DE3650760T2 - Polynukleotide und Proben mit Verwendung in Nukleinsäure-Sandwichassay in Lösungsphase - Google Patents

Polynukleotide und Proben mit Verwendung in Nukleinsäure-Sandwichassay in Lösungsphase

Info

Publication number
DE3650760T2
DE3650760T2 DE3650760T DE3650760T DE3650760T2 DE 3650760 T2 DE3650760 T2 DE 3650760T2 DE 3650760 T DE3650760 T DE 3650760T DE 3650760 T DE3650760 T DE 3650760T DE 3650760 T2 DE3650760 T2 DE 3650760T2
Authority
DE
Germany
Prior art keywords
group
polynucleotides
nucleic acid
hydrogen
solution phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3650760T
Other languages
English (en)
Other versions
DE3650760D1 (de
Inventor
Michael Steven Urdea
Brian Warner
Thomas Horn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25196815&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3650760(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE3650760D1 publication Critical patent/DE3650760D1/de
Publication of DE3650760T2 publication Critical patent/DE3650760T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/706Specific hybridization probes for hepatitis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
DE3650760T 1985-12-11 1986-12-10 Polynukleotide und Proben mit Verwendung in Nukleinsäure-Sandwichassay in Lösungsphase Expired - Lifetime DE3650760T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/807,624 US4868105A (en) 1985-12-11 1985-12-11 Solution phase nucleic acid sandwich assay

Publications (2)

Publication Number Publication Date
DE3650760D1 DE3650760D1 (de) 2001-09-20
DE3650760T2 true DE3650760T2 (de) 2002-04-18

Family

ID=25196815

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3650760T Expired - Lifetime DE3650760T2 (de) 1985-12-11 1986-12-10 Polynukleotide und Proben mit Verwendung in Nukleinsäure-Sandwichassay in Lösungsphase
DE3650103T Expired - Lifetime DE3650103T2 (de) 1985-12-11 1986-12-10 Nukleinsäure-Sandwichassay in Lösungsphase und dafür geeignete Polynukleotidprobe.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3650103T Expired - Lifetime DE3650103T2 (de) 1985-12-11 1986-12-10 Nukleinsäure-Sandwichassay in Lösungsphase und dafür geeignete Polynukleotidprobe.

Country Status (7)

Country Link
US (1) US4868105A (de)
EP (2) EP0225807B1 (de)
JP (2) JP2655569B2 (de)
AT (2) ATE113078T1 (de)
CA (2) CA1303033C (de)
DE (2) DE3650760T2 (de)
ES (2) ES2160569T3 (de)

