DE50013889D1 - Vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen - Google Patents
Vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellenInfo
- Publication number
- DE50013889D1 DE50013889D1 DE50013889T DE50013889T DE50013889D1 DE 50013889 D1 DE50013889 D1 DE 50013889D1 DE 50013889 T DE50013889 T DE 50013889T DE 50013889 T DE50013889 T DE 50013889T DE 50013889 D1 DE50013889 D1 DE 50013889D1
- Authority
- DE
- Germany
- Prior art keywords
- cell
- liquid environment
- membrane
- measuring cells
- negative pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE50013889T DE50013889D1 (de) | 1999-10-08 | 2000-09-12 | Vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19948473A DE19948473A1 (de) | 1999-10-08 | 1999-10-08 | Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen |
PCT/EP2000/008895 WO2001027614A1 (de) | 1999-10-08 | 2000-09-12 | Verfahren und vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen |
DE50013889T DE50013889D1 (de) | 1999-10-08 | 2000-09-12 | Vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen |
Publications (1)
Publication Number | Publication Date |
---|---|
DE50013889D1 true DE50013889D1 (de) | 2007-02-01 |
Family
ID=7924921
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19948473A Ceased DE19948473A1 (de) | 1999-10-08 | 1999-10-08 | Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen |
DE50013889T Expired - Lifetime DE50013889D1 (de) | 1999-10-08 | 2000-09-12 | Vorrichtung zum messen an in einer flüssigen umgebung befindlichen zellen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19948473A Ceased DE19948473A1 (de) | 1999-10-08 | 1999-10-08 | Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen |
Country Status (10)
Country | Link |
---|---|
US (1) | US6984297B2 (de) |
EP (1) | EP1218736B1 (de) |
JP (1) | JP2003511699A (de) |
AT (1) | ATE349008T1 (de) |
AU (1) | AU7419000A (de) |
DE (2) | DE19948473A1 (de) |
DK (1) | DK1218736T3 (de) |
ES (1) | ES2280241T3 (de) |
PT (1) | PT1218736E (de) |
WO (1) | WO2001027614A1 (de) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU9786798A (en) * | 1997-10-10 | 1999-05-03 | Biosepra Inc. | Aligned multiwell multiplate stack and method for processing biological/chemicalsamples using the same |
CA2316966C (en) | 1997-12-17 | 2008-04-08 | Horst Vogel | Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers |
US20020144905A1 (en) * | 1997-12-17 | 2002-10-10 | Christian Schmidt | Sample positioning and analysis system |
US7244349B2 (en) * | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
US6682649B1 (en) | 1999-10-01 | 2004-01-27 | Sophion Bioscience A/S | Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
FR2802078B1 (fr) * | 1999-12-14 | 2003-10-03 | Univ Joseph Fourier | Microelectrode support de cellules a membrane excitable |
GB9930719D0 (en) * | 1999-12-24 | 2000-02-16 | Central Research Lab Ltd | Apparatus for and method of making electrical measurements on an object in a m edium |
EP1278499A2 (de) | 2000-05-05 | 2003-01-29 | Hill-Rom Services, Inc. | Fernbedienung für ein krankenbett |
AU2001261198A1 (en) | 2000-05-05 | 2001-11-20 | Hill-Rom Services, Inc. | Patient point of care computer system |
DE10032568A1 (de) * | 2000-07-05 | 2002-01-24 | Nmi Univ Tuebingen | Vorrichtung und Verfahren zum elektrischen Kontaktieren von in einer Flüssigkeit in Suspension befindlichen biologischen Zellen |
IL153545A0 (en) * | 2000-07-07 | 2003-07-06 | Bristol Myers Squibb Co | Apparatus for measuring cellular electrical activity |
EP1178315A1 (de) * | 2000-07-31 | 2002-02-06 | Albrecht Dr.med. Priv.Doz. Lepple-Wienhues | Verfahren und Vorrichtung zur Untersuchung von Zellen mit Hilfe der Patch Clamp-Methode |
