DE3781170T2 - Hydrolysierbare fluoreszierende substrate und deren verwendung zur analytischen bestimmung. - Google Patents

Hydrolysierbare fluoreszierende substrate und deren verwendung zur analytischen bestimmung.

Info

Publication number
DE3781170T2
DE3781170T2 DE8787300774T DE3781170T DE3781170T2 DE 3781170 T2 DE3781170 T2 DE 3781170T2 DE 8787300774 T DE8787300774 T DE 8787300774T DE 3781170 T DE3781170 T DE 3781170T DE 3781170 T2 DE3781170 T2 DE 3781170T2
Authority
DE
Germany
Prior art keywords
hydrolysable
analytical determination
fluorescent substrates
fluorescent
substrates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787300774T
Other languages
English (en)
Other versions
DE3781170D1 (de
Inventor
Bruce Edward Babb
Robert Troconis Belly
Patricia Marie Scensny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Eastman Kodak Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Kodak Co filed Critical Eastman Kodak Co
Application granted granted Critical
Publication of DE3781170D1 publication Critical patent/DE3781170D1/de
Publication of DE3781170T2 publication Critical patent/DE3781170T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B3/00Dyes with an anthracene nucleus condensed with one or more carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00Other synthetic dyes of known constitution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/80Fluorescent dyes, e.g. rhodamine
DE8787300774T 1986-01-31 1987-01-29 Hydrolysierbare fluoreszierende substrate und deren verwendung zur analytischen bestimmung. Expired - Fee Related DE3781170T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/824,756 US4812409A (en) 1986-01-31 1986-01-31 Hydrolyzable fluorescent substrates and analytical determinations using same

Publications (2)

Publication Number Publication Date
DE3781170D1 DE3781170D1 (de) 1992-09-24
DE3781170T2 true DE3781170T2 (de) 1993-04-01

Family

ID=25242238

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787300774T Expired - Fee Related DE3781170T2 (de) 1986-01-31 1987-01-29 Hydrolysierbare fluoreszierende substrate und deren verwendung zur analytischen bestimmung.

Country Status (5)

