 1998-05-13 Chiron Corp -i(chlamydiae) sonden, zur verwendung in sandwich hybridisierungsmethoden in löslicher phase
ATE329054T1 (de) 1991-12-23 2006-06-15 Chiron Corp Sätze von hiv sonden für solution sandwich hybridationsverfahren
AU3427993A (en) * 1991-12-23 1993-07-28 Chiron Corporation HAV probes for use in solution phase sandwich hybridization assays
CA2124928C (en) * 1991-12-23 2003-06-17 Bruce D. Irvine Hbv amplifier probes for use in solution phase sandwich hybridization assays
US5747244A (en) * 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
JPH07502657A (ja) 1991-12-23 1995-03-23 バイエル コーポレイション 溶液相サンドイッチハイブリダイゼーションアッセイに用いるためのhtlv−1プローブ
EP0571087A1 (de) * 1992-05-18 1993-11-24 Rohm And Haas Company Spaltbare Phosphoramidate
US5543292A (en) * 1992-06-16 1996-08-06 Hitachi, Ltd. Process for the measurement of nucleic acids
AU4681693A (en) * 1992-07-17 1994-02-14 Aprogenex, Inc. Nucleic acid probes and uses thereof to detect double-stranded nucleic acids
US5329461A (en) * 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
RU2158928C2 (ru) 1993-05-10 2000-11-10 Чирон Корпорейшн Способы типирования вируса гепатита с и используемые для этого реагенты
JPH08510649A (ja) * 1993-05-28 1996-11-12 マウント シナイ スクール オブ メディシン オブ ザ シティー ユニバーシティー オブ ニューヨーク Bc200rna、それに対するプローブ及びその使用
US5382512A (en) * 1993-08-23 1995-01-17 Chiron Corporation Assay device with captured particle reagent
FR2710075B1 (fr) * 1993-09-15 1995-10-27 Bio Merieux Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal.
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US6306657B1 (en) * 1994-06-28 2001-10-23 Kalyx Biosciences, Inc. Polynucleotide probe and kit for amplifying signal detection in hybridization assays
NZ291621A (en) 1994-08-12 1998-09-24 Myriad Genetics Inc Isolation and detection of human breast cancer and ovarian cancer predisposing gene, brca1
NZ291624A (en) 1994-08-12 1998-07-28 Myriad Genetics Inc Method of diagnosis of a predisposition to breast cancer
US5580731A (en) * 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5747248A (en) * 1994-12-05 1998-05-05 Chiron Corporation Discontinuous probe design using hybritope mapping
US20030104361A1 (en) * 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US5801155A (en) * 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
US5780227A (en) * 1995-06-07 1998-07-14 Sheridan; Patrick J. Oligonucleotide probe conjugated to a purified hydrophilic alkaline phosphatase and uses thereof
US5853974A (en) 1995-06-07 1998-12-29 Chiron Corporation Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates
FR2737502B1 (fr) 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
US6017700A (en) * 1995-08-04 2000-01-25 Bayer Corporation Cationic oligonucleotides, and related methods of synthesis and use
IL124620A0 (en) 1995-12-18 1998-12-06 Myriad Genetics Inc Chromosome 13-linked breast cancer susceptibility gene
US5837492A (en) 1995-12-18 1998-11-17 Myriad Genetics, Inc. Chromosome 13-linked breast cancer susceptibility gene
JP3449419B2 (ja) 1995-12-22 2003-09-22 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション KVLQT1をコードするQT延長症候群遺伝子およびそのminKとの関連
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
US5824478A (en) * 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
US6103535A (en) * 1996-05-31 2000-08-15 University Of Maryland Optical fiber evanescent field excited fluorosensor and method of manufacture
US20050069923A1 (en) * 1996-07-08 2005-03-31 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
US6083763A (en) * 1996-12-31 2000-07-04 Genometrix Inc. Multiplexed molecular analysis apparatus and method
JPH10253632A (ja) * 1997-03-10 1998-09-25 Nissui Pharm Co Ltd 分析方法、キット及び装置
CA2287570C (en) * 1997-05-02 2008-10-28 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US5939261A (en) * 1997-06-24 1999-08-17 Sarnoff Corporation Method for capturing a nucleic acid
GB9718921D0 (en) * 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
WO1999029890A2 (en) * 1997-12-12 1999-06-17 Digene Corporation Assessment of human papilloma virus-related disease
