DE3822459A1 - Wasserunloesliche polypeptide - Google Patents
Wasserunloesliche polypeptideInfo
- Publication number
- DE3822459A1 DE3822459A1 DE3822459A DE3822459A DE3822459A1 DE 3822459 A1 DE3822459 A1 DE 3822459A1 DE 3822459 A DE3822459 A DE 3822459A DE 3822459 A DE3822459 A DE 3822459A DE 3822459 A1 DE3822459 A1 DE 3822459A1
- Authority
- DE
- Germany
- Prior art keywords
- water
- composition according
- pharmaceutical composition
- peptide
- insoluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Description
D-Ser (0-tBu)⁶-des Gly¹⁰-Azgly¹⁰-LHRH-Embonsäuresalz
D-Ser (But)⁶ LHRH (1-9) Ethylamid-Embonsäuresalz
D-Leu⁶-des Gly¹⁰-LHRH Ethylamid-Embonsäuresalz
0,04, (1 hr) 7,74, (6 hrs) 0,80, (Tag 2) 0,85, (Tag 4) 0,77, (Tag 7) 0,25, (Tag 11) 0,12, (Tag 14) 0,11, (Tag 18) 0,11, (Tag 21) 0,14, (Tag 25) 0,18.
Claims (11)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8722134A GB2209937B (en) | 1987-09-21 | 1987-09-21 | Water insoluble polypeptides |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3822459A1 true DE3822459A1 (de) | 1989-03-30 |
DE3822459C2 DE3822459C2 (de) | 1994-07-07 |
Family
ID=10624108
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3822459A Expired - Lifetime DE3822459C2 (de) | 1987-09-21 | 1988-07-04 | Pharmazeutische Zusammensetzung |
DE122004000023C Active DE122004000023I2 (de) | 1987-09-21 | 1988-07-04 | Pharmazeutische Zusammensetzung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE122004000023C Active DE122004000023I2 (de) | 1987-09-21 | 1988-07-04 | Pharmazeutische Zusammensetzung |
Country Status (23)
Country | Link |
---|---|
US (2) | US5192741A (de) |
JP (1) | JPH0713023B2 (de) |
AT (1) | AT397035B (de) |
AU (1) | AU611944B2 (de) |
BE (1) | BE1001685A5 (de) |
CA (1) | CA1326438C (de) |
CH (1) | CH675968A5 (de) |
DE (2) | DE3822459C2 (de) |
DK (1) | DK175311B1 (de) |
ES (1) | ES2009346A6 (de) |
FI (1) | FI96919C (de) |
FR (1) | FR2620621B1 (de) |
GB (1) | GB2209937B (de) |
GR (1) | GR1002244B (de) |
IE (1) | IE60608B1 (de) |
IL (1) | IL87790A (de) |
IT (1) | IT1225148B (de) |
LU (1) | LU87340A1 (de) |
NL (1) | NL193818C (de) |
NO (2) | NO178604C (de) |
PT (1) | PT88557B (de) |
SE (1) | SE503406C2 (de) |
ZA (1) | ZA886827B (de) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4023134A1 (de) * | 1989-07-28 | 1991-01-31 | Debiopharm Sa | Verfahren zur herstellung einer pharmazeutischen zubereitung in form von mikropartikeln |
DE4223284A1 (de) * | 1991-07-22 | 1993-01-28 | Debio Rech Pharma Sa | Verfahren zur herstellung von mikrokugeln aus einem biologisch abbaubaren polymeren material |
DE4223169C1 (de) * | 1992-07-10 | 1993-11-25 | Ferring Arzneimittel Gmbh | Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe |
EP0617966A1 (de) * | 1988-11-01 | 1994-10-05 | Susan P. Perrine | Erhöhung des fetalen Hämoglobins durch Behandlung mit Activin und/oder Inhibin sowie eine Methode zur Invitro Diagnostik |
DE4342092A1 (de) * | 1993-12-09 | 1995-06-14 | Asta Medica Ag | Langwirkende Injektionssuspension und Verfahren zur Herstellung |
WO1998009613A1 (en) * | 1996-09-04 | 1998-03-12 | Romano Deghenghi | Process to manufacture implants containing bioactive peptides |
WO1998032423A1 (en) * | 1997-01-29 | 1998-07-30 | Takeda Chemical Industries, Ltd. | Sustained-release microspheres, their production and use |
US7871977B2 (en) | 2004-12-22 | 2011-01-18 | Zentaris Gmbh | Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments |
Families Citing this family (184)
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PH30995A (en) * | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
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HU221294B1 (en) * | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
US5225205A (en) * | 1989-07-28 | 1993-07-06 | Debiopharm S.A. | Pharmaceutical composition in the form of microparticles |
CH681425A5 (de) * | 1990-11-14 | 1993-03-31 | Debio Rech Pharma Sa | |
US5439688A (en) * | 1989-07-28 | 1995-08-08 | Debio Recherche Pharmaceutique S.A. | Process for preparing a pharmaceutical composition |
EP0423484B1 (de) * | 1989-10-16 | 1993-11-03 | PCD-Polymere Gesellschaft m.b.H. | Pressling mit retardierter Wirkstofffreisetzung |
DE3935736A1 (de) * | 1989-10-27 | 1991-05-02 | Chemie Linz Deutschland | Pressling mit retardierter wirkstofffreisetzung |
CA2046830C (en) * | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
IE912365A1 (en) * | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
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DE4223169C1 (de) * | 1992-07-10 | 1993-11-25 | Ferring Arzneimittel Gmbh | Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe |
US5503851A (en) * | 1992-07-10 | 1996-04-02 | Ferring Arzneimittel Gmbh | Microencapsulation of water-soluble medicaments |
WO1995015767A1 (en) * | 1993-12-09 | 1995-06-15 | Asta Medica Aktiengesellschaft | Long-acting injection suspensions and a process for their preparation |
DE4342092A1 (de) * | 1993-12-09 | 1995-06-14 | Asta Medica Ag | Langwirkende Injektionssuspension und Verfahren zur Herstellung |
DE4342092B4 (de) * | 1993-12-09 | 2007-01-11 | Zentaris Gmbh | Langwirkende Injektionssuspension und Verfahren zur Herstellung |
WO1998009613A1 (en) * | 1996-09-04 | 1998-03-12 | Romano Deghenghi | Process to manufacture implants containing bioactive peptides |
US5945128A (en) * | 1996-09-04 | 1999-08-31 | Romano Deghenghi | Process to manufacture implants containing bioactive peptides |
WO1998032423A1 (en) * | 1997-01-29 | 1998-07-30 | Takeda Chemical Industries, Ltd. | Sustained-release microspheres, their production and use |
US7871977B2 (en) | 2004-12-22 | 2011-01-18 | Zentaris Gmbh | Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments |
US7906479B2 (en) | 2004-12-22 | 2011-03-15 | Zentraris GmbH | Sterile suspensions of slightly soluble basic peptide complexes and pharmaceutical formulations containing them |
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