DE3751917D1 - Iontotherapeutische vorrichtung mit dosiereinheit - Google Patents

Iontotherapeutische vorrichtung mit dosiereinheit

Info

Publication number
DE3751917D1
DE3751917D1 DE3751917T DE3751917T DE3751917D1 DE 3751917 D1 DE3751917 D1 DE 3751917D1 DE 3751917 T DE3751917 T DE 3751917T DE 3751917 T DE3751917 T DE 3751917T DE 3751917 D1 DE3751917 D1 DE 3751917D1
Authority
DE
Germany
Prior art keywords
pharmaceutical
iontotherapeutic
ionized
iontotherapeutic device
unit dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3751917T
Other languages
English (en)
Other versions
DE3751917T2 (de
Inventor
Yie Chien
Kong-Jiann Li
Jue-Chen Liu
Wei-Min Shi
Ovais Siddiqui
Ying Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Publication of DE3751917D1 publication Critical patent/DE3751917D1/de
Application granted granted Critical
Publication of DE3751917T2 publication Critical patent/DE3751917T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
DE3751917T 1986-07-25 1987-07-22 Iontotherapeutische vorrichtung mit dosiereinheit Expired - Fee Related DE3751917T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89070286A 1986-07-25 1986-07-25
US07/046,984 US5042975A (en) 1986-07-25 1987-05-07 Iontotherapeutic device and process and iontotherapeutic unit dose
PCT/US1987/001676 WO1988000846A1 (en) 1986-07-25 1987-07-22 Iontotherapeutic device and process and unit dose

Publications (2)

Publication Number Publication Date
DE3751917D1 true DE3751917D1 (de) 1996-10-31
DE3751917T2 DE3751917T2 (de) 1997-03-20

Family

ID=26724501

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751917T Expired - Fee Related DE3751917T2 (de) 1986-07-25 1987-07-22 Iontotherapeutische vorrichtung mit dosiereinheit

Country Status (11)