US7067046B2 (en) * | 2000-08-04 | 2006-06-27 | Essen Instruments, Inc. | System for rapid chemical activation in high-throughput electrophysiological measurements |
US6932893B2 (en) | 2000-10-02 | 2005-08-23 | Sophion Bioscience A/S | System for electrophysiological measurements |
CN100520407C (zh) * | 2000-10-02 | 2009-07-29 | 索菲昂生物科学有限公司 | 电生理测量系统 |
GB2401689B (en) * | 2000-10-11 | 2005-03-16 | Axon Instr Inc | Parallel electrode assembly and method of positioning cells for electrophysiological testing |
US6776896B1 (en) | 2000-10-11 | 2004-08-17 | Axon Instruments, Inc. | Method of positioning cells for electrophysiological testing |
KR20020086625A (ko) * | 2001-01-09 | 2002-11-18 | 마쯔시다덴기산교 가부시키가이샤 | 세포외 전위 측정용 디바이스, 그것을 사용한 세포외 전위측정 방법 및 그것을 구비한 고속 약품 스크리닝 장치 |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US20060029955A1 (en) | 2001-03-24 | 2006-02-09 | Antonio Guia | High-density ion transport measurement biochip devices and methods |
WO2002077259A2 (en) | 2001-03-24 | 2002-10-03 | Aviva Biosciences Corporation | Biochips including ion transport detecting structures and methods of use |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
EP1406086A4 (de) * | 2001-06-05 | 2007-10-31 | Matsushita Electric Ind Co Ltd | Signaldetektionssensor mit mehrfachelektrode |
EP3427834A1 (de) * | 2001-07-26 | 2019-01-16 | Handylab, Inc. | Verfahren und systeme zur mikrofluidischen verarbeitung |
EP1423500A4 (de) * | 2001-08-06 | 2008-07-16 | Univ Vanderbilt | Vorrichtung und verfahren zum nachweis der reaktion mehrerer zellen auf wenigstens einen interessierenden analyten |
DK1460415T3 (da) * | 2001-11-19 | 2011-04-26 | Panasonic Corp | Måleindretning til måling af et elektrisk signal, der afgives af en biologisk prøve |
US8003372B2 (en) * | 2002-02-05 | 2011-08-23 | The University Court Of The University Of Glasgow | Device for performing cell assays |
WO2003093494A2 (en) | 2002-05-04 | 2003-11-13 | Aviva Biosciences Corporation | Apparatus including ion transport detecting structures and methods of use |
AU2003234787A1 (en) * | 2002-05-13 | 2003-11-11 | Matsushita Electric Industrial Co., Ltd. | Instrument and method for measuring action signal of biological sample |
FR2839979B1 (fr) | 2002-05-21 | 2004-08-20 | Agronomique Inst Nat Rech | Dispositif de culture de cellules |
FR2839980B1 (fr) * | 2002-05-21 | 2004-08-20 | Agronomique Inst Nat Rech | Dispositif de culture de cellules |
JP4552423B2 (ja) * | 2003-11-21 | 2010-09-29 | パナソニック株式会社 | 細胞外電位測定デバイスおよびこれを用いた細胞外電位の測定方法 |
WO2007072790A1 (ja) | 2005-12-20 | 2007-06-28 | Matsushita Electric Industrial Co., Ltd. | 細胞電気生理センサ |
JP4449519B2 (ja) * | 2004-03-22 | 2010-04-14 | パナソニック株式会社 | 細胞外電位測定デバイスおよびその製造方法 |
US8202439B2 (en) | 2002-06-05 | 2012-06-19 | Panasonic Corporation | Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm |
CN100487456C (zh) | 2002-06-05 | 2009-05-13 | 松下电器产业株式会社 | 细胞外电位测量装置及其制造方法 |
US8257962B2 (en) | 2003-03-07 | 2012-09-04 | Panasonic Corporation | Extracellular potential measuring device and its manufacturing method |
JP4691407B2 (ja) * | 2005-06-29 | 2011-06-01 | パナソニック株式会社 | 細胞電位測定用容器 |
JP3945338B2 (ja) * | 2002-08-01 | 2007-07-18 | 松下電器産業株式会社 | 細胞外電位測定デバイスおよびその製造方法 |
JP3945317B2 (ja) * | 2002-06-05 | 2007-07-18 | 松下電器産業株式会社 | 細胞外電位測定デバイスおよびその製造方法 |
WO2007138902A1 (ja) * | 2006-05-25 | 2007-12-06 | Panasonic Corporation | 細胞電気生理センサ用チップとこれを用いた細胞電気生理センサおよび細胞電気生理センサ用チップの製造方法 |
JP4834335B2 (ja) * | 2005-06-29 | 2011-12-14 | パナソニック株式会社 | 細胞電位測定用容器 |
FR2844052B1 (fr) * | 2002-08-28 | 2005-07-01 | Commissariat Energie Atomique | Dispositif de mesure de l'activite electrique d'elements biologiques et ses applications |
DE10251767A1 (de) * | 2002-11-07 | 2004-05-27 | Forschungszentrum Jülich GmbH | Vorrichtung und Verfahren zur Messung elektrischer Vorgänge an biologischen Membranen |
