DE3781170D1 - Hydrolysierbare fluoreszierende substrate und deren verwendung zur analytischen bestimmung. - Google Patents

Hydrolysierbare fluoreszierende substrate und deren verwendung zur analytischen bestimmung.

Info

Publication number
DE3781170D1
DE3781170D1 DE8787300774T DE3781170T DE3781170D1 DE 3781170 D1 DE3781170 D1 DE 3781170D1 DE 8787300774 T DE8787300774 T DE 8787300774T DE 3781170 T DE3781170 T DE 3781170T DE 3781170 D1 DE3781170 D1 DE 3781170D1
Authority
DE
Germany
Prior art keywords
hydrolysable
analytical determination
fluorescent substrates
fluorescent
substrates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787300774T
Other languages
English (en)
Other versions
DE3781170T2 (de
Inventor
Bruce Edward Babb
Robert Troconis Belly
Patricia Marie Scensny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Eastman Kodak Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Kodak Co filed Critical Eastman Kodak Co
Publication of DE3781170D1 publication Critical patent/DE3781170D1/de
Application granted granted Critical
Publication of DE3781170T2 publication Critical patent/DE3781170T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B3/00—Dyes with an anthracene nucleus condensed with one or more carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
DE8787300774T 1986-01-31 1987-01-29 Hydrolysierbare fluoreszierende substrate und deren verwendung zur analytischen bestimmung. Expired - Fee Related DE3781170T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/824,756 US4812409A (en) 1986-01-31 1986-01-31 Hydrolyzable fluorescent substrates and analytical determinations using same

Publications (2)

Publication Number Publication Date
DE3781170D1 true DE3781170D1 (de) 1992-09-24
DE3781170T2 DE3781170T2 (de) 1993-04-01

Family

ID=25242238

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787300774T Expired - Fee Related DE3781170T2 (de) 1986-01-31 1987-01-29 Hydrolysierbare fluoreszierende substrate und deren verwendung zur analytischen bestimmung.

Country Status (5)