Country Link
US (1) US5042975A (de)
EP (1) EP0316342B1 (de)
JP (1) JPH02500487A (de)
KR (1) KR950008027B1 (de)
AT (1) ATE143278T1 (de)
AU (1) AU7751387A (de)
CA (1) CA1326195C (de)
DE (1) DE3751917T2 (de)
DK (1) DK161688A (de)
NO (1) NO881292L (de)
WO (1) WO1988000846A1 (de)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5651768A (en) * 1983-08-18 1997-07-29 Drug Delivery Systems, Inc. Transdermal drug applicator and electrodes therefor
US5224928A (en) * 1983-08-18 1993-07-06 Drug Delivery Systems Inc. Mounting system for transdermal drug applicator
US6956032B1 (en) * 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5250022A (en) * 1990-09-25 1993-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose
US5961482A (en) * 1986-07-25 1999-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US5746711A (en) * 1987-01-05 1998-05-05 Drug Delivery Systems, Inc. Programmable control and mounting system for transdermal drug applicator
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
JP2907342B2 (ja) * 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア イオン滲透非侵襲的サンプリングまたは送出装置
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
EP0569634B1 (de) * 1989-05-10 1999-03-24 Drug Delivery Systems Inc. Elektrisches System mit mehreren Signalen zur transdermalen Medikamentenverabreichung
US5135478A (en) * 1989-05-10 1992-08-04 Drug Delivery Systems Inc. Multi-signal electrical transdermal drug applicator
CA2071321C (en) * 1989-05-10 2000-12-12 Dan Sibalis Multi-signal electrical transdermal drug applicator
US5320597A (en) * 1991-02-08 1994-06-14 Becton, Dickinson And Company Device and method for renewing electrodes during iontophoresis
IT1244030B (it) * 1989-12-21 1994-06-28 Elan Corp Plc Dispostitivo in due parti per la somministrazione controllata di un ingrediente
CH684725B5 (fr) * 1989-12-26 1995-06-15 Elan Corp Plc Dispositif formé de deux unités pour l'administration sélective d'un médicament.
US6004309A (en) 1990-03-30 1999-12-21 Alza Corporation Method and apparatus for controlled environment electrotransport
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US5236413B1 (en) * 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5499971A (en) * 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5362308A (en) * 1990-09-25 1994-11-08 Rutgers, The State University Of New Jersey Disposable dosage unit for iontophoresis-facilitated transdermal delivery, related devices and processes
US6575957B1 (en) * 1990-11-01 2003-06-10 Robert Tapper Iontophoretic treatment system
US6223076B1 (en) 1990-11-01 2001-04-24 Robert Tapper Sweat control system
US6238381B1 (en) 1990-11-01 2001-05-29 Robert Tapper Iontophoretic treatment system
US6600950B1 (en) * 1990-11-01 2003-07-29 Robert Tapper Iontophoretic treatment system
US6235013B1 (en) 1990-11-01 2001-05-22 Robert Tapper Iontophoretic treatment system
US6582416B2 (en) 1990-11-01 2003-06-24 Robert Tapper Iontophoretic treatment system
US6139537A (en) * 1990-11-01 2000-10-31 Tapper; Robert Iontophoretic treatment system
US5431625A (en) * 1991-02-01 1995-07-11 Empi, Inc. Iontophoresis electronic device having a ramped output current
AU2563292A (en) * 1991-08-26 1993-03-16 Rutgers, The State University Of New Jersey Iontotherapeutic device and process
US5356632A (en) * 1991-09-12 1994-10-18 S.I. Scientific Innovations Ltd. Transdermal drug delivery device
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
US5246417A (en) * 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
US5256137A (en) * 1992-03-10 1993-10-26 Becton Dickinson And Company Biphasic power source for use in an iontophoretic drug delivery system
CA2087087C (en) * 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules for iontophoretic delivery
US5405614A (en) * 1992-04-08 1995-04-11 International Medical Associates, Inc. Electronic transdermal drug delivery system
US5756117A (en) * 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5230703A (en) * 1992-04-09 1993-07-27 Staodyn, Inc. Wound infection resolution utilizing antibiotic agents and electrical stimulation
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US6132419A (en) * 1992-05-22 2000-10-17 Genetronics, Inc. Electroporetic gene and drug therapy
AU4534593A (en) * 1992-06-12 1994-01-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5507724A (en) * 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