US7321795B2 (en) * | 2003-03-24 | 2008-01-22 | Les Bogdanowicz | Compositions for electric stimulation of the eye |
WO2005001018A1 (ja) * | 2003-06-27 | 2005-01-06 | Matsushita Electric Industrial Co., Ltd. | 薬理測定装置およびシステム並びにそれに用いるウェル容器 |
EP2402089A1 (de) | 2003-07-31 | 2012-01-04 | Handylab, Inc. | Verarbeitung partikelhaltiger Proben |
US7399205B2 (en) | 2003-08-21 | 2008-07-15 | Hill-Rom Services, Inc. | Plug and receptacle having wired and wireless coupling |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US7319386B2 (en) | 2004-08-02 | 2008-01-15 | Hill-Rom Services, Inc. | Configurable system for alerting caregivers |
EP1783202B1 (de) * | 2004-08-25 | 2013-10-02 | Panasonic Corporation | Sonde zum messen des elektrischen potentials einer zelle |
JP2006184207A (ja) * | 2004-12-28 | 2006-07-13 | Matsushita Electric Ind Co Ltd | 細胞膜の特性および状態の少なくとも一方の電気的測定方法および電気的測定装置 |
EP1767929B1 (de) | 2005-06-07 | 2014-03-05 | Panasonic Corporation | Vorrichtung zum messen der elektrischen physiologie von zellen |
JP4821319B2 (ja) * | 2005-12-28 | 2011-11-24 | パナソニック株式会社 | 細胞電気生理センサアレイおよびその製造方法 |
JP2007218716A (ja) * | 2006-02-16 | 2007-08-30 | Matsushita Electric Ind Co Ltd | 細胞電気生理センサ |
EP2041478B1 (de) * | 2006-03-07 | 2014-08-06 | QD Vision, Inc. | Halbleiternanokristalle enthaltender artikel |
GB2436145A (en) * | 2006-03-16 | 2007-09-19 | Sophion Bioscience As | A system for monitoring properties of a single cell |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
JP5415253B2 (ja) | 2006-03-24 | 2014-02-12 | ハンディラブ・インコーポレーテッド | 微小流体サンプルを処理するための一体化システム及びその使用方法 |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
JP4582146B2 (ja) * | 2006-05-17 | 2010-11-17 | パナソニック株式会社 | 細胞電位測定デバイスとそれに用いる基板、細胞電位測定デバイス用基板の製造方法 |
WO2008004476A1 (fr) | 2006-07-06 | 2008-01-10 | Panasonic Corporation | Dispositif pour capteur cellulaire électrophysiologique, capteur cellulaire électrophysiologique utilisant le dispositif, et procédé de fabrication du dispositif pour capteur cellulaire électrophysiologique |
WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8836212B2 (en) * | 2007-01-11 | 2014-09-16 | Qd Vision, Inc. | Light emissive printed article printed with quantum dot ink |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
CA2693654C (en) | 2007-07-13 | 2018-02-13 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
JP5458887B2 (ja) | 2007-09-11 | 2014-04-02 | パナソニック株式会社 | シリコン構造体およびセンサチップ |
US8082160B2 (en) | 2007-10-26 | 2011-12-20 | Hill-Rom Services, Inc. | System and method for collection and communication of data from multiple patient care devices |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
EP2302375B1 (de) * | 2009-09-29 | 2012-09-12 | Karlsruher Institut für Technologie | Verfahren und Vorrichtung zum Erfassen der Stromspannungskurve einer Zelle |
WO2011068057A1 (ja) * | 2009-12-01 | 2011-06-09 | ニプロ株式会社 | 細胞電位測定容器及びその製造方法 |
JP5659698B2 (ja) * | 2010-10-29 | 2015-01-28 | ソニー株式会社 | 試料流入装置、試料流入チップ及び試料流入方法 |
CA3082652A1 (en) | 2011-04-15 | 2012-10-18 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
DK2761305T3 (da) | 2011-09-30 | 2017-11-20 | Becton Dickinson Co | Forenet reagensstrimmel |
EP2773892B1 (de) | 2011-11-04 | 2020-10-07 | Handylab, Inc. | Vorrichtung zur vorbereitung von polynukleotidproben |
RU2658773C2 (ru) | 2012-02-03 | 2018-06-22 | Бектон, Дикинсон Энд Компани | Система и способ выполнения автоматизированных тестов над множеством биологических проб |
CN104541104A (zh) | 2012-08-24 | 2015-04-22 | 阿尔斯通技术有限公司 | 利用稀释气体混合器的连续燃烧 |
CA2903481A1 (en) * | 2013-03-13 | 2014-10-09 | The University Of North Carolina At Chapel Hill | Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis |
CN105555945B (zh) * | 2013-08-30 | 2018-05-04 | 国立研究开发法人科学技术振兴机构 | 平面膜片钳装置以及平面膜片钳系统 |
KR20160113136A (ko) * | 2014-01-30 | 2016-09-28 | 나미키 세이미츠 호오세키 가부시키가이샤 | 세포막 관찰 및 해석 장치, 세포막 관찰 및 해석 방법 |
DE102014008606B3 (de) * | 2014-06-10 | 2015-08-27 | Universität Rostock | Elektrophysiologische Messanordnung und elektrophysiologisches Messverfahren |
JP2017518752A (ja) | 2014-06-12 | 2017-07-13 | ウエハージェン インコーポレイテッド | 捕捉用重合体膜を用いた単細胞捕捉 |
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DE102017130518B4 (de) * | 2017-12-19 | 2024-04-18 | ChanPharm GmbH | Messgerät, Messverfahren, Hochdurchsatz-Testgerät und Messkit für elektrophysiologische Messungen, insbesondere an Zellaggregaten |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2727316B2 (ja) * | 1986-09-12 | 1998-03-11 | 株式会社 アドバンス | 流体集積素子 |
JPH01141582A (ja) * | 1987-11-27 | 1989-06-02 | Shimadzu Corp | 遺伝子導入装置 |
JPH0687782B2 (ja) * | 1988-11-10 | 1994-11-09 | 浜松ホトニクス株式会社 | 細胞電気穿孔法およびその装置 |
US5262128A (en) * | 1989-10-23 | 1993-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Array-type multiple cell injector |
EP0627621B1 (de) * | 1993-06-04 | 1997-05-21 | AVL Medical Instruments AG | Einrichtung und Verfahren zur Untersuchung des Stoffwechsels von Zellen |
US5489515A (en) | 1993-12-09 | 1996-02-06 | Avl Medical Instruments Ag | Device for analyzing the metabolism of cells |
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DE19529371C3 (de) * | 1995-08-10 | 2003-05-28 | Nmi Univ Tuebingen | Mikroelektroden-Anordnung |
DE19646505A1 (de) * | 1996-11-12 | 1998-05-14 | Itt Ind Gmbh Deutsche | Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen |
DE19712309A1 (de) * | 1996-11-16 | 1998-05-20 | Nmi Univ Tuebingen | Mikroelementenanordnung, Verfahren zum Kontaktieren von in einer flüssigen Umgebung befindlichen Zellen und Verfahren zum Herstellen einer Mikroelementenanordnung |
EP0938674B1 (de) * | 1996-11-16 | 2005-06-01 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts | Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung |
DE19841337C1 (de) * | 1998-05-27 | 1999-09-23 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle |
DE19827957C2 (de) * | 1998-05-27 | 2000-06-29 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur Messung einer Zustandsgröße |
DE60025929T2 (de) * | 1999-10-01 | 2006-11-09 | Sophion Bioscience A/S | Anordnung und verfahren zum feststellen und/oder überwachen elektrophysiologischer eigenschaften von ionenkanälen |
-
1999
- 1999-10-08 DE DE19948473A patent/DE19948473A1/de not_active Ceased
-
2000
- 2000-09-12 EP EP00962475A patent/EP1218736B1/de not_active Expired - Lifetime
- 2000-09-12 JP JP2001530574A patent/JP2003511699A/ja active Pending
- 2000-09-12 AU AU74190/00A patent/AU7419000A/en not_active Abandoned
- 2000-09-12 WO PCT/EP2000/008895 patent/WO2001027614A1/de active IP Right Grant
- 2000-09-12 AT AT00962475T patent/ATE349008T1/de active
- 2000-09-12 ES ES00962475T patent/ES2280241T3/es not_active Expired - Lifetime
- 2000-09-12 PT PT00962475T patent/PT1218736E/pt unknown
- 2000-09-12 DE DE50013889T patent/DE50013889D1/de not_active Expired - Lifetime
- 2000-09-12 DK DK00962475T patent/DK1218736T3/da active
-
2002
- 2002-11-20 US US10/302,163 patent/US6984297B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT1218736E (pt) | 2007-04-30 |
AU7419000A (en) | 2001-04-23 |
US6984297B2 (en) | 2006-01-10 |
JP2003511699A (ja) | 2003-03-25 |
ES2280241T3 (es) | 2007-09-16 |
WO2001027614A1 (de) | 2001-04-19 |
EP1218736B1 (de) | 2006-12-20 |
EP1218736A1 (de) | 2002-07-03 |
US20030080314A1 (en) | 2003-05-01 |
DK1218736T3 (da) | 2007-03-05 |
ATE349008T1 (de) | 2007-01-15 |
DE19948473A1 (de) | 2001-04-12 |
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