DE4342568A1 - Chewing gum contg. caffeine - used as substitute for coffee, tea, cola, etc. and to control fatigue and migraine - Google Patents

Chewing gum contg. caffeine - used as substitute for coffee, tea, cola, etc. and to control fatigue and migraine

Info

Publication number
DE4342568A1
DE4342568A1 DE19934342568 DE4342568A DE4342568A1 DE 4342568 A1 DE4342568 A1 DE 4342568A1 DE 19934342568 DE19934342568 DE 19934342568 DE 4342568 A DE4342568 A DE 4342568A DE 4342568 A1 DE4342568 A1 DE 4342568A1
Authority
DE
Germany
Prior art keywords
caffeine
chewing gum
contg
gum
coffee
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19934342568
Other languages
German (de)
Inventor
Ralf-Peter Paul
Patricia Ring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAUL RALF PETER
Original Assignee
PAUL RALF PETER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAUL RALF PETER filed Critical PAUL RALF PETER
Priority to DE19934342568 priority Critical patent/DE4342568A1/en
Publication of DE4342568A1 publication Critical patent/DE4342568A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/126—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine

Abstract

Chewing gum contains 0.5-10 wt.% caffeine or caffeine-contg. substance dispersed in a chewing gum base opt. contg. other chewing gum ingredients. Weight ratio relates to pure caffeine and is based on the finished gum weight. USE/ADVANTAGE - The gum is a substitute for caffeine-contg. drinks (e.g. coffee, tea nd cola drinks) and pharmacy prods. (e.g. tablets) and may also be used to control fatigue and migraine. Caffeine content may conveniently correspond to that present in a cup of coffee (60-80 mg), i.e. individual units of gum weighting 2 g may suitably contain 60 mg caffeine. The gum is easy to handle and always available (e.g. can be chewed when driving), permits exact dosing, has no diuretic effect, is pleasant to taste and chew and releases caffeine gradually over an extended period.

Description

Die Erfindung betrifft eine Kaugummiware, die als Ersatzstoff für coffeinhaltige Getränke und Coffeintabletten geeignet ist. Sie besteht aus einer Kaugummigrundmasse, Coffein und gegebenenfalls weiteren üblichen Kaugummibestandteilen, dadurch gekennzeichnet, daß in der Kaugummigrundmasse dispergiert Coffein oder coffeinhaltige Substanzen enthalten sind. Die Menge des Coffeins, berechnet als Reinstoff und bezogen auf das Gewicht des Fertigproduktes beträgt hierbei 0,5 bis 10 Gew.-%.The invention relates to a chewing gum product, which is used as a substitute suitable for caffeinated drinks and caffeine tablets. It consists of a gum base, caffeine and optionally other usual chewing gum ingredients, characterized in that in the chewing gum base dispersed caffeine or caffeine-containing substances are. The amount of caffeine, calculated as pure substance and based on the weight of the finished product is in this case 0.5 to 10 wt .-%.

Coffein regt das Herz-Kreislaufsystem und das Zentral­ nervensystem an und wirkt dadurch Ermüdungszuständen entgegen. Coffein ist vor allem im Kaffee, Tee oder Cola-Getränken ent­ halten und wird auch in dieser Form am häufigsten konsumiert. Der Nachteil der flüssigen Coffeinaufnahme besteht einerseits darin, daß sie nicht immer möglich ist, z. B. während längerer Autofahrten, andererseits in der harntreibenden Wirkung, die auf der Flüssigkeitsaufnahme beruht und durch das Coffein ver­ stärkt wird, da dieses auch die Nierenfunktion anregt. Außerdem ist hier eine exakte Dosierung des Coffeins nicht möglich.Caffeine stimulates the cardiovascular system and the central nervous system and thereby counteract fatigue. Caffeine is mainly in coffee, tea or cola drinks ent keep and is consumed in this form most often. The disadvantage of liquid caffeine intake is on the one hand in that it is not always possible, for B. for a longer time Car journeys, on the other hand in the diuretic effect, the based on the fluid intake and ver through the caffeine strengthens, as it also stimulates kidney function. Moreover, here is an exact dosage of caffeine is not possible.