Families Citing this family (308)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US5605800A (en) * 1978-04-13 1997-02-25 Institut Pasteur Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method
US7220854B1 (en) 1982-06-23 2007-05-22 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US5430136A (en) * 1984-10-16 1995-07-04 Chiron Corporation Oligonucleotides having selectably cleavable and/or abasic sites
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US5192683A (en) * 1987-02-19 1993-03-09 The Royal Institution For The Advancement Of Learning (Mcgill University) Monoclonal antibodies to cruciform DNA structure
US5656731A (en) * 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
CA1339351C (en) * 1987-10-15 1997-08-26 Michael S. Urdea Nucleic acid multimers and amplified nucleic acid hybridization assays using same
JP2565552B2 (ja) * 1987-10-15 1996-12-18 カイロン コーポレイション 核酸マルチマーおよびそれを用いた増幅核酸ハイブリダイゼーション分析法
US5359100A (en) * 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
DE3882040T2 (de) * 1987-12-01 1993-09-30 Biotope Inc Verfahren und vorrichtungen zur durchführung von untersuchungen.
EP0703296B1 (de) 1988-09-29 1998-07-22 Chiron Corporation Nachweis eines Polynukleotids durch Ersätzung einer Kette an einer Fangsonde
FR2642074B1 (fr) * 1989-01-20 1994-04-29 Oris Ind Derives de molecules polyhydroxylees permettant l'introduction d'au moins une ramification dans un oligonucleotide
JP2615200B2 (ja) * 1989-05-31 1997-05-28 株式会社リコー 可逆性感熱記録材料
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
ATE174926T1 (de) * 1989-06-30 1999-01-15 Chiron Corp Hydrophobe nukleinsäure-sonde
CA2065287C (en) 1989-09-15 1999-12-21 Tatsuo Miyamura New hcv isolates
JPH03123500A (ja) * 1989-10-06 1991-05-27 Canon Inc 核酸の分別方法
GB8924989D0 (en) * 1989-11-06 1989-12-28 Scotgen Ltd Method and device for the detection of antibiotic resistance
EP0504321B1 (de) * 1989-12-04 1997-05-07 Microprobe Corporation Verstärkter einfang von ziel-nukleinsäuren mittels verwendung von oligonukleotiden, die kovalent an polymere gebunden sind
WO1991010746A1 (en) 1990-01-10 1991-07-25 Chiron Corporation Dna-dependent rna polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
US5629153A (en) * 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
US5578718A (en) * 1990-01-11 1996-11-26 Isis Pharmaceuticals, Inc. Thiol-derivatized nucleosides
US6114513A (en) * 1990-01-11 2000-09-05 Isis Pharmaceuticals, Inc. Thiol-derivatized oligonucleotides
US5200314A (en) * 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
RU2107730C1 (ru) * 1990-05-04 1998-03-27 Чирон Корпорейшн Молекулярный зонд
WO1992002526A1 (en) * 1990-07-27 1992-02-20 Chiron Corporation Large comb-type branched polynucleotides
US5556751A (en) * 1991-04-25 1996-09-17 Amoco Corporation Selective amplification system using Q-β replicase
US6190864B1 (en) * 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
DE4123540A1 (de) * 1991-07-16 1993-01-21 Boehringer Mannheim Gmbh Immobilisierung von nukleinsaeuren
WO1993003184A1 (en) * 1991-08-09 1993-02-18 Mccann Associates, Inc. Method for detecting lyme disease and composition
WO1993005060A1 (de) * 1991-08-28 1993-03-18 Boehringer Mannheim Gmbh Funktionalisierte trägermaterialien für gleichzeitige synthese und direktmarkierung von oligonukleotiden als primer für matrizenabhängige enzymatische nukleinsäuresynthesen
US5556961A (en) * 1991-11-15 1996-09-17 Foote; Robert S. Nucleosides with 5'-O-photolabile protecting groups
DE69233331T3 (de) * 1991-11-22 2007-08-30 Affymetrix, Inc., Santa Clara Kombinatorische Strategien zur Polymersynthese
US5747244A (en) * 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
JPH07502414A (ja) * 1991-12-23 1995-03-16 バイエル コーポレイション 溶液相サンドイッチハイブリダイゼーションアッセイに用いるためのクラミジアプローブ
JP3907201B2 (ja) 1991-12-23 2007-04-18 カイロン コーポレイション 溶液相サンドイッチハイブリダイゼーションアッセイに用いるためのhivプローブ
WO1993013225A1 (en) 1991-12-23 1993-07-08 Chiron Corporation Htlv-1 probes for use in solution phase sandwich hybridization assays
EP0672175A4 (de) * 1991-12-23 1997-08-06 Chiron Corp Hav-proben in sandwichhybridisierungsverfahren in lösungen.
DE69231693T2 (de) * 1991-12-23 2001-05-31 Bayer Ag Hbv amplifizierungssonden zur verwendung in hybridisierungssandwichassay in der lösungsphase
EP0571087A1 (de) * 1992-05-18 1993-11-24 Rohm And Haas Company Spaltbare Phosphoramidate
US5543292A (en) * 1992-06-16 1996-08-06 Hitachi, Ltd. Process for the measurement of nucleic acids
AU4774293A (en) * 1992-07-17 1994-02-14 Aprogenex, Inc. Oligonucleotide probes and primers for detecting chromosomal translocation
US5329461A (en) * 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
GEP20012421B (en) 1993-05-10 2001-04-25 Chiron Corp Method for Typing Hepatitis C Virus and Reagents for Use Therein
DE69434809T2 (de) * 1993-05-28 2007-03-29 The Mount Sinai School Of Medicine Of New York University Bc200 rna, daraus abgeleitete proben und entsprechende anwendungen
US5382512A (en) * 1993-08-23 1995-01-17 Chiron Corporation Assay device with captured particle reagent
FR2710075B1 (fr) * 1993-09-15 1995-10-27 Bio Merieux Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal.
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US6306657B1 (en) * 1994-06-28 2001-10-23 Kalyx Biosciences, Inc. Polynucleotide probe and kit for amplifying signal detection in hybridization assays
AU691958B2 (en) 1994-08-12 1998-05-28 Myriad Genetics, Inc. 17q-linked breast and ovarian cancer susceptibility gene
ATE201445T1 (de) 1994-08-12 2001-06-15 Myriad Genetics Inc Mutationen des mit 17q verbundenen ovarial- und brustkrebs empfindlichkeitsgens
US5580731A (en) * 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5747248A (en) * 1994-12-05 1998-05-05 Chiron Corporation Discontinuous probe design using hybritope mapping
US20030104361A1 (en) * 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US5801155A (en) * 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