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US6458533B1 (en) 1997-12-19 2002-10-01 High Throughput Genomics, Inc. High throughput assay system for monitoring ESTs
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
GB9805935D0 (en) * 1998-03-19 1998-05-13 Ciba Geigy Ag Organic compounds
US6683173B2 (en) * 1998-04-03 2004-01-27 Epoch Biosciences, Inc. Tm leveling methods
US7715989B2 (en) * 1998-04-03 2010-05-11 Elitech Holding B.V. Systems and methods for predicting oligonucleotide melting temperature (TmS)
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
US7045610B2 (en) * 1998-04-03 2006-05-16 Epoch Biosciences, Inc. Modified oligonucleotides for mismatch discrimination
US6127121A (en) * 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
US6183957B1 (en) 1998-04-16 2001-02-06 Institut Pasteur Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria
JP2002518026A (ja) * 1998-06-19 2002-06-25 エムティー テクノロジー, インコーポレイテッド Srprnaを用いる非ウイルス生物の検出
US6306643B1 (en) * 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
EP0990903B1 (de) 1998-09-18 2003-03-12 Massachusetts Institute Of Technology Biologische Verwendungen von halbleitenden Nanokristallen
US6326149B1 (en) 1998-11-03 2001-12-04 Sarnoff Corporation Method for controlled electrostatic adherent deposition of particles on a substrate
US6432642B1 (en) 1999-01-15 2002-08-13 Pe Corporation (Ny) Binary probe and clamp composition and methods for a target hybridization detection
DE60042738D1 (de) * 1999-05-07 2009-09-24 Life Technologies Corp Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen
US6750357B1 (en) 1999-06-25 2004-06-15 Syngen, Inc. Rhodamine-based fluorophores useful as labeling reagents
US6465183B2 (en) * 1999-07-01 2002-10-15 Agilent Technologies, Inc. Multidentate arrays
US7122303B2 (en) 1999-09-17 2006-10-17 Agilent Technologies, Inc. Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
US7078167B2 (en) * 1999-09-17 2006-07-18 Agilent Technologies, Inc. Arrays having background features and methods for using the same
US6428957B1 (en) * 1999-11-08 2002-08-06 Agilent Technologies, Inc. Systems tools and methods of assaying biological materials using spatially-addressable arrays
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US7205105B2 (en) * 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US20020009728A1 (en) * 2000-01-18 2002-01-24 Quantum Dot Corporation Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
JP2003525292A (ja) 2000-03-01 2003-08-26 エポック・バイオサイエンシーズ・インコーポレイテッド ミスマッチ識別のための修飾オリゴヌクレオチド
EP1944310A3 (de) 2000-03-01 2008-08-06 Epoch Biosciences, Inc. Modifizierte Oligonukleotide zur Erkennung von Fehlanpassungen
DE60128908T2 (de) * 2000-06-02 2008-02-28 Bayer Corp. Verfahren zum Nachweis und zur Lokalisierung von Genen in situ durch Hybridisierung einer verzweigten DNA
US7601497B2 (en) * 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US7439016B1 (en) * 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
GB0016836D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
GB0016833D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (2)
WO2002004122A2 (en) * 2000-07-07 2002-01-17 Helen Lee Improved stability of hybridisation interactions in dipstick assays
ATE414794T1 (de) 2000-09-01 2008-12-15 Gen Probe Inc Amplifizierung von hiv-1 sequenzen zur detektion von sequenzen, die mit wirkstoff-resistenz mutationen einhergehen
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
CA2422956C (en) 2000-10-23 2010-10-19 Gen-Probe Incorporated Compositions and methods for detecting human immunodeficiency virus 2 (hiv-2)
EP1390530A2 (de) * 2001-01-05 2004-02-25 Genomicfx, Inc. Verfahren zur relativen quantifizierung von immobilisierten nukleinsäuren
US7018795B2 (en) * 2001-03-23 2006-03-28 Fuji Photo Film Co., Ltd. Hybridization probe and target nucleic acid detecting kit, target nucleic acid detecting apparatus and target nucleic acid detecting method using the same