Bei coffeinhaltigen Pharmaerzeugnissen ist zwar eine exakte Dosierung des Coffeins möglich, jedoch ist diese Einnahmeform mit keinerlei Genuß verbunden, da hier das Geschmackserlebnis fehlt.For caffeine-containing pharmaceutical products is indeed an exact Dosage of caffeine possible, however, this form of administration not associated with any enjoyment, since here is the taste experience is missing.

Die Einnahme von Coffein durch Kauen von coffeinhaltiger Kaugummiware bietet im Vergleich zu den o.g. Möglichkeiten folgende Vorteile:The intake of caffeine by chewing caffeinated Chewing gum product offers compared to the o.g. possibilities the following advantages:

  • a) einfache Handhabung und ständige Verfügbarkeit (die Kaugummiware kann z. B. während einer Autofahrt gekaut werden)a) easy handling and constant availability (the Chewing gum can z. B. chewed during a drive)
  • b) exakte Dosierung möglichb) exact dosage possible
  • c) keine harntreibende Wirkungc) no diuretic effect
  • d) Geschmackserlebnis und Kaugenußd) Taste and kiss
  • e) länger anhaltende Wirkung des Coffeins, da dieses nicht auf einmal sondern nach und nach während des Kauvorganges freige­ setzt wird. Im Gegensatz hierzu sind beim Kaffeegenuß bereits nach 30 Minuten etwa 80% des Coffeins aus dem Magen-Darm-Trakt resorbiert. (Quelle: Broschüre "Kaffee Tee Kakao", 1989, herausgegeben vom AID).e) longer-lasting effect of caffeine, since this does not occur once but gradually released during the chewing process is set. In contrast, the coffee enjoyment already after 30 minutes about 80% of the caffeine from the gastrointestinal tract absorbed. (Source: brochure "Coffee Tea Cocoa", 1989, issued by the AID).

In Bezug auf die langsame Freisetzung des Coffeins während des Kauvorganges sei hier auf die deutsche Auslegeschrift 21 36 118 verwiesen. Diese Auslegeschrift beschreibt einen nikotinhaltigen Kaugummi als Rauchwarenersatz. Viele der dort gewonnenen Erkenntnisse lassen sich auch auf den coffeinhaltigen Kaugummi übertragen.Regarding the slow release of caffeine during the Kauvorganges here is the German Auslegeschrift 21 36 118 referenced. This excerpt describes one nicotine-containing chewing gum as a smoking substitute. Many of them there The insights gained can also be applied to the caffeine-containing chewing gum transferred.

Die o.g. Vorteile können erzielt werden, indem man Coffein in einer geeigneten Menge in eine Kaugummimasse einarbeitet. Die unterschiedlichen Typen von Kaugummigrundmasse, sowie die weiteren Kaugummibestandteile werden in der deutschen Auslegeschrift 21 36 118 ausführlich beschrieben.The o.g. Advantages can be achieved by adding caffeine in a suitable amount incorporated into a chewing gum mass. The different types of chewing gum base, as well as the further chewing gum ingredients are in German Auslegeschrift 21 36 118 described in detail.

Der Coffeingehalt eines Kaugummis könnte dem Coffeingehalt einer Tasse Kaffee entsprechen, die im Schnitt 60 bis 80 mg Coffein enthält.(Quelle: Broschüre "Kaffee Tee Kakao", 1989, AID). Bei handelsüblichen Kaugummiprodukten beträgt das Gewicht einer Kaugummieinheit normalerweise 1 bis 2 g. Da das Coffein einen sehr bitteren Eigengeschmack hat, sollte die Coffeinmenge im Vergleich zur Menge der Kaugummimasse nicht zu hoch sein.The caffeine content of a chewing gum could be the caffeine content a cup of coffee that averages 60 to 80 mg Contains caffeine (Source: brochure "Coffee Tea Cocoa", 1989, AID). For commercial chewing gum products this is Weight of a chewing gum unit usually 1 to 2 g. Since that Caffeine has a very bitter taste, should the Caffeine amount compared to the amount of chewing gum mass not too be high.

Durch Geschmackstests hat sich gezeigt, daß eine Coffeindosis von 60 mg pro 2 g Fertigprodukt sinnvoll ist. Daher bildet diese Dosierung die Grundlage für die im folgenden aufgeführten Rezepturen.Taste tests have shown that a Coffeindosis of 60 mg per 2 g of finished product makes sense. Therefore forms This dosage is the basis for the following listed recipes.

