DE4319612A1 - Arrangement for metering CO2 gas for subcutaneous injection for therapeutic purposes - Google Patents

Arrangement for metering CO2 gas for subcutaneous injection for therapeutic purposes

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Publication number
DE4319612A1
DE4319612A1 DE19934319612 DE4319612A DE4319612A1 DE 4319612 A1 DE4319612 A1 DE 4319612A1 DE 19934319612 DE19934319612 DE 19934319612 DE 4319612 A DE4319612 A DE 4319612A DE 4319612 A1 DE4319612 A1 DE 4319612A1
Authority
DE
Germany
Prior art keywords
gas
arrangement according
metering
piston
arrangement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19934319612
Other languages
German (de)
Inventor
Frank Dipl Ing Beyer
Siegmar Dr Ing Hecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wincor Nixdorf International GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19934319612 priority Critical patent/DE4319612A1/en
Publication of DE4319612A1 publication Critical patent/DE4319612A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A61M13/003—Blowing gases other than for carrying powders, e.g. for inflating, dilating or rinsing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M2005/006—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for gases, e.g. CO2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/204—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31536—Blocking means to immobilize a selected dose, e.g. to administer equal doses
    • A61M5/31538—Permanent blocking, e.g. by medical personnel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted

Abstract

The invention is based on the object of providing an arrangement with which CO2 can be metered for subcutaneous injection for CO2 source gas therapy. An arrangement according to Fig. 1 is proposed for metering CO2 gas. By means of this arrangement metering of a constant amount of gas takes place independently of the internal pressure prevailing in the tissues of the patient. Metering is effected via a cylinder (1) whose two ends are connected by tube couplings (3, 4) to the outlets (11, 12) of the two valves (5, 6) which are controlled in alternate directions, the gas flowing in through the inlet (13) displacing the movable piston (2) and hence ejecting the escaping volume of gas through the outlet (16). The invention relates to the field of medical technology. It is intended for therapy of pain of the locomotor system, neck pain, migraine-like headaches and other reflex headaches, for relaxation of muscular tension and partially in rheumatoid disorders. It is employed in sanatoriums, therapy centres and medical practices. <IMAGE>

Description

Die Erfindung betrifft das Gebiet der Medizintechnik. Sie dient der Therapie von Schmerzen am Bewegungsapparat, Nackenschmerzen, migräneartigen Kopfschmerzen und anderweitiger reflektorisch bedingter Kopfschmerzen, zur Lockerung von Muskelverspannungen und teilweise bei rheumatischen Erkrankungen. Der Einsatz erfolgt in Kureinrichtungen, Therapiezentren und Arztpraxen.The invention relates to the field of medical technology. It is used to treat pain on the musculoskeletal system, neck pain, migraine-like headache and otherwise headache caused by reflex, to relax muscle tension and partly with rheumatic diseases. They are used in spa facilities, Therapy centers and medical practices.

Zur Dosierung von CO₂-Gas sind mechanisch gesteuerte Dosiersysteme bekannt, bei denen sich ein definiertes Gasvolumen von einem Überdruck pÜ auf den Gewebeinnendruck pG des Patienten entspannt. Da der Gewebeinnendruck des Patienten, in Abhängigkeit von Lebensalter, Gesundheitszustand u. a. Faktoren, großen Schwankungen unterliegt, kann nicht garantiert werden, daß die jeweils notwendige Gasmenge in den Körper gebracht wird. Die im Dosiervolumen verbliebene Gasmenge mit dem im Körper vorherrschenden Gewebeinnendruck kann dem Patienten nicht weiter zugeführt werden. Dies hat zur Folge, daß der Therapeut die Anzahl der Injektionen nicht jedoch die injizierte Gasmenge bestimmen kann. Mit dem erneuten Füllen der Dosiereinrichtung für eine weitere Injektion ist bei bekannten Verfahren eine hohe Wiederholzeit notwendig. Funktionsbedingte Überdosierungen sind möglich. Die Nachteile bekannter Systeme liegen in der geringen Flexibilität und geringen Komplexität der Steuerungs- und Regelungstechnik ohne Einbeziehung von elektronischen Steuerungen.Mechanically controlled metering systems are known for metering CO₂ gas, in which a defined gas volume relaxes from an overpressure p Ü to the patient's internal tissue pressure p G. Since the internal tissue pressure of the patient is subject to large fluctuations depending on age, health condition and other factors, it cannot be guaranteed that the required amount of gas will be brought into the body. The amount of gas remaining in the dosing volume with the internal tissue pressure prevailing in the body can no longer be supplied to the patient. As a result, the therapist cannot determine the number of injections but the amount of gas injected. With the refilling of the metering device for a further injection, a long repetition time is necessary in known methods. Functional overdoses are possible. The disadvantages of known systems lie in the low flexibility and low complexity of the control and regulation technology without the inclusion of electronic controls.

