US5185258A
(en)
*
|
1984-05-29 |
1993-02-09 |
Genencor International, Inc. |
Subtilisin mutants
|
WO1987004461A1
(en)
*
|
1986-01-15 |
1987-07-30 |
Amgen |
THERMALLY STABLE AND pH STABLE SUBTILISIN ANALOGS AND METHOD FOR PRODUCTION THEREOF
|
ES2068181T3
(es)
*
|
1986-04-30 |
1995-04-16 |
Genencor Int |
Mutantes de la carbonil hidrolasa no humana, secuencias de adn y vectores que codifican las mismas y huespedes transformados con dichos vectores.
|
US5260207A
(en)
*
|
1987-04-06 |
1993-11-09 |
Enzon Labs Inc. |
Engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins
|
WO1988008028A1
(en)
*
|
1987-04-06 |
1988-10-20 |
Genex Corporation |
The engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins
|
DK6488D0
(da)
*
|
1988-01-07 |
1988-01-07 |
Novo Industri As |
Enzymer
|
US5324653A
(en)
*
|
1988-02-11 |
1994-06-28 |
Gist-Brocades N.V. |
Recombinant genetic means for the production of serine protease muteins
|
US6287841B1
(en)
|
1988-02-11 |
2001-09-11 |
Genencor International, Inc. |
High alkaline serine protease
|
CN1056187C
(zh)
*
|
1988-02-11 |
2000-09-06 |
金克克国际有限公司 |
新的蛋白水解酶及其在洗涤剂中的应用
|
US5246849A
(en)
*
|
1988-04-12 |
1993-09-21 |
Enzon, Inc. |
Thermally stable serine proteases
|
US5116741A
(en)
*
|
1988-04-12 |
1992-05-26 |
Genex Corporation |
Biosynthetic uses of thermostable proteases
|
US5122449A
(en)
*
|
1988-10-07 |
1992-06-16 |
Eastman Kodak Company |
Use of a protease in the extraction of chlamydial, gonococcal and herpes antigens
|
AU618675B2
(en)
*
|
1989-05-17 |
1992-01-02 |
Amgen, Inc. |
Multiply mutated subtilisins
|
DK316989D0
(da)
*
|
1989-06-26 |
1989-06-26 |
Novo Nordisk As |
Enzymer
|
ES2227508T3
(es)
*
|
1989-06-26 |
2005-04-01 |
Unilever N.V. |
Composiciones detergentes enzimaticas.
|
US5665587A
(en)
*
|
1989-06-26 |
1997-09-09 |
Novo Nordisk A/S |
Modified subtilisins and detergent compositions containing same
|
US5658871A
(en)
*
|
1989-07-07 |
1997-08-19 |
Lever Brothers Company, Division Of Conopco, Inc. |
Microbial lipase muteins and detergent compositions comprising same
|
DE69033388T2
(de)
*
|
1989-08-25 |
2000-05-11 |
Henkel Research Corp |
Alkalisches proteolytisches enzym und verfahren zur herstellung
|
US6271012B1
(en)
*
|
1989-10-11 |
2001-08-07 |
Genencor International, Inc. |
Protease muteins and their use in detergents
|
US5541062A
(en)
*
|
1990-02-23 |
1996-07-30 |
Arch Development Corporation |
Methods and compositions for preparing protein processing enzymes
|
IT1239733B
(it)
*
|
1990-02-23 |
1993-11-15 |
Eniricerche Spa |
Mutanti della proteasi neutra termostabili e mezzi e metodi per la loro preparazione
|
DK271490D0
(da)
*
|
1990-11-14 |
1990-11-14 |
Novo Nordisk As |
Detergentkomposition
|
US5340735A
(en)
*
|
1991-05-29 |
1994-08-23 |
Cognis, Inc. |
Bacillus lentus alkaline protease variants with increased stability
|
EP0995801A1
(de)
*
|
1991-07-27 |
2000-04-26 |
Genencor International GmbH |
Verfahren zur Verbesserung des Stabilität von Enzymen und stabilisierte Enzyme
|
US5399484A
(en)
*
|
1991-10-08 |
1995-03-21 |
Eastman Kodak Company |
Use of blocking protein with high pH extraction in method to determine a microorganism associated with periodontal disease and kit useful therefor
|
US5567601A
(en)
*
|
1993-06-01 |
1996-10-22 |
University Of Maryland |
Subtilisin mutants lacking a primary calcium binding site
|
US5470733A
(en)
*
|
1993-06-01 |
1995-11-28 |
University Of Maryland |
Calcium free subtilisin mutants
|
US6436690B1
(en)
*
|
1993-09-15 |
2002-08-20 |
The Procter & Gamble Company |
BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
|
US6440717B1
(en)
|
1993-09-15 |
2002-08-27 |
The Procter & Gamble Company |