Country Link
US (1) US4812409A (de)
EP (1) EP0231125B1 (de)
JP (1) JPS62215399A (de)
CA (1) CA1336306C (de)
DE (1) DE3781170T2 (de)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3811097A1 (de) * 1988-03-31 1989-10-12 Orpegen Med Molekularbioforsch Verfahren zur steuerung biologischer klaerstufen
JP2627503B2 (ja) * 1986-04-01 1997-07-09 和光純薬工業株式会社 新規なペプチド誘導体
US5429933A (en) * 1986-06-30 1995-07-04 Edberg; Stephen C. Detection of first generation environmental sourced microbes in an environmentally-derived sample
US4925789A (en) * 1986-06-30 1990-05-15 Edberg Stephen C Method and medium for use in detecting target microbes in situ in a specimen sample of a possibly contaminated material
DE3629175A1 (de) * 1986-08-28 1988-03-17 Behringwerke Ag Chromogene verbindungen, verfahren zu deren herstellung und ihre verwendung
WO1989010972A1 (en) * 1988-05-02 1989-11-16 Eastman Kodak Company Novel reagent and method for assaying hydrogen peroxide
US5093239A (en) * 1988-05-02 1992-03-03 Eastman Kodak Company Reagents for detecting oxidase positive microorganisms
US5094944A (en) * 1989-04-26 1992-03-10 Hayes Kenneth R Flourescent aquatic bioassay and procedure
JP3043063B2 (ja) * 1989-04-27 2000-05-22 バイオコントロール システムズ インコーポレイテッド 微生物のための沈澱テスト
US5059527A (en) * 1989-12-08 1991-10-22 White David C Detection of endotoxins of gram negative bacteria
US5208148A (en) * 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
US5095099A (en) * 1990-12-10 1992-03-10 E. I. Du Pont De Nemours And Company Fluorescent compounds for absorption and re-emission of radiation
EP0516814B1 (de) * 1990-12-28 1996-09-04 Dade MicroScan Inc. Verfahren und zusammensetzung zur bestimmung der antimikrobiellen empfindlichkeit der mehrheit klinisch signifikanter grampositiver organismen
USRE38723E1 (en) * 1991-08-23 2005-04-12 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
US5242805A (en) * 1991-08-23 1993-09-07 Molecular Probes, Inc. Long wavelength lipophilic fluorogenic glycosidase substrates
EP0603266B1 (de) * 1991-08-23 1999-05-12 Molecular Probes, Inc. Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen
US5576424A (en) * 1991-08-23 1996-11-19 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
US5650290A (en) * 1994-04-01 1997-07-22 Hach Company Method & Medium for use in detecting E. coli and total coliforms
US5849515A (en) * 1994-04-01 1998-12-15 Hach Company Method and medium for use in detecting E. coli and total coliforms
US5605812A (en) * 1995-05-19 1997-02-25 Charm Sciences, Inc. Test kit and method for the quantitative determination of coliform bacteria and E. coli
US5700655A (en) * 1995-11-14 1997-12-23 Idexx Laboratories, Inc. Method for quantification of biological material in a sample
US5985594A (en) * 1995-11-14 1999-11-16 Idexx Laboratories, Inc. Method for quantification of biological material in a sample
US7122338B2 (en) * 1995-11-14 2006-10-17 Biocontrol Systems, Inc. Method for quantification of biological material in a sample
US5773236A (en) * 1997-04-25 1998-06-30 Molecule Probes, Inc. Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules
AU8826598A (en) 1997-10-10 1999-05-03 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
ATE233795T1 (de) 1999-04-23 2003-03-15 Molecular Probes Inc Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen
US6323337B1 (en) 2000-05-12 2001-11-27 Molecular Probes, Inc. Quenching oligonucleotides
US7579463B2 (en) 2000-12-20 2009-08-25 Life Technologies Corporation Crown ether derivatives
US6962992B2 (en) 2000-12-20 2005-11-08 Molecullar Probes, Inc. Crown ether derivatives
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
GB0208989D0 (en) 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
US7102005B2 (en) * 2002-05-03 2006-09-05 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
EP1546359A4 (de) * 2002-09-12 2007-05-09 Molecular Probes Inc Stellenspezifische markierung von affinitätstags in fusionsproteinen
US20040101822A1 (en) * 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
US7429472B2 (en) 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
WO2004072232A2 (en) 2003-01-31 2004-08-26 Promega Corporation Covalent tethering of functional groups to proteins