US5853974A (en) * 1995-06-07 1998-12-29 Chiron Corporation Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates
US5780227A (en) * 1995-06-07 1998-07-14 Sheridan; Patrick J. Oligonucleotide probe conjugated to a purified hydrophilic alkaline phosphatase and uses thereof
FR2737502B1 (fr) 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
US6017700A (en) * 1995-08-04 2000-01-25 Bayer Corporation Cationic oligonucleotides, and related methods of synthesis and use
ATE230759T1 (de) 1995-12-18 2003-01-15 Myriad Genetics Inc Chromosom 13 verbundene brustkrebsempfindlichkeitsgen brca2
US5837492A (en) 1995-12-18 1998-11-17 Myriad Genetics, Inc. Chromosome 13-linked breast cancer susceptibility gene
ES2325820T3 (es) 1995-12-22 2009-09-18 University Of Utah Research Foundation Gen del sindrome qt largo que codifica kvlqt1 y su asociacion con mink.
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
US5824478A (en) * 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
US6103535A (en) * 1996-05-31 2000-08-15 University Of Maryland Optical fiber evanescent field excited fluorosensor and method of manufacture
US20050069923A1 (en) * 1996-07-08 2005-03-31 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
JP4663824B2 (ja) * 1996-12-31 2011-04-06 ハイ スループット ジェノミクス インコーポレイテッド 多重化分子分析装置および方法
JPH10253632A (ja) * 1997-03-10 1998-09-25 Nissui Pharm Co Ltd 分析方法、キット及び装置
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
ATE340868T1 (de) * 1997-05-02 2006-10-15 Gen Probe Inc Zwei-schritt hybridisierung und einfang von einem polynukleotid
US5939261A (en) * 1997-06-24 1999-08-17 Sarnoff Corporation Method for capturing a nucleic acid
GB9718921D0 (en) * 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
EP1038022B1 (de) * 1997-12-12 2005-07-20 Digene Corporation Bewertung von humaner papillomvirus verwandter krankheit
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6458533B1 (en) 1997-12-19 2002-10-01 High Throughput Genomics, Inc. High throughput assay system for monitoring ESTs
US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
GB9805935D0 (en) * 1998-03-19 1998-05-13 Ciba Geigy Ag Organic compounds
US7045610B2 (en) * 1998-04-03 2006-05-16 Epoch Biosciences, Inc. Modified oligonucleotides for mismatch discrimination
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
US6683173B2 (en) * 1998-04-03 2004-01-27 Epoch Biosciences, Inc. Tm leveling methods
US7715989B2 (en) * 1998-04-03 2010-05-11 Elitech Holding B.V. Systems and methods for predicting oligonucleotide melting temperature (TmS)
US6127121A (en) * 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
US6183957B1 (en) 1998-04-16 2001-02-06 Institut Pasteur Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria
JP2002518026A (ja) * 1998-06-19 2002-06-25 エムティー テクノロジー, インコーポレイテッド Srprnaを用いる非ウイルス生物の検出
US6306643B1 (en) * 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
EP2306195A3 (de) 1998-09-18 2012-04-25 Massachusetts Institute of Technology Biologische Anwendungen von Halbleiternanokristallen
US6326149B1 (en) * 1998-11-03 2001-12-04 Sarnoff Corporation Method for controlled electrostatic adherent deposition of particles on a substrate
US6432642B1 (en) 1999-01-15 2002-08-13 Pe Corporation (Ny) Binary probe and clamp composition and methods for a target hybridization detection
WO2000068692A1 (en) * 1999-05-07 2000-11-16 Quantum Dot Corporation A method of detecting an analyte using semiconductor nanocrystals
US6750357B1 (en) 1999-06-25 2004-06-15 Syngen, Inc. Rhodamine-based fluorophores useful as labeling reagents
US6465183B2 (en) 1999-07-01 2002-10-15 Agilent Technologies, Inc. Multidentate arrays
US7078167B2 (en) * 1999-09-17 2006-07-18 Agilent Technologies, Inc. Arrays having background features and methods for using the same
US7122303B2 (en) 1999-09-17 2006-10-17 Agilent Technologies, Inc. Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
US6428957B1 (en) * 1999-11-08 2002-08-06 Agilent Technologies, Inc. Systems tools and methods of assaying biological materials using spatially-addressable arrays
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US7205105B2 (en) * 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US20020009728A1 (en) * 2000-01-18 2002-01-24 Quantum Dot Corporation Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
WO2001064958A2 (en) 2000-03-01 2001-09-07 Epoch Bioscienecs, Inc. Modified oligonucleotides for mismatch discrimination
EP1944310A3 (de) 2000-03-01 2008-08-06 Epoch Biosciences, Inc. Modifizierte Oligonukleotide zur Erkennung von Fehlanpassungen
JP2003535600A (ja) * 2000-06-02 2003-12-02 バイエル コーポレイション インサイチュ分枝dnaハイブリダイゼーションを用いた高感度遺伝子検出および位置決定
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
GB0016836D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
GB0016833D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (2)
WO2002004122A2 (en) * 2000-07-07 2002-01-17 Helen Lee Improved stability of hybridisation interactions in dipstick assays
WO2002020852A1 (en) 2000-09-01 2002-03-14 Gen-Probe Incorporated Amplification of hiv-1 sequences for detection of sequences associated with drug-resistance mutations
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
JP4202750B2 (ja) 2000-10-23 2008-12-24 ジェン−プローブ・インコーポレーテッド ヒト免疫不全ウイルス2(hiv−2)を検出するための組成物および方法
JP2004535769A (ja) * 2001-01-05 2004-12-02 インヴィトロジェン コーポレーション 結合した核酸の比較定量のための方法
US20020168667A1 (en) * 2001-03-23 2002-11-14 Fuji Photo Film Co., Ltd. Antigen detecting agent and antigen detecting kit, antigen detecting apparatus and antigen detecting method using the same
US7018795B2 (en) * 2001-03-23 2006-03-28 Fuji Photo Film Co., Ltd. Hybridization probe and target nucleic acid detecting kit, target nucleic acid detecting apparatus and target nucleic acid detecting method using the same
US7077982B2 (en) * 2001-03-23 2006-07-18 Fuji Photo Film Co., Ltd. Molecular electric wire, molecular electric wire circuit using the same and process for producing the molecular electric wire circuit