WO1994017792A2 (en) * 1993-01-27 1994-08-18 Affymax Technologies N.V. Compositions and methods for transdermal drug delivery
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US7448375B2 (en) 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US5533971A (en) * 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
ATE211655T1 (de) 1993-09-22 2002-01-15 Hisamitsu Pharmaceutical Co Iontophoresematrix
US20050159700A1 (en) * 1993-09-30 2005-07-21 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
DE69535897D1 (de) * 1994-03-07 2009-01-22 Nektar Therapeutics Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin
KR0134151B1 (ko) * 1994-05-23 1998-04-14 이형도 인슐린 패치
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
IE960312A1 (en) * 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US5676648A (en) 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
US6385487B1 (en) 1996-05-08 2002-05-07 Biophoretic Therapeutic Systems, Llc Methods for electrokinetic delivery of medicaments
US6718201B1 (en) * 1996-06-07 2004-04-06 Alza Corporation Electrotransport agent delivery method and apparatus
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
DE69826705T2 (de) * 1997-11-12 2006-02-23 Alza Corp., Palo Alto Verfahren zur dermalen verabreichung von polypeptiden
USRE37796E1 (en) 1997-12-16 2002-07-23 Biophoretic Therapeutic Systems, Llc Methods for iontophoretic delivery of antiviral agents
CA2337129A1 (en) * 1998-07-13 2000-01-20 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
US6148231A (en) * 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US6792306B2 (en) 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US7127285B2 (en) 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
US6553253B1 (en) * 1999-03-12 2003-04-22 Biophoretic Therapeutic Systems, Llc Method and system for electrokinetic delivery of a substance
EP1171195B1 (de) 1999-04-16 2005-03-16 Johnson & Johnson Consumer Companies, Inc. Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren
CA2366900A1 (en) 1999-04-16 2000-10-26 Stephen J. Wisniewski Drug delivery device comprising a dual chamber reservoir
US6385488B1 (en) * 1999-05-20 2002-05-07 Vyteris, Inc. Circuits for increasing the reliability of an iontophoretic system
FI106364B (fi) 1999-06-21 2001-01-31 Lehtoluoto Eeva Liisa Ihonpuhdistuslaite
US9006175B2 (en) * 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP2280020B1 (de) * 1999-06-29 2016-02-17 MannKind Corporation Pharmazeutische zusammensetzungen enthaltend ein peptid welches mit diketopiperazin komplexiert ist.
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
CA2381951A1 (en) 1999-08-18 2001-02-22 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
CA2393603C (en) 1999-12-10 2010-09-21 Massachusetts Institute Of Technology Microchip devices for delivery of molecules and methods of fabrication thereof
WO2001060448A1 (en) 2000-02-18 2001-08-23 University Of Utah Research Foundation Methods for extracting substances using alternating current
EP1259285A1 (de) 2000-02-18 2002-11-27 University of Utah Verfahren zur abreichung von medikamenten durch wechselstrom
ES2420279T3 (es) * 2000-03-02 2013-08-23 Microchips, Inc. Dispositivos microfabricados y métodos para almacenamiento y exposición selectiva de productos químicos
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
WO2001091902A2 (en) 2000-05-30 2001-12-06 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
WO2002030264A2 (en) * 2000-10-10 2002-04-18 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
AU2002224453A1 (en) 2000-10-11 2002-04-22 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
CA2432438C (en) * 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US20050177892A1 (en) * 2001-02-12 2005-08-11 Pioneer Hi-Bred International, Inc. Maize Rar1-interactor polynucleotides and methods of use
US7137975B2 (en) * 2001-02-13 2006-11-21 Aciont, Inc. Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent
AU2007216942B2 (en) * 2001-04-27 2010-05-13 Nitric Biotherapeutics, Inc. Method and system for electrokinetic delivery of a substance
DK1390099T3 (da) * 2001-04-27 2008-06-09 Transport Pharmaceuticals Inc System til elektrokinetisk fremföring af substans
AU2002326304A1 (en) * 2001-05-31 2002-12-16 Massachusetts Institute Of Technology Microchip devices with improved reservoir opening
EP1494732B1 (de) 2002-03-20 2008-01-30 MannKind Corporation Inhalationsgerät