Aus der DE-OS 38 42 852 A1 ist eine Dosiereinrichtung zur CO₂-Gas-Insufflation mit den vorgenannten Nachteilen bekannt.From DE-OS 38 42 852 A1 is a metering device for CO₂ gas insufflation with known disadvantages.

Nach der Kenntnis des Standes der Technik ist es die Aufgabe der vorliegenden Erfindung ein Gerät zur Insufflation von CO₂-Gas zu entwickeln, bei dem eine Dosierung des Gases unabhängig vom Gewebeinnendruck des Patienten erfolgt. Dies wird mit dem unter Anspruch 1 beschriebenen Gerät gelöst. Optional werden weitere Verbesserungen der Eigenschaften (Verhinderung einer Überdosierung, Automatikmodus, . . . ) durch die Unteransprüche 2 bis 8 bewirkt. Die Erfindung soll im folgenden näher beschrieben werden.According to the knowledge of the prior art, it is the object of the present invention to develop a device for insufflation of CO₂ gas, in which a metering of the gas regardless of the patient's internal tissue pressure. This is claimed under the 1 described device solved. Further improvements to the properties are optional (Prevention of overdosing, automatic mode,...) By subclaims 2 to 8 causes. The invention will be described in more detail below.

Nach dem Öffnen des Flaschenventils der CO₂-Druckgasflasche und dem Einstellen des Arbeitsdruckes von 0.14 MPa an der Wartungseinheit mit Druckminderventil strömt das CO₂-Gas durch einen Bakterienfilter über eine Schlauchverbindung zum Magnetventil (5) und von dort über die Schlauchverbindung (3) zum Zylinder (1). Dadurch, daß der Arbeitsdruck höher als der Gewebeinnendruck des Menschen ist, füllt sich das Vorratsvolumen (17) mit CO₂-Gas und schiebt dabei den Kolben (2) in die Endstellung (15), wobei das Gasvolumen (18) über die Schlauchverbindung (4) durch das Magnetventil (6) sowie eine weitere Schlauchverbindung über die Injektionskanüle in die Gewebeschichten des Patienten gelangt. Der Infusionsvorgang ist beendet wenn der Zylinder die Endstellung (15) erreicht hat, welches optisch und/oder akustisch signalisiert wird. Durch einen Auslöseimpuls des Arztes über den Taster (9) wird ein Signal über die Steuerleitung (9a) an die Auswerteeinheit weitergegeben. Diese veranlaßt die beiden Magnetventile (5, 6) umzusteuern, so daß das CO₂-Gas aus der Druckgasflasche durch das Magnetventil (6) über die Schlauchverbindung (4) in den Zylinder (1) gedrückt wird und somit den Kolben (2) in Richtung der Endstellung (14) bewegt. Das CO₂-Gas wird nun aus dem Vorratsvolumen (17) über die Schlauchverbindung (3), das Magnetventil (5) über die Injektionskanüle in das Gewebe des Patienten gedrückt. Durch erneutes Auslösen des Tasters (9) kann der Vorgang sooft wiederholt werden, bis die erforderliche Dosiermenge für den Patienten erreicht ist. Eine Sperre in der Steuerung verhindert eine Überdosierung mit CO₂-Gas derart, daß bei Erreichen einer intern festgelegten Anzahl von Kolbenhüben nmax bzw. einer vom Arzt festgelegten Anzahl von notwendigen Kolbenhüben n < nmax der Dosiervorgang abgebrochen wird, indem ein erneutes Drücken des Tasters (9) von der Ansteuereinheit ignoriert wird. Diese Sperre wird erst durch Betätigung von Tasten im