US20030003476A1 (en) * 2001-03-23 2003-01-02 Fuji Photo Film Co., Ltd. Waste water inspecting agent and waste water inspecting apparatus using the same
US20020168667A1 (en) * 2001-03-23 2002-11-14 Fuji Photo Film Co., Ltd. Antigen detecting agent and antigen detecting kit, antigen detecting apparatus and antigen detecting method using the same
US20020168756A1 (en) * 2001-03-23 2002-11-14 Fuji Photo Film Co., Ltd. Particle size variable reactor
US7077982B2 (en) * 2001-03-23 2006-07-18 Fuji Photo Film Co., Ltd. Molecular electric wire, molecular electric wire circuit using the same and process for producing the molecular electric wire circuit
US20030082571A1 (en) * 2001-04-10 2003-05-01 Kachab Edward Hanna Linear nucleic acid and sequence therefor
EP1925672A1 (de) 2001-06-22 2008-05-28 Syngeta Participations AG Auf abiotischen Stress ansprechende Polynukleotide und Polypeptide
KR20040039349A (ko) * 2001-09-21 2004-05-10 다카라 바이오 가부시키가이샤 리간드 고정화용 담체
US6946245B2 (en) 2001-12-04 2005-09-20 Quest Diagnostics Investments Incorporated Oligonucleotides and methods for detecting hepatitis C viral nucleic acids
US20030175709A1 (en) * 2001-12-20 2003-09-18 Murphy George L. Method and system for depleting rRNA populations
US20030179381A1 (en) * 2002-03-18 2003-09-25 Fuji Photo Film Co., Ltd. Sensor, color sensor and apparatus for inspection using the same
US20040023267A1 (en) 2002-03-21 2004-02-05 Morris David W. Novel compositions and methods in cancer
US20030219755A1 (en) * 2002-05-24 2003-11-27 Nanibhushan Dattagupta Compositions and methods for performing hybridization assays using target enhanced signal amplification (TESA)
AU2003253651C1 (en) 2002-06-14 2010-06-03 Gen-Probe Incorporated Compositions and methods for detecting hepatitis B virus
WO2004026804A1 (en) * 2002-09-20 2004-04-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
CA2501946C (en) 2002-10-16 2014-12-23 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
AU2003293015A1 (en) * 2002-11-26 2004-06-18 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
JP4294946B2 (ja) * 2002-12-13 2009-07-15 富士フイルム株式会社 標的検出装置及び標的検出方法並びに標的検出用基材
US7076127B2 (en) * 2003-01-14 2006-07-11 Fuji Photo Film Co., Ltd. Optical switch and safety apparatus using the same
US20040170982A1 (en) 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
US7767387B2 (en) 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
EP1592708A2 (de) 2003-02-14 2005-11-09 Sagres Discovery, Inc. Therapeutische zielmolekulen von g-protein gekoppelter rezeptor in krebs
US20040241661A1 (en) * 2003-05-29 2004-12-02 Arindam Bhattacharjee Pseudo single color method for array assays
DE20310332U1 (de) * 2003-07-04 2004-11-11 Mwg-Biotech Ag Vorrichtung zum automatischen Öffnen und Schließen von Reaktionsgefäßen
US7348146B2 (en) * 2003-10-02 2008-03-25 Epoch Biosciences, Inc. Single nucleotide polymorphism analysis of highly polymorphic target sequences
PT1687609E (pt) * 2003-10-28 2015-03-02 Epoch Biosciences Inc Sondas fluorescentes para a detecção de adn por hibridação com uma maior sensibilidade e menor ruído de fundo
WO2005049849A2 (en) 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
CA2547750C (en) 2003-12-19 2014-04-08 Gen-Probe Incorporated Compositions, methods and kits for detecting the nucleic acids of hiv-1 and hiv-2
US20050244984A1 (en) * 2004-04-28 2005-11-03 Parker Russell A Methods and compositions for calibrating chemical array readers
AU2005262317B2 (en) 2004-07-13 2009-07-16 Gen-Probe Incorporated Compositions and methods for detection of hepatitis A virus nucleic acid
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
EP2975139B1 (de) 2004-09-30 2019-11-06 Gen-Probe Incorporated Verfahren zum nachweis und zur quantifizierung von hiv-1
AU2005333163B2 (en) * 2004-11-09 2011-06-16 Gen-Probe Incorporated Compositions and methods for detecting Group A streptococci
US20060172314A1 (en) * 2005-01-31 2006-08-03 Song Min-Sun Quantification of amplified nucleic acids
US20060177859A1 (en) * 2005-02-07 2006-08-10 Gen-Probe Incorporated Compositions and methods for detecting group B streptococci
