DE3888357T2 - Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. - Google Patents

Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.

Info

Publication number: DE3888357T2
Authority: DE; Germany
Prior art keywords: carry; amino acid; modified amino; cyclosporin derivatives; cyclosporin
Prior art date: 1987-06-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE3888357T

Other languages

English (en)

Other versions

DE3888357D1 (de

Inventor

Arthur A Patchett

Raymond F White

Robert T Goegelman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-22

Filing date

1988-12-12

Publication date

1994-09-15

1988-12-12 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1994-04-14 Application granted granted Critical

1994-04-14 Publication of DE3888357D1 publication Critical patent/DE3888357D1/de

1994-09-15 Publication of DE3888357T2 publication Critical patent/DE3888357T2/de

2008-12-13 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

DE3888357T 1987-06-22 1988-12-12 Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. Expired - Fee Related DE3888357T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US6467487A	1987-06-22	1987-06-22
EP88202845A EP0373260B1 (de)	1987-06-22	1988-12-12	Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen
US31126789A	1989-02-16	1989-02-16
US63078690A	1990-12-21	1990-12-21
US80921391A	1991-12-16	1991-12-16

Publications (2)

Publication Number	Publication Date
DE3888357D1 DE3888357D1 (de)	1994-04-14
DE3888357T2 true DE3888357T2 (de)	1994-09-15

Family

ID=39710817

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE3888357T Expired - Fee Related DE3888357T2 (de)	1987-06-22	1988-12-12	Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.

Country Status (3)

Country	Link
US (1)	US5318901A (de)
EP (1)	EP0373260B1 (de)
DE (1)	DE3888357T2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69124459T3 (de) *	1990-11-02	2001-05-31	Novartis Ag	Zyklosporine
ES2181734T3 (es) *	1990-11-20	2003-03-01	Dade Behring Marburg Gmbh	Ensayo inmunologico de ciclosporina.
US6334997B1 (en)	1994-03-25	2002-01-01	Isotechnika, Inc.	Method of using deuterated calcium channel blockers
ATE372966T1 (de) *	1994-03-25	2007-09-15	Isotechnika Inc	Verbesserung der effektivität von arzneimitteln duren deuterierung
KR0126610B1 (ko) *	1994-10-18	1997-12-29	김충환	고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법
US5747330A (en) *	1996-06-05	1998-05-05	Poli Industria Chimica	Antibiotic producing microbe
NZ502362A (en)	1997-10-08	2001-05-25	Isotechnika Inc	Deuterated cyclosporine A derivatives and their use as immunomodulating agents
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
ES2326040T3 (es)	2001-10-19	2009-09-29	Isotechnika Inc.	Sintesis de analogos de ciclosporina.
KR100512019B1 (ko) *	2002-07-25	2005-09-02	신득용	사이클로스포린 ａ 또는 이의 유도체를 이용한 세포의노화를 억제하는 방법 및 배양배지
KR100641295B1 (ko) *	2002-11-11	2006-10-31	김성수	사이클로필린의 항산화제로서의 용도 및 사이클로필린의과발현에 의해 세포이식에서 사이클로스포린 ａ에 의해유발되는 세포독성의 방지
EP1603512A2 (de) *	2003-03-17	2005-12-14	Albany Molecular Research, Inc.	Neue cyclosporine
EP1809656A4 (de) *	2004-09-29	2009-03-25	Amr Technology Inc	Cyclosporinalkinanaloga und deren pharmazeutische anwendungen
US7511013B2 (en) *	2004-09-29	2009-03-31	Amr Technology, Inc.	Cyclosporin analogues and their pharmaceutical uses
JP2008515886A (ja) *	2004-10-06	2008-05-15	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
US7696166B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
WO2012079172A1 (en)	2010-12-15	2012-06-21	Isotechnika Pharma Inc.	Cyclosporine analogue molecules modified at amino acid 1 and 3
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (de) *	1975-11-04	1979-12-28	Sandoz Ag
US4210581A (en) *	1975-11-04	1980-07-01	Sandoz Ltd.	Organic compounds
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
US4102877A (en) *	1976-07-28	1978-07-25	Merck & Co., Inc.	Cyclization of peptides
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv) *	1978-10-18	1987-02-16	Sandoz Ag	Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) *	1980-02-14	1983-08-02	Sandoz Ltd.	Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4384996A (en) *	1981-01-09	1983-05-24	Sandoz Ltd.	Novel cyclosporins
CH667274A5 (de) *	1984-03-23	1988-09-30	Sandoz Ag	Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
GB8422253D0 (en) *	1984-09-04	1984-10-10	Sandoz Ltd	Organic compounds
ATE78040T1 (de) *	1985-01-16	1992-07-15	Ciba Geigy Ag	Oligopeptide sowie zwischenprodukte und verfahren zu ihrer herstellung.
EP0194972B1 (de) *	1985-03-11	1992-07-29	Sandoz Ag	Cyclosporine
US4798823A (en) *	1987-06-03	1989-01-17	Merck & Co., Inc.	New cyclosporin analogs with modified "C-9 amino acids"
GB2206119B (en) *	1987-06-22	1990-10-31	Merck & Co Inc	A new cyclosporin derivative with modified "8-amino acid"