BPN′ variants having decreased adsorption and increased hydrolysis
|
EP0723580B1
(de)
*
|
1993-10-14 |
2003-07-16 |
The Procter & Gamble Company |
Proteasen enthaltende bleichmittelzusammensetzungen
|
US5679630A
(en)
*
|
1993-10-14 |
1997-10-21 |
The Procter & Gamble Company |
Protease-containing cleaning compositions
|
MA23346A1
(fr)
*
|
1993-10-14 |
1995-04-01 |
Genencor Int |
Variantes de la subtilisine
|
WO1995015371A1
(en)
*
|
1993-12-03 |
1995-06-08 |
Buckman Laboratories International, Inc. |
Enzyme stabilization by block-copolymers
|
US6599730B1
(en)
|
1994-05-02 |
2003-07-29 |
Procter & Gamble Company |
Subtilisin 309 variants having decreased adsorption and increased hydrolysis
|
US6066611A
(en)
*
|
1994-10-13 |
2000-05-23 |
The Procter & Gamble Company |
Bleaching compositions comprising protease enzymes
|
US6455295B1
(en)
|
1995-03-08 |
2002-09-24 |
The Procter & Gamble Company |
Subtilisin Carlsberg variants having decreased adsorption and increased hydrolysis
|
US6475765B1
(en)
*
|
1995-03-09 |
2002-11-05 |
Procter & Gamble Company |
Subtilisin DY variants having decreased adsorption and increased hydrolysis
|
IL117350A0
(en)
|
1995-03-09 |
1996-07-23 |
Procter & Gamble |
Proteinase k variants having decreased adsorption and increased hydrolysis
|
ATE510910T1
(de)
|
1996-11-04 |
2011-06-15 |
Novozymes As |
Subtilase-varianten und verbindungen
|
AU4773197A
(en)
|
1996-11-04 |
1998-05-29 |
Novo Nordisk A/S |
Subtilase variants and compositions
|
AU8798198A
(en)
|
1997-08-29 |
1999-03-22 |
Novo Nordisk A/S |
Protease variants and compositions
|
BR9811412A
(pt)
|
1997-08-29 |
2000-08-22 |
Novo Nordisk As |
Variante de enzima subtilase tendo melhorado desempenho de lavagem em detergentes, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, processos para produzir uma variante e para identificar uma variante de protease, composição, e, uso de uma variante de subtilase
|
ES2367505T3
(es)
*
|
1997-10-23 |
2011-11-04 |
Danisco Us Inc. |
Variantes de proteasa con sustituciones múltiples con carga neta alterada para usar en detergentes.
|
US6773907B2
(en)
|
1997-11-21 |
2004-08-10 |
Peter Kamp Hansen |
Subtilase enzymes
|
US6780629B2
(en)
|
1997-11-21 |
2004-08-24 |
Novozymes A/S |
Subtilase enzymes
|
CA2310454C
(en)
|
1997-11-21 |
2012-01-24 |
Novo Nordisk A/S |
Protease variants and compositions
|
KR20010034697A
(ko)
*
|
1998-03-26 |
2001-04-25 |
데이비드 엠 모이어 |
아미노산 치환을 갖는 세린 프로테아제 변이체
|
US6908757B1
(en)
|
1998-03-26 |
2005-06-21 |
The Procter & Gamble Company |
Serine protease variants having amino acid deletions and substitutions
|
US6495136B1
(en)
|
1998-03-26 |
2002-12-17 |
The Procter & Gamble Company |
Proteases having modified amino acid sequences conjugated to addition moieties
|
US6642011B2
(en)
|
1998-04-15 |
2003-11-04 |
Genencor International, Inc. |
Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
|
US6831053B1
(en)
|
1998-10-23 |
2004-12-14 |
The Procter & Gamble Company |
Bleaching compositions comprising multiply-substituted protease variants
|
US6376450B1
(en)
|
1998-10-23 |
2002-04-23 |
Chanchal Kumar Ghosh |
Cleaning compositions containing multiply-substituted protease variants
|
ATE504651T1
(de)
|
1998-12-18 |
2011-04-15 |
Novozymes As |
Subtilase enzyme der i-s1- und i-s2-untergruppen mit einem zusätzlichen aminosäurerest in einer aktiven schleifenregion
|
DE60040285D1
(de)
|
1999-05-20 |
2008-10-30 |
Novozymes As |
Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 127 und 128
|
AU4393000A
(en)
|
1999-05-20 |
2000-12-12 |
Novozymes A/S |
Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 128 and 129
|
AU4392700A
(en)