WO2006089154A1 (en) * 2005-02-18 2006-08-24 Gen-Probe Incorporated Sample preparation method incorporating an alkaline shock
US20060257902A1 (en) * 2005-03-25 2006-11-16 Ambion, Inc. Methods and compositions for depleting abundant RNA transcripts
EP2062591A1 (de) 2005-04-07 2009-05-27 Novartis Vaccines and Diagnostics, Inc. CACNA1E in der Krebsdiagnose-Erkennung und -Behandlung
EP2083088A3 (de) 2005-04-07 2009-10-14 Novartis Vaccines and Diagnostics, Inc. Gene in Verbindung mit Krebs
US7993853B2 (en) 2005-05-06 2011-08-09 Gen-Probe Incorporated Methods of nucleic acid target capture
AU2006244460B2 (en) 2005-05-06 2010-04-08 Gen-Probe Incorporated Compositions and assays to detect influenza virus A and B nucleic acids
US8628918B2 (en) * 2005-05-09 2014-01-14 Affymetrix, Inc. Multiplex capture of nucleic acids
US8632970B2 (en) 2005-05-09 2014-01-21 Affymetrix, Inc. Multiplex capture of nucleic acids
CA2607221A1 (en) * 2005-05-12 2006-11-23 Panomics, Inc. Multiplex branched-chain dna assays
AU2006251637B2 (en) * 2005-05-20 2012-06-14 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
DK2500439T4 (da) * 2005-06-20 2017-11-13 Advanced Cell Diagnostics Inc Kits og produkter til detektering af nukleinsyrer i individuelle celler og til identifikation af sjældne celler fra store heterogene cellepopulationer
US7927798B2 (en) * 2005-10-05 2011-04-19 Panomics, Inc. Detection of nucleic acids from whole blood
JP2009511086A (ja) 2005-10-17 2009-03-19 ジェン−プローブ・インコーポレーテッド レジオネラ・ニューモフィラ核酸を検出するための組成物及び方法
US8017360B2 (en) * 2005-11-10 2011-09-13 Panomics, Inc. Detection of nucleic acids through amplification of surrogate nucleic acids
EP1955241B1 (de) 2005-11-14 2011-03-30 Gen-Probe Incorporated Parametrisches kalibrationsverfahren
JP4858751B2 (ja) * 2005-11-30 2012-01-18 日本精機株式会社 マグネットロータおよびそのマグネットロータを備えた可動磁石式計器、そのマグネットロータを備えたステッピングモータ
AU2007249286B2 (en) * 2006-05-12 2013-06-13 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
AU2007252306B2 (en) 2006-05-22 2013-10-17 Clinical Genomics Pty Ltd Detection method
JP5635772B2 (ja) 2006-08-01 2014-12-03 ジェン−プロウブ インコーポレイテッド 核酸の非特異的標的の捕捉方法
JP2008043332A (ja) * 2006-08-17 2008-02-28 Panomics Inc 組織スライドからの核酸定量
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
WO2008069884A2 (en) 2006-12-01 2008-06-12 Panomics, Inc. Two-stage nucleic acid amplification using an amplification oligomer
JP5340167B2 (ja) 2006-12-21 2013-11-13 ジェン−プロウブ インコーポレイテッド 核酸増幅のための方法および組成物
WO2008094370A2 (en) 2006-12-22 2008-08-07 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
WO2009048530A2 (en) 2007-10-05 2009-04-16 Panomics, Inc. Highly multiplexed particle-based assays
AU2008316319A1 (en) 2007-10-23 2009-04-30 Clinical Genomics Pty. Ltd. A method of diagnosing neoplasms
RU2565540C2 (ru) 2007-10-23 2015-10-20 Клиникал Джиномикс Пти. Лтд. Способ диагностики неоплазм-ii
EP2235214B1 (de) * 2007-12-26 2014-07-09 Gen Probe Inc Zusammensetzungen und verfahren für den nachweis von candida albicans-nukleinsäure
US9273365B2 (en) 2008-04-21 2016-03-01 Gen-Probe Incorporated Method for detecting Chikungunya virus
CA2723726C (en) * 2008-05-13 2017-09-12 Michael M. Becker Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
US20090298709A1 (en) * 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
WO2010062546A1 (en) * 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay on an automated platform
WO2010088292A1 (en) * 2009-01-28 2010-08-05 Qiagen Gaithersburg, Inc. Sequence-specific large volume sample preparation method and assay
WO2010099378A2 (en) 2009-02-26 2010-09-02 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
US8986958B2 (en) 2009-03-30 2015-03-24 Life Technologies Corporation Methods for generating target specific probes for solution based capture
US9797000B2 (en) * 2009-05-01 2017-10-24 Qiagen Gaithersburg Inc. Non-target amplification method for detection of RNA splice-forms in a sample
US9212397B2 (en) 2009-06-23 2015-12-15 Gen-Probe Incorporated Compositions and methods for detecting nucleic acid from mollicutes
US9169512B2 (en) 2009-07-01 2015-10-27 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US20120015821A1 (en) * 2009-09-09 2012-01-19 Life Technologies Corporation Methods of Generating Gene Specific Libraries
EP2478087B1 (de) 2009-09-14 2017-01-18 QIAGEN Gaithersburg, Inc. Zusammensetzungen und verfahren zur rückgewinnung von nukleinsäuren oder proteinen aus in zytologischen medien fixierten gewebeproben
SG179196A1 (en) 2009-09-16 2012-04-27 Genentech Inc Coiled coil and/or tether containing protein complexes and uses thereof
WO2011038403A1 (en) 2009-09-28 2011-03-31 Yuling Luo Methods of detecting nucleic acid sequences with high specificity
EP2529026B1 (de) 2010-01-25 2013-11-13 Rd Biosciences Inc. Selbstfaltende amplifikation einer zielnukleinsäure
US9689047B2 (en) 2010-01-29 2017-06-27 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9605303B2 (en) 2010-01-29 2017-03-28 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an HPV in a sample
US9181593B2 (en) 2010-02-17 2015-11-10 Gen-Probe Incorporated Compositions and methods to detect Atopobium vaginae nucleic acid
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
US20120108799A1 (en) 2010-09-07 2012-05-03 Integrated Dna Technologies, Inc. Modifications for Antisense Compounds
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
AU2011230496B2 (en) 2010-03-26 2015-09-17 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
WO2011133811A2 (en) 2010-04-21 2011-10-27 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acid
AU2011255638B2 (en) 2010-05-19 2016-08-25 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
US9234249B2 (en) 2010-07-12 2016-01-12 Gen-Probe Incorporated Compositions and assays to detect swine H1N1 influenza A virus, seasonal H1 influenza A virus and seasonal H3 influenza A virus nucleic acids
EP2611932A2 (de) 2010-08-30 2013-07-10 Gen-Probe Incorporated Zusammensetzungen, verfahren und reaktionsmischungen für den nachweis von xenotropic murine leukemia virus-related virus (xmrv)
GB2497495B (en) 2010-10-04 2018-06-06 Gen Probe Prodesse Inc Compositions, methods and kits to detect adenovirus nucleic acids
US8658361B2 (en) 2010-10-21 2014-02-25 Advanced Cell Diagnostics, Inc. Ultra sensitive method for in situ detection of nucleic acids
JP6162044B2 (ja) 2010-12-23 2017-07-12 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 結合剤
EP2659269B1 (de) 2010-12-23 2016-10-26 Roche Diagniostics GmbH Erkennung von posttranslational modifiziertem polypeptid durch ein bivalentes bindungsmolekül
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
WO2012116220A2 (en) 2011-02-24 2012-08-30 Qiagen Gaithersburg, Inc. Materials and methods for detection of hpv nucleic acid
WO2012122571A1 (en) 2011-03-10 2012-09-13 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
US9657352B2 (en) 2011-04-25 2017-05-23 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
US8679760B2 (en) * 2011-05-03 2014-03-25 National Cheng Kung University Biomarker and method for evaluating risk of proliferation, invasion, or metastasis of cancer
EP3536810B1 (de) 2011-07-15 2023-05-10 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von menschlicher parvovirus-nukleinsäure und hepatitis-a-virus-nukleinsäure
EP3722423A1 (de) 2011-08-05 2020-10-14 Illumina, Inc. Funktionalisierung und reinigung von molekülen durch reversiblen gruppenaustausch
US9663829B2 (en) 2011-09-08 2017-05-30 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
PT2766393T (pt) 2011-10-14 2018-10-15 Hoffmann La Roche Anticorpos anti-htra1 e métodos de utilização
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
KR20140127854A (ko) 2012-02-10 2014-11-04 제넨테크, 인크. 단일-쇄 항체 및 다른 이종다량체
JP6237237B2 (ja) * 2012-02-17 2017-11-29 味の素株式会社 塩基部保護オリゴヌクレオチド
CA2865281C (en) 2012-02-24 2021-11-23 Gen-Probe Prodesse, Inc. Detection of shiga toxin genes in bacteria
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
CA2871880A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