Country Link
US (1) US4812409A (de)
EP (1) EP0231125B1 (de)
JP (1) JPS62215399A (de)
CA (1) CA1336306C (de)
DE (1) DE3781170T2 (de)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3811097A1 (de) * 1988-03-31 1989-10-12 Orpegen Med Molekularbioforsch Verfahren zur steuerung biologischer klaerstufen
JP2627503B2 (ja) * 1986-04-01 1997-07-09 和光純薬工業株式会社 新規なペプチド誘導体
US4925789A (en) * 1986-06-30 1990-05-15 Edberg Stephen C Method and medium for use in detecting target microbes in situ in a specimen sample of a possibly contaminated material
US5429933A (en) 1986-06-30 1995-07-04 Edberg; Stephen C. Detection of first generation environmental sourced microbes in an environmentally-derived sample
DE3629175A1 (de) * 1986-08-28 1988-03-17 Behringwerke Ag Chromogene verbindungen, verfahren zu deren herstellung und ihre verwendung
WO1989010972A1 (en) * 1988-05-02 1989-11-16 Eastman Kodak Company Novel reagent and method for assaying hydrogen peroxide
US5093239A (en) * 1988-05-02 1992-03-03 Eastman Kodak Company Reagents for detecting oxidase positive microorganisms
US5094944A (en) * 1989-04-26 1992-03-10 Hayes Kenneth R Flourescent aquatic bioassay and procedure
WO1990012888A1 (en) * 1989-04-27 1990-11-01 Biocontrol Systems, Incorporated Precipitate test for microorganisms
US5059527A (en) * 1989-12-08 1991-10-22 White David C Detection of endotoxins of gram negative bacteria
US5208148A (en) * 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
US5095099A (en) * 1990-12-10 1992-03-10 E. I. Du Pont De Nemours And Company Fluorescent compounds for absorption and re-emission of radiation
AU652603B2 (en) * 1990-12-28 1994-09-01 Dade International Inc. Method and composition for determining antimicrobial susceptibility of the majority of clinically significant gram positive organisms
US5242805A (en) * 1991-08-23 1993-09-07 Molecular Probes, Inc. Long wavelength lipophilic fluorogenic glycosidase substrates
US5576424A (en) * 1991-08-23 1996-11-19 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
WO1993004192A1 (en) * 1991-08-23 1993-03-04 Molecular Probes, Inc. Use of haloalkyl derivatives of reporter molecules to analyze metabolic activity in cells
USRE38723E1 (en) * 1991-08-23 2005-04-12 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
US5849515A (en) * 1994-04-01 1998-12-15 Hach Company Method and medium for use in detecting E. coli and total coliforms
US5650290A (en) * 1994-04-01 1997-07-22 Hach Company Method & Medium for use in detecting E. coli and total coliforms
US5605812A (en) * 1995-05-19 1997-02-25 Charm Sciences, Inc. Test kit and method for the quantitative determination of coliform bacteria and E. coli
US5985594A (en) * 1995-11-14 1999-11-16 Idexx Laboratories, Inc. Method for quantification of biological material in a sample
US5700655A (en) * 1995-11-14 1997-12-23 Idexx Laboratories, Inc. Method for quantification of biological material in a sample
US7122338B2 (en) * 1995-11-14 2006-10-17 Biocontrol Systems, Inc. Method for quantification of biological material in a sample
US5773236A (en) * 1997-04-25 1998-06-30 Molecule Probes, Inc. Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules
US6548021B1 (en) 1997-10-10 2003-04-15 President And Fellows Of Harvard College Surface-bound, double-stranded DNA protein arrays
CA2335359C (en) 1999-04-23 2007-07-17 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
US6323337B1 (en) 2000-05-12 2001-11-27 Molecular Probes, Inc. Quenching oligonucleotides
US7579463B2 (en) * 2000-12-20 2009-08-25 Life Technologies Corporation Crown ether derivatives
US6962992B2 (en) 2000-12-20 2005-11-08 Molecullar Probes, Inc. Crown ether derivatives
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
GB0208989D0 (en) 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
WO2004042347A2 (en) * 2002-05-03 2004-05-21 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
AU2003270619A1 (en) * 2002-09-12 2004-04-30 Molecular Probes, Inc. Site-specific labeling of affinity tags in fusion proteins
US20040101822A1 (en) * 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
US7429472B2 (en) 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
US7238842B2 (en) 2003-01-31 2007-07-03 Promega Corporation Covalent tethering of functional groups to proteins