Bedienfeld des Gerätes wieder aufgehoben, um eine weitere Insufflation durchführen zu können. Eine weitere Verbesserung der Anordnung erreicht man, wenn die beiden 3/2-Magnetventile (5, 6) durch ein 5/3- Magnetventil ersetzt wird. Dies hat den Vorteil, daß sich bei einer eventuellen Unterbrechung der Stromzufuhr ein definierter Zustand des Magnetventils einstellt und somit keine Gefährdung des Patienten auftritt. Der Vorteil dieser Anordnung gegenüber bekannten CO₂- Dosiereinrichtungen besteht darin, daß mit jedem Kolbenhub, unabhängig vom Gewebeinnendruck des Patienten, die gleiche Gasmenge in die Gewebeschichten des Patienten insuffliert wird.After opening the cylinder valve of the CO₂ compressed gas bottle and setting the working pressure of 0.14 MPa on the maintenance unit with pressure reducing valve, the CO₂ gas flows through a bacterial filter via a hose connection to the solenoid valve ( 5 ) and from there via the hose connection ( 3 ) to the cylinder ( 1 ). The fact that the working pressure is higher than the internal tissue pressure of the person fills the storage volume ( 17 ) with CO₂ gas and pushes the piston ( 2 ) into the end position ( 15 ), the gas volume ( 18 ) via the hose connection ( 4 ) through the solenoid valve ( 6 ) and another hose connection via the injection cannula into the patient's tissue layers. The infusion process ends when the cylinder has reached the end position ( 15 ), which is signaled optically and / or acoustically. A trigger pulse from the doctor via the button ( 9 ) transmits a signal to the evaluation unit via the control line ( 9 a). This causes the two solenoid valves ( 5 , 6 ) to change over so that the CO₂ gas from the compressed gas bottle is pressed through the solenoid valve ( 6 ) via the hose connection ( 4 ) into the cylinder ( 1 ) and thus the piston ( 2 ) in the direction the end position ( 14 ) moves. The CO₂ gas is now pressed from the supply volume ( 17 ) via the hose connection ( 3 ), the solenoid valve ( 5 ) via the injection cannula into the patient's tissue. By pressing the button ( 9 ) again, the process can be repeated until the required dosage for the patient is reached. A lock in the control prevents overdosing with CO₂ gas in such a way that when an internally determined number of piston strokes n max or a number of necessary piston strokes n <n max determined by the doctor, the dosing process is interrupted by pressing the button again ( 9 ) is ignored by the control unit. This lock is only released again by pressing buttons in the control panel of the device in order to be able to carry out another insufflation. A further improvement of the arrangement can be achieved if the two 3/2 solenoid valves ( 5 , 6 ) are replaced by a 5/3 solenoid valve. This has the advantage that, if the power supply is interrupted, a defined state of the solenoid valve is set and thus there is no danger to the patient. The advantage of this arrangement over known CO₂ metering devices is that with each piston stroke, regardless of the patient's internal tissue pressure, the same amount of gas is insufflated into the patient's tissue layers.