BR112014028368A2 (pt) 2012-06-27 2017-11-14 Hoffmann La Roche método de produção de conjugado de região fc de anticorpo, conjugado de região fc de anticorpo e formulação farmacêutica
AU2013205087B2 (en) 2012-07-13 2016-03-03 Gen-Probe Incorporated Method for detecting a minority genotype
WO2014012147A1 (en) 2012-07-20 2014-01-23 Latrobe University Method of diagnosis and treatment
US9932628B2 (en) 2012-07-27 2018-04-03 Gen-Probe Incorporated Dual reference calibration method and system for quantifying polynucleotides
CA2883219C (en) 2012-08-30 2020-12-29 Gen-Probe Incorporated Multiphase nucleic acid amplification
US9783841B2 (en) 2012-10-04 2017-10-10 The Board Of Trustees Of The Leland Stanford Junior University Detection of target nucleic acids in a cellular sample
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
EP2948566A4 (de) 2013-01-24 2016-10-05 California Inst Of Techn Chromophorenbasierte charakterisierungs- und erkennungsverfahren
US9273349B2 (en) 2013-03-14 2016-03-01 Affymetrix, Inc. Detection of nucleic acids
EP2971090B1 (de) 2013-03-15 2020-05-06 Gen-Probe Incorporated Kalibrierungsverfahren, vorrichtung und computerprogrammprodukt
CA2908266A1 (en) 2013-03-27 2014-10-02 Sample Technologies, Inc. Recombinant phage and bacterial detection methods
AU2014278152A1 (en) * 2013-06-14 2015-12-24 Nanostring Technologies, Inc. Multiplexable tag-based reporter system
US9828625B2 (en) 2013-06-19 2017-11-28 Phage Diagnostics, Inc. Phage-based bacterial detection assay
WO2015023892A1 (en) 2013-08-14 2015-02-19 Gen-Probe Incorporated Compositions and methods for detecting hev nucleic acid
PL3227332T3 (pl) 2014-12-03 2020-06-15 F. Hoffmann-La Roche Ag Wielospecyficzne przeciwciała
JP6944873B2 (ja) 2015-01-09 2021-10-06 ジェン−プローブ・インコーポレーテッド 細菌性膣症を診断するための方法および組成物
JP6796593B2 (ja) 2015-03-16 2020-12-09 ジェン−プローブ・インコーポレーテッド 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物
DK3362462T3 (da) 2015-10-12 2021-10-11 Advanced Cell Diagnostics Inc In situ-detektion af nukleotidvarianter i prøver med højt støjniveau, og sammensætninger og fremgangsmåder relateret dertil
MX2018004509A (es) 2015-10-30 2018-08-01 Genentech Inc Anticuerpos anti-htra1 y metodos de uso de los mismos.
WO2017120216A2 (en) 2016-01-04 2017-07-13 Gen-Probe Incorporated Methods and compositions for detecting candida species
JP6803930B2 (ja) 2016-06-10 2021-01-06 ジェン−プローブ・インコーポレーテッド Zikaウイルス核酸を検出するための組成物および方法
EP3481843B1 (de) 2016-07-05 2022-01-26 California Institute of Technology Hybridisierungskettenreaktion mit fraktioniertem initiator
US11447835B2 (en) 2016-10-19 2022-09-20 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis C virus
JP7125395B2 (ja) 2016-11-21 2022-08-24 ジェン-プローブ・インコーポレーテッド B型肝炎ウイルスを検出または定量化するための組成物および方法
EP4056716A1 (de) 2017-03-24 2022-09-14 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis oder zur quantifizierung des parainfluenzavirus
EP4212634A1 (de) 2017-03-24 2023-07-19 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von flu b in proben
EP4276201A3 (de) 2017-06-07 2024-01-17 Gen-Probe Incorporated Nachweis von nukleinsäure der babesia-spezies in einer probe
AU2018300000B2 (en) 2017-07-10 2021-11-11 Gen-Probe Incorporated Analytical systems and methods for nucleic acid amplification using sample assigning parameters
AU2018316218A1 (en) 2017-08-11 2020-03-05 Gen-Probe Incorporated Compositions and methods for detecting Staphylococcus aureus
WO2019099629A1 (en) 2017-11-17 2019-05-23 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID
WO2019118735A1 (en) 2017-12-15 2019-06-20 Gen-Probe Incorporated Compositions and methods for detecting toxigenic clostridium difficile
US20210071242A1 (en) 2018-01-29 2021-03-11 Gen-Probe Incorporated Analytical systems and methods
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
EP3820616A1 (de) 2018-07-10 2021-05-19 Gen-Probe Incorporated Verfahren und systeme zur detektion und quantifizierung von nukleinsäuren
CA3106975A1 (en) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