US6823202B2 (en) * 2002-04-01 2004-11-23 Iomed, Inc. Iontophoretic power supply
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
WO2004026281A2 (en) 2002-09-23 2004-04-01 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
US20060254912A1 (en) * 2003-03-04 2006-11-16 Amos Nussinovitch System and method for treating biological tissue usiing curret electrical field
US7479133B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Methods of treating acne and rosacea with galvanic generated electricity
US7477939B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of treating a wound with galvanic generated electricity
US20040265395A1 (en) * 2003-06-30 2004-12-30 Ying Sun Device for delivery of reducing agents to barrier membranes
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US7477941B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of exfoliating the skin with electricity
US7480530B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US7507228B2 (en) * 2003-06-30 2009-03-24 Johnson & Johnson Consumer Companies, Inc. Device containing a light emitting diode for treatment of barrier membranes
US7476222B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of reducing the appearance of pigmentation with galvanic generated electricity
US7477938B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Cosumer Companies, Inc. Device for delivery of active agents to barrier membranes
US7486989B2 (en) * 2003-06-30 2009-02-03 Johnson & Johnson Consumer Companies, Inc. Device for delivery of oxidizing agents to barrier membranes
US7477940B2 (en) * 2003-06-30 2009-01-13 J&J Consumer Companies, Inc. Methods of administering an active agent to a human barrier membrane with galvanic generated electricity
WO2005016558A2 (en) * 2003-08-04 2005-02-24 Microchips, Inc. Methods for accelerated release of material from a reservoir device
US7338171B2 (en) * 2003-10-27 2008-03-04 Jen-Chuen Hsieh Method and apparatus for visual drive control
EP1694200B1 (de) * 2003-11-03 2010-09-29 MicroCHIPS, Inc. Medizinprodukt zum messen von glucose
ES2584867T3 (es) * 2004-01-12 2016-09-29 Mannkind Corporation Un método que reduce los niveles séricos de proinsulina en diabéticos de tipo 2
US20080090753A1 (en) * 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
EP2319500B1 (de) * 2004-03-12 2012-10-24 Biodel, Inc. Schnell wirkende Arzneimittelabgabezusammensetzungen
US7537590B2 (en) * 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
PL2322180T3 (pl) 2004-08-23 2015-10-30 Mannkind Corp Sole diketopiperazyny do dostarczania leków
CN100488635C (zh) * 2004-09-01 2009-05-20 微芯片公司 用于控制释放或者暴露储库内容物的多盖储库装置
US7413846B2 (en) * 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
AU2006208131A1 (en) 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
CN104324366B (zh) 2005-09-14 2016-10-05 曼金德公司 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
WO2007041481A1 (en) * 2005-09-29 2007-04-12 Biodel, Inc. Rapid acting and prolonged acting insulin preparations
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
MX360812B (es) 2006-02-22 2018-11-16 Mannkind Corp Un método para mejorar las propiedades farmacéuticas de micropartículas que contienen dicetopiperazina y un agente activo.
AU2007238114B2 (en) * 2006-04-12 2010-10-14 Biodel, Inc. Rapid acting and long acting insulin combination formulations
WO2007120747A2 (en) * 2006-04-13 2007-10-25 Nupathe Inc. Transdermal methods and systems for the delivery of anti-migraine compounds
US20070275035A1 (en) * 2006-05-24 2007-11-29 Microchips, Inc. Minimally Invasive Medical Implant Devices for Controlled Drug Delivery
KR100730582B1 (ko) * 2006-11-20 2007-06-20 아람휴비스(주) 이온토포레시스 장치
WO2008124522A2 (en) * 2007-04-04 2008-10-16 Biodel, Inc. Amylin formulations
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
JP2010529897A (ja) * 2007-06-15 2010-09-02 ニトリツク・バイオ・セラピユーテイクス・インコーポレーテツド 動電学的薬剤配送の電流集中緩和方法とシステム
CN101878053B (zh) 2007-10-30 2014-04-09 麦克内尔-Ppc股份有限公司 具有感觉提示的微电流装置
US20090175840A1 (en) * 2008-01-04 2009-07-09 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
DE202009018480U1 (de) 2008-06-13 2012-01-26 Mannkind Corp. Trockenpulverinhalator und System zur Medikamentenabgabe
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8150525B2 (en) 2008-08-27 2012-04-03 Johnson & Johnson Consumer Companies, Inc. Treatment of hyperhydrosis
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