US20020168756A1 (en) * 2001-03-23 2002-11-14 Fuji Photo Film Co., Ltd. Particle size variable reactor
US20030003476A1 (en) * 2001-03-23 2003-01-02 Fuji Photo Film Co., Ltd. Waste water inspecting agent and waste water inspecting apparatus using the same
US20030082571A1 (en) * 2001-04-10 2003-05-01 Kachab Edward Hanna Linear nucleic acid and sequence therefor
EP1925672A1 (de) 2001-06-22 2008-05-28 Syngeta Participations AG Auf abiotischen Stress ansprechende Polynukleotide und Polypeptide
CN1639568A (zh) * 2001-09-21 2005-07-13 宝生物工程株式会社 用于固定配体的载体
US6946245B2 (en) * 2001-12-04 2005-09-20 Quest Diagnostics Investments Incorporated Oligonucleotides and methods for detecting hepatitis C viral nucleic acids
US20030175709A1 (en) * 2001-12-20 2003-09-18 Murphy George L. Method and system for depleting rRNA populations
US20030179381A1 (en) * 2002-03-18 2003-09-25 Fuji Photo Film Co., Ltd. Sensor, color sensor and apparatus for inspection using the same
CA2479730A1 (en) 2002-03-21 2003-10-02 Sagres Discovery, Inc. Novel compositions and methods in cancer
US20030219755A1 (en) * 2002-05-24 2003-11-27 Nanibhushan Dattagupta Compositions and methods for performing hybridization assays using target enhanced signal amplification (TESA)
EP1513958B1 (de) 2002-06-14 2011-08-10 Gen-Probe Incorporated Zusammensetzungen zum nachweis von hepatitis-b-virus
US7803536B2 (en) * 2002-09-20 2010-09-28 Integrated Dna Technologies, Inc. Methods of detecting fluorescence with anthraquinone quencher dyes
WO2004036190A2 (en) 2002-10-16 2004-04-29 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
WO2004048936A2 (en) * 2002-11-26 2004-06-10 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
JP4294946B2 (ja) * 2002-12-13 2009-07-15 富士フイルム株式会社 標的検出装置及び標的検出方法並びに標的検出用基材
US7076127B2 (en) * 2003-01-14 2006-07-11 Fuji Photo Film Co., Ltd. Optical switch and safety apparatus using the same
US20040170982A1 (en) 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
JP2007524362A (ja) 2003-02-14 2007-08-30 サイグレス ディスカバリー, インコーポレイテッド 癌における治療gpcr標的
US7767387B2 (en) 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US20040241661A1 (en) * 2003-05-29 2004-12-02 Arindam Bhattacharjee Pseudo single color method for array assays
DE20310332U1 (de) * 2003-07-04 2004-11-11 Mwg-Biotech Ag Vorrichtung zum automatischen Öffnen und Schließen von Reaktionsgefäßen
US7348146B2 (en) * 2003-10-02 2008-03-25 Epoch Biosciences, Inc. Single nucleotide polymorphism analysis of highly polymorphic target sequences
EP1687609B1 (de) * 2003-10-28 2014-12-10 Epoch Biosciences, Inc. Fluoreszenzsonden zum nachweis von dna durch hybridisierung mit verbesserter empfindlichkeit und geringem hintergrund
WO2005049849A2 (en) 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
EP1694871B1 (de) 2003-12-19 2010-08-25 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits zum nachweis der nukleinsäuren von hiv-1 und hiv-2
US20050244984A1 (en) * 2004-04-28 2005-11-03 Parker Russell A Methods and compositions for calibrating chemical array readers
CA2573532C (en) * 2004-07-13 2014-01-07 Gen-Probe Incorporated Compositions and methods for detection of hepatitis a virus nucleic acid
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
CA2582055C (en) 2004-09-30 2014-04-08 Gen-Probe Incorporated Assay for detecting and quantifying hiv-1
US20060223080A1 (en) * 2004-11-09 2006-10-05 Gen-Probe Incorporated Compositions and methods for detecting group a streptococci
US20060172314A1 (en) * 2005-01-31 2006-08-03 Song Min-Sun Quantification of amplified nucleic acids
US20060177859A1 (en) * 2005-02-07 2006-08-10 Gen-Probe Incorporated Compositions and methods for detecting group B streptococci
AU2006214141B2 (en) * 2005-02-18 2010-07-15 Gen-Probe Incorporated Sample preparation method incorporating an alkaline shock
WO2006110314A2 (en) 2005-03-25 2006-10-19 Ambion, Inc. Methods and compositions for depleting abundant rna transcripts
US20090214536A1 (en) 2005-04-07 2009-08-27 Guoying Yu CACNA1E in Cancer Diagnosis, Detection and Treatment
EP1871911A2 (de) 2005-04-07 2008-01-02 Chiron Corporation Gene in verbindung mit krebs (prlr)
EP1877418B1 (de) 2005-05-06 2013-11-20 Gen-Probe Incorporated Zusammensetzungen und testanordnungen zur erkennung von nukleinsäuren des influenza-virus a
EP1877581B1 (de) 2005-05-06 2012-03-28 Gen-Probe Incorporated Verfahren und produkte zum erfassen von nukleinsäurezielen
US8632970B2 (en) 2005-05-09 2014-01-21 Affymetrix, Inc. Multiplex capture of nucleic acids
US8628918B2 (en) * 2005-05-09 2014-01-14 Affymetrix, Inc. Multiplex capture of nucleic acids
US7803541B2 (en) 2005-05-12 2010-09-28 Panomics, Inc. Multiplex branched-chain DNA assays
CA2601554A1 (en) 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
CN104673903B (zh) 2005-06-20 2018-11-13 领先细胞医疗诊断有限公司 检测单个细胞中的核酸和鉴定异质大细胞群中罕见细胞的方法
WO2007044427A2 (en) * 2005-10-05 2007-04-19 Panomics, Inc. Detection of nucleic acids from whole blood
WO2007047912A2 (en) 2005-10-17 2007-04-26 Gen-Probe Incorporated Compositions and methods to detect legionella pneumophila nucleic acid
EP1951905B1 (de) * 2005-11-10 2012-04-11 Affymetrix, Inc. Nachweis von nukleinsäuren über amplifikation von stellvertreternukleinsäuren
CA2627259C (en) 2005-11-14 2016-02-23 Gen-Probe Incorporated Parametric calibration method
JP4858751B2 (ja) * 2005-11-30 2012-01-18 日本精機株式会社 マグネットロータおよびそのマグネットロータを備えた可動磁石式計器、そのマグネットロータを備えたステッピングモータ
WO2007134208A2 (en) * 2006-05-12 2007-11-22 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
EP2024509A4 (de) 2006-05-22 2010-08-04 Clinical Genomics Pty Ltd Nachweisverfahren
CA2658105C (en) 2006-08-01 2016-07-05 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
JP2008043332A (ja) * 2006-08-17 2008-02-28 Panomics Inc 組織スライドからの核酸定量
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
US7615351B2 (en) 2006-12-01 2009-11-10 Panomics, Inc. Two stage nucleic acid amplification using an amplification oligomer