AU2019319203A1 (en) 2018-08-08 2021-03-11 Gen-Probe Incorporated Compositions, methods and kits for detecting
US20220074002A1 (en) 2018-08-21 2022-03-10 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
JP7389111B2 (ja) 2018-08-24 2023-11-29 ジェン-プローブ・インコーポレーテッド 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
EP3856934A2 (de) 2018-09-27 2021-08-04 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von bordetella-pertussis- und bordetella-parapertussis-nukleinsäure
AU2019365821A1 (en) 2018-10-22 2021-06-10 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human polyomavirus BK virus
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
US20220080425A1 (en) 2018-12-31 2022-03-17 Gen-Probe Incorporated Tray for transfering solid reagents to a multi-well cartridge
US20220098647A1 (en) 2019-03-22 2022-03-31 Gen-Probe Incorporated Compositions and Methods for Detecting Group A Streptococcus
AU2020268193A1 (en) 2019-05-03 2021-12-23 Gen-Probe Incorporated Receptacle transport system for an analytical system
WO2021003331A1 (en) 2019-07-03 2021-01-07 Gen-Probe Incorporated Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample
CA3152309A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
AU2020343334A1 (en) 2019-09-05 2022-04-07 Gen-Probe Incorporated Detection of Chlamydia trachomatis nucleic acid variants
WO2021119124A1 (en) 2019-12-09 2021-06-17 Gen-Probe Incorporated Quantification of polynucleotide analytes from dried samples
US20230227896A1 (en) 2020-01-16 2023-07-20 Dnae Diagnostics Limited Compositions, Kits and Methods for Isolating Target Polynucleotides
EP4114985A1 (de) 2020-03-04 2023-01-11 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von sars-cov-2-nukleinsäure
AU2021308095A1 (en) 2020-07-17 2023-03-09 Gen-Probe Incorporated Detection of macrolide-resistant mycoplasma genitalium
CA3177256A1 (en) 2020-10-21 2022-04-28 Gen-Probe Incorporated Fluid container management system
US11873485B2 (en) 2021-01-26 2024-01-16 California Institute Of Technology Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas
AU2022273052A1 (en) 2021-05-14 2023-11-30 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
AU2022304654A1 (en) 2021-07-01 2023-12-14 Gen-Probe Incorporated Enzyme formulations and reaction mixtures for nucleic acid amplification
CA3226451A1 (en) 2021-07-21 2023-01-26 Sam Reed Method and system comprising a cartridge for sequencing target polynucleotides
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
WO2023010008A1 (en) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
EP4282980A1 (de) 2022-05-23 2023-11-29 Mobidiag Oy Methoden zum verstärken einer nukleinsäure
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB215607A (en) * 1923-06-11 1924-05-15 Emory Winship Improvements in or relating to steering mechanism for vehicles
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
WO1984003285A1 (en) * 1983-02-22 1984-08-30 Molecular Biosystems Inc Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis
GB8306426D0 (en) * 1983-03-09 1983-04-13 Malcolm A D B Detecting polynucleotide sequence
DK188184A (da) * 1983-04-20 1984-10-21 Enzo Biochem Inc Fremgangsmaade til dannelse af et kompleks af biologisk aktive eller funktionelle forbindelser og anvendelse af forbindelserne
CA1228811A (en) * 1983-05-05 1987-11-03 Robert G. Pergolizzi Assay method utilizing polynucleotide sequences
CA1256005A (en) * 1983-09-26 1989-06-20 W. Peter Hansen Sandwich hybridization method for nucleic acid detection
US4699876A (en) * 1984-01-27 1987-10-13 E. I. Du Pont De Nemours And Company Nonradiometric polynucleotide probes
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
GB8405437D0 (en) * 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
FR2567523B1 (fr) * 1984-07-12 1987-11-13 Pasteur Institut Polynucleotides lies de facon covalente a un support solide, et procede pour leur obtention
US4755458A (en) * 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
FI72146C (fi) * 1985-01-02 1987-04-13 Orion Yhtymae Oy Foerfarande foer identifiering av nukleinsyror.