Beispiel 1 (Coffeinhaltige Kaugummiware mit Spearmint-Geschmack)Example 1 (caffeinated gum with spearmint flavor) KaugummigrundmasseChewing gum base 51,0 Gew.-%51.0% by weight Sorbitpulversorbitol 37,5 Gew.-%37.5% by weight Flüssigsüßstoffliquid sweetener 5,0 Gew.-%5.0% by weight Pyrogene KieselsäurePyrogenic silica 0,5 Gew.-%0.5% by weight Glyceringlycerin 1,0 Gew.-%1.0% by weight Spearmintölspearmint 2,0 Gew.-%2.0% by weight Coffeinpulver (wasserfrei)Caffeine powder (anhydrous) 3,0 Gew.-%3.0% by weight

Beispiel 2 (Coffeinhaltige Kaugummiware mit Zitronengeschmack)Example 2 (caffeinated chewing gum with lemon flavor) KaugummigrundmasseChewing gum base 50,0 Gew.-%50.0% by weight Sorbitpulversorbitol 35,5 Gew.-%35.5% by weight Flüssigsüßstoffliquid sweetener 5,0 Gew.-%5.0% by weight Pyrogene KieselsäurePyrogenic silica 0,5 Gew.-%0.5% by weight Glyceringlycerin 1,0 Gew.-%1.0% by weight Zitronenöllemon oil 2,0 Gew.-%2.0% by weight Ascorbinsäureascorbic acid 3,0 Gew.-%3.0% by weight Coffeinpulver (wasserfrei)Caffeine powder (anhydrous) 3,0 Gew.-%3.0% by weight

Als Kaugummigrundmasse kann im ersten Beispiel das Produkt "XYLGUM" und im zweiten Beispiel das Produkt "LEMERY T" der Gum Base Company S.P.A. verwendet werden. Als pyrogene Kieselsäure kann z. B. das Produkt HDK N 20 der Wacker-Chemie zum Einsatz kommen. Bei dem in den Rezepturen aufgeführten 5 Flüssigsüßstoff handelt es sich um eine handelsübliche Mischung aus 10 Teilen Cyclamat und 1 Teil Saccharin. Bei der Herstellung der erfindungsgemäßen Kaugummiware verfährt man folgendermaßen:As chewing gum base in the first example, the product "XYLGUM" and in the second example the product "LEMERY T" the Gum Base Company S.P.A. be used. As pyrogenic Silica may, for. For example, the HDK N 20 product from Wacker-Chemie be used. At the 5 listed in the recipes Liquid sweetener is a commercial Mixture of 10 parts of cyclamate and 1 part of saccharin. In the production of the chewing gum product according to the invention The procedure is as follows:

Alle pulverförmigen Bestandteile (Sorbitpulver, pyrogene Kieselsäure, Ascorbinsäure und Coffein) werden fein vermahlen und zu einer gleichmäßigen Mischung vermengt.All powdered ingredients (sorbitol powder, pyrogenic Silicic acid, ascorbic acid and caffeine) are finely ground and mixed to a uniform mixture.

Die Kaugummigrundmasse wird im Wasserbad geschmolzen und solange gerührt, bis keine Klumpen mehr vorhanden sind. Dann wird unter ständigem Rühren die Mischung der pulverförmigen Bestandteile und der Flüssigsüßstoff hinzugegeben. Schließlich werden die Aromaöle und das Glycerin eingegossen und verrührt.The chewing gum base is melted in a water bath and stirred until no lumps are left. Then is the mixture of powdery with constant stirring Added ingredients and the liquid sweetener. Finally, the aroma oils and the glycerin are poured and mulled.

Die so entstandene Kaugummimasse wird abgekühlt, ausgewalzt und so geschnitten, daß das Gewicht einer Kaugummieinheit 2 g beträgt.The resulting chewing gum mass is cooled, rolled and cut so that the weight of a chewing gum unit is 2 g is.