JP5888645B2 (ja) * 2008-12-30 2016-03-22 テバ・ファーマシューティカルズ・インターナショナル・ゲー・エム・ベー・ハー 薬物投与システムの電子制御
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
KR101875969B1 (ko) 2009-06-12 2018-07-06 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
BR112012011411A2 (pt) * 2009-11-13 2017-12-12 Johnson & Johnson Consumer Companies Inc dispositivo galvânico de tratamento da pele
US8986279B2 (en) * 2010-02-10 2015-03-24 Incube Labs, Llc Methods and architecture for power optimization of iontophoretic transdermal drug delivery
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
CN103228318B (zh) 2010-11-23 2016-03-23 泰华制药国际有限公司 使用者激活的自包含共封装的离子透入给药系统
BR122020008875B8 (pt) 2011-04-01 2022-12-06 Mannkind Corp Embalagem de bolha e método de fabricação de uma embalagem de bolhas
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
WO2013190489A1 (en) * 2012-06-19 2013-12-27 Cetroni Bruno Massimo Device for transdermal and/or intradermal transport
ITTO20120533A1 (it) * 2012-06-19 2013-12-20 Bruno Massimo Cetroni Dispositivo per la veicolazione transdermica e/o intradermica
KR102264177B1 (ko) 2012-07-12 2021-06-11 맨카인드 코포레이션 건조 분말 약물 전달 시스템 및 방법
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
BR112015023168B1 (pt) 2013-03-15 2021-08-10 Mannkind Corporation Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina
CN114848614A (zh) 2013-07-18 2022-08-05 曼金德公司 热稳定性干粉药物组合物和方法
EP3030294B1 (de) 2013-08-05 2020-10-07 MannKind Corporation Insufflationsvorrichtung
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9375478B1 (en) 2015-01-30 2016-06-28 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US10561838B2 (en) 2016-03-03 2020-02-18 P Tech, Llc Systems and methods for delivery of therapeutic agents
CN107596553A (zh) * 2017-09-05 2018-01-19 陈家林 一种电子针灸设备
CN107693940A (zh) * 2017-09-05 2018-02-16 陈家林 一种电子针灸设备
CN107595597A (zh) * 2017-09-05 2018-01-19 陈家林 一种电子针灸设备系统及其控制方法
CN107693941A (zh) * 2017-09-05 2018-02-16 陈家林 一种电子针灸设备系统及其控制方法
CN107596551A (zh) * 2017-09-05 2018-01-19 陈家林 一种电子针灸设备
CN107595599A (zh) * 2017-09-05 2018-01-19 陈家林 一种电子针灸设备系统及其控制方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3077884A (en) * 1957-06-13 1963-02-19 Batrow Lab Inc Electro-physiotherapy apparatus
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
JPS5347192A (en) * 1976-10-13 1978-04-27 Matsushita Electric Ind Co Ltd Device for introducing fluorine ion to tooth
SU936928A1 (ru) * 1979-03-05 1982-06-23 Киевский Научно-Исследовательский Институт Медицинских Проблем Физической Культуры Способ проведени электрофореза лекарственных веществ и устройство дл его осуществлени
US4403984A (en) * 1979-12-28 1983-09-13 Biotek, Inc. System for demand-based adminstration of insulin
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
SU1088730A1 (ru) * 1980-12-30 1984-04-30 Свердловский Научно-Исследовательский Институт Курортологии И Физиотерапии Способ лечени больных сахарным диабетом
US4416274A (en) * 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
DE3266982D1 (en) * 1981-03-05 1985-11-28 Medtronic Inc Iontophoretic device
FR2502015B1 (fr) * 1981-03-17 1985-09-06 Benoit Gino Procede et appareil pour l'embellissement de la peau en vue d'obtenir un raffermissement de cette derniere, une suppression des rides et l'elimination de la cellulite
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
DE3130260C2 (de) * 1981-07-31 1984-09-20 Zahnräderfabrik Renk AG, 8900 Augsburg Mechanisch schaltbares einfaches angetriebenes Planetengetriebe
JPS58124457A (ja) * 1982-01-19 1983-07-25 林原　健 イオン導入電子美顔器
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
JPS6131169A (ja) * 1984-07-23 1986-02-13 株式会社アドバンス イオントフォレ−ゼ用デバイス
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US4786277A (en) * 1986-11-21 1988-11-22 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation

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DK161688D0 (da) 1988-03-24
KR950008027B1 (ko) 1995-07-24
EP0316342B1 (de) 1996-09-25
DK161688A (da) 1988-05-24
US5042975A (en) 1991-08-27
DE3751917T2 (de) 1997-03-20
NO881292L (no) 1988-05-13
ATE143278T1 (de) 1996-10-15
CA1326195C (en) 1994-01-18
JPH02500487A (ja) 1990-02-22
KR880701573A (ko) 1988-11-03
AU7751387A (en) 1988-02-24
NO881292D0 (no) 1988-03-24
WO1988000846A1 (en) 1988-02-11
EP0316342A4 (de) 1989-06-14
EP0316342A1 (de) 1989-05-24

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