US8445702B2 (en) * 2003-05-05 2013-05-21 Life Technologies Corporation Zinc binding compounds and their method of use
US20050250214A1 (en) * 2004-05-05 2005-11-10 Gee Kyle R Zinc binding compounds and their method of use
CA2445420A1 (en) * 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7727752B2 (en) * 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
US7619059B2 (en) * 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
US7271265B2 (en) * 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
ATE458200T1 (de) * 2003-09-12 2010-03-15 Life Technologies Corp Anwendungen des resonanzenergietransfers zwischen terbium und gfp
US7282339B2 (en) * 2003-09-17 2007-10-16 Invitrogen Corporation Competitive immunoassay
US20050214807A1 (en) * 2003-11-19 2005-09-29 Iain Johnson Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection
WO2005056689A2 (en) * 2003-12-05 2005-06-23 Molecular Probes, Inc. Cyanine dye compounds
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
EP1711504A2 (de) 2004-01-21 2006-10-18 Molecular Probes Inc. Derivate von cephalosporin und clavulansäure zum nachweis von beta-lactamase in einer probe
US20060024833A1 (en) 2004-07-27 2006-02-02 Molecular Probes, Inc. Fluorescent metal ion indicators with large stokes shift
EP3179252B1 (de) 2004-07-30 2018-11-14 Promega Corporation Kovalentes anbinden von funktionellen gruppen an proteine und substrate dafür
US8084001B2 (en) * 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
JP5306811B2 (ja) * 2005-05-11 2013-10-02 ライフ テクノロジーズ コーポレーション ２本鎖ｄｎａへの高い選択性を有する蛍光化学物質及びそれらの使用
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
US8093012B2 (en) * 2005-10-13 2012-01-10 Aureon Laboratories, Inc. Multiplex in situ immunohistochemical analysis
US7521577B2 (en) 2006-01-12 2009-04-21 Molecular Probes, Inc. Heavy metal binding compounds and their method of use
US20070196860A1 (en) * 2006-01-18 2007-08-23 Invitrogen Corporation Methods for Measuring Real Time Kinase Activity
JP2009524832A (ja) 2006-01-24 2009-07-02 ライフ テクノロジーズ コーポレーション 検体を定量するためのデバイスおよび方法
US20080038761A1 (en) * 2006-01-30 2008-02-14 Invitrogen Corporation Compositions and methods for detecting and quantifying toxic substances in disease states
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
US8716033B2 (en) 2006-02-10 2014-05-06 Life Technologies Corporation Oligosaccharide modification and labeling of proteins
US8562802B1 (en) 2006-02-13 2013-10-22 Life Technologies Corporation Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems
SG171599A1 (en) 2006-03-23 2011-06-29 Absorber Ab Blood group antigens of different types for diagnostic and therapeutic applications
EP2029799B1 (de) 2006-04-20 2012-08-22 Becton, Dickinson and Company Thermisch stabile proteine und verfahren zu ihrer herstellung und verwendung
EP2064290B1 (de) 2006-10-27 2013-10-09 Life Technologies Corporation Fluorgene ph-sensitive farbstoffe und ihre verwendung
WO2008054821A2 (en) 2006-10-30 2008-05-08 Promega Corporation Mutant hydrolase proteins with enhanced kinetics and functional expression
US8586743B2 (en) 2007-01-30 2013-11-19 Life Technologies Corporation Labeling reagents and methods of their use
US8513451B2 (en) * 2007-05-30 2013-08-20 Hee Chol Kang Fluorescent phospholipase A2 indicators
US8759109B2 (en) * 2008-03-11 2014-06-24 Urobiologics Llc Use of female mammal's urine for determination of fetal gender related characteristics
US10996218B2 (en) 2008-03-11 2021-05-04 Ournextbaby Llc Methods for chemotaxis / redox driven separation of X and Y chromosome bearing sperm and their insemination in gender specific menstrual cycles
EP2269064B1 (de) 2008-03-27 2016-11-30 Promega Corporation Proteinetikettierung mit cyanbenzothiazol-konjugaten
JP2012519170A (ja) 2009-02-26 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー 生体内の腫瘍細胞のｅｍｔステータスをモニターするためのｉｎｓｉｔｕ法
CN106421817A (zh) 2009-07-02 2017-02-22 斯隆-凯特林癌症研究院 基于二氧化硅的荧光纳米颗粒
GB0915664D0 (en) 2009-09-08 2009-10-07 Enigma Diagnostics Ltd Reaction method
WO2011054731A1 (en) 2009-11-05 2011-05-12 Basf Se Fluorescent materials
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
EP2912459A2 (de) 2012-10-25 2015-09-02 Life Technologies Corporation Verfahren und zusammensetzungen zur enzymvermittelten stellenspezifischen radioaktiven markierung von glykoproteinen