EP2121956B1 (de) 2006-12-21 2016-08-17 Gen-Probe Incorporated Verfahren und zusammensetzungen zur amplizierung von nukleinsäuren
WO2008094370A2 (en) 2006-12-22 2008-08-07 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
US8114681B2 (en) * 2007-10-05 2012-02-14 Affymetrix, Inc. Highly multiplexed particle-based assays
US20100292094A1 (en) 2007-10-23 2010-11-18 Clinical Genomics Pty. Ltd. Method of diagnosing neoplasms
ES2684219T3 (es) 2007-10-23 2018-10-01 Clinical Genomics Pty Ltd Un método para el diagnóstico de neoplasias - II
AU2008343380B2 (en) * 2007-12-26 2012-07-12 Gen-Probe Incorporated Compositions and methods to detect Candida albicans nucleic acid
CA3128538C (en) 2008-04-21 2023-08-08 Gen-Probe Incorporated Method for detecting chikungunya virus
AU2009246363B2 (en) 2008-05-13 2013-10-24 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
US20090298709A1 (en) * 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
WO2010062556A1 (en) 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay and system
ES2644516T3 (es) * 2009-01-28 2017-11-29 Qiagen Gaithersburg, Inc. Método y ensayo de preparación de muestras de gran volumen específico de secuencia
CA2756659A1 (en) 2009-02-26 2010-09-02 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
WO2010117817A2 (en) 2009-03-30 2010-10-14 Life Technologies Corporation Methods for generating target specific probes for solution based capture
CN102414327B (zh) * 2009-05-01 2015-04-08 奇亚根盖瑟斯堡股份有限公司 用于在样品中检测rna剪接形式的非靶向扩增方法
WO2010151566A1 (en) 2009-06-23 2010-12-29 Gen-Probe Incorporated Compositions and methods for detecting nucleic acid from mollicutes
WO2011003020A1 (en) 2009-07-01 2011-01-06 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US20120015821A1 (en) * 2009-09-09 2012-01-19 Life Technologies Corporation Methods of Generating Gene Specific Libraries
WO2011032124A1 (en) 2009-09-14 2011-03-17 Qiagen Gaithersburg, Inc. Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
RU2573915C2 (ru) 2009-09-16 2016-01-27 Дженентек, Инк. Содержащие суперспираль и/или привязку белковые комплексы и их применение
WO2011038403A1 (en) 2009-09-28 2011-03-31 Yuling Luo Methods of detecting nucleic acid sequences with high specificity
CN102725424B (zh) 2010-01-25 2014-07-09 Rd生物科技公司 靶核酸的自折叠扩增
WO2011094528A2 (en) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an hpv in a sample
JP6103941B2 (ja) 2010-01-29 2017-03-29 キアジェン ゲイサーズバーグ インコーポレイテッド 核酸の配列特異的精製および多重分析のための方法および組成物
EP3604558B1 (de) 2010-02-17 2022-10-12 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von atopobium-vaginae-nukleinsäure
US20120108799A1 (en) 2010-09-07 2012-05-03 Integrated Dna Technologies, Inc. Modifications for Antisense Compounds
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
AU2011230496B2 (en) 2010-03-26 2015-09-17 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
CA3074551C (en) 2010-04-21 2021-05-04 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acids
WO2011146629A2 (en) 2010-05-19 2011-11-24 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
US9234249B2 (en) 2010-07-12 2016-01-12 Gen-Probe Incorporated Compositions and assays to detect swine H1N1 influenza A virus, seasonal H1 influenza A virus and seasonal H3 influenza A virus nucleic acids
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
EP2625297B1 (de) 2010-10-04 2018-10-10 Gen-Probe Prodesse, Inc. Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
ES2648564T3 (es) 2010-10-21 2018-01-04 Advanced Cell Diagnostics, Inc. Método ultrasensible para la detección in situ de ácidos nucleicos
CN103384681B (zh) 2010-12-23 2018-05-18 霍夫曼-拉罗奇有限公司 结合剂
WO2012085064A1 (en) 2010-12-23 2012-06-28 Roche Diagnostics Gmbh Detection of a posttranslationally modified polypeptide by a bi-valent binding agent
WO2012085111A1 (en) 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
US9885092B2 (en) 2011-02-24 2018-02-06 Qiagen Gaithersburg Inc. Materials and methods for detection of HPV nucleic acids
USRE48732E1 (en) 2011-03-10 2021-09-14 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
EP3272886B1 (de) 2011-04-25 2019-09-25 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
US8679760B2 (en) * 2011-05-03 2014-03-25 National Cheng Kung University Biomarker and method for evaluating risk of proliferation, invasion, or metastasis of cancer
EP2732054B1 (de) 2011-07-15 2019-04-03 Gen-Probe Incorporated Verfahren zum nachweis von menschlichen parvovirus nukleinsäuren in einem single-plex- oder multiplex-testverfahren
WO2013137922A2 (en) 2011-08-05 2013-09-19 Illumina, Inc. Functionalization and purification of molecules by reversible group exchange
EP2753713B1 (de) 2011-09-08 2017-07-19 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
KR102102862B1 (ko) 2011-10-14 2020-04-22 제넨테크, 인크. 항-HtrA1 항체 및 사용 방법
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
BR112014019579A2 (pt) 2012-02-10 2019-10-15 Genentech, Inc Anticorpo de cadeia única, polinucleotídeo, vetor, célula hospedeira, método de produção de um anticorpo de cadeia única, heteromultímero e método de produção do heteromultímero
IN2014DN06768A (de) * 2012-02-17 2015-05-22 Ajinomoto Kk
CA2865281C (en) 2012-02-24 2021-11-23 Gen-Probe Prodesse, Inc. Detection of shiga toxin genes in bacteria
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
BR112014032193A2 (pt) 2012-06-27 2017-06-27 Hoffmann La Roche métodos de produção de anticorpos biespecíficos e de determinação de combinação, anticorpo biespecífico, formulação e uso de anticorpo biespecífico
CA2871882A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
AU2013205087B2 (en) 2012-07-13 2016-03-03 Gen-Probe Incorporated Method for detecting a minority genotype
WO2014012147A1 (en) 2012-07-20 2014-01-23 Latrobe University Method of diagnosis and treatment
US9932628B2 (en) 2012-07-27 2018-04-03 Gen-Probe Incorporated Dual reference calibration method and system for quantifying polynucleotides