US20050250214A1 (en) * 2004-05-05 2005-11-10 Gee Kyle R Zinc binding compounds and their method of use
US8445702B2 (en) * 2003-05-05 2013-05-21 Life Technologies Corporation Zinc binding compounds and their method of use
US7727752B2 (en) * 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
CA2445420A1 (en) * 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7619059B2 (en) * 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
US7271265B2 (en) * 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
DE602004025592D1 (de) * 2003-09-12 2010-04-01 Life Technologies Corp Anwendungen des Resonanzenergietransfers zwischen Terbium und GFP
WO2005050206A2 (en) * 2003-09-17 2005-06-02 Molecular Probes, Inc. Competitive immunoassay
US20050214807A1 (en) * 2003-11-19 2005-09-29 Iain Johnson Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
WO2005056689A2 (en) 2003-12-05 2005-06-23 Molecular Probes, Inc. Cyanine dye compounds
WO2005071096A2 (en) 2004-01-21 2005-08-04 Molecular Probes, Inc. Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample
WO2006023231A2 (en) 2004-07-27 2006-03-02 Molecular Probes, Inc. Fluorescent metal ion indicators with large stokes shift
EP3179252B1 (de) 2004-07-30 2018-11-14 Promega Corporation Kovalentes anbinden von funktionellen gruppen an proteine und substrate dafür
US8084001B2 (en) * 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
WO2006124816A1 (en) * 2005-05-11 2006-11-23 Molecular Probes, Inc. Fluorescent chemical compounds having high selectivity for double stranded dna, and methods for their use
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
PT1934607E (pt) * 2005-10-13 2013-11-13 Fundacao D Anna Sommer Champalimaud E Dr Carlos Montez Champalimaud Análise imuno-histoquímica in situ multiplex
US7521577B2 (en) 2006-01-12 2009-04-21 Molecular Probes, Inc. Heavy metal binding compounds and their method of use
US20070196860A1 (en) * 2006-01-18 2007-08-23 Invitrogen Corporation Methods for Measuring Real Time Kinase Activity
WO2007087582A1 (en) 2006-01-24 2007-08-02 Invitrogen Corporation Device and methods for quantifying analytes
WO2007090126A2 (en) * 2006-01-30 2007-08-09 Invitrogen Corporation Compositions and methods for detecting and quantifying toxic substances in disease states
DK1991273T4 (da) 2006-02-10 2022-02-07 Life Technologies Corp Mærkning og påvisning af post-translationelt modificerede proteiner
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
US8562802B1 (en) 2006-02-13 2013-10-22 Life Technologies Corporation Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems
CA2643991A1 (en) 2006-03-23 2007-11-29 Absorber Ab Blood group antigens of different types for diagnostic and therapeutic applications
AU2007240316A1 (en) 2006-04-20 2007-11-01 Becton, Dickinson And Company Thermostable proteins and methods of making and using thereof
EP2727965B1 (de) 2006-10-27 2019-03-06 Life Technologies Corporation FLUOROGENE pH-SENSITIVE FARBSTOFFE UND IHRE VERWENDUNG
US8420367B2 (en) 2006-10-30 2013-04-16 Promega Corporation Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression
US8586743B2 (en) * 2007-01-30 2013-11-19 Life Technologies Corporation Labeling reagents and methods of their use
US8513451B2 (en) * 2007-05-30 2013-08-20 Hee Chol Kang Fluorescent phospholipase A2 indicators
US10996218B2 (en) 2008-03-11 2021-05-04 Ournextbaby Llc Methods for chemotaxis / redox driven separation of X and Y chromosome bearing sperm and their insemination in gender specific menstrual cycles
JP5774471B2 (ja) 2008-03-27 2015-09-09 プロメガ コーポレイションPromega Corporation シアノベンゾチアゾールコンジュゲートによるタンパク質標識
WO2010099137A2 (en) 2009-02-26 2010-09-02 Osi Pharmaceuticals, Inc. In situ methods for monitoring the emt status of tumor cells in vivo
EP3499233A3 (de) 2009-07-02 2019-09-18 Sloan-Kettering Institute for Cancer Research Fluoreszente nanopartikel auf silicabasis
GB0915664D0 (en) 2009-09-08 2009-10-07 Enigma Diagnostics Ltd Reaction method
WO2011054731A1 (en) 2009-11-05 2011-05-12 Basf Se Fluorescent materials
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
