DE50211485D1 - Verfahren zur Herstellung einer mRNA Tumorantigen Bibliothek - Google Patents
Verfahren zur Herstellung einer mRNA Tumorantigen BibliothekInfo
- Publication number
- DE50211485D1 DE50211485D1 DE50211485T DE50211485T DE50211485D1 DE 50211485 D1 DE50211485 D1 DE 50211485D1 DE 50211485 T DE50211485 T DE 50211485T DE 50211485 T DE50211485 T DE 50211485T DE 50211485 D1 DE50211485 D1 DE 50211485D1
- Authority
- DE
- Germany
- Prior art keywords
- preparing
- mrna
- tumor antigen
- producing
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 108020004999 messenger RNA Proteins 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- 230000035897 transcription Effects 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 108700020796 Oncogene Proteins 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000001086 cytosolic effect Effects 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10162480A DE10162480A1 (de) | 2001-12-19 | 2001-12-19 | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
PCT/EP2002/014577 WO2003051401A2 (de) | 2001-12-19 | 2002-12-19 | Stabilisierte mrna tumor-vakzine |
Publications (1)
Publication Number | Publication Date |
---|---|
DE50211485D1 true DE50211485D1 (de) | 2008-02-14 |
Family
ID=7709862
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10162480A Withdrawn DE10162480A1 (de) | 2001-12-19 | 2001-12-19 | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
DE50211485T Expired - Lifetime DE50211485D1 (de) | 2001-12-19 | 2002-12-19 | Verfahren zur Herstellung einer mRNA Tumorantigen Bibliothek |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10162480A Withdrawn DE10162480A1 (de) | 2001-12-19 | 2001-12-19 | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
Country Status (8)
Country | Link |
---|---|
US (9) | US8217016B2 (de) |
EP (4) | EP1905844A3 (de) |
AT (1) | ATE382712T1 (de) |
AU (1) | AU2002360055B2 (de) |
CA (1) | CA2473135C (de) |
DE (2) | DE10162480A1 (de) |
ES (1) | ES2298418T3 (de) |
WO (1) | WO2003051401A2 (de) |
Families Citing this family (225)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2340499T3 (es) | 2001-06-05 | 2010-06-04 | Curevac Gmbh | Arnm de antigeno tumoral estabilizado con un contenido de g/c aumentado. |
DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
JP4722481B2 (ja) | 2002-06-28 | 2011-07-13 | プロティバ バイオセラピューティクス リミテッド | リポソーム製造方法および装置 |
DE10229872A1 (de) | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
DE10335833A1 (de) * | 2003-08-05 | 2005-03-03 | Curevac Gmbh | Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie |
DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
JP2007538112A (ja) * | 2004-01-29 | 2007-12-27 | ピナクル ファーマシューティカルズ | β−シクロデキストリン誘導体およびそれらの炭疽致死毒に対する使用 |
GB0501125D0 (en) * | 2005-01-19 | 2005-02-23 | Ribostem Ltd | Method of genotypically modifying cells by administration of rna |
DE102004035227A1 (de) * | 2004-07-21 | 2006-02-16 | Curevac Gmbh | mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen |
DE102004042546A1 (de) | 2004-09-02 | 2006-03-09 | Curevac Gmbh | Kombinationstherapie zur Immunstimulation |
DE102005023170A1 (de) * | 2005-05-19 | 2006-11-23 | Curevac Gmbh | Optimierte Formulierung für mRNA |
LT2578685T (lt) | 2005-08-23 | 2019-06-10 | The Trustees Of The University Of Pennsylvania | Rnr, apimančios modifikuotus nukleozidus ir jų panaudojimo būdai |
DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
JP5564249B2 (ja) | 2006-06-23 | 2014-07-30 | アレシア・バイオセラピューティクス・インコーポレーテッド | 癌に関与するポリヌクレオチド配列およびポリペプチド配列 |
DE102006035618A1 (de) * | 2006-07-31 | 2008-02-07 | Curevac Gmbh | Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz |
JP2010507361A (ja) | 2006-07-31 | 2010-03-11 | キュアバック ゲーエムベーハー | 具体的には免疫刺激剤/アジュバントとしての、一般式(I):GlXmGn、または一般式(II):ClXmCnで表される核酸 |
DE102007001370A1 (de) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-kodierte Antikörper |
ES2926805T3 (es) * | 2007-01-31 | 2022-10-28 | Yeda Res & Dev | Linfocitos T reguladores redirigidos y modificados por ingeniería genética y su uso en la supresión de enfermedades autoinmunitarias e inflamatorias |
WO2009030254A1 (en) * | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
US20130108663A1 (en) * | 2007-09-14 | 2013-05-02 | Vrije Universiteit Brussel | Enhancing the t-cell stimulatory capacity of human antigen presenting cells in vitro and in vivo and their use in vaccination |