Claims (1)

Kaugummiware, die als Ersatzstoff für coffeinhaltige Getränke und coffeinhaltige Pharmaerzeugnisse geeignet ist, bestehend aus einer Kaugummmigrundmasse, Coffein und gegebenenfalls weiteren üblichen Kaugummibestandteilen, dadurch gekenn­ zeichnet, daß sie in der Kaugummigrundmasse dispergiert Coffein oder coffeinhaltige Substanzen enthält, wobei die Menge des Coffeins, berechnet als Reinstoff und bezogen auf das Gewicht des Fertigproduktes, 0,5 bis 10 Gew.-% beträgt.Chewing gum suitable as a substitute for caffeine-containing beverages and caffeine-containing pharmaceutical products consisting of a chewing gum base, caffeine and optionally other conventional chewing gum ingredients, characterized in that it contains caffeine or caffeine-containing substances dispersed in the chewing gum base, the amount of caffeine calculated as Pure substance and based on the weight of the finished product, 0.5 to 10 wt .-% is.
DE19934342568 1993-12-14 1993-12-14 Chewing gum contg. caffeine - used as substitute for coffee, tea, cola, etc. and to control fatigue and migraine Ceased DE4342568A1 (en)

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DE19934342568 DE4342568A1 (en) 1993-12-14 1993-12-14 Chewing gum contg. caffeine - used as substitute for coffee, tea, cola, etc. and to control fatigue and migraine

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DE19934342568 DE4342568A1 (en) 1993-12-14 1993-12-14 Chewing gum contg. caffeine - used as substitute for coffee, tea, cola, etc. and to control fatigue and migraine

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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0711116A1 (en) * 1993-06-23 1996-05-15 Wm. Wrigley Jr. Company Improved chewing gum and candy products
EP0969733A1 (en) * 1996-11-27 2000-01-12 Wm. Wrigley Jr. Company Method of controlling release of caffeine in chewing gum and gum produced thereby
US6165516A (en) * 1996-11-27 2000-12-26 Wm. Wrigley Jr. Company Method of controlling release of caffeine in chewing gum
US6322806B1 (en) 1999-04-06 2001-11-27 Wm. Wrigley Jr. Company Over-coated chewing gum formulations including tableted center
US6444241B1 (en) 2000-08-30 2002-09-03 Wm. Wrigley Jr. Company Caffeine coated chewing gum product and process of making
US6465003B2 (en) 1999-04-06 2002-10-15 Wm. Wrigley Jr. Company Over-coated chewing gum formulations
US6476042B1 (en) * 1999-06-30 2002-11-05 Pfizer Inc. Combination therapy for the treatment of migraine
US6531114B1 (en) 1999-04-06 2003-03-11 Wm. Wrigley Jr. Company Sildenafil citrate chewing gum formulations and methods of using the same
US6541048B2 (en) 1999-09-02 2003-04-01 Wm. Wrigley Jr. Company Coated chewing gum products containing an acid blocker and process of preparing
US6569472B1 (en) 2000-09-01 2003-05-27 Wm. Wrigley Jr. Company Coated chewing gum products containing antacid and method of making
US6572900B1 (en) 2000-06-09 2003-06-03 Wm. Wrigley, Jr. Company Method for making coated chewing gum products including a high-intensity sweetener
US6579545B2 (en) 2000-12-22 2003-06-17 Wm. Wrigley Jr. Company Coated chewing gum products containing an antigas agent
US6586023B1 (en) 1998-12-15 2003-07-01 Wm. Wrigley Jr. Company Process for controlling release of active agents from a chewing gum coating and product thereof
US6627234B1 (en) 1998-12-15 2003-09-30 Wm. Wrigley Jr. Company Method of producing active agent coated chewing gum products
US6645535B2 (en) 1999-09-02 2003-11-11 Wm. Wrigley Jr. Company Method of making coated chewing gum products containing various antacids
US6663849B1 (en) 2000-09-01 2003-12-16 Wm. Wrigley Jr. Company Antacid chewing gum products coated with high viscosity materials
US7078052B2 (en) 1999-04-06 2006-07-18 Wm. Wrigley Jr. Company Pharmaceutical chewing gum formulations
US7935362B2 (en) 1999-04-06 2011-05-03 Wm. Wrigley Jr. Company Over-coated product including consumable center and medicament

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3149419A1 (en) * 1980-12-15 1982-08-05 Gerhard Dr.-Ing. 1050 Wien Gergely CONFECTIONERY PRODUCT, ESPECIALLY CHEWING GUM, AND METHOD FOR THE PRODUCTION THEREOF
JPS5925646A (en) * 1982-07-30 1984-02-09 Lotte Co Ltd Chewing gum for preventing sleepiness
JPH03112450A (en) * 1989-09-24 1991-05-14 Masahiko Maeda Chewing gum for shaking off drowsiness
JPH03251533A (en) * 1990-02-27 1991-11-11 Lotte Co Ltd Chewing gum for preventing sleepiness
EP0472428A2 (en) * 1990-08-23 1992-02-26 Wm. Wrigley Jr. Company Low moisture chewing gum