|
1999-05-20 |
2000-12-12 |
Novozymes A/S |
Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 129 and 130
|
WO2000071685A1
(en)
|
1999-05-20 |
2000-11-30 |
Novozymes A/S |
Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 132 and 133
|
ATE407201T1
(de)
|
1999-05-20 |
2008-09-15 |
Novozymes As |
Subtilase-enzyme der i-s1 und i-s2 untergruppen mit wenigstens einem zusätzlichen aminosäurerest zwischen positionen 126 und 127
|
AU4393100A
(en)
|
1999-05-20 |
2000-12-12 |
Novozymes A/S |
Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 125 and 126
|
US6946128B1
(en)
|
1999-07-22 |
2005-09-20 |
The Procter & Gamble Company |
Protease conjugates having sterically protected epitope regions
|
CZ2002171A3
(cs)
|
1999-07-22 |
2002-06-12 |
The Procter & Gamble Company |
Proteinázový konjugát, čistící prostředek a prostředek osobní péče
|
CZ2002212A3
(cs)
|
1999-07-22 |
2002-07-17 |
The Procter & Gamble Company |
Varianty subtilisinové proteasy mající aminokyselinové substituce v definovaných epitopových oblastech
|
AU5928100A
(en)
*
|
1999-07-22 |
2001-02-13 |
Procter & Gamble Company, The |
Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions
|
US6727085B2
(en)
*
|
1999-12-15 |
2004-04-27 |
Fanoe Tina Sejersgaard |
Subtilase variants having an improved wash performance on egg stains
|
US6777218B1
(en)
|
2000-03-14 |
2004-08-17 |
Novozymes A/S |
Subtilase enzymes having an improved wash performance on egg stains
|
WO2002010183A1
(en)
*
|
2000-07-31 |
2002-02-07 |
Menzel, Rolf |
Compositions and methods for directed gene assembly
|
US6541234B1
(en)
*
|
2000-09-11 |
2003-04-01 |
University Of Maryland Biotechnology Institute |
Calcium free subtilisin mutants
|
US6541235B1
(en)
*
|
2000-09-29 |
2003-04-01 |
University Of Maryland Biotechnology Institute |
Calcium free subtilisin mutants
|
CN100404673C
(zh)
|
2001-02-19 |
2008-07-23 |
默克专利有限公司 |
鉴定t细胞表位的方法及制备具有降低的免疫原性的分子的用途
|
US6929939B2
(en)
*
|
2001-03-23 |
2005-08-16 |
Genencor International, Inc. |
Proteins producing an altered immunogenic response and methods of making and using the same
|
DE10163884A1
(de)
|
2001-12-22 |
2003-07-10 |
Henkel Kgaa |
Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
|
WO2003062380A2
(en)
*
|
2002-01-16 |
2003-07-31 |
Genencor International, Inc. |
Multiply-substituted protease variants
|
JP4680512B2
(ja)
|
2002-03-29 |
2011-05-11 |
ジェネンコー・インターナショナル・インク |
バチルスにおけるタンパク質発現の増大
|
US7294499B2
(en)
|
2003-01-30 |
2007-11-13 |
Novozymes A/S |
Subtilases
|
ATE407202T1
(de)
*
|
2003-05-07 |
2008-09-15 |
Novozymes As |
Enzymvarianten von subtilisin (subtilasen)
|
WO2005040372A1
(en)
|
2003-10-23 |
2005-05-06 |
Novozymes A/S |
Protease with improved stability in detergents
|
DE10360805A1
(de)
|
2003-12-23 |
2005-07-28 |
Henkel Kgaa |
Neue Alkalische Protease und Wasch- und Reinigungsmittel, enthaltend diese neue Alkalische Protease
|
EP2305821A3
(de)
*
|
2004-02-13 |
2011-04-13 |
Novozymes A/S |
Proteasevarianten
|
JP2007532114A
(ja)
*
|
2004-04-09 |
2007-11-15 |
ジェネンコー・インターナショナル・インク |
バチルスにおけるpckA修飾および増強されたタンパク質発現
|
DE102004019751A1
(de)
|
2004-04-23 |
2005-11-17 |
Henkel Kgaa |
Neue Alkalische Proteasen und Wasch- und Reinigungsmittel, enthaltend diese neuen Alkalischen Proteasen
|
KR100750659B1
(ko)
*
|
2005-02-18 |
2007-08-20 |
인하대학교 산학협력단 |
계면활성제 및 산화제에 매우 안정한 호염, 호알카리성 단백질 분해효소 및 이를 암호화하는 유전자
|
PT2007942E
(pt)
|
2006-04-14 |
2014-10-07 |
Danisco Us Inc |
Tratamento de têxteis num passo
|
CN101460618A
(zh)
|
2006-04-20 |
2009-06-17 |
诺维信公司 |
对蛋渍具有改进的洗涤性能的洒维奈斯变体
|
US20080090745A1
(en)
*
|
2006-10-13 |
2008-04-17 |
Fox Bryan P |
Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp.
