DE3877811T2 - Pasteurisierbares, lyophilisierbares blutsurrogat auf haemoglobinbasis. - Google Patents

Pasteurisierbares, lyophilisierbares blutsurrogat auf haemoglobinbasis.

Info

Publication number
DE3877811T2
DE3877811T2 DE8888304059T DE3877811T DE3877811T2 DE 3877811 T2 DE3877811 T2 DE 3877811T2 DE 8888304059 T DE8888304059 T DE 8888304059T DE 3877811 T DE3877811 T DE 3877811T DE 3877811 T2 DE3877811 T2 DE 3877811T2
Authority
DE
Germany
Prior art keywords
hemosafe
derived
hemoglobin
human
hemosafes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888304059T
Other languages
English (en)
Other versions
DE3877811D1 (de
Inventor
Jen-Chang Hsia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minister of National Defence of Canada
UK Government
Original Assignee
Minister of National Defence of Canada
UK Government
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minister of National Defence of Canada, UK Government filed Critical Minister of National Defence of Canada
Application granted granted Critical
Publication of DE3877811D1 publication Critical patent/DE3877811D1/de
Publication of DE3877811T2 publication Critical patent/DE3877811T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
DE8888304059T 1987-05-05 1988-05-05 Pasteurisierbares, lyophilisierbares blutsurrogat auf haemoglobinbasis. Expired - Lifetime DE3877811T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878710598A GB8710598D0 (en) 1987-05-05 1987-05-05 Hemoglobin based blood substitute

Publications (2)

Publication Number Publication Date
DE3877811D1 DE3877811D1 (de) 1993-03-11
DE3877811T2 true DE3877811T2 (de) 1993-05-27

Family

ID=10616838

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888304059T Expired - Lifetime DE3877811T2 (de) 1987-05-05 1988-05-05 Pasteurisierbares, lyophilisierbares blutsurrogat auf haemoglobinbasis.

Country Status (15)