Claims (8)

1. Anordnung zur Dosierung von CO₂-Gas zur subkutanen Injektion, mit einem CO₂- Speicher, Armaturen, Filter und Griffstück zur Aufnahme der Injektionskanüle, dadurch gekennzeichnet, daß ein Zylinder (1), dessen beide Enden durch Verbindungsschläuche (3, 4) mit den Ausgängen (11, 12) der beiden wechselsinnig angesteuerten 3/2-Magnetventile (5, 6) verbunden sind wobei das durch den Eingang (13) einströmende Gas den beweglichen Kolben (2) aus der Ausgangsstellung (14) in die Endstellung (15) schiebt und damit das entweichende Gasvolumen V₁ (18) über den Ablaß (16) ausstößt und bei Umsteuerung der Ventile den Kolben in die Stellung (14) drückt und dabei das Gasvolumen V₂ (17) über den Ablaß (16) ausstößt und damit eine definierte Gasmenge in den Körper des Patienten einbringt.1. Arrangement for metering CO₂ gas for subcutaneous injection, with a CO₂ memory, fittings, filter and handle for receiving the injection cannula, characterized in that a cylinder ( 1 ), the two ends of which are connected by connecting tubes ( 3 , 4 ) the outputs ( 11 , 12 ) of the two alternately controlled 3/2-way solenoid valves ( 5 , 6 ) are connected, the gas flowing in through the inlet ( 13 ) moving the movable piston ( 2 ) from the initial position ( 14 ) to the end position ( 15 ) pushes and thus the escaping gas volume V₁ ( 18 ) through the outlet ( 16 ) and pushes the piston into position ( 14 ) when the valves are reversed, thereby expelling the gas volume V₂ ( 17 ) through the outlet ( 16 ) and thus one introduces a defined amount of gas into the patient's body. 2. Anordnung nach Anspruch 1, dadurch gekennzeichnet, daß die beiden 3/2-Magnet­ ventile durch ein 5/2- bzw. 5/3-Magnetventil ersetzt werden.2. Arrangement according to claim 1, characterized in that the two 3/2 magnet valves are replaced by a 5/2 or 5/3 solenoid valve. 3. Anordnung nach Anspruch 1, dadurch gekennzeichnet, daß zur Vermeidung einer Überdosierung die Maximalzahl nmax der Kolbenhübe je Patient durch eine elektronische Steuerung (8) begrenzt und optisch und akustisch das Erreichen der Maximalzahl signalisiert.3. Arrangement according to claim 1, characterized in that in order to avoid overdosing the maximum number n max of piston strokes per patient is limited by an electronic control ( 8 ) and signals the reaching of the maximum number optically and acoustically. 4. Anordnung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß die Anzahl der Kolbenhübe (n < nmax) je Patient über eine Steuerelektronik voreingestellt werden kann und bei Erreichen der vorgegebenen Anzahl den Dosiervorgang selbständig beendet. 4. Arrangement according to one of claims 1 to 3, characterized in that the number of piston strokes (n <n max ) per patient can be preset via control electronics and automatically stops the metering process when the predetermined number is reached. 5. Anordnung nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß im Automatikmodus eine bestimmte Anzahl von Kolbenhüben nach einem in der Steuerelektronik festgelegten Zeitregime die Dosierung durchgeführt wird.5. Arrangement according to one of claims 1 to 4, characterized in that in Automatic mode a certain number of piston strokes after one in the Control electronics specified time regime the dosing is carried out. 6. Anordnung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß der Kolben durch den Gasdruck an den Enden des Zylinders gegen Dichtungen (10) gedrückt wird.6. Arrangement according to one of claims 1 to 5, characterized in that the piston is pressed by the gas pressure at the ends of the cylinder against seals ( 10 ). 7. Anordnung nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, daß die Ansteuerung der Magnetventile über eine Steuerelektronik (8) mit elektrischem Auslösetaster (9) am Griffstück betrieben wird.7. Arrangement according to one of claims 1 to 6, characterized in that the control of the solenoid valves is operated via control electronics ( 8 ) with an electrical trigger button ( 9 ) on the handle. 8. Anordnung nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß die verwendeten Kolben (2) ohne Kolbenringe arbeiten.8. Arrangement according to one of claims 1 to 7, characterized in that the pistons used ( 2 ) work without piston rings.
DE19934319612 1993-06-14 1993-06-14 Arrangement for metering CO2 gas for subcutaneous injection for therapeutic purposes Withdrawn DE4319612A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19934319612 DE4319612A1 (en) 1993-06-14 1993-06-14 Arrangement for metering CO2 gas for subcutaneous injection for therapeutic purposes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19934319612 DE4319612A1 (en) 1993-06-14 1993-06-14 Arrangement for metering CO2 gas for subcutaneous injection for therapeutic purposes