US9408909B2 (en) * | 2007-09-14 | 2016-08-09 | Vrije Universiteit Brussel | Enhancing the T-cell stimulatory capacity of human antigen presenting cells in vitro and in vivo and its use in vaccination |
WO2009046739A1 (en) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating prostate cancer (pca) |
SG188104A1 (en) | 2008-01-31 | 2013-03-28 | Curevac Gmbh | Nucleic acids comprising formula (nuglxmgnnv)a and derivatives thereof as an immunostimulating agents /adjuvants |
ES2872377T3 (es) * | 2008-05-26 | 2021-11-02 | Univ Zuerich | Nanopartículas de protamina/ARN para inmunoestimulación |
CN102076354A (zh) * | 2008-07-03 | 2011-05-25 | 杜克大学 | 用于引发免疫应答的组合物和方法 |
WO2010037408A1 (en) * | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
WO2010060186A1 (en) | 2008-11-03 | 2010-06-03 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
PT2506857T (pt) | 2009-12-01 | 2018-05-14 | Translate Bio Inc | Entrega de arnm para o acréscimo de proteínas e enzimas em doenças genéticas humanas |
WO2011069529A1 (en) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
BR112013002298A2 (pt) | 2010-07-30 | 2016-05-24 | Curevac Gmbh | complexação de ácidos nucleicos com componentes catiônicos reticulados com dissulfeto para transfecção e estimulação imunológica. |
WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
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PT2633034T (pt) * | 2010-10-26 | 2018-03-05 | Univ Friedrich Alexander Er | Caminho de sinal nfkb-manipulado em células dendríticas |
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-
2001
- 2001-12-19 DE DE10162480A patent/DE10162480A1/de not_active Withdrawn
-
2002
- 2002-12-19 EP EP07015834A patent/EP1905844A3/de not_active Withdrawn
- 2002-12-19 AT AT02795235T patent/ATE382712T1/de active
- 2002-12-19 ES ES02795235T patent/ES2298418T3/es not_active Expired - Lifetime
- 2002-12-19 WO PCT/EP2002/014577 patent/WO2003051401A2/de active IP Right Grant
- 2002-12-19 CA CA2473135A patent/CA2473135C/en not_active Expired - Fee Related
- 2002-12-19 EP EP14001339.2A patent/EP2769733A1/de not_active Withdrawn
- 2002-12-19 DE DE50211485T patent/DE50211485D1/de not_active Expired - Lifetime
- 2002-12-19 AU AU2002360055A patent/AU2002360055B2/en not_active Ceased
- 2002-12-19 EP EP07013494A patent/EP1925317A1/de not_active Withdrawn
- 2002-12-19 EP EP02795235A patent/EP1458410B1/de not_active Expired - Lifetime
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2004
- 2004-06-18 US US10/870,110 patent/US8217016B2/en not_active Expired - Fee Related
-
2011
- 2011-05-12 US US13/106,548 patent/US20110311472A1/en not_active Abandoned
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2014
- 2014-07-08 US US14/325,850 patent/US9155788B2/en not_active Expired - Fee Related
-
2015
- 2015-08-31 US US14/840,305 patent/US9439956B2/en not_active Expired - Fee Related
- 2015-12-10 US US14/965,418 patent/US20160089425A1/en not_active Abandoned
- 2015-12-10 US US14/965,551 patent/US9433670B2/en not_active Expired - Lifetime
- 2015-12-10 US US14/965,613 patent/US9655955B2/en not_active Expired - Fee Related
- 2015-12-10 US US14/965,340 patent/US9463228B2/en not_active Expired - Fee Related
- 2015-12-10 US US14/965,485 patent/US9433669B2/en not_active Expired - Lifetime
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US8217016B2 (en) | 2012-07-10 |
AU2002360055B2 (en) | 2008-01-17 |
US20050059624A1 (en) | 2005-03-17 |
US9463228B2 (en) | 2016-10-11 |
DE10162480A1 (de) | 2003-08-07 |
EP1905844A3 (de) | 2008-04-09 |
EP1905844A2 (de) | 2008-04-02 |
US20160095911A1 (en) | 2016-04-07 |
US20160082092A1 (en) | 2016-03-24 |
CA2473135A1 (en) | 2003-06-26 |
EP1925317A1 (de) | 2008-05-28 |
US20160089425A1 (en) | 2016-03-31 |
US20160089426A1 (en) | 2016-03-31 |
US20110311472A1 (en) | 2011-12-22 |
US20150030633A1 (en) | 2015-01-29 |
ES2298418T3 (es) | 2008-05-16 |
EP2769733A1 (de) | 2014-08-27 |
WO2003051401A2 (de) | 2003-06-26 |
US9655955B2 (en) | 2017-05-23 |
EP1458410B1 (de) | 2008-01-02 |
US9433669B2 (en) | 2016-09-06 |
EP1458410A2 (de) | 2004-09-22 |
US9439956B2 (en) | 2016-09-13 |
US9433670B2 (en) | 2016-09-06 |
US9155788B2 (en) | 2015-10-13 |
ATE382712T1 (de) | 2008-01-15 |
US20160095912A1 (en) | 2016-04-07 |
AU2002360055A1 (en) | 2003-06-30 |
CA2473135C (en) | 2012-05-08 |
WO2003051401A3 (de) | 2003-12-18 |
US20160089424A1 (en) | 2016-03-31 |
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