EP2969435B1 (de) 2013-03-15 2021-11-03 Promega Corporation Substrate für kovalentes binden von proteinen an funktionelle gruppen oder feste oberflächen
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
SG11201602522VA (en) 2013-10-02 2016-04-28 Medimmune Llc Neutralizing anti-influenza a antibodies and uses thereof
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
US9504405B2 (en) 2013-10-23 2016-11-29 Verily Life Sciences Llc Spatial modulation of magnetic particles in vasculature by external magnetic field
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
CA2947895C (en) 2014-05-29 2023-08-08 Barney Yoo Nanoparticle drug conjugates
EP3242690B1 (de) 2015-01-06 2020-09-16 De Haas, Anthony H. Chirurgische nahinfrarot-fluoreszenzfarbstoffmarker
US9861710B1 (en) 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
US10028659B2 (en) 2015-03-26 2018-07-24 Verily Life Sciences Llc Aptamer-based sensors, implantable devices and detection system
KR20180012299A (ko) 2015-05-29 2018-02-05 메모리얼 슬로안-케터링 캔서 센터 초소형 나노입자를 사용하여 페로토시스를 통해 영양분-결핍 암 세포의 세포 사멸을 유도하는 치료 방법
WO2016196956A1 (en) 2015-06-05 2016-12-08 Promega Corporation Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements
JP6967006B2 (ja) 2016-01-15 2021-11-17 クアンタポール， インコーポレイテッド 低減されたバックグラウンドの光学に基づくナノポア分析
WO2017147309A1 (en) * 2016-02-24 2017-08-31 Ohio Northern University Fluorescent compounds as sensing agents
WO2017181176A1 (en) 2016-04-15 2017-10-19 Lcahn School Of Medicine At Mount Sinai Tissue profiling using multiplexed immunohistochemical consecutive staining
CA3025031A1 (en) 2016-05-20 2017-11-23 Quantum-Si Incorporated Labeled nucleotide compositions and methods for nucleic acid sequencing
EP3500684A4 (de) 2016-08-19 2020-02-26 Quantapore Inc. Optische nanoporensequenzierung mit quenchern
CN110546273A (zh) 2017-03-30 2019-12-06 生命技术公司 通过衔接子序列定量ngs dna
BR112019024717A2 (pt) 2017-05-25 2020-06-09 Univ Cornell nanopartículas ultrapequenas marcadas com zircônio-89 e métodos das mesmas
WO2019232225A1 (en) 2018-05-30 2019-12-05 Promega Corporation Broad-spectrum kinase binding agents
WO2020117954A2 (en) 2018-12-04 2020-06-11 Promega Corporation Broad spectrum gpcr binding agents
US20210363565A1 (en) 2020-05-22 2021-11-25 Promega Corporation Enhancement of kinase target engagement
US20220002716A1 (en) 2020-07-02 2022-01-06 Life Technologies Corporation Trinucleotide cap analogs, preparation and uses thereof
JP2023540934A (ja) 2020-08-28 2023-09-27 プロメガ コーポレイション Ｒａｓタンパク質のターゲットエンゲージメントアッセイ
CN117897454A (zh) 2021-07-21 2024-04-16 生命技术公司 二苯并呫吨猝灭剂、用途和制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7302561A (de) * 1972-03-01 1973-09-04
CA1095819A (en) * 1977-01-14 1981-02-17 Eastman Kodak Company Element for analysis of liquids
US4297273A (en) * 1978-07-24 1981-10-27 Miles Laboratories, Inc. Chemiluminescent phthalhydrazide-labeled protein and polypeptide conjugates
GB2031949B (en) * 1978-10-16 1983-01-06 American Home Prod Identification of microrganisms
US4409140A (en) * 1979-04-23 1983-10-11 Smith Robert E Substrates and method for determining enzymes
US4294923A (en) * 1979-04-23 1981-10-13 Smith Robert E Substrates and method for determining enzymes
EP0018825B1 (de) * 1979-05-02 1985-02-13 National Research Development Corporation Verfahren zur Identifizierung von Bakterien und Reagenzsatz zur Verwendung in diesem Verfahren
US4404366A (en) * 1980-05-06 1983-09-13 Miles Laboratories, Inc. Beta-galactosyl-umbelliferone-labeled hapten conjugates
GB2128204B (en) * 1982-04-14 1987-02-25 Unilever Plc Microbiological test processes and apparatus
DE3303871A1 (de) * 1983-02-05 1984-08-09 Bayer Ag, 5090 Leverkusen Fluorogene phosphorsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur fluorimetrischen bestimmung von phosphatasen
JPS59192099A (ja) * 1983-04-12 1984-10-31 Ajinomoto Co Inc 微生物菌数の測定法
US4857271A (en) * 1985-02-07 1989-08-15 Eastman Kodak Company Reducible compounds and analytical compositions, elements and methods utilizing same

Also Published As

Publication number Publication date
CA1336306C (en) 1995-07-11
EP0231125A2 (de) 1987-08-05
EP0231125A3 (en) 1989-08-16
JPS62215399A (ja) 1987-09-22
US4812409A (en) 1989-03-14
EP0231125B1 (de) 1992-08-19
DE3781170T2 (de) 1993-04-01
JPH0426624B2 (de) 1992-05-07

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