DE3888357T2 - Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. - Google Patents

Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.

Info

Publication number
DE3888357T2
DE3888357T2 DE3888357T DE3888357T DE3888357T2 DE 3888357 T2 DE3888357 T2 DE 3888357T2 DE 3888357 T DE3888357 T DE 3888357T DE 3888357 T DE3888357 T DE 3888357T DE 3888357 T2 DE3888357 T2 DE 3888357T2
Authority
DE
Germany
Prior art keywords
carry
amino acid
modified amino
cyclosporin derivatives
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3888357T
Other languages
English (en)
Other versions
DE3888357D1 (de
Inventor
Arthur A Patchett
Raymond F White
Robert T Goegelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE3888357D1 publication Critical patent/DE3888357D1/de
Application granted granted Critical
Publication of DE3888357T2 publication Critical patent/DE3888357T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE3888357T 1987-06-22 1988-12-12 Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. Expired - Fee Related DE3888357T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6467487A 1987-06-22 1987-06-22
EP88202845A EP0373260B1 (de) 1987-06-22 1988-12-12 Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen
US31126789A 1989-02-16 1989-02-16
US63078690A 1990-12-21 1990-12-21
US80921391A 1991-12-16 1991-12-16

Publications (2)

Publication Number Publication Date
DE3888357D1 DE3888357D1 (de) 1994-04-14
DE3888357T2 true DE3888357T2 (de) 1994-09-15

Family

ID=39710817

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3888357T Expired - Fee Related DE3888357T2 (de) 1987-06-22 1988-12-12 Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.

Country Status (3)

Country Link
US (1) US5318901A (de)
EP (1) EP0373260B1 (de)
DE (1) DE3888357T2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69124459T3 (de) * 1990-11-02 2001-05-31 Novartis Ag Zyklosporine
CA2055813A1 (en) * 1990-11-20 1992-05-21 Dariush Davalian Cyclosporin immunoassay
JP3696884B2 (ja) * 1994-03-25 2005-09-21 アイソテクニカ、インコーポレーテッド ジュウテリウム化による薬物の効能の増強
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
KR0126610B1 (ko) * 1994-10-18 1997-12-29 김충환 고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
BR9811716A (pt) 1997-10-08 2000-07-18 Isotechnika Inc Análogos de ciclosporina deuterados e o seu emprego como agentes de modulação imunológica
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ES2266564T3 (es) 2001-10-19 2007-03-01 Isotechnika Inc. Sintesis de analogos de cicloporinas.
KR100512019B1 (ko) * 2002-07-25 2005-09-02 신득용 사이클로스포린 ａ 또는 이의 유도체를 이용한 세포의노화를 억제하는 방법 및 배양배지
KR100641295B1 (ko) * 2002-11-11 2006-10-31 김성수 사이클로필린의 항산화제로서의 용도 및 사이클로필린의과발현에 의해 세포이식에서 사이클로스포린 ａ에 의해유발되는 세포독성의 방지
AU2004222306A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
WO2006039163A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
US7361636B2 (en) * 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
SI2651965T1 (sl) 2010-12-15 2019-03-29 Contravir Pharmaceuticals, Inc. Analogne molekule ciklosporina, modificirane pri aminokislini 1 v 3
EP2705856A1 (de) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Verbindungen zur Behandlung von neurodegenerativen Erkrankungen

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
CH614931A5 (de) * 1975-11-04 1979-12-28 Sandoz Ag
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4102877A (en) * 1976-07-28 1978-07-25 Merck & Co., Inc. Cyclization of peptides
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0056782B1 (de) * 1981-01-09 1984-08-01 Sandoz Ag Cyclosporine
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
EP0188400B1 (de) * 1985-01-16 1992-07-08 Ciba-Geigy Ag Oligopeptide sowie Zwischenprodukte und Verfahren zu ihrer Herstellung
EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
GB2206119B (en) * 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"

Also Published As

Publication number Publication date
EP0373260A1 (de) 1990-06-20
EP0373260B1 (de) 1994-03-09
US5318901A (en) 1994-06-07
DE3888357D1 (de) 1994-04-14

Similar Documents

Publication Publication Date Title
DE3888357T2 (de) Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
DE68915207D1 (de) Aminosäure-Derivate.
DE68914619T2 (de) Verabreichungssystem für eine zusammensetzung.
NO901399D0 (no) Aminosyrederivater.
NO901033L (no) Aminosyrederivater.
NO884434D0 (no) Aminosyrederivater.
NO884333D0 (no) 1,4-dihydropyridiner.
DE68913498T2 (de) 1,1-dioxo-cephem-4-carbothiolsäure-derivate.
DE3887281D1 (de) 1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
FI881829A0 (fi) 1,3-dioxaner.
FI880552A0 (fi) Substituerade 2,6-substituerade pyridinfoereningar.
NO892728D0 (no) Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler.
DE3886959T2 (de) 1,2-Propandiolderivate.
DE3888097D1 (de) 1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
DE3780156D1 (de) Herbizide 1,5-diphenyl-1h-1,2,4-triazol-3-carboxamidderivate.
DE68909873D1 (de) 1,4-Dihydropyridin-Derivate.
DE69018816T2 (de) Aminosäurederivate.
NO880088D0 (no) 2,1-benzotiazepin-2,2-dioksyd-5-karboksylsyrederivater.
ES2015605B3 (es) 3,4-dihidro-2h-piranos.
NO901519L (no) Aminosyrederivater.
DE3874027D1 (de) 1,3-dithiol-2-yliden-derivate.
DE3780162D1 (de) Heribizide 4,5-dihydro-1h-1,2,4-triazol-3-carboxamid-derivate.
ATE102207T1 (de) 1,1-dioxo-cephem-4-carbothiolsaeure-derivate.
DE69013332T2 (de) N-(3',4'-dimethoxyzimtsäure)anthranilsäure.
ATE70830T1 (de) 1,5-diphenylpyrazol-3-carbonsaeurederivate zum schuetzen von kulturpflanzen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee