DE3866010D1 - Mit einer phenylgruppe und einer heterobicyclischen gruppe disubstituierte acetylene mit retinoidaehnlicher wirkung. - Google Patents

Mit einer phenylgruppe und einer heterobicyclischen gruppe disubstituierte acetylene mit retinoidaehnlicher wirkung.

Info

Publication number
DE3866010D1
DE3866010D1 DE8888302703T DE3866010T DE3866010D1 DE 3866010 D1 DE3866010 D1 DE 3866010D1 DE 8888302703 T DE8888302703 T DE 8888302703T DE 3866010 T DE3866010 T DE 3866010T DE 3866010 D1 DE3866010 D1 DE 3866010D1
Authority
DE
Germany
Prior art keywords
retinoid
group
disubstituted
acetylene
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888302703T
Other languages
English (en)
Inventor
Roshantha A S Chandraratna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of DE3866010D1 publication Critical patent/DE3866010D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
DE8888302703T 1987-03-26 1988-03-25 Mit einer phenylgruppe und einer heterobicyclischen gruppe disubstituierte acetylene mit retinoidaehnlicher wirkung. Expired - Fee Related DE3866010D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/031,476 US4810804A (en) 1987-03-26 1987-03-26 Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid-like activity

Publications (1)

Publication Number Publication Date
DE3866010D1 true DE3866010D1 (de) 1991-12-12

Family

ID=21859663

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888302703T Expired - Fee Related DE3866010D1 (de) 1987-03-26 1988-03-25 Mit einer phenylgruppe und einer heterobicyclischen gruppe disubstituierte acetylene mit retinoidaehnlicher wirkung.

Country Status (22)

Country Link
US (1) US4810804A (de)
EP (1) EP0290130B1 (de)
JP (1) JP2820690B2 (de)
KR (1) KR960016543B1 (de)
CN (1) CN1032204C (de)
AT (1) ATE69224T1 (de)
AU (1) AU613608B2 (de)
CA (1) CA1314891C (de)
DE (1) DE3866010D1 (de)
DK (1) DK156588A (de)
ES (1) ES2038752T3 (de)
FI (1) FI92485C (de)
GR (1) GR3003556T3 (de)
HU (1) HU201041B (de)
IE (1) IE62775B1 (de)
IL (1) IL85795A (de)
MY (1) MY103250A (de)
NO (1) NO171636C (de)
NZ (1) NZ224009A (de)
PH (1) PH27108A (de)
PT (1) PT86976B (de)
ZA (1) ZA881516B (de)

Families Citing this family (94)

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US5089509A (en) * 1988-09-15 1992-02-18 Allergan, Inc. Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
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US4895868A (en) * 1988-06-29 1990-01-23 Allergan, Inc. Thiochroman esters of phenols and terephthallates having retinoid-like activity
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US5183827A (en) * 1989-09-19 1993-02-02 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity
US5399561A (en) * 1989-09-19 1995-03-21 Allergan, Inc. Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-oxochromanyl, 2-oxothiochromanyl or 2-oxo-1,2,3,4-tetrahydro-quinolinyl group having retinoid-like biological activity
US5162546A (en) * 1989-09-19 1992-11-10 Allergan, Inc. Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity
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US5175185A (en) * 1989-12-29 1992-12-29 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and a substituted phenyl group having retinoid like activity
US5202471A (en) * 1990-02-06 1993-04-13 Allergan, Inc. Alkyl, alkoxy and thioalkoxy substituted diphenyl acetylenes having retinoid like activity
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JP3062248B2 (ja) * 1991-02-13 2000-07-10 アラーガン、インコーポレイテッド レチノイド様生物学的活性を有する７位にフェニルエチニル置換基を有するクロマンおよびチオクロマン
IE920949A1 (en) * 1991-03-26 1992-10-07 Allergan Inc Chromans and thiochromans with heteroarylethynyl¹substituents at the 7-position having retinoid-like¹biological activity
US5134159A (en) * 1991-03-26 1992-07-28 Allergan, Inc. 7-chromanyl esters of phenols and benzoic acids having retinoid-like activity
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Also Published As

Publication number Publication date
GR3003556T3 (de) 1993-03-16
PH27108A (en) 1993-03-16
NO881326D0 (no) 1988-03-25
NO881326L (no) 1988-09-27
CN1032204C (zh) 1996-07-03
IE62775B1 (en) 1995-02-22
DK156588D0 (da) 1988-03-22
IL85795A (en) 1992-08-18
NZ224009A (en) 1990-04-26
NO171636B (no) 1993-01-04
MY103250A (en) 1993-05-29
JPS63264578A (ja) 1988-11-01
CN1031230A (zh) 1989-02-22
KR880011138A (ko) 1988-10-26
US4810804A (en) 1989-03-07
ES2038752T3 (es) 1993-08-01
PT86976B (pt) 1992-06-30
FI92485B (fi) 1994-08-15
PT86976A (pt) 1988-04-01
IL85795A0 (en) 1988-09-30
KR960016543B1 (ko) 1996-12-14
DK156588A (da) 1988-09-27
AU1373288A (en) 1988-09-29
AU613608B2 (en) 1991-08-08
EP0290130B1 (de) 1991-11-06
FI92485C (fi) 1994-11-25
IE880907L (en) 1988-09-26
HUT50153A (en) 1989-12-28
NO171636C (no) 1993-04-14
HU201041B (en) 1990-09-28
JP2820690B2 (ja) 1998-11-05
ATE69224T1 (de) 1991-11-15
FI881446A (fi) 1988-09-27
CA1314891C (en) 1993-03-23
EP0290130A1 (de) 1988-11-09
ZA881516B (en) 1989-01-25
FI881446A0 (fi) 1988-03-25

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