Country Link
US (2) US4857636A (de)
EP (1) EP0290252B1 (de)
JP (1) JPS63297330A (de)
KR (1) KR910009343B1 (de)
CN (1) CN1032471C (de)
AT (1) ATE84970T1 (de)
AU (1) AU610883B2 (de)
CA (1) CA1306583C (de)
DE (1) DE3877811T2 (de)
DK (1) DK174286B1 (de)
ES (1) ES2053729T3 (de)
GB (1) GB8710598D0 (de)
IL (1) IL86258A (de)
NZ (1) NZ224479A (de)
ZA (1) ZA883171B (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5854209A (en) * 1995-03-23 1998-12-29 Biopure Corporation Method for oxygenating tissue having reduced red blood cell flow
EP0277289B8 (de) * 1986-11-10 2003-05-21 Biopure Corporation Hochreines, halbsynthetisches Blutsurrogat
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US5189146A (en) * 1987-05-05 1993-02-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Pasteurizable, freeze-driable hemoglobin-based blood substitute
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5844090A (en) * 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
US5386014A (en) * 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
ES2086532T3 (es) * 1989-12-29 1996-07-01 Univ Texas Tech Polihemoglobina esterilizada por derivados de la purina y glutation.
CA2078141C (en) * 1990-03-14 1996-10-08 Ronald H. Kluger Acyl phosphate esters and modification of proteins therewith
US5248766A (en) * 1990-08-17 1993-09-28 Baxter International Inc. Oxirane-modified hemoglobin based composition
WO1992008478A1 (en) * 1990-11-20 1992-05-29 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
PL167340B1 (pl) * 1990-11-29 1995-08-31 Upjohn Co Sposób wytwarzania usieciowanej hemoglobiny PL
CA2103680C (en) * 1991-02-12 1999-11-23 Mario Feola Improved blood substitute
US5250665A (en) * 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
GB9617611D0 (en) * 1996-08-22 1996-10-02 Vasogen Inc Treatment of autoimmune disease
US5591457A (en) * 1992-02-07 1997-01-07 Vasogen Inc Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
US6669965B2 (en) 1992-02-07 2003-12-30 Vasogen Ireland Limited Method of treating atherosclerosis
US5646252A (en) * 1992-02-10 1997-07-08 Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid Hemoglobin composition and preparation thereof
US5399671A (en) * 1992-11-18 1995-03-21 Kluger; Ronald Specifically crosslinked hemoglobin with free functionality
CA2131455C (en) * 1993-03-16 1998-08-18 Diana Pliura Selective crosslinking of hemoglobin by oxidized, ring-opened saccharides
EP0804244A1 (de) * 1993-03-26 1997-11-05 Biorelease Technologies, Inc. Häm-proteine enthaltende zusammensetzungen und dazu gehörende methoden
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5578564A (en) * 1993-07-23 1996-11-26 Somatogen, Inc. Nickel-free hemoglobin and methods for producing such hemoglobin
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
CA2135739C (en) * 1994-11-14 1997-10-21 Felice D'agnillo Hemoglobin-enzyme complexes
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US5895810A (en) * 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US5691452A (en) * 1995-03-23 1997-11-25 Biopure Corporation Method for preserving a hemoglobin blood substitute
US5691453A (en) * 1995-06-07 1997-11-25 Biopure Corporation Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC
US5865784A (en) * 1995-06-07 1999-02-02 Alliance Pharmaceutical Corp. Method of hemodilution facilitated by monitoring oxygenation status
US5952470A (en) * 1995-06-07 1999-09-14 Biopure Corporation Method for separating unmodified hemoglobin from cross-linked hemoglobin
CA2229408A1 (en) * 1995-09-11 1997-03-20 Jeroen Joost Valentijn Tahey Spray-drying haemoglobin
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
AU1946397A (en) * 1996-03-15 1997-10-01 Staat Der Nederlanden, De Minister Van Defensie Methods for producing hemoglobin preparations and preparations obtainable thereby
US5917020A (en) * 1997-01-15 1999-06-29 Kluger; Ronald H. Bis-tetrameric hemoglobin and reagents for its production
US6358678B1 (en) 1998-02-11 2002-03-19 The United States Of America As Represented By The Secretary Of The Navy Applications of reversible crosslinking and co-treatment in stabilization and viral inactivations of erythrocytes
US6436705B1 (en) 1997-02-18 2002-08-20 The United States Of America As Represented By The Secretary Of The Navy Shape stabilized erythrocytes
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6054427A (en) * 1997-02-28 2000-04-25 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
CA2233725A1 (en) 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes
DE10031740A1 (de) * 2000-06-29 2002-02-14 Sanguibio Tech Ag Künstliche Sauerstoffträger aus vernetztem modifizierten Human- oder Schweinehämoglobin mit verbesserten Eigenschaften, Verfahren zu ihrer technisch einfachen Herstellung aus gereinigtem Material in hohen Ausbeuten, sowie deren Verwendung
DE10031744A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Mit Blutplasma verträgliche, vernetzte und mit Polyalkylenoxiden konjugierte Säugetierhämoglobine als künstliche medizinische Sauerstoffträger, ihre Herstellung und ihre Verwendung
DE10031741A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Einen Sauerstoffträger, ausgewählt aus Hämoglobin oder Hämoglobin- und Myoglobin-enthaltende Zubereitung als Externum zur natürlichen Regeneration der Haut bei Sauerstoff-Mangel
DE10031742A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Verfahren zur Herstellung künstlicher Sauerstoffträger aus kovalent vernetzten Hämoglobinen mit verbesserten funktionellen Eigenschaften durch Vernetzung in Anwesenheit chemisch nicht reagierender Effektoren der Sauerstoffaffinität der Hämoglobine
CA2319966A1 (en) * 2000-09-19 2002-03-19 Dextro-Sang Corporation Improved dextran-hemoglobin conjugate as potential blood substitute
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6518010B2 (en) * 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
US6884228B2 (en) * 2001-03-06 2005-04-26 Baxter International Inc. Automated system adaptable for use with different fluid circuits