CA1272443A (en) * 1985-02-22 1990-08-07 Nanibhushan Dattagupta Solution-phase dual hybridization assay for detecting polynucleotide sequences
WO1986006412A1 (en) * 1985-05-02 1986-11-06 Genetics Institute, Inc. Process and nucleic acid construct for producing reagent complexes useful in determining target nucleotide sequences
WO1986006726A1 (en) * 1985-05-15 1986-11-20 Integrated Genetics, Inc. Cytidine analogs
US4751177A (en) * 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
ES8707343A1 (es) * 1985-06-13 1987-07-16 Amgen Un metodo para aislar una secuencia de acido nucleico objetivo seleccionada
JPS622164A (ja) * 1985-06-25 1987-01-08 シスカ・ダイアグノステイツクス・インコ−ポレ−テツド N4−(置換アミノ)シチジンを含む核酸プロ−ブ
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸

Also Published As

Publication number Publication date
CA1317207C (en) 1993-05-04
EP0225807A3 (en) 1988-09-07
CA1303033C (en) 1992-06-09
EP0423839A3 (en) 1991-09-25
EP0423839B1 (de) 2001-08-16
EP0225807A2 (de) 1987-06-16
ES2061441T3 (es) 1994-12-16
ATE113078T1 (de) 1994-11-15
DE3650103T2 (de) 1995-03-30
JPS62188970A (ja) 1987-08-18
ATE204288T1 (de) 2001-09-15
DE3650103D1 (de) 1994-11-24
DE3650760D1 (de) 2001-09-20
US4868105A (en) 1989-09-19
JPH06339378A (ja) 1994-12-13
EP0225807B1 (de) 1994-10-19
ES2160569T3 (es) 2001-11-16
JP2655569B2 (ja) 1997-09-24
EP0423839A2 (de) 1991-04-24

Similar Documents

Publication Publication Date Title
ATE204288T1 (de) Polynukleotide und proben mit verwendung in nukleinsäure-sandwichassay in lösungsphase
DE3688150T2 (de) Antikrebs-chinazolinon-derivate.
FI860077A0 (fi) Fotokemiskt foerfarande foer maerkning av nukleinsyror vid detektering i ett hybridisationstest.
ES2001246A6 (es) Un metodo para producir una composicion polimera liquida
EP0283206A3 (de) Polysiloxane mit kovalent gebundenen Markierungsgruppen
DK0392560T3 (da) Diaminoethylenforbindelser
MX165080B (es) Composicion liquida estable a la temperatura
IT8521867A0 (it) Composizioni covulcanizzabili di fluoroelastomeri a migliorata stabilita' chimica.
MX170732B (es) Composicion de derivados de succinimida y su uso
ATE48850T1 (de) Spezifische jodierung von nukleinsaeure.
ATE38675T1 (de) Phosphatesterderivate und ihre verwendung als anti-krebsmittel.
DK274086A (da) Substituerede phenyleddikesyreamidforbindelser og farmaceutisk acceptable salte heraf samt farmaceutisk komposition med antiinflammatorisk og analgetisk virkning indeholdende disse
ATE147372T1 (de) Neue quaternäre ammoniumsalze und deren medizinische verwendung
DK19885D0 (da) 3-alkoxy-2-(n-pyrrolidino)-n-pyridyl-n-furyl (eller thienyl)-methyl-propylaminer, fremgangsmaade til fremstilling deraf, samt farmaceutiske midler indeholdende disse
ATE90356T1 (de) 21-alkoxy-steroid-derivate.
FR2566720B3 (fr) Support d'articles tels que bouteilles, cassettes, adaptable aux portes de vehicules
ES2064052T3 (es) Un compuesto de yodo radiactivo para marcar un anticuerpo.
TH2442A (th) อนุพันธ์ของเอโซลิล-เท็ตตระไฮโดร-ฟิวแรน-2-อิลลีดีนมีเธนที่มีกลุ่มแทนที่ต่าง ๆ
ES2019633B3 (es) Compuestos de azaantraceno.
BR8501239A (pt) Plataforma autopropulsionada com sistema de direcao ate 360 graus

Legal Events

Date Code Title Description
8364 No opposition during term of opposition