CA2883219C (en) 2012-08-30 2020-12-29 Gen-Probe Incorporated Multiphase nucleic acid amplification
US9783841B2 (en) 2012-10-04 2017-10-10 The Board Of Trustees Of The Leland Stanford Junior University Detection of target nucleic acids in a cellular sample
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
JP2016509480A (ja) 2013-01-24 2016-03-31 カリフォルニア インスティチュート オブ テクノロジー 発色団に基づく特徴づけおよび検出方法
US9273349B2 (en) 2013-03-14 2016-03-01 Affymetrix, Inc. Detection of nucleic acids
ES2795677T3 (es) 2013-03-15 2020-11-24 Gen Probe Inc Método, aparato y producto de programa informático para calibración
WO2014160818A2 (en) 2013-03-27 2014-10-02 Sample Technologies, Inc. Recombinant phage and bacterial detection methods
JP2016521575A (ja) * 2013-06-14 2016-07-25 ナノストリング テクノロジーズ,インコーポレイティド 多重化可能なタグベースのレポーターシステム
WO2014205221A2 (en) 2013-06-19 2014-12-24 Sample6 Technologies, Inc. Phage-based bacterial detection assay
CN105452488B (zh) 2013-08-14 2020-07-14 简·探针公司 用于检测hev核酸的组合物和方法
WO2016087416A1 (en) 2014-12-03 2016-06-09 F. Hoffmann-La Roche Ag Multispecific antibodies
CA2972475C (en) 2015-01-09 2024-01-16 Gen-Probe Incorporated Methods and compositions for diagnosing bacterial vaginosis
AU2016233298B2 (en) 2015-03-16 2021-09-02 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
ES2893100T3 (es) 2015-10-12 2022-02-08 Advanced Cell Diagnostics Inc Detección in situ de variantes de nucleótidos en muestras con un elevado nivel de ruido, y composiciones y métodos relacionados con ésta
IL295097A (en) 2015-10-30 2022-09-01 Genentech Inc Anti-htra1 antibodies and methods of using them
EP3400309A2 (de) 2016-01-04 2018-11-14 Gen-Probe Incorporated Verfahren und zusammensetzungen zum nachweis von candida-spezies
AU2017278065B2 (en) 2016-06-10 2020-09-10 Gen-Probe Incorporated Compositions and methods for detecting Zika virus nucleic acid
ES2908919T3 (es) 2016-07-05 2022-05-04 California Inst Of Techn Reacción en cadena de hibridación de iniciador fraccionario
CA3040907A1 (en) 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
JP7125395B2 (ja) 2016-11-21 2022-08-24 ジェン-プローブ・インコーポレーテッド B型肝炎ウイルスを検出または定量化するための組成物および方法
WO2018175883A1 (en) 2017-03-24 2018-09-27 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
EP4219770A3 (de) 2017-03-24 2023-08-16 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von rsv b in proben
US11667978B2 (en) 2017-06-07 2023-06-06 Gen-Probe Incorporated Detecting Babesia species nucleic acid in a sample
EP4289507A3 (de) 2017-07-10 2024-02-28 Gen-Probe Incorporated Analytische systeme und verfahren zur nukleinsäure-amplifikation mit der verwendung von den proben zugeteilten parametern
CN111094595A (zh) 2017-08-11 2020-05-01 简·探针公司 用于检测金黄色葡萄球菌的组合物和方法
CA3082909C (en) 2017-11-17 2023-07-25 Gen-Probe Incorporated Compositions and methods for detecting c1orf43 nucleic acid
EP3724354A1 (de) 2017-12-15 2020-10-21 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von toxigenem clostridium difficile
EP3746225A1 (de) 2018-01-29 2020-12-09 Gen-Probe Incorporated Analytische systeme und verfahren
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
CA3105684A1 (en) 2018-07-10 2020-01-16 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
AU2019314449A1 (en) 2018-08-01 2021-03-11 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of Epstein-Barr virus
WO2020033557A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
JP2021534758A (ja) 2018-08-21 2021-12-16 ジェン−プローブ・インコーポレーテッド ヒトサイトメガロウイルスを増幅、検出、または定量化するための組成物および方法
KR20210063347A (ko) 2018-08-24 2021-06-01 젠-프로브 인코포레이티드 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
WO2020069085A2 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
CA3116895A1 (en) 2018-10-22 2020-04-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
WO2020142347A2 (en) 2018-12-31 2020-07-09 Gen-Probe Incorporated Systems and methods for filling multi-well cartridges with solid reagents
WO2020197987A1 (en) 2019-03-22 2020-10-01 Gen-Probe Incorporated Compositions and methods for detecting group a streptococcus
CA3137749C (en) 2019-05-03 2023-12-05 Gen-Probe Incorporated Receptacle transport system for an analytical system
EP3994284A1 (de) 2019-07-03 2022-05-11 Gen-Probe Incorporated Trichomonas vaginalis oligonukleotide zur verwendung bei der bestimmung der anwesenheit in einer probe
JP2022545280A (ja) 2019-08-23 2022-10-26 ジェン-プローブ・インコーポレーテッド Treponema pallidumを検出するための組成物、方法、およびキット
EP4025715A1 (de) 2019-09-05 2022-07-13 Gen-Probe Incorporated Nachweis von chlamydia-trachomatis-nukleinsäurevarianten
WO2021119124A1 (en) 2019-12-09 2021-06-17 Gen-Probe Incorporated Quantification of polynucleotide analytes from dried samples
JP2023510395A (ja) 2020-01-16 2023-03-13 ディーエヌエイイー ダイアグノスティックス リミテッド 標的ポリヌクレオチドを単離するための組成物、キットおよび方法
JP2023516683A (ja) 2020-03-04 2023-04-20 ジェン-プローブ・インコーポレーテッド SARS-CoV-2核酸を検出するための組成物および方法
JP2023534457A (ja) 2020-07-17 2023-08-09 ジェン-プローブ・インコーポレーテッド マクロライド耐性Mycoplasma genitaliumの検出
CN116323440A (zh) 2020-10-21 2023-06-23 简·探针公司 流体容器管理系统
EP4284925A1 (de) 2021-01-26 2023-12-06 California Institute of Technology Allosterische bedingte guide-rnas zur zellselektiven regulierung von crispr/cas
WO2022241291A1 (en) 2021-05-14 2022-11-17 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
AU2022304654A1 (en) 2021-07-01 2023-12-14 Gen-Probe Incorporated Enzyme formulations and reaction mixtures for nucleic acid amplification
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
CA3226451A1 (en) 2021-07-21 2023-01-26 Sam Reed Method and system comprising a cartridge for sequencing target polynucleotides
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
AU2022319876A1 (en) 2021-07-27 2024-01-18 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
EP4282980A1 (de) 2022-05-23 2023-11-29 Mobidiag Oy Methoden zum verstärken einer nukleinsäure
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
WO2024081776A1 (en) 2022-10-13 2024-04-18 Gen-Probe Incorporated Cellularity control for nucleic acid assays