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DE4319612A1 true DE4319612A1 (en) 1994-12-15

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7017573B1 (en) 1999-07-12 2006-03-28 Capnia, Incorporated Methods and apparatus for relieving headaches, rhinitis and other common ailments
WO2007034522A1 (en) * 2005-09-23 2007-03-29 Promoitalia Group Spa Apparatus for the simultaneous application of the carboxytherapy and the mesotherapy
WO2007072514A1 (en) * 2005-12-21 2007-06-28 Carbossiterapia Italiana S.R.L. Apparatus and method for subcutaneous gas delivery for therapeutic purpose
WO2007090253A1 (en) * 2006-02-08 2007-08-16 De Sa Roriz Paraguassu Electronic device for controlling the infusion of medical-grade carbon dioxide gas
US8096968B2 (en) 1999-11-08 2012-01-17 Capnia, Inc. Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
US8398580B2 (en) 1999-11-08 2013-03-19 Capnia, Inc. Methods and apparatus for treating rhinitis
IT201700075194A1 (en) * 2017-07-05 2019-01-05 Francesca Montanari Device for the application of carboxytherapy treatment in the dental field.

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7845348B2 (en) 1999-07-12 2010-12-07 Capnia, Inc. Methods for treating trigeminal neuralgia
US8763604B2 (en) 1999-07-12 2014-07-01 Capnia, Inc. Methods for treating allergy
US8464711B2 (en) 1999-07-12 2013-06-18 Capnia, Inc. Methods for treating headaches
US7017573B1 (en) 1999-07-12 2006-03-28 Capnia, Incorporated Methods and apparatus for relieving headaches, rhinitis and other common ailments
US7748379B2 (en) 1999-07-12 2010-07-06 Capnia, Inc. Methods and apparatus for relieving headaches, rhinitis and other common ailments
US7827986B2 (en) 1999-07-12 2010-11-09 Capnia, Inc. Methods for treating jaw pain
US7836883B2 (en) 1999-07-12 2010-11-23 Capnia, Inc. Methods for treating rhinitis and conjunctivitis
US7845347B2 (en) 1999-07-12 2010-12-07 Capnia, Inc. Methods for treating headaches
US8096968B2 (en) 1999-11-08 2012-01-17 Capnia, Inc. Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
US8398580B2 (en) 1999-11-08 2013-03-19 Capnia, Inc. Methods and apparatus for treating rhinitis
WO2007034522A1 (en) * 2005-09-23 2007-03-29 Promoitalia Group Spa Apparatus for the simultaneous application of the carboxytherapy and the mesotherapy
WO2007072514A1 (en) * 2005-12-21 2007-06-28 Carbossiterapia Italiana S.R.L. Apparatus and method for subcutaneous gas delivery for therapeutic purpose
WO2007090253A1 (en) * 2006-02-08 2007-08-16 De Sa Roriz Paraguassu Electronic device for controlling the infusion of medical-grade carbon dioxide gas
IT201700075194A1 (en) * 2017-07-05 2019-01-05 Francesca Montanari Device for the application of carboxytherapy treatment in the dental field.

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