EP2619573B1 (de) 2010-09-16 2017-06-14 Urobiologics LLC Verwendung des harns von weiblichen säugetieren zur bestimmung von fetalen geschlechtsspezifischen merkmalen
EP2912459A2 (de) 2012-10-25 2015-09-02 Life Technologies Corporation Verfahren und zusammensetzungen zur enzymvermittelten stellenspezifischen radioaktiven markierung von glykoproteinen
US11072811B2 (en) 2013-03-15 2021-07-27 Promega Corporation Substrates for covalent tethering of proteins to functional groups or solid surfaces
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
LT3052192T (lt) 2013-10-02 2020-12-10 Medimmune, Llc Neutralizuojantys antikūnai prieš gripą a ir jų naudojimas
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
US9636034B2 (en) 2013-10-23 2017-05-02 Verily Life Sciences Llc Non-invasive analyte detection system with modulation source
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
CA3201974A1 (en) 2014-05-29 2015-12-03 Memorial Sloan Kettering Cancer Center Nanoparticle drug conjugates
WO2016111915A1 (en) 2015-01-06 2016-07-14 De Haas Anthony H Near-infrared fluorescent surgical dye markers
US9861710B1 (en) 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
US10028659B2 (en) 2015-03-26 2018-07-24 Verily Life Sciences Llc Aptamer-based sensors, implantable devices and detection system
CN108377643B (zh) 2015-05-29 2021-09-21 纪念斯隆凯特琳癌症中心 使用超小纳米粒子通过铁死亡诱导营养素剥夺癌细胞的细胞死亡的治疗方法
EP3304078B1 (de) 2015-06-05 2022-08-31 Promega Corporation Zelldurchlässige, zellkompatible und spaltbare linker zur kovalenten bindung von funktionselementen
JP6967006B2 (ja) 2016-01-15 2021-11-17 クアンタポール, インコーポレイテッド 低減されたバックグラウンドの光学に基づくナノポア分析
US11199497B2 (en) 2016-02-24 2021-12-14 Ohio Northern University Fluorescent compounds as sensing agents
US20190120845A1 (en) 2016-04-15 2019-04-25 Icahn School Of Medicine At Mount Sinai Tissue profiling using multiplexed immunohistochemical consecutive staining
BR112018073378A2 (pt) 2016-05-20 2019-03-06 Quantum-Si Incorporated composições de nucleotídeos marcados e métodos para sequenciamento de ácidos nucleicos
CN109804087A (zh) 2016-08-19 2019-05-24 昆塔波尔公司 使用猝灭剂的基于光学的纳米孔测序
CN110546273A (zh) 2017-03-30 2019-12-06 生命技术公司 通过衔接子序列定量ngs dna
US11559591B2 (en) 2017-05-25 2023-01-24 Memorial Sloan Kettering Cancer Center Ultrasmall nanoparticles labeled with Zirconium-89 and methods thereof
JP7432529B2 (ja) 2018-05-30 2024-02-16 プロメガ コーポレイション 広域スペクトルキナーゼ結合剤
JP2022510437A (ja) 2018-12-04 2022-01-26 プロメガ コーポレイション 広域スペクトルgpcr結合剤
WO2021237118A2 (en) 2020-05-22 2021-11-25 Promega Corporation Enhancement of kinase target engagement
CN115803333A (zh) 2020-07-02 2023-03-14 生命技术公司 三核苷酸帽类似物、其制备和用途
WO2022047186A1 (en) 2020-08-28 2022-03-03 Promega Corporation Target engagement assay for ras proteins
WO2023004400A1 (en) 2021-07-21 2023-01-26 Life Technologies Corporation Dibenzoxanthene quenchers, uses, and methods of preparation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7302561A (de) * 1972-03-01 1973-09-04
CA1095819A (en) * 1977-01-14 1981-02-17 Eastman Kodak Company Element for analysis of liquids
US4297273A (en) * 1978-07-24 1981-10-27 Miles Laboratories, Inc. Chemiluminescent phthalhydrazide-labeled protein and polypeptide conjugates
GB2031949B (en) * 1978-10-16 1983-01-06 American Home Prod Identification of microrganisms
US4409140A (en) * 1979-04-23 1983-10-11 Smith Robert E Substrates and method for determining enzymes
US4294923A (en) * 1979-04-23 1981-10-13 Smith Robert E Substrates and method for determining enzymes
JPH0321160B2 (de) * 1979-05-02 1991-03-22 Nat Res Dev
US4404366A (en) * 1980-05-06 1983-09-13 Miles Laboratories, Inc. Beta-galactosyl-umbelliferone-labeled hapten conjugates
GB2128204B (en) * 1982-04-14 1987-02-25 Unilever Plc Microbiological test processes and apparatus
DE3303871A1 (de) * 1983-02-05 1984-08-09 Bayer Ag, 5090 Leverkusen Fluorogene phosphorsaeureester, verfahren zu deren herstellung sowie verfahren und mittel zum nachweis und zur fluorimetrischen bestimmung von phosphatasen
JPS59192099A (ja) * 1983-04-12 1984-10-31 Ajinomoto Co Inc 微生物菌数の測定法
US4857271A (en) * 1985-02-07 1989-08-15 Eastman Kodak Company Reducible compounds and analytical compositions, elements and methods utilizing same

Also Published As

Publication number Publication date
US4812409A (en) 1989-03-14
CA1336306C (en) 1995-07-11
EP0231125A2 (de) 1987-08-05
DE3781170D1 (de) 1992-09-24
EP0231125B1 (de) 1992-08-19
EP0231125A3 (en) 1989-08-16
JPH0426624B2 (de) 1992-05-07
JPS62215399A (ja) 1987-09-22

Similar Documents

Publication Publication Date Title
DE3781170D1 (de) Hydrolysierbare fluoreszierende substrate und deren verwendung zur analytischen bestimmung.
DE3778293D1 (de) Glaskeramikmassen zur verwendung als dielektrische substrate.
DE3786205D1 (de) Titanocene und deren verwendung.
ATE16820T1 (de) Testelement zur bestimmung von glukose in hoher konzentration.
DE3767755D1 (de) Mikrobiologische entschwefelung von gasen.
DE69119312D1 (de) Analyt-Austauschreagenz zur Verwendung in spezifischen Bindungstests, -vorrichtungen und -sätzen
DE3784199D1 (de) Titanocene und deren verwendung.
DE3787590T2 (de) Polytetrafluoräthylenhaltige Beschichtungsmasse und ihre Verwendung.
DE3765446D1 (de) Uebertragungsmaterial von musterungen.
DE3684679D1 (de) Keramische substrate und verfahren zur herstellung derselben.
DE68924118D1 (de) Hoch-pH-Extraktionszusammensetzung und deren Verwendung zur Bestimmung von Antigenen aus Chlamydia, Gonokokken oder Herpes.
DE3788828T2 (de) Stabilisierte flüssige Enzymzusammensetzung zur Bestimmung von Glucose.
DE68916362T2 (de) Immunologische Reagenz-Zusammensetzung und deren Verwendung zur Bestimmung von chlamydialen oder gonokokkalen Antigenen.
ATA116482A (de) Vorgefertigter naehrbodentraeger zur qualitativen und quantitativen bestimmung von mikroorganismen
BR8701763A (pt) Composicao de revestimento;e substrato
DE267674T1 (de) Zusammensetzungen zur verhinderung von inkrustierungen und deren verwendungen.
PT87809A (pt) Promotoren zur expression von freemd-dna in methylotrophen bakterien deren gewinnung und deren verwendung
IT8647616A0 (it) Bilirubin-ossidasi termostabile eprocedimento per produrla
DE59408245D1 (de) Rollenträger zur Bestimmung von immanenten Kräften
DE3766441D1 (de) Anilinotriazine und deren verwendung.
DE68909995T2 (de) Reagenz zur Bestimmung von Kreatinkinase und Messverfahren dafür.
DE3785086T2 (de) Zubereitung fuer zellkultur und ihre verwendung.
DE68919982T2 (de) Ein Sulfydril enthaltendes Reduktionsmittel enthaltende stabilisierte Extraktionszusammensetzung und deren Verwendung zur Bestimmung von Chlamydia und Gonokokken.
DE69123013T2 (de) Mehrschichtiges analytisches Element zur Bestimmung von Fructosamin
DE266872T1 (de) Zusammensetzungen von gemischten basischen komplexen zur verhinderung von inkrustierungen und deren verwendung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC., ROCH

8328 Change in the person/name/address of the agent

Free format text: STREHL, SCHUEBEL-HOPF, GROENING & PARTNER, 80538 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN

8339 Ceased/non-payment of the annual fee