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB215607A (en) * 1923-06-11 1924-05-15 Emory Winship Improvements in or relating to steering mechanism for vehicles
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
EP0135587B2 (de) * 1983-02-22 2002-12-18 Syngene, Inc. Einzelstrang-oligonukleotide bestimmter sequenz, markergruppen enthaltend, verfahren zu deren chemischer synthese und nukleotide zur verwendung darin
GB8306426D0 (en) * 1983-03-09 1983-04-13 Malcolm A D B Detecting polynucleotide sequence
DK188184A (da) * 1983-04-20 1984-10-21 Enzo Biochem Inc Fremgangsmaade til dannelse af et kompleks af biologisk aktive eller funktionelle forbindelser og anvendelse af forbindelserne
CA1228811A (en) * 1983-05-05 1987-11-03 Robert G. Pergolizzi Assay method utilizing polynucleotide sequences
NO843838L (no) * 1983-09-26 1985-03-27 Ortho Diagnostic Systems Inc Fremgangsmaate for detektering av nukleinsyre
US4699876A (en) * 1984-01-27 1987-10-13 E. I. Du Pont De Nemours And Company Nonradiometric polynucleotide probes
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
GB8405437D0 (en) * 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
FR2567523B1 (fr) * 1984-07-12 1987-11-13 Pasteur Institut Polynucleotides lies de facon covalente a un support solide, et procede pour leur obtention
US4755458A (en) * 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
FI72146C (fi) * 1985-01-02 1987-04-13 Orion Yhtymae Oy Foerfarande foer identifiering av nukleinsyror.
CA1272443A (en) * 1985-02-22 1990-08-07 Nanibhushan Dattagupta Solution-phase dual hybridization assay for detecting polynucleotide sequences
DE3688965T2 (de) * 1985-05-02 1994-03-24 Genetics Inst Verfahren und aufbau einer nukleinsäure zur erzeugung von reagenzienkomplexen zur verwendung bei der bestimmung von zielnukleotidsequenzen.
WO1986006726A1 (en) * 1985-05-15 1986-11-20 Integrated Genetics, Inc. Cytidine analogs
US4751177A (en) * 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
IL79112A (en) * 1985-06-13 1992-01-15 Abbott Lab Method for the isolation of a nucleic acid sequence and kit for performing a hybridization assay
EP0209996A3 (de) * 1985-06-25 1987-09-02 Siska Diagnostics,Inc. N4-(Amino-substituierte) Cytidin enthaltendes Nukleinsäuretestmittel
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸