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3149419A1 (en) * 1980-12-15 1982-08-05 Gerhard Dr.-Ing. 1050 Wien Gergely CONFECTIONERY PRODUCT, ESPECIALLY CHEWING GUM, AND METHOD FOR THE PRODUCTION THEREOF
JPS5925646A (en) * 1982-07-30 1984-02-09 Lotte Co Ltd Chewing gum for preventing sleepiness
JPH03112450A (en) * 1989-09-24 1991-05-14 Masahiko Maeda Chewing gum for shaking off drowsiness
JPH03251533A (en) * 1990-02-27 1991-11-11 Lotte Co Ltd Chewing gum for preventing sleepiness
EP0472428A2 (en) * 1990-08-23 1992-02-26 Wm. Wrigley Jr. Company Low moisture chewing gum

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0711116A4 (en) * 1993-06-23 1998-12-09 Wrigley W M Jun Co Improved chewing gum and candy products
EP0711116A1 (en) * 1993-06-23 1996-05-15 Wm. Wrigley Jr. Company Improved chewing gum and candy products
EP0969733A1 (en) * 1996-11-27 2000-01-12 Wm. Wrigley Jr. Company Method of controlling release of caffeine in chewing gum and gum produced thereby
EP0969733A4 (en) * 1996-11-27 2000-04-05 Wrigley W M Jun Co Method of controlling release of caffeine in chewing gum and gum produced thereby
US6165516A (en) * 1996-11-27 2000-12-26 Wm. Wrigley Jr. Company Method of controlling release of caffeine in chewing gum
US6586023B1 (en) 1998-12-15 2003-07-01 Wm. Wrigley Jr. Company Process for controlling release of active agents from a chewing gum coating and product thereof
US6627234B1 (en) 1998-12-15 2003-09-30 Wm. Wrigley Jr. Company Method of producing active agent coated chewing gum products
US6322806B1 (en) 1999-04-06 2001-11-27 Wm. Wrigley Jr. Company Over-coated chewing gum formulations including tableted center
US6465003B2 (en) 1999-04-06 2002-10-15 Wm. Wrigley Jr. Company Over-coated chewing gum formulations
US6531114B1 (en) 1999-04-06 2003-03-11 Wm. Wrigley Jr. Company Sildenafil citrate chewing gum formulations and methods of using the same
US7935362B2 (en) 1999-04-06 2011-05-03 Wm. Wrigley Jr. Company Over-coated product including consumable center and medicament
US6558692B2 (en) 1999-04-06 2003-05-06 Wm. Wrigley Jr. Company Over-coated chewing gum formulations
US7078052B2 (en) 1999-04-06 2006-07-18 Wm. Wrigley Jr. Company Pharmaceutical chewing gum formulations
US6476042B1 (en) * 1999-06-30 2002-11-05 Pfizer Inc. Combination therapy for the treatment of migraine
US6645535B2 (en) 1999-09-02 2003-11-11 Wm. Wrigley Jr. Company Method of making coated chewing gum products containing various antacids
US6541048B2 (en) 1999-09-02 2003-04-01 Wm. Wrigley Jr. Company Coated chewing gum products containing an acid blocker and process of preparing
US6572900B1 (en) 2000-06-09 2003-06-03 Wm. Wrigley, Jr. Company Method for making coated chewing gum products including a high-intensity sweetener
US6444241B1 (en) 2000-08-30 2002-09-03 Wm. Wrigley Jr. Company Caffeine coated chewing gum product and process of making
US6663849B1 (en) 2000-09-01 2003-12-16 Wm. Wrigley Jr. Company Antacid chewing gum products coated with high viscosity materials
US6569472B1 (en) 2000-09-01 2003-05-27 Wm. Wrigley Jr. Company Coated chewing gum products containing antacid and method of making
US6579545B2 (en) 2000-12-22 2003-06-17 Wm. Wrigley Jr. Company Coated chewing gum products containing an antigas agent

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