US6808503B2 (en) * 2001-03-06 2004-10-26 Baxter International Inc. Automated system and method for pre-surgical blood donation and fluid replacement
AU2002254646B2 (en) 2001-04-18 2008-05-15 Northfield Laboratories, Inc. Flexible container system for storage of stabilized hemoglobin solutions
JP4416356B2 (ja) * 2001-07-10 2010-02-17 克博 山本 食肉・食肉加工品退色防止方法
EP1469811A4 (de) * 2002-01-11 2006-01-04 Sangart Inc Verfahren und zusammensetzungen für den sauerstofftransport mit modifiziertem hämoglobin in plasma
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
EP1472280A4 (de) * 2002-01-11 2005-09-21 Sangart Inc Verfahren und zusammen setzungen zum sauerstofftransport, umfassend einen sauerstoffträger und ein kristalloid in einer hypertonen lösung
US20030153491A1 (en) 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
SI1465643T1 (sl) 2002-01-11 2008-06-30 Sangart Inc Postopki in sestavki za transport kisika z visokoafiniteto za kisik
US7001715B2 (en) * 2002-02-28 2006-02-21 Biopure Corporation Purification of red blood cells by separation and diafiltration
IL149611A (en) * 2002-05-13 2011-07-31 Safetin Ltd Method for extended storage of viable and pathogen-safe blood and blood components using carbon monoxide
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
US20040072729A1 (en) * 2002-10-10 2004-04-15 Sunbio Inc. High oxygen affinity PEG-hemoglobin as treatment for brain stroke
EP1592437A4 (de) * 2003-01-29 2007-12-26 Northfield Lab Polymerisierte hämoglobin-lösungen mit verringerter tetramer-menge und herstellungsverfahren
MX2007002187A (es) * 2004-08-31 2007-10-08 Sangart Inc Metodos para mejorar la estabilidad hemodinamica utilizando composiciones que contienen oxigeno.
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
JP2009524436A (ja) * 2006-01-24 2009-07-02 ノースフィールド ラボラトリーズ、インコーポレイテッド 重合したヘモグロビンの培地、並びに島細胞の単離及び移植におけるその使用
US7759306B2 (en) * 2006-05-16 2010-07-20 Simoni Jan S Methods of treating acute blood loss
US10172949B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
US10172950B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
PT2440239T (pt) 2009-06-09 2017-10-19 Prolong Pharmaceuticals Llc Composições de hemoglobina
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US20110319858A1 (en) * 2010-06-23 2011-12-29 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical compositions and the use thereof
EP2550973B1 (de) * 2011-07-23 2013-08-28 SastoMed GmbH Wundspray
US20150094267A1 (en) 2012-04-03 2015-04-02 Kim D. Vandegriff Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins
US10821158B2 (en) 2013-03-15 2020-11-03 William Schindler Polyalkylene oxide valerate hemoglobin conjugates
WO2014179793A1 (en) 2013-05-03 2014-11-06 Washington University Blood substitute composition and method of use
CN103387613B (zh) * 2013-08-02 2016-12-28 西北大学 一种血红蛋白及血红蛋白氧载体病毒灭活的方法
WO2021072194A1 (en) * 2019-10-11 2021-04-15 Medical Technology Associates Ii, Inc. Stabilized hemoglobin compositions and pharmaceutical formulations thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049673A (en) * 1971-06-08 1977-09-20 Israel Herbert Scheinberg Preparation of ferrous hemoglobin and enzymatic digestion products thereof active for absorption of carbon monoxide
US3925344A (en) * 1973-04-11 1975-12-09 Community Blood Council Plasma protein substitute
DE2449885C3 (de) * 1974-10-21 1980-04-30 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release
FR2387658A1 (fr) * 1977-03-25 1978-11-17 Ciba Geigy Ag Procede pour combattre les microorganismes
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
DE3130770C2 (de) * 1981-08-04 1986-06-19 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Gewinnung von hepatitissicheren, sterilen, pyrogenfreien und stromafreien Hämoglobinlösungen
US4473496A (en) * 1981-09-14 1984-09-25 The United States Of America As Represented By The Secretary Of The Army Intramolecularly crosslinked hemoglobin
SE451542B (sv) * 1982-08-23 1987-10-19 Rationell Golftrening Hb Utslagsanordning for golftrening
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
AU2965284A (en) * 1983-05-04 1984-11-19 Tye, R.W. Modified crosslinked stroma-free tetrameric hemoglobin
US4764369A (en) * 1983-07-14 1988-08-16 New York Blood Center Inc. Undenatured virus-free biologically active protein derivatives
DE3330770A1 (de) * 1983-08-26 1985-03-14 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von humanplasma
JPS60258126A (ja) * 1984-06-02 1985-12-20 Teruo Tomota 重合化ヘモグロビンの製造方法
US4600531A (en) * 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
NL8403425A (nl) * 1984-11-09 1986-06-02 Stichting Gastransport Stromavrije hemoglobine-oplossing, werkwijze voor de bereiding daarvan en toepassing daarvan.
US4584130A (en) * 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
US4863964A (en) * 1985-07-02 1989-09-05 Biomedical Frontiers, Inc. Method for the stabilization of deferoxamine to chelate free ions in physiological fluid
EP0277289B8 (de) * 1986-11-10 2003-05-21 Biopure Corporation Hochreines, halbsynthetisches Blutsurrogat
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US5069936A (en) * 1987-06-25 1991-12-03 Yen Richard C K Manufacturing protein microspheres

Also Published As

Publication number Publication date
IL86258A (en) 1994-11-28
KR910009343B1 (ko) 1991-11-12
EP0290252B1 (de) 1993-01-27
AU1563588A (en) 1988-11-10
AU610883B2 (en) 1991-05-30
CN1032471C (zh) 1996-08-07
DK242888A (da) 1988-11-06
DK242888D0 (da) 1988-05-04
DK174286B1 (da) 2002-11-11
JPH0532372B2 (de) 1993-05-14
EP0290252A2 (de) 1988-11-09
CA1306583C (en) 1992-08-18
KR880013571A (ko) 1988-12-21
GB8710598D0 (en) 1987-06-10
DE3877811D1 (de) 1993-03-11
CN1030425A (zh) 1989-01-18
ES2053729T3 (es) 1994-08-01
NZ224479A (en) 1991-04-26
ZA883171B (en) 1989-03-29
ATE84970T1 (de) 1993-02-15
IL86258A0 (en) 1988-11-15
JPS63297330A (ja) 1988-12-05
US4857636A (en) 1989-08-15
US5364932A (en) 1994-11-15
EP0290252A3 (en) 1989-01-18

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