1988
- 1988-12-12 EP EP88202845A patent/EP0373260B1/de not_active Expired - Lifetime
- 1988-12-12 DE DE3888357T patent/DE3888357T2/de not_active Expired - Fee Related
1992
- 1992-07-10 US US07/911,433 patent/US5318901A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0373260B1 (de)	1994-03-09
US5318901A (en)	1994-06-07
DE3888357D1 (de)	1994-04-14
EP0373260A1 (de)	1990-06-20

Legal Events

Date	Code	Title	Description
1995-04-06	8364	No opposition during term of opposition
2003-10-09	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE3888357T2 (de)	1994-09-15	Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
DE68915207T2 (de)	1994-08-18	Aminosäure-Derivate.
DE68914619T2 (de)	1994-07-21	Verabreichungssystem für eine zusammensetzung.
NO901399L (no)	1990-10-01	Aminosyrederivater.
NO903832L (no)	1991-03-05	Aminosyrederivater.
NO884434D0 (no)	1988-10-05	Aminosyrederivater.
NO884333L (no)	1989-03-31	1,4-dihydropyridiner.
NO901533L (no)	1990-10-08	Aminosyrederivater.
DE68913498T2 (de)	1994-06-09	1,1-dioxo-cephem-4-carbothiolsäure-derivate.
DE3887281D1 (de)	1994-03-03	1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
FI880552A0 (fi)	1988-02-08	Substituerade 2,6-substituerade pyridinfoereningar.
FI881829A0 (fi)	1988-04-19	1,3-dioxaner.
NO892728L (no)	1990-01-02	Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler.
DE3886959T2 (de)	1994-05-11	1,2-Propandiolderivate.
DE3888097D1 (de)	1994-04-07	1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
DE3780156D1 (de)	1992-08-06	Herbizide 1,5-diphenyl-1h-1,2,4-triazol-3-carboxamidderivate.
DE68909873T2 (de)	1994-02-10	1,4-Dihydropyridin-Derivate.
DE69018816T2 (de)	1995-11-16	Aminosäurederivate.
DE58903154D1 (de)	1993-02-11	2,2-difluorcyclopropyl-derivate.
NO880088D0 (no)	1988-01-11	2,1-benzotiazepin-2,2-dioksyd-5-karboksylsyrederivater.
DE3860187D1 (de)	1990-07-05	3,4-dihydro-2h-pyrane.
DE3874027D1 (de)	1992-10-01	1,3-dithiol-2-yliden-derivate.
DE3780162T2 (de)	1992-12-24	Heribizide 4,5-dihydro-1h-1,2,4-triazol-3-carboxamid-derivate.
ATE102207T1 (de)	1994-03-15	1,1-dioxo-cephem-4-carbothiolsaeure-derivate.
DE69013332T2 (de)	1995-03-23	N-(3',4'-dimethoxyzimtsäure)anthranilsäure.