|
JP5867984B2
(ja)
|
2007-03-12 |
2016-02-24 |
ダニスコ・ユーエス・インク |
修飾プロテアーゼ
|
CN101675160A
(zh)
|
2007-04-30 |
2010-03-17 |
丹尼斯科美国公司 |
蛋白质水解产物稳定金属蛋白酶洗涤剂制剂的用途
|
DK2152732T3
(da)
|
2007-05-10 |
2012-06-04 |
Danisco Us Inc |
Modificeret sekretionssystem til at øge ekspression af polypeptider i bakterier
|
SG148934A1
(en)
|
2007-06-11 |
2009-01-29 |
Novozymes As |
A process for combined biopolishing and bleach clean-up
|
DE102007032111B4
(de)
|
2007-07-09 |
2017-07-20 |
Henkel Ag & Co. Kgaa |
Neue Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen
|
DE102007036756A1
(de)
|
2007-08-03 |
2009-02-05 |
Henkel Ag & Co. Kgaa |
Neue Proteasen und Wasch- und Reinigungsmittel, enthaltend diese neuen Proteasen
|
DE102007051092A1
(de)
*
|
2007-10-24 |
2009-04-30 |
Henkel Ag & Co. Kgaa |
Subtilisin aus Becillus pumilus und Wasch- und Reinigungsmittel enthaltend dieses neue Subtilisin
|
JP5629584B2
(ja)
|
2007-12-21 |
2014-11-19 |
ダニスコ・ユーエス・インク |
バチルス内での促進されたタンパク質生成
|
MX2010010310A
(es)
*
|
2008-03-28 |
2010-10-08 |
Danisco Us Inc |
Metodo para amplificar un locus en una celula bacteriana.
|
EP2947147A3
(de)
*
|
2008-06-06 |
2015-12-23 |
Danisco US Inc. |
Zusammensetzungen und verfahren mit mikrobiellen proteasevarianten
|
AR076941A1
(es)
|
2009-06-11 |
2011-07-20 |
Danisco Us Inc |
Cepa de bacillus para una mayor produccion de proteina
|
US20130224757A1
(en)
|
2010-08-19 |
2013-08-29 |
Novozymes A/S |
Induced sporulation screening method
|
MX2014006205A
(es)
*
|
2011-11-25 |
2014-07-14 |
Novozymes As |
Variantes de subtilasa y polinucleotidos que las codifican.
|
JP6585602B2
(ja)
|
2013-12-31 |
2019-10-02 |
ダニスコ・ユーエス・インク |
タンパク質発現の増大
|
US10626388B2
(en)
|
2014-07-04 |
2020-04-21 |
Novozymes A/S |
Subtilase variants and polynucleotides encoding same
|
JP7012533B2
(ja)
|
2014-12-16 |
2022-02-14 |
ダニスコ・ユーエス・インク |
タンパク質発現の増強
|
CN107278230B
(zh)
|
2014-12-19 |
2021-10-29 |
丹尼斯科美国公司 |
增强的蛋白质表达
|
KR102375732B1
(ko)
|
2017-02-24 |
2022-03-16 |
다니스코 유에스 인크. |
바실러스 리체니포르미스에서 단백질 생산을 증가시키기 위한 조성물 및 방법
|
US11879127B2
(en)
|
2017-08-23 |
2024-01-23 |
Danisco Us Inc. |
Methods and compositions for efficient genetic modifications of Bacillus licheniformis strains
|
WO2019055261A1
(en)
|
2017-09-13 |
2019-03-21 |
Danisco Us Inc |
MODIFIED 5 'NON-TRANSLATED REGION (UTR) SEQUENCES FOR INCREASED PROTEIN PRODUCTION IN BACILLUS
|
WO2019089898A1
(en)
|
2017-11-02 |
2019-05-09 |
Danisco Us Inc |
Freezing point depressed solid matrix compositions for melt granulation of enzymes
|
JP7280269B2
(ja)
|
2018-01-03 |
2023-05-23 |
ダニスコ・ユーエス・インク |
タンパク質の産生増加のための変異及び遺伝子改変バチルス属(bacillus)細胞、並びにその方法
|
WO2020099490A1
(en)
|
2018-11-14 |
2020-05-22 |
Novozymes A/S |
Oral care composition comprising enzymes
|
JP2023524334A
(ja)
|
2020-01-15 |
2023-06-12 |
ダニスコ・ユーエス・インク |
バチルス・リケニフォルミス(bacillus licheniformis)における強化したタンパク質産生のための組成物及び方法
|
US20230332124A1
(en)
|
2020-08-24 |
2023-10-19 |
Novozymes A/S |
Oral care composition comprising a fructanase
|
CN117881772A
(zh)
|
2021-08-20 |
2024-04-12 |
丹尼斯科美国公司 |
编码新型核酸酶的多核苷酸、其组合物及其从蛋白质制剂中消除dna的方法
|