Also Published As

Publication number Publication date
CA1303033C (en) 1992-06-09
JP2655569B2 (ja) 1997-09-24
EP0423839A2 (de) 1991-04-24
EP0423839B1 (de) 2001-08-16
CA1317207C (en) 1993-05-04
ATE113078T1 (de) 1994-11-15
JPS62188970A (ja) 1987-08-18
EP0225807B1 (de) 1994-10-19
JPH06339378A (ja) 1994-12-13
DE3650760D1 (de) 2001-09-20
EP0225807A2 (de) 1987-06-16
ES2160569T3 (es) 2001-11-16
ATE204288T1 (de) 2001-09-15
US4868105A (en) 1989-09-19
EP0225807A3 (en) 1988-09-07
EP0423839A3 (en) 1991-09-25
DE3650103D1 (de) 1994-11-24
DE3650103T2 (de) 1995-03-30
ES2061441T3 (es) 1994-12-16

Similar Documents

Publication Publication Date Title
DE3650760T2 (de) Polynukleotide und Proben mit Verwendung in Nukleinsäure-Sandwichassay in Lösungsphase
DE3688150D1 (de) Antikrebs-chinazolinon-derivate.
FI860077A0 (fi) Fotokemiskt foerfarande foer maerkning av nukleinsyror vid detektering i ett hybridisationstest.
ES2001246A6 (es) Un metodo para producir una composicion polimera liquida
IT8521213A0 (it) Composizioni covulcanizzabili di fluoroelastomeri a migliorata stabilita' chimica.
EP0283206A3 (de) Polysiloxane mit kovalent gebundenen Markierungsgruppen
DK0392560T3 (da) Diaminoethylenforbindelser
MX165080B (es) Composicion liquida estable a la temperatura
IT8521867A0 (it) Composizioni covulcanizzabili di fluoroelastomeri a migliorata stabilita' chimica.
MX170732B (es) Composicion de derivados de succinimida y su uso
ATE38675T1 (de) Phosphatesterderivate und ihre verwendung als anti-krebsmittel.
DK274086A (da) Substituerede phenyleddikesyreamidforbindelser og farmaceutisk acceptable salte heraf samt farmaceutisk komposition med antiinflammatorisk og analgetisk virkning indeholdende disse
ATE147372T1 (de) Neue quaternäre ammoniumsalze und deren medizinische verwendung
DK19885A (da) 3-alkoxy-2-(n-pyrrolidino)-n-pyridyl-n-furyl (eller thienyl)-methyl-propylaminer, fremgangsmaade til fremstilling deraf, samt farmaceutiske midler indeholdende disse
ATE90356T1 (de) 21-alkoxy-steroid-derivate.
FR2566720B3 (fr) Support d'articles tels que bouteilles, cassettes, adaptable aux portes de vehicules
ES2064052T3 (es) Un compuesto de yodo radiactivo para marcar un anticuerpo.
TH2442A (th) อนุพันธ์ของเอโซลิล-เท็ตตระไฮโดร-ฟิวแรน-2-อิลลีดีนมีเธนที่มีกลุ่มแทนที่ต่าง ๆ
TH5978A (th) อนุพันธ์ไดแซ็กคาไรด์
ES2019633B3 (es) Compuestos de azaantraceno.
BR8501239A (pt) Plataforma autopropulsionada com sistema de direcao ate 360 graus
IT8502710V0 (it) Punta o lancia panoramica

Legal Events

Date Code Title Description
8364 No opposition during term of opposition